Claire de Moreuil, Yesim Dargaud, Christophe Nougier, Pierre-François Dupré, Christophe Trémouilhac, Delphine Le Joliff, Sylvain Rosec, Sandy Lucier, Ingrid Pabinger, Cihan Ay, Francis Couturaud, Brigitte Pan-Petesch
BACKGROUND: Severe postpartum hemorrhage (PPH), defined as a blood loss ≥1000 mL, is associated with maternal morbidity and mortality. OBJECTIVES: We aimed at characterizing coagulation properties of predelivery plasmas from pregnant women with thrombin generation assay and hemostatic biomarkers (plasminogen activator inhibitor-1, tissue factor [TF], and thrombomodulin). METHODS: A nested case-control study was conducted within the "Study of Biological Determinants of Bleeding Postpartum," a French prospective cohort study, in order to compare women with severe PPH (cases) and controls matched for age, body mass index, term, and mode of delivery...
August 2, 2023: Journal of Thrombosis and Haemostasis: JTH