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https://www.readbyqxmd.com/read/28446016/biodegradation-and-biocompatibility-of-poly-l-lactic-acid-implantable-mesh
#1
Sang-Don Yoon, Young-Sam Kwon, Kyu-Sung Lee
PURPOSE: The purpose of this study was to evaluate the biodegradation and biocompatibility of poly L-lactic acid (PLLA) implantable mesh under in vitro and in vivo conditions. METHODS: PLLA mesh was examined for changes in weight and tensile strength. The histology of the tissue around the PLLA implant was also evaluated. RESULTS: The weight and tensile strength of the PLLA prosthesis was stable for 180 days. In addition, the surface of the PLLA mesh was not digested under in vitro or in vivo conditions as determined by scanning electron microscope...
April 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28445904/-are-there-sex-differences-regarding-ski-length-to-height-ratio-ski-length-to-weight-ratio-sidecut-radius-and-ski-boot-sole-abrasion-among-acl-injured-male-and-female-skiers
#2
Markus Posch, Gerhard Ruedl, Katja Tecklenburg, Kenneth Helle, Alois Schranz, Martin Burtscher
Introduction Female skiers suffer from knee injuries twice as much as male skiers, and the risk of an injury to the anterior cruciate ligament (ACL) is three times greater among females compared to males. The sex-specific ACL injury risk depends on internal (e. g. age, skiing skills, fitness level) and external (e. g. slope and weather conditions, ski equipment) factors. However, it is not clear whether male and female recreational skiers with an ACL injury differ regarding the sidecut radius and ski boot sole abrasion...
April 26, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28445878/differential-allelic-expression-of-htr1b-in-suicide-victims-genetic-and-epigenetic-effect-of-the-cis-acting-variants
#3
Ali Bani-Fatemi, Aaron Howe, Clement Zai, James L Kennedy, John Vincent, John Strauss, Albert Wong, Vincenzo De Luca
OBJECTIVES: In the present study, we tested the allelic imbalance of the C861G single nucleotide polymorphism (SNP) of HTR1B in the frontal cortex of suicide victims. METHODS: The study was conducted using 3 sets of samples. First, C861G allele-specific mRNA levels in the frontal cortex were compared between suicide (n = 13) and nonsuicide controls (n = 13) from the Stanley Medical Research postmortem brain collection. Second, we tested common variants in the HTR1B promoter for linkage disequilibrium (LD) with the C861G variant in an unrelated sample of suicide attempters (SA; n = 38) and non-SA (NSA; n = 42)...
April 27, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28445867/the-mir-106a-363xpcl1-mirna-cluster-induces-murine-t-cell-lymphoma-despite-transcriptional-activation-of-the-p27kip1-cell-cycle-inhibitor
#4
Daniel A Kuppers, Thomas M Schmitt, Harry C Hwang, Lavanya Samraj, Bruce E Clurman, Matthew L Fero
The miR-106a~363 cluster encodes 6 miRNAs on the X-chromosome which are abundant in blood cells and overexpressed in a variety of malignancies. The constituent miRNA of miR-106a~363 have functional activities in vitro that are predicted to be both oncogenic and tumor suppressive, yet little is known about their physiological functions in vivo. Mature miR-106a~363 (Mirc2) miRNAs are processed from an intragenic, non-protein encoding gene referred to as Xpcl1 (or Kis2), situated at an X-chromosomal locus frequently targeted by retroviruses in murine lymphomas...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445860/brephedrone-a-new-psychoactive-substance-seized-in-brazil
#5
Yuri Machado, José Coelho Neto, Paulo Eduardo Nunes Barbosa, Rogério Araújo Lordeiro, Rosemeire Brondi Alves
At the beginning of 2015, sixty-two capsules containing red-brown crystals seized in a historical city in Brazil were sent to this forensic laboratory for drug testing analysis. The material was identified as being Brephedrone, a new psychoactive substance and a bromine synthetic cathinone that is related to serotonin transportation. This substance was analyzed by ATR-FTIR, GC-MS, LC-MS, (1)H, (13)C and 2D NMR. Brephedrone apprehensions have been previously reported in Finland, France and Spain. It was the first detection of this substance in the State of Minas Gerais...
April 15, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28445748/directional-force-originating-from-atp-hydrolysis-drives-the-groel-conformational-change
#6
Jie Liu, Kannan Sankar, Yuan Wang, Kejue Jia, Robert L Jernigan
Protein functional mechanisms usually require conformational changes, and often there are known structures for the different conformational states. However, usually neither the origin of the driving force nor the underlying pathways for these conformational transitions is known. Exothermic chemical reactions may be an important source of forces that drive conformational changes. Here we investigate this type of force originating from ATP hydrolysis in the chaperonin GroEL, by applying forces originating from the chemical reaction...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445520/serum-irisin-levels-correlated-to-peritoneal-dialysis-adequacy-in-nondiabetic-peritoneal-dialysis-patients
#7
Zhijun Tan, Zengchun Ye, Jun Zhang, Yanru Chen, Cailian Cheng, Cheng Wang, Xun Liu, Tanqi Lou, Hui Peng
BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. METHODS: A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28445515/correlation-of-histopathologic-characteristics-to-protein-expression-and-function-in-malignant-melanoma
#8
Charlotte Welinder, Krzysztof Pawłowski, A Marcell Szasz, Maria Yakovleva, Yutaka Sugihara, Johan Malm, Göran Jönsson, Christian Ingvar, Lotta Lundgren, Bo Baldetorp, Håkan Olsson, Melinda Rezeli, Thomas Laurell, Elisabet Wieslander, György Marko-Varga
BACKGROUND: Metastatic melanoma is still one of the most prevalent skin cancers, which upon progression has neither a prognostic marker nor a specific and lasting treatment. Proteomic analysis is a versatile approach with high throughput data and results that can be used for characterizing tissue samples. However, such analysis is hampered by the complexity of the disease, heterogeneity of patients, tumors, and samples themselves. With the long term aim of quest for better diagnostics biomarkers, as well as predictive and prognostic markers, we focused on relating high resolution proteomics data to careful histopathological evaluation of the tumor samples and patient survival information...
2017: PloS One
https://www.readbyqxmd.com/read/28445471/a-randomized-trial-comparing-concise-and-standard-consent-forms-in-the-start-trial
#9
Christine Grady, Giota Touloumi, A Sarah Walker, Mary Smolskis, Shweta Sharma, Abdel G Babiker, Nikos Pantazis, Jorge Tavel, Eric Florence, Adriana Sanchez, Fleur Hudson, Antonios Papadopoulos, Ezekiel Emanuel, Megan Clewett, David Munroe, Eileen Denning
BACKGROUND: Improving the effectiveness and efficiency of research informed consent is a high priority. Some express concern about longer, more complex, written consent forms creating barriers to participant understanding. A recent meta-analysis concluded that randomized comparisons were needed. METHODS: We conducted a cluster-randomized non-inferiority comparison of a standard versus concise consent form within a multinational trial studying the timing of starting antiretroviral therapy in HIV+ adults (START)...
2017: PloS One
https://www.readbyqxmd.com/read/28445400/targeting-the-epidermal-growth-factor-receptor-in-addition-to-chemotherapy-in-patients-with-advanced-pancreatic-cancer-a-systematic-review-and-meta-analysis
#10
REVIEW
Jaseela Chiramel, Alison C Backen, Rille Pihlak, Angela Lamarca, Melissa Frizziero, Noor-Ul-Ain Tariq, Richard A Hubner, Juan W Valle, Eitan Amir, Mairéad G McNamara
Overexpression of epidermal growth factor receptors (EGFR) occurs in >90% of pancreatic ductal adenocarcinomas (PDACs) and is associated with a poorer prognosis. A systematic review of electronic databases identified studies exploring the addition of EGFR-targeted treatment to chemotherapy in patients with locally advanced (LA)/metastatic PDAC. Efficacy, safety and tolerability of EGFR-targeted therapy were explored using meta-analysis of randomised controlled trials (RCTs). Meta-regression was utilised to explore factors associated with improved prognosis (all studies) and benefit from EGFR-targeted therapy (RCTs)...
April 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28445364/n-acetylcysteine-prevents-retrograde-motor-neuron-death-after-neonatal-peripheral-nerve-injury
#11
Joseph Catapano, Jennifer Zhang, David Scholl, Cameron Chiang, Tessa Gordon, Gregory H Borschel
BACKGROUND: Neuronal death may be an overlooked and unaddressed component of disability following neonatal nerve injuries, such as obstetric brachial plexus injury. N-acetylcysteine and acetyl-L-carnitine improve survival of neurons after adult nerve injury, but it is unknown whether they improve survival after neonatal injury, when neurons are most susceptible to retrograde neuronal death. The authors' objective was to examine whether N-acetylcysteine or acetyl-L-carnitine treatment improves survival of neonatal motor or sensory neurons in a rat model of neonatal nerve injury...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445324/nurse-practitioner-physician-comanagement-of-primary-care-patients-the-promise-of-a-new-delivery-care-model-to-improve-quality-of-care
#12
Allison Andreno Norful, Kyleen Swords, Mickaela Marichal, Hwayoung Cho, Lusine Poghosyan
BACKGROUND: The U.S. primary care system is under tremendous strain to deliver care to an increased volume of patients with a concurrent primary care physician shortage. Nurse practitioner (NP)-physician comanagement of primary care patients has been proposed by some policy makers to help alleviate this strain. To date, no collective evidence demonstrates the effects of NP-physician comanagement in primary care. PURPOSE: This is the first review to synthesize all available studies that compare the effects of NP-physician comanagement to an individual physician managing primary care...
April 25, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28445318/renal-failure-caused-by-a-partly-calcified-aortic-aneurysm-in-a-patient-with-dabigatran-therapy-a-case-report
#13
Philipp Jud, Thomas Gary, Kurt Tiesenhausen, Rupert Portugaller, Gerald Hackl, Marianne Brodmann
RATIONALE: Abdominal aortic aneurysms (AAAs) are mostly asymptomatic. If aortic aneurysms become symptomatic, complications include peripheral embolization, acute aortic occlusion, and aortic rupture. However, there are also unusual complications caused by aortic aneurysms. PATIENT CONCERNS: An 87-old male with dabigatran therapy presented with newly developed melena and acute renal failure. Radiological imaging revealed an AAA with thrombotic and calcified deposits which affected the renal arteries...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445224/impact-of-6-consecutive-days-of-sprint-training-in-hypoxia-on-performance-in-competitive-sprint-runners
#14
Nobukazu Kasai, Sahiro Mizuno, Sayuri Ishimoto, Etsuko Sakamoto, Misato Maruta, Toshiyuki Kurihara, Yuko Kurosawa, Kazushige Goto
The purpose of the present study was to determine the effects of 6 successive days of repeated sprint training in moderate hypoxia on anaerobic capacity in 100-200-m sprint runners. Eighteen male sprint runners (age, 20.0 ± 0.3 years; height, 175.9 ± 1.1 cm; body mass, 65.0 ± 1.2 kg) performed repeated cycling sprints for 6 consecutive days in either normoxic (NOR; fraction of inspired oxygen [FiO2], 20.9%; n = 9) or hypoxic conditions (HYPO; FiO2, 14.5%; n = 9). The repeated sprint ability (10 × 6-s sprints), 30-s maximal sprint ability, maximal oxygen uptake (VO2max), and 60-m running time on the track were measured before and after the training period...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28445132/targeting-autophagic-cancer-stem-cells-to-reverse-chemoresistance-in-human-triple-negative-breast-cancer
#15
Guilhem Bousquet, Morad El Bouchtaoui, Tan Sophie, Christophe Leboeuf, Cédric de Bazelaire, Philippe Ratajczak, Sylvie Giacchetti, Anne de Roquancourt, Philippe Bertheau, Laurence Verneuil, Jean-Paul Feugeas, Marc Espié, Anne Janin
There is growing evidence for the role of cancer stem-cells in drug resistance, but with few in situ studies on human tumor samples to decipher the mechanisms by which they resist anticancer agents.Triple negative breast cancer (TNBC) is the most severe sub-type of breast cancer, occurring in younger women and associated with poor prognosis even when treated at a localized stage.We investigated here the relationship between complete pathological response after chemotherapy and breast cancer stem-cell characteristics in pre-treatment biopsies of 78 women with triple negative breast carcinoma (TNBC)...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445110/normobaric-hypoxia-increases-the-growth-hormone-response-to-maximal-resistance-exercise-in-trained-men
#16
Dean Filopoulos, Stuart J Cormack, Douglas G Whyte
This study examined the effect of hypoxia on growth hormone (GH) release during an acute bout of high-intensity, low-volume resistance exercise. Using a single-blinded, randomised crossover design, 16 resistance-trained males completed two resistance exercise sessions in normobaric hypoxia (HYP; inspiratory oxygen fraction, (FiO2) 0.12, arterial oxygen saturation (SpO2) 82 ± 2%) and normoxia (NOR; FiO2 0.21, SpO2 98 ± 0%). Each session consisted of five sets of three repetitions of 45° leg press and bench press at 85% of one repetition maximum...
April 26, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28444965/serum-free-light-chain-quantitative-assays-dilemma-of-a-biomarker
#17
Giovanni Cigliana, Francesca Gulli, Cecilia Napodano, Krizia Pocino, Elena De Santis, Luigi Colacicco, Iole Cordone, Laura Conti, Umberto Basile
BACKGROUND: Serum free light chains detection assays are consistently meeting greater interest for the diagnosis and monitoring of monoclonal gammopathies and plasma cell dyscrasias. Nowadays, there are neither standardized methods nor reference material for the determination of free light chains; for this reason, it is important to compare two different assays used in clinical laboratory. METHODS: We evaluated 300 serum samples from patients with B-cell disorders and compared the analytical performances of both assay...
April 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28444742/the-effect-of-rituximab-on-anti-platelet-autoantibody-levels-in-patients-with-immune-thrombocytopenia
#18
Donald M Arnold, John R Vrbensky, Nadia Karim, James W Smith, Yang Liu, Nikola Ivetic, John G Kelton, Ishac Nazy
Rituximab is an effective therapy resulting in a platelet count improvement in 60% of patients with immune thrombocytopenia (ITP). Rituximab depletes B cells; thus, a reduction in platelet autoantibody levels would be anticipated in patients who achieve a clinical response to this treatment. The objectives of this study were to determine whether rituximab was associated with a reduction in platelet autoantibody levels, and to correlate the loss of autoantibodies with the achievement of a treatment response...
April 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28444692/a-profile-likelihood-approach-for-longitudinal-data-analysis
#19
Ziqi Chen, Man-Lai Tang, Wei Gao
Inappropriate choice of working correlation structure in generalized estimating equations (GEE) could lead to inefficient parameter estimation while impractical normality assumption in likelihood approach would limit its applicability in longitudinal data analysis. In this article, we propose a profile likelihood method for estimating parameters in longitudinal data analysis via maximizing the estimated likelihood. The proposed method yields consistent and efficient estimates without specifications of the working correlation structure nor the underlying error distribution...
April 25, 2017: Biometrics
https://www.readbyqxmd.com/read/28444502/preliminary-study-on-the-role-of-tmem39a-gene-in-multiple-sclerosis
#20
Marta Wagner, Maciej Sobczyński, Małgorzata Bilińska, Anna Pokryszko-Dragan, Małgorzata Cyrul, Piotr Kuśnierczyk, Monika Jasek
Genome-wide association studies (GWAS) have identified hundreds of new potential genetic risk loci associated with numerous complex diseases such as multiple sclerosis (MS). Genes which have been discovered by GWAS are now the focus of numerous ongoing studies. The goal of this study was to confirm and understand the potential role of one of such genes-transmembrane protein 39A gene (TMEM39A)-in multiple sclerosis.We showed the difference in TMEM39A messenger RNA (mRNA) expression between MS patients and controls (T (2)2;74 = 5...
April 25, 2017: Journal of Molecular Neuroscience: MN
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