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https://www.readbyqxmd.com/read/28944681/chemical-characteristics-of-the-fungus-ganoderma-lucidum-and-their-inhibitory-effects-on-acetylcholinesterase
#1
Jiang-Chun Wei, An-Hua Wang, Yun-Long Wei, Xiao-Kui Huo, Xiang-Ge Tian, Lei Feng, Xiao-Chi Ma, Chao Wang, Shan-Shan Huang, Jing-Ming Jia
The chemical characteristic of a well-known folk medicine Ganoderma lucidum has been investigated by a series of chromatographic technologies, which displayed the presences of 45 lanostane type triterpenoids, including two new nor-lanostane triterpenoids (40, 41). Their structures were identified on the basis of spectroscopic data analysis (UV, IR, HRESIMS, 1D, and 2D NMR). Notably, some triterpenoids displayed moderate inhibitory effects against AChE (acetylcholinesterase) by an in vitro screened experiment...
September 25, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28944457/dietary-niche-variation-and-its-relationship-to-lizard-population-density
#2
Maria Novosolov, Gordon H Rodda, Alison M Gainsbury, Shai Meiri
(1) Insular species are predicted to broaden their niches, in response to having fewer competitors. They can thus exploit a greater proportion of the resource spectrum. In turn, broader niches are hypothesized to facilitate (or be a consequence of) increased population densities. (2) We tested whether insular lizards have broader dietary niches than mainland species, how it relates to competitor and predator richness, and the nature of the relationship between population density and dietary niche breadth. (3) We collected population density and dietary niche breadth data for 36 insular and 59 mainland lizard species, and estimated competitor and predator richness at the localities where diet data were collected...
September 25, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28944273/defining-the-determinants-of-endurance-running-performance-in-the-heat
#3
Carl A James, Mark Hayes, Ashley G B Willmott, Oliver R Gibson, Andreas D Flouris, Zachary J Schlader, Neil S Maxwell
In cool conditions, physiologic markers accurately predict endurance performance, but it is unclear whether thermal strain and perceived thermal strain modify the strength of these relationships. This study examined the relationships between traditional determinants of endurance performance and time to complete a 5-km time trial in the heat. Seventeen club runners completed graded exercise tests (GXT) in hot (GXTHOT; 32°C, 60% RH, 27.2°C WBGT) and cool conditions (GXTCOOL; 13°C, 50% RH, 9.3°C WBGT) to determine maximal oxygen uptake (V̇O2max), running economy (RE), velocity at V̇O2max (vV̇O2max), and running speeds corresponding to the lactate threshold (LT, 2 mmol...
2017: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/28944028/the-underestimated-role-of-temperature-oxygen-relationship-in-large-scale-studies-on-size-to-temperature-response
#4
Aleksandra Walczyńska, Łukasz Sobczyk
The observation that ectotherm size decreases with increasing temperature (temperature-size rule; TSR) has been widely supported. This phenomenon intrigues researchers because neither its adaptive role nor the conditions under which it is realized are well defined. In light of recent theoretical and empirical studies, oxygen availability is an important candidate for understanding the adaptive role behind TSR. However, this hypothesis is still undervalued in TSR studies at the geographical level. We reanalyzed previously published data about the TSR pattern in diatoms sampled from Icelandic geothermal streams, which concluded that diatoms were an exception to the TSR...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28944027/symbiosis-constraints-strong-mycobiont-control-limits-nutrient-response-in-lichens
#5
Kristin Palmqvist, Oskar Franklin, Torgny Näsholm
Symbioses such as lichens are potentially threatened by drastic environmental changes. We used the lichen Peltigera aphthosa-a symbiosis between a fungus (mycobiont), a green alga (Coccomyxa sp.), and N2-fixing cyanobacteria (Nostoc sp.)-as a model organism to assess the effects of environmental perturbations in nitrogen (N) or phosphorus (P). Growth, carbon (C) and N stable isotopes, CNP concentrations, and specific markers were analyzed in whole thalli and the partners after 4 months of daily nutrient additions in the field...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28944014/honey-bee-collected-pollen-in-agro-ecosystems-reveals-diet-diversity-diet-quality-and-pesticide-exposure
#6
Megan J Colwell, Geoffrey R Williams, Rodger C Evans, Dave Shutler
European honey bees Apis mellifera are important commercial pollinators that have suffered greater than normal overwintering losses since 2007 in North America and Europe. Contributing factors likely include a combination of parasites, pesticides, and poor nutrition. We examined diet diversity, diet nutritional quality, and pesticides in honey bee-collected pollen from commercial colonies in the Canadian Maritime Provinces in spring and summer 2011. We sampled pollen collected by honey bees at colonies in four site types: apple orchards, blueberry fields, cranberry bogs, and fallow fields...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943952/mirna-biogenesis-associated-rnase-iii-nucleases-drosha-and-dicer-are-upregulated-in-colorectal-adenocarcinoma
#7
Shin Kim, Mei Ling Song, Hyeonji Min, Ilseon Hwang, Seong Kyu Baek, Taeg Kyu Kwon, Jong-Wook Park
Drosha and Dicer are important regulators of microRNA (miRNA) biogenesis, and it has been suggested that their aberrant regulation may cause colorectal cancer (CRC). The aim of the present study was to evaluate the mRNA expression levels of these two important RNase III nucleases and their association with clinical features in CRC specimens from South Korean patients. The expression levels of Drosha and Dicer mRNA were investigated in 77 CRC tissues and adjacent histologically non-neoplastic tissues using the quantitative polymerase chain reaction...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943852/metabolic-stress-induced-activation-of-ampk-and-inhibition-of-constitutive-phosphoproteins-controlling-smooth-muscle-contraction-evidence-for-smooth-muscle-fatigue
#8
Corey A Smith, Amy S Miner, Robert W Barbee, Paul H Ratz
Metabolic stress diminishes smooth muscle contractile strength by a poorly defined mechanism. To test the hypothesis that metabolic stress activates a compensatory cell signaling program to reversibly downregulate contraction, arterial rings and bladder muscle strips in vitro were deprived of O2 and glucose for 30 and 60 min ("starvation") to induce metabolic stress, and the phosphorylation status of proteins involved in regulation of contraction and metabolic stress were assessed in tissues under basal and stimulated conditions...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28943742/academic-procrastination-and-goal-accomplishment-a-combined-experimental-and-individual-differences-investigation
#9
Daniel E Gustavson, Akira Miyake
This study examined the relationship between academic procrastination and goal accomplishment in two novel ways. First, we experimentally tested whether undergraduate students (N = 177) could reduce their academic procrastination over a course of three weeks after performing goal-related exercises to set so-called SMART goals and/or to prepare those students with specific strategies to resist their temptations (forming implementation intentions). Second, we conducted systematic regression analyses to examine whether academic procrastination at baseline uniquely predicts later goal-related outcomes, controlling for various correlated variables, including personality traits (e...
February 2017: Learning and Individual Differences
https://www.readbyqxmd.com/read/28943602/deltamethrin-increases-neurite-outgrowth-in-cortical-neurons-through-endogenous-bdnf-trkb-pathways
#10
Daisuke Ihara, Mamoru Fukuchi, Momoko Katakai, Yo Shinoda, Ritsuko Katoh-Semba, Teiichi Furuichi, Mitsuru Ishikawa, Akiko Tabuchi, Masaaki Tsuda
Deltamethrin (DM), a type II pyrethroid, robustly increases brain-derived neurotrophic factor (Bdnf) expression and has a neurotrophic effect in primary cultures of rat cortical neurons. In this study, we investigated the effect of DM on neurite morphology in cultured rat cortical neurons. DM significantly increased neurite outgrowth, but this increase was abolished when the BDNF scavenger tropomyosin receptor kinase B (TrkB)-Fc was added 10 min before the DM treatment. In contrast, the addition of TrkB-Fc 1 h after the treatment did not affect DM-induced neurite outgrowth...
September 23, 2017: Cell Structure and Function
https://www.readbyqxmd.com/read/28943458/feedback-facility-assisted-balance-training-in-a-patient-with-multiple-system-atrophy-a-case-report
#11
Hyo Jeong Lee, Ko Eun Lee, Tae Im Yi, Hyun Young Kim
Multiple system atrophy is a rare neurodegenerative disease with poor prognosis. Furthermore, there are no pharmacology or notable rehabilitation strategies available to prevent the worsening of the disease. This case report assessed the outcome of feedback facility-assisted balance training in combination with physical therapy in a 61-year-old man. The patient participated in 30 training sessions over six weeks for 30 minutes each that involved balance training. His static and dynamic balance abilities were improved on the Berg Balance Scale, Trunk Impairment Scale, Functional Independence Measure, and Functional Reach...
September 21, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28943331/impact-of-granulocyte-colony-stimulating-factor-on-bleomycin-induced-pneumonitis-in-chemotherapy-treated-germ-cell-tumors
#12
Edmond M Kwan, Sophie Beck, Eitan Amir, Michael A Jewett, Jeremy F Sturgeon, Lynn Anson-Cartwright, Peter W Chung, Padraig R Warde, Malcolm J Moore, Philippe L Bedard, Ben Tran
OBJECTIVE: To examine the impact of granulocyte-colony stimulating factor (G-CSF) use on the incidence and severity of bleomycin-induced pneumonitis (BIP) in patients with germ cell tumor (GCT) receiving first-line chemotherapy. PATIENTS AND METHODS: Clinical data from our institutional GCT database was complemented by review of radiology, pharmacy, and medical records. All patients receiving first line chemotherapy between January 1, 2000 and December 31, 2010 were included...
September 4, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28943010/neck-diameter-and-inner-curve-seal-zone-predict-endograft-related-complications-in-highly-angulated-necks-after-endovascular-aneurysm-repair-using-the-aorfix-endograft
#13
Sophie Wang, Caitlin W Hicks, Mahmoud B Malas
OBJECTIVE: Many studies have found that preoperative aneurysm anatomy can determine the postoperative complication rates for endovascular aneurysm repair (EVAR). With continual improvement in endograft technology, patients with challenging anatomy are increasingly able to undergo successful treatment with EVAR. This study aimed to quantify the influence of proximal neck anatomy on contemporary outcomes in a cohort of abdominal aortic aneurysm patients with highly angulated aneurysm necks...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942952/persistent-impairment-on-spirometry-in-chronic-eosinophilic-pneumonia-a-longitudinal-observation-study-shizuoka-cep-study
#14
Yuzo Suzuki, Yoshiyuki Oyama, Hironao Hozumi, Shiro Imokawa, Mikio Toyoshima, Koshi Yokomura, Hidenori Nakamura, Shigeki Kuroishi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Naoki Koshimizu, Takashi Yamada, Kazutaka Mori, Masafumi Masuda, Toshihiro Shirai, Hiroshi Hayakawa, Mitsuhiro Sumikawa, Takeshi Johkoh, Takafumi Suda
BACKGROUND: Chronic eosinophilic pneumonia (CEP) is characterized by the accumulation of eosinophils in the lung with unknown etiology. Although systemic corticosteroid administration leads to dramatic improvement, nearly half the patients with CEP experience relapse and some develop persistent impairment of pulmonary function. However, predictive factors for this persistent impairment have not been determined. OBJECTIVE: To investigate the occurrence of persistent impairment of pulmonary function in CEP and determine its predictive factors...
September 21, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28942562/abnormal-levels-of-vascular-endothelial-biomarkers-in-schizophrenia
#15
Tanya T Nguyen, Sheena I Dev, Guanqing Chen, Sharon C Liou, Averria Sirkin Martin, Michael R Irwin, Judith E Carroll, Xin Tu, Dilip V Jeste, Lisa T Eyler
Schizophrenia is associated with chronic low-grade inflammation, which has been linked to increased vascular risk and rates of cardiovascular disease. Levels of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) have been related to aging and neurodegeneration, but their role in schizophrenia remains uncertain. Using a cross-sectional, case-control design, this study included 99 outpatients with schizophrenia and 99 healthy comparison subjects (HCs)...
September 23, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28941811/reversible-induction-of-tdp-43-granules-in-cortical-neurons-after-traumatic-injury
#16
Diana Wiesner, Lilla Tar, Birgit Linkus, Akila Chandrasekar, Florian Olde Heuvel, Luc Dupuis, William Tsao, Philip C Wong, Albert Ludolph, Francesco Roselli
Traumatic brain injury (TBI) has been proposed as a risk factor for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To determine whether TBI might trigger or exacerbate ALS-relevant pathology, we delivered a mild stab-wound injury to the motor cortex of three different ALS mouse models expressing mutations in SOD1, TDP-43 or FUS and scrutinized the effects on the formation of phospho-TDP-43 (pTDP-43) cytoplasmic granules. Stab-injury induced the formation of cytoplasmic TDP-43 granules in wt animals, peaking at 3dpi; a much larger response was seen in mutant TDP-43 mice, whose response peaked at 7dpi...
September 20, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28941782/level-of-parenting-stress-in-mothers-of-singletons-and-mothers-of-twins-until-one-year-postpartum-a-cross-sectional-study
#17
Marjon De Roose, Dimitri Beeckman, Katrijn Eggermont, Elke Vanhouche, Ann Van Hecke, Sofie Verhaeghe
PROBLEM: To date, it is unclear which factors are associated with parenting stress. BACKGROUND: There are no studies investigating the association between parenting stress and coping strategies such as coparenting and social support, while simultaneously considering demographic and obstetric factors, in mothers of singletons and twins. AIM: To investigate if parenting stress is associated with personal, and obstetric characteristics, the level of coparenting, and the availability of and satisfaction with social support in mothers of singletons and twins until one year postpartum...
September 20, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28941327/the-influence-of-two-common-sterilization-techniques-on-the-corrosion-of-mg-and-its-alloys-for-biomedical-applications
#18
Sean Johnston, Zhiming Shi, Cherilyn Hoe, Peter J Uggowitzer, Martina Cihova, Jörg F Löffler, Matthew S Dargusch, Andrej Atrens
This paper studied the influence of two common sterilization techniques, ethylene oxide (EO) and gamma irradiation (GI), on the corrosion rate of four Mg-based materials in CO2 -bicarbonate buffered Hanks' solution. The four materials were: high-purity (HP)-Mg, ZE41, ultra-high purity (XHP)-Mg, and XHP-ZX00. The corrosion rate was measured through mass loss (Pm ) and hydrogen evolution (PH ). Two-way analysis of variance (ANOVA) was conducted to assess the effect of the sterilization techniques on the corrosion rates across the four materials...
September 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28941158/prognostic-and-predictive-role-of-18-f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-in-patients-with-unresectable-malignant-pleural-mesothelioma-mpm-treated-with-up-front-pemetrexed-based-chemotherapy
#19
Paolo Andrea Zucali, Egesta Lopci, Giovanni Luca Ceresoli, Laura Giordano, Matteo Perrino, Gianluigi Ciocia, Letizia Gianoncelli, Elena Lorenzi, Matteo Simonelli, Fabio De Vincenzo, Lucia Rebecca Setti, Cristiana Bonifacio, Maria Bonomi, Emilio Bombardieri, Arturo Chiti, Armando Santoro
The aim of this study was to evaluate the role of metabolic parameters analyzed at baseline and at interim FDG-PET in predicting disease outcome in unresectable MPM patients receiving pemetrexed-based chemotherapy. A consecutive series of MPM patients treated between February 2004 and July 2013 with first-line pemetrexed-based chemotherapy, and evaluated by FDG-PET and CT scan at baseline and after two cycles of chemotherapy, was reviewed. Best CT scan response was assessed according to modified RECIST criteria...
September 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28940976/fracture-resistance-of-simulated-immature-teeth-after-internal-bleaching-procedures
#20
Emel Uzunoglu, Ayhan Eymirli, Mehmet Özgür Uyanik, Emre Nagas, Zafer Cavit Çehreli
The aim of this study was to evaluate the fracture resistance of simulated immature teeth after internal bleaching. The teeth were assigned as follows (n = 12/group); Group-1: The pulp chamber was filled with ProRootMTA and bleached intracoronally with sodium perborate mixed with 37% carbamide peroxide gel; Group-2: The pulp chamber was filled with ProRootMTA without bleaching; Group-3: The pulp chamber was filled with Biodentine and bleached intracoronally as Group-1; Group-4: The pulp chamber was filled with Biodentine without bleaching; and Group-5: Teeth received no intervention (control)...
September 21, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
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