Hayden J Selvadurai, Erika Luis, Kinjal Desai, Xiaoyang Lan, Maria C Vladoiu, Owen Whitley, Ciaran Galvin, Robert J Vanner, Lilian Lee, Heather Whetstone, Michelle Kushida, Tomasz Nowakowski, Phedias Diamandis, Cynthia Hawkins, Gary Bader, Arnold Kriegstein, Michael D Taylor, Peter B Dirks
Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2+ cells at the apex of tumor progression and relapse. To test whether this mechanism is rooted in a normal developmental process, we studied the role of Sox2 in cerebellar development. We find that the external germinal layer (EGL) is derived from embryonic Sox2+ precursors and that the EGL maintains a rare fraction of Sox2+ cells during the first postnatal week...
April 14, 2020: Cell Reports