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https://www.readbyqxmd.com/read/27913963/erratum-to-altered-nr4a-subfamily-gene-expression-level-in-peripheral-blood-of-parkinson-s-and-alzheimer-s-disease-patients
#1
Francesca Montarolo, Simona Perga, Serena Martire, De'sire'e Nicole Navone, Alberto Marchet, Daniela Leotta, Antonio Bertolotto
No abstract text is available yet for this article.
December 2, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27871853/nur77-downregulation-triggers-pulmonary-artery-smooth-muscle-cell-proliferation-and-migration-in-mice-with-hypoxic-pulmonary-hypertension-via-the-axin2-%C3%AE-catenin-signaling-pathway
#2
Xiaowei Nie, Jianxin Tan, Youai Dai, Wenjun Mao, Yuan Chen, Guowei Qin, Guirong Li, Chenyou Shen, Jingjing Zhao, Jingyu Chen
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by remodeling of the pulmonary vasculature, including marked proliferation and reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Members of the nuclear receptor 4A (NR4A) subfamily are involved in a variety of biological events, such as cell apoptosis, proliferation, inflammation, and metabolism. Activation of Nur77 (an orphan nuclear receptor that belongs to NR4A subfamily) has recently been reported to be as a beneficial agent in the treatment of cardiovascular and metabolic diseases...
November 15, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27834392/pharmacological-activators-of-the-nr4a-nuclear-receptors-enhance-ltp-in-a-creb-cbp-dependent-fashion
#3
Morgan S Bridi, Joshua D Hawk, Snehajyoti Chatterjee, Stephen Safe, Ted Abel
Nr4a nuclear receptors contribute to long-term memory formation and are required for long-term memory enhancement by a class of broad-acting drugs known as histone deacetylase (HDAC) inhibitors. Understanding the molecular mechanisms that regulate these genes and identifying ways to increase their activity may provide novel therapeutic approaches for ameliorating cognitive dysfunction. In the present study, we find that Nr4a gene expression after learning requires the cAMP-response element binding (CREB) interaction domain of the histone acetyltransferase CREB-binding protein (CBP)...
November 11, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27820700/the-transcription-factor-nr4a3-controls-cd103-dendritic-cell-migration
#4
Kiwon Park, Zbigniew Mikulski, Goo-Young Seo, Aleksander Y Andreyev, Paola Marcovecchio, Amy Blatchley, Mitchell Kronenberg, Catherine C Hedrick
The transcription factor NR4A3 (also known as NOR-1) is a member of the Nr4a family of nuclear receptors and is expressed in myeloid and lymphoid cells. Here, we have shown that Nr4a3 is essential for the migration of CD103+ dendritic cells (DCs) to lymph nodes (LNs). Nr4a3-deficient mice had very few CD103+ migratory DCs (mDCs) present in LNs, and mixed-chimera studies revealed that this migratory defect was cell intrinsic. We further found that CD103+ DCs from Nr4a3-deficient mice displayed a marked loss of surface expression of the chemokine CCR7...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27646469/adenovirus-mediated-expression-of-orphan-nuclear-receptor-nr4a2-targeting-hepatic-stellate-cell-attenuates-liver-fibrosis-in-rats
#5
Pengguo Chen, Jie Li, Yan Huo, Jin Lu, Lili Wan, Quanjun Yang, Jinlu Huang, Run Gan, Cheng Guo
Liver fibrosis is a wound-healing response characterized with the accumulation of extracellular matrix (ECM). And hepatic stellate cells (HSCs) are the principal cell source of ECM. NR4A2 (Nurr1) is a member of orphan nuclear receptor NR4A family and acts as transcription factor. It participates in regulating cell differentiation, proliferation and apoptosis. We previously demonstrated that NR4A2 expression in fibrotic liver reduced significantly compared with normal liver and NR4A2 knockout in HSCs promoted ECM production...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27587263/crtc1-function-during-memory-encoding-is-disrupted-in-neurodegeneration
#6
Arnaldo Parra-Damas, Meng Chen, Lilian Enriquez-Barreto, Laura Ortega, Sara Acosta, Judith Camats Perna, M Neus Fullana, José Aguilera, José Rodríguez-Alvarez, Carlos A Saura
BACKGROUND: Associative memory impairment is an early clinical feature of dementia patients, but the molecular and cellular mechanisms underlying these deficits are largely unknown. In this study, we investigated the functional regulation of the cyclic adenosine monophosphate response element binding protein (CREB)-regulated transcription coactivator 1 (CRTC1) by associative learning in physiological and neurodegenerative conditions. METHODS: We evaluated the activation of CRTC1 in the hippocampus of control mice and mice lacking the Alzheimer's disease-linked presenilin genes (presenilin conditional double knockout [PS cDKO]) after one-trial contextual fear conditioning by using biochemical, immunohistochemical, and gene expression analyses...
July 11, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27515096/decreased-expression-of-nr4a-nuclear-receptors-in-adenomyosis-impairs-endometrial-decidualization
#7
Yue Jiang, Ruiwei Jiang, Xi Cheng, Qun Zhang, Yali Hu, Hui Zhang, Yun Cao, Mei Zhang, Junxia Wang, Lijun Ding, Zhenyu Diao, Haixiang Sun, Guijun Yan
STUDY QUESTION: How do NR4A receptors drive decidualization of human endometrial stromal cells (hESCs)? SUMMARY ANSWER: NR4A receptors modulate endometrial decidualization by transcriptional activation of FOXO1A, and in adenomyosis patients, the reduced expression of NR4A receptors in the eutopic endometrium may represent a novel mechanism to explain impaired decidualization and subfertility. WHAT IS KNOWN ALREADY: A close relationship between impaired decidualization and subfertility has been established...
September 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27435855/nurr1-and-ppar%C3%AE-protect-pc12-cells-against-mpp-toxicity-involvement-of-selective-genes-anti-inflammatory-ros-generation-and-antimitochondrial-impairment
#8
Mohammad Jodeiri Farshbaf, Mahboobeh Forouzanfar, Kamran Ghaedi, Abbas Kiani-Esfahani, Maryam Peymani, Alireza Shoaraye Nejati, Tayebeh Izadi, Khadijeh Karbalaie, Maryam Noorbakhshnia, Soheila Rahgozar, Hossein Baharvand, Mohammad Hossein Nasr-Esfahani
Parkinson's disease (PD) can degenerate dopaminergic (DA) neurons in midbrain, substantia-nigra pars compacta. Alleviation of its symptoms and protection of normal neurons against degeneration are the main aspects of researches to establish novel therapeutic strategies. PPARγ as a member of PPARs have shown neuroprotection in a number of neurodegenerative disorders such as Alzheimer's disease and PD. Nuclear receptor related 1 protein (Nurr1) is, respectively, member of NR4A family and has received great attentions as potential target for development, maintenance, and survival of DA neurons...
September 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27221116/%C3%AE-cell-deletion-of-nr4a1-and-nr4a3-nuclear-receptors-impedes-mitochondrial-respiration-and-insulin-secretion
#9
Merrick S Reynolds, Chad R Hancock, Jason D Ray, Kyle B Kener, Carrie Draney, Kevin Garland, Jeremy Hardman, Benjamin T Bikman, Jeffery S Tessem
β-Cell insulin secretion is dependent on proper mitochondrial function. Various studies have clearly shown that the Nr4a family of orphan nuclear receptors is essential for fuel utilization and mitochondrial function in liver, muscle, and adipose. Previously, we have demonstrated that overexpression of Nr4a1 or Nr4a3 is sufficient to induce proliferation of pancreatic β-cells. In this study, we examined whether Nr4a expression impacts pancreatic β-cell mitochondrial function. Here, we show that β-cell mitochondrial respiration is dependent on the nuclear receptors Nr4a1 and Nr4a3...
July 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27166283/ap2-nr4a3-transgenic-mice-display-reduced-serum-epinephrine-because-of-increased-catecholamine-catabolism-in-adipose-tissue
#10
R Grace Walton, Xiaolin Zhu, Ling Tian, Elizabeth B Heywood, Jian Liu, Helliner S Hill, Jiarong Liu, Dennis Bruemmer, Qinglin Yang, Yuchang Fu, W Timothy Garvey
The NR4A orphan nuclear receptors function as early response genes to numerous stimuli. Our laboratory has previously demonstrated that overexpression of NR4A3 (NOR-1, MINOR) in 3T3-L1 adipocytes enhances insulin-stimulated glucose uptake. To assess the in vivo effect of NR4A3 on adipocytes, we generated transgenic mice with NR4A3 overexpression driven by the adipocyte fatty acid-binding protein (AP2) promoter (AP2-NR4A3 mice). We hypothesized that AP2-NR4A3 mice would display enhanced glucose tolerance and insulin sensitivity...
July 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27159982/altered-nr4a-subfamily-gene-expression-level-in-peripheral-blood-of-parkinson-s-and-alzheimer-s-disease-patients
#11
Francesca Montarolo, Simona Perga, Serena Martire, Désirée Nicole Navone, Alberto Marchet, Daniela Leotta, Antonio Bertolotto
Parkinson's disease (PD) is a neurodegenerative pathology characterized by the degeneration of midbrain dopamine neurons, whose development and maintenance in brain is related to the transcription factor NR4A2 (also called Nurr1). Notably, NR4A2 is a neuroprotective agent with anti-inflammatory role in microglia and astrocytes. Furthermore, mutations in NR4A2 gene are associated to the familial form of PD, and its gene expression level is down-regulated in blood obtained from PD patients. NR4A2 belongs to the NR4A subfamily consisting of three members: NR4A1, NR4A2, and NR4A3...
October 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27128111/identification-of-a-binding-site-for-unsaturated-fatty-acids-in-the-orphan-nuclear-receptor-nurr1
#12
Ian Mitchelle S de Vera, Pankaj K Giri, Paola Munoz-Tello, Richard Brust, Jakob Fuhrmann, Edna Matta-Camacho, Jinsai Shang, Sean Campbell, Henry D Wilson, Juan Granados, William J Gardner, Trevor P Creamer, Laura A Solt, Douglas J Kojetin
Nurr1/NR4A2 is an orphan nuclear receptor, and currently there are no known natural ligands that bind Nurr1. A recent metabolomics study identified unsaturated fatty acids, including arachidonic acid and docosahexaenoic acid (DHA), that interact with the ligand-binding domain (LBD) of a related orphan receptor, Nur77/NR4A1. However, the binding location and whether these ligands bind other NR4A receptors were not defined. Here, we show that unsaturated fatty acids also interact with the Nurr1 LBD, and solution NMR spectroscopy reveals the binding epitope of DHA at its putative ligand-binding pocket...
July 15, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/26970203/roles-of-transcription-factors-and-epigenetic-modifications-in-differentiation-and-maintenance-of-regulatory-t-cells
#13
Takashi Sekiya, Hiroko Nakatsukasa, Qianjin Lu, Akihiko Yoshimura
Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively...
June 2016: Microbes and Infection
https://www.readbyqxmd.com/read/26946093/high-expression-of-orphan-nuclear-receptor-nr4a1-in-a-subset-of-ovarian-tumors-with-worse-outcome
#14
Evan Delgado, Michelle M Boisen, Robin Laskey, Rui Chen, Chi Song, Jad Sallit, Zachary A Yochum, Courtney L Andersen, Matthew J Sikora, Jacob Wagner, Stephen Safe, Esther Elishaev, Adrian Lee, Robert P Edwards, Paul Haluska, George Tseng, Mark Schurdak, Steffi Oesterreich
OBJECTIVE: Nuclear receptors (NRs) play a vital role in the development and progression of several cancers including breast and prostate. Using TCGA data, we sought to identify critical nuclear receptors in high grade serous ovarian cancers (HGSOC) and to confirm these findings using in vitro approaches. METHODS: In silico analysis of TCGA data was performed to identify relevant NRs in HGSOC. Ovarian cancer cell lines were screened for NR expression and functional studies were performed to determine the significance of these NRs in ovarian cancers...
May 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/26938745/genome-wide-mapping-of-nr4a-binding-reveals-cooperativity-with-ets-factors-to-promote-epigenetic-activation-of-distal-enhancers-in-acute-myeloid-leukemia-cells
#15
Ryan P Duren, Seth P Boudreaux, Orla M Conneely
Members of the NR4A subfamily of orphan nuclear receptors regulate cell fate decisions via both genomic and non-genomic mechanisms in a cell and tissue selective manner. NR4As play a key role in maintenance of hematopoietic stem cell homeostasis and are critical tumor suppressors of acute myeloid leukemia (AML). Expression of NR4As is broadly silenced in leukemia initiating cell enriched populations from human patients relative to normal hematopoietic stem/progenitor cells. Rescue of NR4A expression in human AML cells inhibits proliferation and reprograms AML gene signatures via transcriptional mechanisms that remain to be elucidated...
2016: PloS One
https://www.readbyqxmd.com/read/26839514/nur77-mediated-traf6-signalling-protects-against-lps-induced-sepsis-in-mice
#16
Xiu-Ming Li, Shen Zhang, Xiao-Shun He, Peng-Da Guo, Xing-Xing Lu, Jing-Ru Wang, Jian-Ming Li, Hua Wu
BACKGROUND: Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains largely elusive. In this study, we used Nur77-deficient (Nur77(-/-)) mice and investigated the function of Nur77 in sepsis. FINDINGS: Compared to wild-type (Nur77(+/+)) mice, Nur77(-/-) mice are more susceptible to LPS-induced sepsis and acute liver inflammation...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/26713258/orphan-nuclear-receptor-nr4a2-inhibits-hepatic-stellate-cell-proliferation-through-mapk-pathway-in-liver-fibrosis
#17
Pengguo Chen, Jie Li, Yan Huo, Jin Lu, Lili Wan, Bin Li, Run Gan, Cheng Guo
Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis, which is a pathological process characterized by extracellular matrix accumulation. NR4A2 is a nuclear receptor belonging to the NR4A subfamily and vital in regulating cell growth, metabolism, inflammation and other biological functions. However, its role in HSCs is unclear. We analyzed NR4A2 expression in fibrotic liver and stimulated HSCs compared with control group and studied the influence on cell proliferation, cell cycle, cell apoptosis and MAPK pathway after NR4A2 knockdown...
2015: PeerJ
https://www.readbyqxmd.com/read/26325389/production-of-nurr-1-specific-polyclonal-antibodies-free-of-cross-reactivity-against-its-close-homologs-nor1-and-nur77
#18
Pierre Leblanc, Minho Moon, Woori Kim, Inhye Jeong, Chun-Hyung Kim, Kwang-Soo Kim
The nuclear receptor subfamily 4 (NR4A) is composed of 3 related proteins sharing a DNA binding domain (DBD) and a ligand-binding domain (LBD). The nuclear receptor related 1 protein (Nurr1 or NR4A2) plays a key role in the maintenance of the dopaminergic system. Dopamine dysfunctions associated with the Nurr1 gene include Parkinson's disease, schizophrenia and manic depression among others. Furthermore, recent evidence indicates that Nurr1 is also expressed in other brain areas such as the hippocampus and plays critical roles for learning and memory...
2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26304965/suppression-of-th2-and-tfh-immune-reactions-by-nr4a-receptors-in-mature-t-reg-cells
#19
Takashi Sekiya, Taisuke Kondo, Takashi Shichita, Rimpei Morita, Hiroshi Ichinose, Akihiko Yoshimura
Regulatory T (T reg) cells are central mediators of immune suppression. As such, T reg cells are characterized by a distinct pattern of gene expression, which includes up-regulation of immunosuppressive genes and silencing of inflammatory cytokine genes. Although an increasing number of transcription factors that regulate T reg cells have been identified, the mechanisms by which the T reg cell-specific transcriptional program is maintained and executed remain largely unknown. The Nr4a family of nuclear orphan receptors, which we recently identified as essential for the development of T reg cells, is highly expressed in mature T reg cells as well, suggesting that Nr4a factors play important roles even beyond T reg cell development...
September 21, 2015: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/26150530/adenosine-modulates-nr4a-orphan-nuclear-receptors-to-attenuate-hyperinflammatory-responses-in-monocytic-cells
#20
Daniel Crean, Eoin P Cummins, Bojlul Bahar, Helen Mohan, Jason P McMorrow, Evelyn P Murphy
Adenosine receptor-mediated regulation of monocyte/macrophage inflammatory responses is critical in the maintenance of tissue homeostasis. In this study, we reveal that adenosine potently modulates the expression of NR4A1, 2, and 3 orphan nuclear receptors in myeloid cells, and this modulation is primarily through the adenosine A2a receptor subtype. We demonstrate that A2a receptor activation of NR4A1-3 receptor synthesis is further enhanced in TLR4-stimulated monocytes. After TLR4 stimulation, NR4A receptor-depleted monocyte/macrophage cells display significantly altered expression of cell-surface markers and produce increased inflammatory cytokine and chemokine secretion rendering the cells an enhanced proinflammatory phenotype...
August 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
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