keyword
https://read.qxmd.com/read/38534880/successful-bone-marrow-transplantation-in-a-patient-with-acute-myeloid-leukemia-developed-from-severe-congenital-neutropenia-using-modified-chemotherapy-and-conditioning-regimen-for-leukemia
#1
Risa Matsumura, Shinji Mochizuki, Yusuke Morishita, Hiroko Hayakawa, Shuhei Karakawa, Hiroshi Kawaguchi, Satoshi Okada, Nobuyuki Hyakuna, Masao Kobayashi
Severe congenital neutropenia (SCN) is characterized by chronic neutropenia with recurrent infections from early infancy and a predisposition to myelodysplastic syndrome/acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with SCN who develop myelodysplastic syndrome/AML. We report an 8-year-old girl with SCN carrying an ELANE mutation that had been refractory to granulocyte colony-stimulating factor. The patient experienced recurrent infections and then developed AML...
February 26, 2024: Hematology Reports
https://read.qxmd.com/read/38532120/nilotinib-induced-alterations-in-endothelial-cell-function-recapitulate-clinical-vascular-phenotypes-independent-of-abl1
#2
JOURNAL ARTICLE
Emily A Pinheiro, Jean-Marc DeKeyser, Brian Lenny, Yadav Sapkota, Paul W Burridge
Nilotinib is a highly effective treatment for chronic myeloid leukemia but has been consistently associated with the development of nilotinib-induced arterial disease (NAD) in a subset of patients. To date, which cell types mediate this effect and whether NAD results from on-target mechanisms is unknown. We utilized human induced pluripotent stem cells (hiPSCs) to generate endothelial cells and vascular smooth muscle cells for in vitro study of NAD. We found that nilotinib adversely affects endothelial proliferation and migration, in addition to increasing intracellular nitric oxide...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530748/htlv-in-sweden
#3
JOURNAL ARTICLE
Jan Vesterbacka, Anna-Karin Svensson, Piotr Nowak
Sweden is a country with a low prevalence of human lymphotropic T-cell virus (HTLV) infection, estimated at < 0.005%, but the infection rate is notably higher in specific risk groups such as HTLV-2 among intravenous drug users (IVDU) and people originating from HTLV-1 highly endemic areas. Thus, in the most recent study from 2012, the prevalence of HTLV-2 among IVDU in Stockholm was 3.2%. However, much of the epidemiological data on HTLV in Sweden stems from studies conducted primarily between the 1990s and 2007, and the impact of migration to Sweden during the past 15 years has not been evaluated...
2024: AIDS Reviews
https://read.qxmd.com/read/38530315/exclusive-breastfeeding-duration-and-risk-of-childhood-cancers
#4
JOURNAL ARTICLE
Signe Holst Søegaard, Mie Mølgaard Andersen, Klaus Rostgaard, Olafur Birgir Davidsson, Sjurdur Frodi Olsen, Kjeld Schmiegelow, Henrik Hjalgrim
IMPORTANCE: Breastfeeding has been suggested to protect against childhood cancers, particularly acute lymphoblastic leukemia (ALL). However, the evidence stems from case-control studies alone. OBJECTIVE: To investigate whether longer duration of exclusive breastfeeding is associated with decreased risk of childhood ALL and other childhood cancers. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study used administrative data on exclusive breastfeeding duration from the Danish National Child Health Register...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38528080/differential-prognostic-values-of-the-three-akt-isoforms-in-acute-myeloid-leukemia
#5
JOURNAL ARTICLE
Eulalie Corre, Cécile Soum, Romain Pfeifer, Chloé Bessière, Sandra Dailhau, Catherine Marbœuf, Fabienne Meggetto, Christian Touriol, Christian Récher, Marina Bousquet, Stéphane Pyronnet
The PI3K-AKT-mTOR pathway lies at the confluence of signaling pathways in which various components are subjected to activating genetic alterations in acute myeloid leukemia (AML), thus contributing to oncogenesis. Three AKT isoforms exist in humans. However, whether one isoform predominates in AML remains unknown. This study reveals that AKT3 behaves very distinctly than AKT1 or AKT2 in both normal myeloid differentiation and AML. During normal differentiation, AKT3 is preferentially expressed in hematopoietic stem cells whilst AKT1 becomes preferentially expressed as cells differentiate into granulocytes or monocytes...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527842/-safety-and-efficacy-of-donor-derived-chimeric-antigen-receptor-t-cell-therapy-in-patients-with-relapsed-b-cell-acute-lymphoblastic-leukemia-after-allogeneic-hematopoietic-stem-cell-transplantation
#6
JOURNAL ARTICLE
Y Q Zhuo, S F Tu, X Zhou, J L Yang, L J Zhou, R Huang, Y X Huang, M F Li, B Jin, B Wang, S Q Li, Z T Yuan, L H Zhang, L Liu, S B Wang, Y H Li
Objective: To investigated the safety and efficacy of donor-derived CD19+ or sequential CD19+ CD22+ chimeric antigen receptor T-cell (CAR-T) therapy in patients with B-cell acute lymphoblastic leukemia (B-ALL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: The data of 22 patients with B-ALL who relapsed after allo-HSCT and who underwent donor-derived CAR-T therapy at the Zhujiang Hospital of Southern Medical University and the 920th Hospital of Joint Logistics Support Force of the People's Liberation Army of China from September 2015 to December 2022 were retrospectively analyzed...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527837/-efficacy-and-prognostic-factors-of-allogeneic-hematopoietic-stem-cell-transplantation-in-the-treatment-of-secondary-acute-myeloid-leukemia
#7
MULTICENTER STUDY
X L Yuan, Y B Wu, X L Song, Y Chen, Y Lu, X Y Lai, J M Shi, L Z Liu, Y M Zhao, J Yu, L X Yang, J P Lan, Z Cai, H Huang, Y Luo
Objective: To evaluate the efficacy and prognostic factors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with secondary acute myeloid leukemia (sAML) . Methods: In this multicenter, retrospective clinical study, adult patients aged ≥18 years who underwent allo-HSCT for sAML at four centers of the Zhejiang Hematopoietic Stem Cell Transplantation Collaborative Group from January 2014 to November 2022 were included, and the efficacy and prognostic factors of allo-HSCT were analyzed...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527836/-efficacy-and-safety-of-chimeric-antigen-receptor-t-cell-therapy-followed-by-allogeneic-hematopoietic-stem-cell-transplantation-in-21-patients-with-ph-like-acute-lymphoblastic-leukemia
#8
JOURNAL ARTICLE
H P Dai, H J Shen, Z Li, W Cui, Q Y Cui, M Y Li, S F Chen, M Q Zhu, D P Wu, X W Tang
Objective: To evaluate the efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with Ph-like acute lymphoblastic leukemia (Ph-ALL) . Methods: Patients with Ph-ALL who underwent CAR-T therapy followed by allo-HSCT from March 2018 to August 2023 at the First Affiliated Hospital of Soochow University were included, and their clinical data were retrospectively analyzed. Results: Of the 21 patients, 14 were male and 7 were female...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527834/-clinical-features-and-risk-factors-for-invasive-fungal-sinusitis-after-allogeneic-hematopoietic-stem-cell-transplantation
#9
JOURNAL ARTICLE
H X Fu, J J Li, Y Y Zhang, Y Q Sun, X D Mo, T T Han, J Kong, M Lyu, W Han, H Chen, Y Y Chen, F R Wang, C H Yan, Y Chen, J Z Wang, Y Wang, L P Xu, X J Huang, X H Zhang
Objective: To analyze the clinical characteristics and outcomes of patients with invasive fungal sinusitis (invasive fungal rhinosinusitis, IFR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and explored the risk factors for IFR after allo-HSCT. Methods: Nineteen patients with IFR after allo-HSCT at Peking University People's Hospital from January 2012 to December 2021 were selected as the study group, and 95 patients without IFR after allo-HSCT during this period were randomly selected as the control group (1:5 ratio) ...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527833/-clinical-outcomes-of-allogeneic-hematopoietic-stem-cell-transplantation-for-chronic-myelomonocytic-leukemia
#10
JOURNAL ARTICLE
X H Zhang, J Y Zhou
Chronic myelomonocytic leukemia (CMML) is a clonal disease derived from bone marrow hematopoietic stem cells, with a poor prognosis. Allogeneic hematopoietic stem cell transplantation (allo- HSCT) is one of the curable methods for CMML. The outcome of patient transplantation is influenced by various factors such as disease characteristics and comorbidities. Based on the existing prognostic stratification system, screening suitable CMML patients for transplantation and early transplantation is beneficial for their long-term survival...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38525239/diverting-the-food-freezing-technology-improves-the-cryopreservation-efficiency-of-induced-pluripotent-stem-cells-and-derived-neurospheres
#11
JOURNAL ARTICLE
Kenzo Bamba, Midori Ozawa, Hiroaki Daitoku, Arihiro Kohara
INTRODUCTION: Recent advances in induced pluripotent stem (iPS) technology and regenerative medicine require effective cryopreservation of iPSC-derived differentiated cells and three-dimensional cell aggregates (eg. Spheroids and organoids). Moreover, innovative freezing technologies for keeping food fresh over the long-term rapidly developed in the food industry. Therefore, we examined whether one of such freezing technologies, called "Dynamic Effect Powerful Antioxidation Keeping (DEPAK)," could be effective for the cryopreservation of biological materials...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38523911/case-report-treatment-of-two-cases-of-recurrent-refractory-early-t-cell-precursor-acute-lymphoblastic-leukemia-with-venetoclax-combined-with-the-cag-regimen
#12
Yuxia Jiang, Lin Ji, Xin Jin, Haiying Wu, Mingxia He, Fenglin Shen, Xiaofeng Xu, Huifang Jiang
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a highly aggressive subtype of T-ALL. No standard chemotherapy regimen exists for patients with recurrent/refractory (R/R) ETP-ALL; in these patients, the primary goal of salvage therapy is to achieve remission as a foundation for consolidation and intensification treatments. This study reports cases of two patients with R/R ETP-ALL who underwent salvage therapy of venetoclax combined with the CAG regimen and achieved complete remission in the bone marrow...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38523628/cellular-abundance-based-prognostic-model-associated-with-deregulated-gene-expression-of-leukemic-stem-cells-in-acute-myeloid-leukemia
#13
JOURNAL ARTICLE
Dong-Jin Han, Sunmin Kim, Seo-Young Lee, Su Jung Kang, Youngbeen Moon, Hoon Seok Kim, Myungshin Kim, Tae-Min Kim
Background: Previous studies have reported that genes highly expressed in leukemic stem cells (LSC) may dictate the survival probability of patients and expression-based cellular deconvolution may be informative in forecasting prognosis. However, whether the prognosis of acute myeloid leukemia (AML) can be predicted using gene expression and deconvoluted cellular abundances is debatable. Methods: Nine different cell-type abundances of a training set composed of the AML samples of 422 patients, were used to build a model for predicting prognosis by least absolute shrinkage and selection operator Cox regression...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38522578/the-role-of-molecular-or-cytogenetic-response-as-a-favorable-prognostic-factor-before-hematopoietic-stem-cell-transplantation-for-chronic-myeloid-leukemia
#14
JOURNAL ARTICLE
Giuliana Rosendo de Oliveira Medeiros, Vaneuza Araújo Moreira Funke, Alberto Cardoso Martins Lima, Ana Lúcia Vieira Mion, Isabela Menezes, Daniela Carinhanha Setubal, Caroline Bonamin Dos Santos Sola, Gláucia Tagliari, Rafael Marchesini, Samir Kanaan Nabhan, Ricardo Pasquini
Tyrosine kinase inhibitors (TKIs) have revolutionized therapy for patients with chronic myeloid leukemia (CML) over the last two decades. However, some patients still do not achieve an adequate response to these drugs, and hematopoietic stem cell transplantation (HSCT) is indicated in this scenario. We present the results of a 20-year follow-up study of 70 patients who underwent transplantation after TKI failure. The primary objective of the study was to evaluate overall survival (OS) and the secondary objective was to evaluate the outcomes of relapse-free survival (RFS), GVHD-free, relapse-free survival (GFRS) and the incidences of relapse (RI), non-relapse mortality (NRM), acute and chronic GVHD...
March 22, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38520796/eltrombopag-treatment-in-thrombocytopenia-following-hematopoietic-stem-cell-transplantation-a-multicenter-real-world-experience
#15
JOURNAL ARTICLE
Ebru Kilic Gunes, Sureyya Yigit Kaya, Fatih Yaman, Mustafa Kemal Yeniay, Kurtulus Vural, Melda Comert, Omur Gokmen Sevindik, Neslihan Andic, Simten Dagdas, Ilknur Nizam Ozen, Leylagul Kaynar, Filiz Yavasoglu, Gulsum Ozet, Volkan Karakus, Meltem Ayli
INTRODUCTION: Thrombocytopenia is among the most common complications following hematopoietic stem cell transplantation and is associated with increased mortality and morbidity with no standard treatment yet. In this multicenter and retrospective study, we aim to present our multi-center experience of Eltrombopag treatment in patients with isolated thrombocytopenia following HSCT. MATERIAL-METHOD: A total of 73 patients from 5 centers who underwent autologous or allogeneic stem cell transplantation, had no primary disease relapse, all of whom had neutrophil engraftment, complete chimerism, and who were diagnosed with Prolonged Isolated Thrombocytopenia (PIT) or Secondary Failure Of Platelet Recovery (SFPR) were included in the study...
March 15, 2024: Leukemia Research
https://read.qxmd.com/read/38520720/significant-impact-of-antibiotic-exposure-on-gi-gvhd-nrm-and-grfs-following-allogeneic-hct-with-non-myeloablative-flu-tbi-conditioning
#16
JOURNAL ARTICLE
Lenneke F J van Groningen, Suzanne van Dorp, Manita E J Bremmers, Shahira Fazel, Mieke W H Roeven, Nicole M A Blijlevens, Walter J F M van der Velden
BACKGROUND: Acute gastro-intestinal graft- versus -host disease (GI-GVHD) and non-relapse mortality (NRM) after allogeneic HCT are closely related to loss of microbial diversity and intestinal dominance by single taxa resulting from the use of antibiotics, dietary changes, and mucosal barrier injury. There is a paucity of data on the impact of use of antibiotics in HCT after Flu-TBI-based non-myeloablative (NMA) conditioning where there is absence of mucositis and limited malnutrition...
March 23, 2024: Leukemia & Lymphoma
https://read.qxmd.com/read/38517548/secondary-solid-malignancies-and-precancerous-lesions-after-allogeneic-hematopoietic-stem-cell-transplantation-using-non-total-body-irradiation-based-conditioning-in-acute-myeloid-leukemia
#17
JOURNAL ARTICLE
Gruber Isabella, Appel Katharina, Edinger Matthias, Koelbl Oliver, Wolff Daniel
INTRODUCTION: Long-term survivors have an increased risk of developing secondary solid malignancies (SSMs) after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) with graft-versus-host disease (GVHD) potentially modulating these risks. METHODS: This retrospective study analyzed the cumulative incidences of SSMs after chemotherapy-based conditioning for allo-HSCT patients with acute myeloid leukemia (n = 266) transplanted at the University Hospital Regensburg between 1999 and 2016...
March 22, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38517058/computer-aided-drug-discovery-of-c-abl-kinase-inhibitors-from-plant-compounds-against-chronic-myeloid-leukemia
#18
JOURNAL ARTICLE
Mohammed M Alshehri, Neeraj Kumar, Najwa Ahmad Kuthi, Zainab Olaide, Mohammed Kanan Alshammari, Ridwan Opeyemi Bello, Mohammed Khalid Alghazwni, Ahmed Mughram Alshehri, Omaymah Mohammed Alshlali, Zainab Ashimiyu-Abdusalam, Haruna Isiyaku Umar
Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the neoplastic transformation of hematopoietic stem cells, driven by the Philadelphia (Ph) chromosome resulting from a translocation between chromosomes 9 and 22. This Ph chromosome harbors the breakpoint cluster region (BCR) and the Abelson (ABL) oncogene (BCR-ABL1) which have a constitutive tyrosine kinase activity. However, the tyrosine kinase activity of BCR-ABL1 have been identified as a key player in CML initiation and maintenance through c-Abl kinase...
March 22, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38515317/the-relationship-between-hematologic-malignancies-on-male-hypogonadism-a-scoping-review
#19
JOURNAL ARTICLE
Bradley Roth, Muhammed A Moukhtar Hammad, Daniel I Sanford, Molly Piper, David W Barham, Faysal A Yafi, Lawrence C Jenkins
INTRODUCTION: The associated symptoms of hypogonadism have been reported in patients with various types of cancer. However, the prevalence and significance of hypogonadism among certain hematologic malignancies have not been completely summarized in recent literature. OBJECTIVE: In this review we aimed to examine the current literature on hypogonadism in patients with hematologic malignancies, with emphasis on leukemias, lymphomas, and multiple myeloma (MM). METHODS: This review included relevant studies published before July 2023 that were retrieved through a search of PubMed using the keywords "hematologic cancer," "hematologic malignancy," blood cancer," "leukemia," "lymphoma," "hypogonadism," "multiple myeloma," and "testosterone...
March 21, 2024: Sexual Medicine Reviews
https://read.qxmd.com/read/38514887/an-immunophenotype-coupled-transcriptomic-atlas-of-human-hematopoietic-progenitors
#20
JOURNAL ARTICLE
Xuan Zhang, Baobao Song, Maximillian J Carlino, Guangyuan Li, Kyle Ferchen, Mi Chen, Evrett N Thompson, Bailee N Kain, Dan Schnell, Kairavee Thakkar, Michal Kouril, Kang Jin, Stuart B Hay, Sidharth Sen, David Bernardicius, Siyuan Ma, Sierra N Bennett, Josh Croteau, Ornella Salvatori, Melvin H Lye, Austin E Gillen, Craig T Jordan, Harinder Singh, Diane S Krause, Nathan Salomonis, H Leighton Grimes
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) enables coupled surface protein and transcriptome profiling, thereby revealing genomic programs underlying progenitor states. To perform CITE-seq systematically on primary human bone marrow cells, we used titrations with 266 CITE-seq antibodies (antibody-derived tags) and machine learning to optimize a panel of 132 antibodies...
March 21, 2024: Nature Immunology
keyword
keyword
21837
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.