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non-coding RNA

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https://www.readbyqxmd.com/read/28944909/long-non%C3%A2-coding-rna-associated%C3%A2-competing-endogenous-rnas-are-induced-by-clusterin-in-retinal-pigment-epithelial-cells
#1
Zi Ye, Zhaohui Li, Shouzhi He
Age related macular degeneration is one of the most common causes of vision loss in the elderly. Long noncoding RNAs (lncRNAs) serve important roles in regulating gene expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of specific lncRNAs and their associated ceRNA function induced by clusterin in cultured retinal pigment epithelial (RPE) cells remain to be fully elucidated. Based on high throughput sequencing data from RPE cells treated with or without clusterin, the present study identified differentially expressed mRNAs, lncRNAs and microRNAs (miRNAs)...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944536/transcriptomic-repertoires-depict-the-initiation-of-lint-and-fuzz-fibers-in-cotton-gossypium-hirsutum-l
#2
Haiyan Hu, Maojun Wang, Yuanhao Ding, Sitao Zhu, Guannan Zhao, Lili Tu, Xianlong Zhang
Cotton fiber is an important natural fiber for the textile industry. The number of fiber initials determines the lint percentage, which is an important factor for cotton fiber yield. Although fiber development has been described by transcriptomic analysis, the mechanism by which the long non-coding RNA manipulate the initiation of lint and fuzz fibers remains unknown. In this study, three lines with different lint percentages were developed by crossing Xu142 with its fiberless mutant Xu142 fl. We collected the epidermal cells from the ovules with attached fibers at 0 and 5 days post-anthesis (DPA) from Xu142, the fiberless mutant Xu142 fl and the three lint percent diversified lines for deep transcriptome sequencing...
September 25, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28943972/small-non-coding-rna-abundance-in-adrenocortical-carcinoma-a-footprint-of-a-rare-cancer
#3
Srinivas V Koduru, Ashley N Leberfinger, Dino J Ravnic
BACKGROUND: Adrenocortical carcinoma (ACC) is a relatively rare, but aggressive type of cancer, which affects both children and adults. OBJECTIVE: Small non-coding RNAs (sncRNAs) play important roles and may serve as biomarkers for disease diagnosis, prognosis and treatment. METHODS: In our study, we sought to identify sncRNAs associated with malignant adrenal tumors. We obtained publicly available, small RNA sequencing data derived from 45 ACC and 30 benign tumors arising from the cortex of the adrenal gland, adrenocortical adenomas (ACA), and compared their sncRNA expression profiles...
2017: Journal of Genomics
https://www.readbyqxmd.com/read/28943874/a-genome-wide-prediction-and-identification-of-intergenic-small-rnas-by-comparative-analysis-in-mesorhizobium-huakuii-7653r
#4
Xie Fuli, Zhao Wenlong, Wang Xiao, Zhang Jing, Hao Baohai, Zou Zhengzheng, Ma Bin-Guang, Li Youguo
In bacteria, small non-coding RNAs (sRNAs) are critical regulators of cellular adaptation to changes in metabolism, physiology, or the external environment. In the last decade, more than 2000 of sRNA families have been reported in the Rfam database and have been shown to exert various regulatory functions in bacterial transcription and translation. However, little is known about sRNAs and their functions in Mesorhizobium. Here, we predicted putative sRNAs in the intergenic regions (IGRs) of M. huakuii 7653R by genome-wide comparisons with four related Mesorhizobial strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28943452/long-non-coding-rna-hnf1a-as1-mediated-repression-of-mir-34a-sirt1-p53-feedback-loop-promotes-the-metastatic-progression-of-colon-cancer-by-functioning-as-a-competing-endogenous-rna
#5
Changyi Fang, Shenglong Qiu, Feng Sun, Wei Li, Ziqi Wang, Ben Yue, Xuesong Wu, Dongwang Yan
In recent years, accumulating evidence indicates that long noncoding RNAs (lncRNAs) have emerged as powerful influence factors in the progression of multiple malignancies. Dysregulation of lncRNA HNF1A-antisense 1 (HNF1A-AS1) has been reported in many types of human cancers, and studies on HNF1A-AS1 function in cancers revealed that HNF1A-AS1could act as either oncogene or tumor suppressor. Nevertheless, the functional involvement of HNF1A-AS1 in colon cancer remains unknown. In this study, we reported that HNF1A-AS1 was frequently upregulated in colon cancer tissues and associated with poor prognosis...
September 21, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28943432/highly-expressed-lncrna-loc730101-promotes-lung-cancer-cell-growth-through-wnt-canonical-pathway
#6
Lei Liu, Yongxue Zhang, Wangkai Cao
Many long non-coding RNA (lncRNA) has recently been reported to be dysregulated and involved in the progression of non-small-cell lung cancer. However, the biological role of LOC730101 in NSCLC carcinogenesis remains unclear. In the present study, we found that LOC730101 was up-regulated in TCGA and GEO database, so were in NSCLC tissues and cell lines. Overexpression of LOC730101 prompted the proliferation of NSCLC both in vitro and in vivo while Silencing observed opposite phenomenon. Furthermore, we found that LOC730101 enhances the activity of Wnt/β-catenin signaling to promote the progression of cell cycle and ultimate promotes cell proliferation and growth...
September 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28943299/interaction-of-quindoline-derivative-with-telomeric-repeat-containing-rna-induces-telomeric-dna-damage-response-in-cancer-cells-through-inhibition-of-telomeric-repeat-factor-2
#7
Yan Zhang, Deying Zeng, Jiaojiao Cao, Mingxue Wang, Bing Shu, Guotao Kuang, Tian-Miao Ou, Jia-Heng Tan, Lian-Quan Gu, Zhi-Shu Huang, Ding Li
BACKGROUND: Telomeric repeat-containing RNA (TERRA) is a large non-coding RNA in mammalian cells, which forms an integral component of telomeric heterochromatin. TERRA can bind to an allosteric site of telomeric repeat factor 2 (TRF2), a key component of Shelterin that protect chromosome termini. Both TERRA and TRF2 have been recognized as promising new therapeutic targets for cancer treatment. METHODS: Our methods include FRET assay, SPR, CD, microscale thermophoresis (MST), enzyme-linked immunosorbent assay (ELISA), chromatin immunoprecipitation (ChIP), colony formation assays, Western blot, immunofluorescence, cell cycle arrest and apoptosis detection, and xCELLigence real-time cell analysis (RTCA)...
September 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28942956/long-non-coding-and-endogenous-retroviral-rna-levels-are-associated-with-proinflammatory-cytokine-mrna-expression-in-peripheral-blood-cells-implications-for-schizophrenia
#8
Jennifer K Melbourne, Kayla A Chase, Benjamin Feiner, Cherise Rosen, Rajiv P Sharma
Recent research indicates that the expression of long non-coding and endogenous retroviral RNAs is coordinated with the activity of immune molecules often dysregulated in schizophrenia. We measured the expression of TMEVPG1, NRON, HERV-W env and HERV-W gag in blood cells from participants with schizophrenia and controls. We report that a) expression levels of these non-coding RNAs are correlated with proinflammatory cytokine mRNA expression in all participants, b) HERV-W transcripts are negatively correlated with atypical antipsychotic use in participants with schizophrenia, and c) that these RNAs are transcribed in response to proinflammatory stimuli in a THP-1 monocyte cell line...
September 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28942451/the-human-rna-surveillance-factor-upf1-modulates-gastric-cancer-progression-by-targeting-long-non-coding-rna-malat1
#9
Li Li, Yingying Geng, Ru Feng, Qinqin Zhu, Bei Miao, Jiang Cao, Sujuan Fei
BACKGROUND/AIMS: The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is overexpressed in numerous cancers. However, whether MALAT1 is regulated and the related mechanisms in gastric cancer remain unclear. METHODS: Immunohistochemistry and qRT-PCR analyses were used to detect the expression levels of UPF1 and MALAT1 in gastric cancer and adjacent normal tissues. MTT, cell cycle, apoptosis and transwell assays were performed to examine the effects of UPF1 on cell cycle progression, cell proliferation, apoptosis, migration and invasion...
August 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28942241/long-non-coding-rna-hoxa11-as-in-human-cancer-a-meta-analysis
#10
REVIEW
Na Li, Meilan Yang, Ke Shi, Wei Li
BACKGROUND: Homeobox A11 antisense (HOXA11-AS), a newly identified lncRNA, is up-regulated in various carcinomas. We conducted the present meta-analysis to explore the potential of HOXA11-AS as a common predictive biomarker for metastasis and prognosis in malignant tumors. METHODS: A systematic literature search on the online electronic databases of PubMed, Web of Science, and Embase was carried out to determine relevant studies (as of July 9, 2017). The pooled hazard ratios (HRs)/odds rates (ORs), and their 95% confidence intervals (CIs) were used to evaluate the relationship...
September 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28942151/molecular-characterization-of-mitochondrial-zucchini-and-its-relation-to-nuage-pirna-pathway-components-in-bombyx-mori-ovary-derived-bmn4-cells
#11
Anandrao Ashok Patil, Tsuneyuki Tatsuke, Hiroaki Mon, Jae Man Lee, Daisuke Morokuma, Masato Hino, Takahiro Kusakabe
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with PIWI subfamily proteins, which play an important role in transposon silencing in animal germ cell. The piRNAs biogenesis is divided into two major pathways: primary and secondary, and both pathways are independent of double-stranded RNA-processing enzyme Dicer, which processes the single-stranded RNA transcripts in microRNA (miRNA) and siRNA (small interfering RNA) pathway. Primary piRNAs are processed from long non-coding RNA precursors transcribed from piRNA clusters...
September 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28941129/mechanisms-of-drug-resistance-in-cancer-the-role-of-extracellular-vesicles
#12
REVIEW
Priya Samuel, Muller Fabbri, David Raul Francisco Carter
Drug resistance remains a major barrier to the successful treatment of cancer. The mechanisms by which therapeutic resistance arises multifactorial. Recent evidence has shown that extracellular vesicles (EVs) play a role in mediating drug resistance. EVs are small vesicles carrying a variety of macromolecular cargo released by cells into the extracellular space and can be taken up into recipient cells, resulting in transfer of cellular material. EVs can mediate drug resistance by several mechanisms. They can serve as a pathway for sequestration of cytotoxic drugs, reducing the effective concentration at target sites...
September 23, 2017: Proteomics
https://www.readbyqxmd.com/read/28941018/role-of-non-coding-rnas-in-head-and-neck-squamous-cell-carcinoma-a-narrative-review
#13
REVIEW
M K Sannigrahi, Rajni Sharma, Naresh K Panda, Madhu Khullar
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides), responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor-suppressors miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and, have been also implicated in carcinogenesis...
September 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28941008/non-canonical-bases-in-the-genome-the-regulatory-information-layer-in-dna
#14
Thomas Carell, Matthias Q Kurz, Markus Müller, Martin Rossa, Fabio Spada
The sequence of the four canonical bases dA, dC, dG and dT forming two defined Watson-Crick base pairs (dT:dA, dG:dC), held together by H-bonding, establish the sequence information in the DNA double strand. The faithful replication of the sequence information during cell division, the transcription of the DNA information into RNA and the final translation of the sequence information into proteins is the basis for life on earth. Multicellular organisms developed the concept of specialized cells that perform specific functions...
September 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28940804/long-non-coding-rna-crnde-sponges-mir-384-to-promote-proliferation-and-metastasis-of-pancreatic-cancer-cells-through-upregulating-irs1
#15
Gang Wang, Jingen Pan, Lu Zhang, Yajun Wei, Cheng Wang
OBJECTIVE: Colorectal neoplasia differentially expressed (CRNDE), a vital cancer-related long non-coding RNA (lncRNA), has been brought to reports for playing quintessential functions in the growth and progression of several human malignancies. Nevertheless, the expression as well as the functional mechanisms of CRNDE in pancreatic cancer is not known so for. This study aimed at investigating the biological and clinical importance of CRNDE in human pancreatic cancer. MATERIALS AND METHODS: The expression levels of CRNDE in pancreatic cancer tissues as well as cell lines were identified with the help of quantitative real-time PCR (qRT-PCR)...
September 21, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28940102/micrornas-in-heart-failure-cardiac-transplantation-and-myocardial-recovery-biomarkers-with-therapeutic-potential
#16
REVIEW
Palak Shah, Michael R Bristow, J David Port
PURPOSE OF REVIEW: Heart failure is increasing in prevalence with a lack of recently developed therapies that produce major beneficial effects on its associated mortality. MicroRNAs are small non-coding RNA molecules that regulate gene expression, are differentially regulated in heart failure, and are found in the circulation serving as a biomarker of heart failure. RECENT FINDINGS: Data suggests that microRNAs may be used to detect allograft rejection in cardiac transplantation and may predict the degree of myocardial recovery in patients with a left ventricular assist device or treated with beta-blocker therapy...
September 22, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28938673/quantitative-assessment-of-lncrna-hotair-polymorphisms-and-cancer-risk-in-chinese-population-a-meta-analysis-based-on-26-810-subjects
#17
Xu Liu, Qiongyu Duan, Jian Zhang
As a well-known long non-coding RNA, HOTAIR has been demonstrated to be involved in carcinogenesis and progression of various human cancers. Previous studies have investigated the potential association between HOTAIR polymorphisms and cancer risk in Chinese population. However, the results remain conflicting. Therefore, for the first time, we conducted a meta-analysis to derive a more precise estimation of these associations for Chinese. PubMed, Embase, CNKI and Wanfang databases were systematically searched...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938655/prognostic-value-of-decreased-long-non-coding-rna-tusc7-expression-in-some-solid-tumors-a-systematic-review-and-meta-analysis
#18
Na Li, Meilan Yang, Ke Shi, Wei Li
Accumulating evidences indicated that tumor suppressor candidate 7 (TUSC7) is a putatively tumor suppressor gene in various tumors. We carried out current systematic review and meta-analysis to explore the decreased expression of TUSC7 associate with prognostic and clinicopathological characteristic in cancer patients. A literature collection search in the online electronic databases PubMed, Embase, Web of Science, and CNKI was conducted to obtain eligible studies (up to February 20, 2017). A total of nine studies comprise 757 patients were identified and included in present meta-analysis based on the selection and inclusion criteria...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938647/long-non-coding-rna-malat1-for-promoting-metastasis-and-proliferation-by-acting-as-a-cerna-of-mir-144-3p-in-osteosarcoma-cells
#19
Yong Wang, Yueyang Zhang, Tao Yang, Wei Zhao, Ningning Wang, Pengcheng Li, Xiandong Zeng, Weiguo Zhang
Long non-coding RNAs (lncRNAs) are involved in various biological processes and diseases including osteosarcoma. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is overly expressed in osteosarcoma. But the function and mechanism it works on in osteosarcoma proliferation and metastasis mediated by Rho associated coiled-coil containing protein kinase 1 (ROCK1) and Rho associated coiled-coil containing protein kinase 2 (ROCK2) remain unclear. In the present study, an elevated MALAT1 was found in osteosarcoma tissues and cell lines, and the elevated MALAT1 was correlated with a poor prognosis in osteosarcoma patients...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938617/development-and-validation-of-nomogram-based-on-lncrna-zfas1-for-predicting-survival-in-lymph-node-negative-esophageal-squamous-cell-carcinoma-patients
#20
Hongtai Shi, Zhenhua Liu, Dong Pei, Youqin Jiang, Haiwen Zhu, Bin Chen
BACKGROUND: There is increasing evidence of a relationship between long non-coding RNA (lncRNA) and cancer. This study aimed to examine the prognostic value of the lncRNA ZFAS1 in esophageal squamous cell carcinoma (ESCC). RESULTS: The results showed that ZFAS1 expression was significantly higher in ESCC tissues compared with the corresponding adjacent normal tissues (P < 0.001). ESCC patients with high ZFAS1 expression had a poor overall survival (OS). Histological grade, T stage and ZFAS1 expression were integrated to develop the nomogram...
August 29, 2017: Oncotarget
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