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https://www.readbyqxmd.com/read/29245173/patient-perception-of-disease-related-symptoms-and-complications-in-relapsing-polychondritis
#1
Marcela A Ferrada, Peter C Grayson, Shubhasree Banerjee, Keith Sikora, Robert Colbert, Ninet Sinaii, James D Katz
OBJECTIVE: To assess patient-reported symptoms and burden of disease in relapsing polychondritis (RP). METHODS: Patients with RP completed a disease-specific online survey to identify symptoms attributed to illness. Patients were divided into subgroups based upon presence or absence of ear/nose, airway, or joint involvement. Pathway to diagnosis, treatment, and disease-related complications were assessed within each subgroup. RESULTS: Data from 304 respondents were included in this analysis...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29244969/treatment-of-open-upper-limb-injuries-with-infection-prevention-and-negative-pressure-wound-therapy-a-systematic-review
#2
E Ali, M Raghuvanshi
OBJECTIVE: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Furthermore, treatment of these injuries is often more difficult and requires complicated strategies...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244831/antimicrobial-susceptibility-and-molecular-epidemiology-of-clinical-enterobacter-cloacae-bloodstream-isolates-in-shanghai-china
#3
Su Wang, Shu-Zhen Xiao, Fei-Fei Gu, Jin Tang, Xiao-Kui Guo, Yu-Xing Ni, Jie-Ming Qu, Li-Zhong Han
BACKGROUND: Enterobacter cloacae is a major nosocomial pathogen causing bloodstream infections. We retrospectively conducted a study to assess antimicrobial susceptibility and phylogenetic relationships of E. cloacae bloodstream isolates in two tertiary university-affiliated hospitals in Shanghai, in order to facilitate managements of E. cloacae bloodstream infections and highlight some unknowns for future prevention. METHODS: Fifty-three non-duplicate E. cloacae bloodstream isolates were consecutively collected from 2013 to 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29244755/doped-halloysite-nanotubes-for-use-in-the-3d-printing-of-medical-devices
#4
Jeffery A Weisman, Udayabhanu Jammalamadaka, Karthik Tappa, David K Mills
Previous studies have established halloysite nanotubes (HNTs) as viable nanocontainers capable of sustained release of a variety of antibiotics, corrosion agents, chemotherapeutics and growth factors either from their lumen or in outer surface coatings. Accordingly, halloysite nanotubes (HNTs) hold great promise as drug delivery carriers in the fields of pharmaceutical science and regenerative medicine. This study explored the potential of 3D printing drug doped HNT constructs. We used a model drug, gentamicin (GS) and polylactic acid (PLA) to fabricate GS releasing disks, beads, and pellets...
December 15, 2017: Bioengineering
https://www.readbyqxmd.com/read/29244034/rehabilitation-nurses-knowledge-attitudes-and-behaviors-for-preventing-urinary-tract-infections-from-intermittent-catheterization
#5
Tenzin Dawa, Mary Randolph, Penelope Moyers, Patricia Finch Guthrie, Brenda Frie, Debra Filer
PURPOSE: The aim of this study was to develop and examine the reliability of a survey to assess knowledge, attitudes, and behaviors (KAB) of rehabilitation nurses for preventing urinary tract infections in persons requiring intermittent catheterization. DESIGN: Cross-sectional survey with principal component analysis. METHODS: Survey development and administration based on national guidelines. FINDINGS: Principal component analysis produced three reliable components of KAB explaining 54...
December 13, 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29243978/reduction-of-shunt-dependency-rates-following-aneurysmal-subarachnoid-hemorrhage-by-tandem-fenestration-of-the-lamina-terminalis-and-membrane-of-liliequist-during-microsurgical-aneurysm-repair
#6
Ethan A Winkler, Jan-Karl Burkhardt, W Caleb Rutledge, Jonathan W Rick, Carlene P Partow, John K Yue, Harjus Birk, Ashley M Bach, Kunal P Raygor, Michael T Lawton
OBJECTIVE Shunt-dependent hydrocephalus is an important cause of morbidity following aneurysmal subarachnoid hemorrhage (aSAH) in excess of 20% of cases. Hydrocephalus leads to prolonged hospital and ICU stays, well as to repeated surgical interventions, readmissions, and complications associated with ventriculoperitoneal (VP) shunts, including shunt failure and infection. Whether variations in surgical technique at the time of aneurysm treatment may modify rates of shunt dependency remains a matter of debate...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29243859/neuroinflammatory-reactions-in-sickness-behavior-induced-by-bacterial-infection-protective-effect-of-minocycline
#7
Hanaa A Mansour, Wedad A Hassan, Gehan S Georgy
The neurological changes elicited by bacterial infection are called sickness behavior. Minocycline (MIN) is neuroprotective with a remarkable brain tissue penetration. MIN was orally administered at a dose 90 mg/kg for 3 days, whereas Escherichia coli was given as a single intraperitoneal injection (0.2 mL of 24 h growth) on the third day. After 24 h of bacterial infection, behavioral tests namely open field and forced swimming were carried out, then animals were decapitated. Rats infected with E. coli displayed reduced struggling time in forced swimming test, as well as, exploration and locomotion in open field test with reduction in neurotransmitters (norepinephrine, dopamine, and serotonin) versus elevation in the inflammatory (tumor necrosis factor-alpha, interferon-gamma) and oxidative stress (thiobarbituric acid reactive substance, reduced glutathione) biomarkers...
December 15, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29243495/the-recombinant-fusion-protein-cfp10-esat6-difn-has-protective-effect-against-tuberculosis-in-guinea-pigs
#8
Natalya V Permyakova, Pavel A Belavin, Dariya S Pirozhkova, Elena G Ufimtseva, Sergey M Rozov, Sergey R Mursalimov, Yuriy V Sidorchuk, Elena A Uvarova, Alla A Zagorskaya, Tatiana V Marenkova, Svetlana V Bannikova, Evgeniy A Demidov, Konstantin V Starostin, Marionella A Kravchenko, Diana V Vakhrusheva, Roman B Berdnikov, Natalya I Eremeeva, Sergey N Skornyakov, Sergey E Peltek, Elena V Deineko
Development of effective vaccine candidates against tuberculosis (TB) is currently the most important challenge in the prevention of this disease since the BCG vaccine fails to guarantee a lifelong protection, while any other approved vaccine with better efficiency is still absent. The protective effect of the recombinant fusion protein CFP10-ESAT6-dIFN produced in a prokaryotic expression system (Escherichia coli) has been assessed in a guinea pig model of acute TB. The tested antigen comprises the Mycobacterium tuberculosis (Mtb) proteins ESAT6 and CFP10 as well as modified human γ-interferon (dIFN) for boosting the immune response...
December 15, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29243402/national-burden-of-hospitalized-and-non-hospitalized-influenza-associated-severe-acute-respiratory-illness-in-kenya-2012-2014
#9
Jeanette A Dawa, Sandra S Chaves, Bryan Nyawanda, Henry N Njuguna, Carolyne Makokha, Nancy A Otieno, Omu Anzala, Marc-Alain Widdowson, Gideon O Emukule
BACKGROUND: Influenza-associated respiratory illness was substantial during the emergence of the 2009 influenza pandemic. Estimates of influenza burden in the post-pandemic period are unavailable to guide Kenyan vaccine policy. OBJECTIVES: To update estimates of hospitalized and non-hospitalized influenza-associated severe acute respiratory illness (SARI) during a post-pandemic period (2012-2014) and describe the incidence of disease by narrow age categories. METHODS: We used data from Siaya County Referral Hospital to estimate age-specific base rates of SARI...
December 15, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29243399/diabetic-foot-ulcer-management-in-clinical-practice-in-the-uk-costs-and-outcomes
#10
Julian F Guest, Graham W Fuller, Peter Vowden
The aim of this study was to estimate the patterns of care and annual levels of health care resource use attributable to managing diabetic foot ulcers (DFUs) in clinical practice by the UK's National Health Service (NHS), and the associated costs of patient management. This was a retrospective cohort analysis of the records of 130 patients with a newly diagnosed DFU in The Health Improvement Network (THIN) database. Patients' characteristics, wound-related health outcomes and health care resource use were quantified, and the total NHS cost of patient management was estimated at 2015-2016 prices...
December 15, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29243368/a-2000-patient-retrospective-assessment-of-a-new-strategy-for-burn-wound-management-in-view-of-infection-prevention-and-treatment
#11
Justyna Glik, Wojciech Łabuś, Diana Kitala, Karolina Mikuś-Zagórska, Christopher D Roberts, Mariusz Nowak, Aleksandra Kasperczyk, Marek Kawecki
Infections in burn patients are still the principal cause of complications in burn injuries. The aim of this study is to assess a new strategy for burn wound management in view of infection prevention and treatment in the experience of the Burn Treatment Center in Siemianowice Śląskie. The applied methodology involved the analysis of patient records describing the hospital's epidemiological situation between 2014 and 2016. The analysis also included the use and cost of antibiotics, silver-containing dressings, and other antiseptics relative to the number of sepsis cases, including those caused by Pseudomonas aeruginosa, as well as the mortality ratio...
December 15, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29243070/extensive-evolution-analysis-of-the-global-chikungunya-virus-strains-revealed-the-origination-of-chikv-epidemics-in-pakistan-in-2016
#12
Junming Shi, Zhengyuan Su, Zhaojun Fan, Jun Wang, Siqing Liu, Bo Zhang, Hongping Wei, Shoukat Jehan, Nadia Jamil, Shu Shen, Fei Deng
Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mosquito species and their distributions. In this study, we reported the complete genome sequences of eight CHIKV isolates from the outbreak in Pakistan last year. Then we reviewed the evolutionary history using extensive phylogenetic analysis, analyzed lineagespecific substitutions in viral proteins, and characterized the spreading pathway of CHIKV strains including the Pakistani strains...
December 11, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/29243033/incontinence-associated-dermatitis-pathogenesis-contributing-factors-prevention-and-management-options
#13
Hilde Beele, Steven Smet, Nele Van Damme, Dimitri Beeckman
Incontinence-associated dermatitis (IAD) is a common type of irritant contact dermatitis, seen in patients with urinary or faecal incontinence. Mechanical factors such as traumata and friction may aggravate the lesions. The fragile skin in elderly patients is more prone to developing IAD. The clinical picture of IAD consists of persistent redness on the one hand and skin loss on the other. Both categories may be associated with clinical signs of major colonisation or infection. It is important to distinguish IAD from pressure ulcers and other dermatoses in the genital region...
December 14, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29242769/vaccines-for-the-prevention-of-melioidosis-and-glanders
#14
Monica M Johnson, Kristy M Ainslie
Purpose of review: Burkholderia pseudomallei's and Burkholderia mallei's high rate of infectivity, limited treatment options, and potential use as biological warfare agents underscore the need for development of effective vaccines against these bacteria. Research efforts focused on vaccines against these bacteria are in pre-clinical stages, with no approved formulations currently on the market. Recent findings: Several live attenuated and subunit vaccine formulations have been evaluated in animal studies, with no reports of significant long term survival after lethal challenge...
September 2017: Current Tropical Medicine Reports
https://www.readbyqxmd.com/read/29242711/effect-of-point-of-care-diagnostics-on-maternal-outcomes-in-human-immunodeficiency-virus-infected-women-systematic-review-and-meta-analysis
#15
Tivani P Mashamba-Thompson, Rebecca L Morgan, Benn Sartorius, Brittany Dennis, Paul K Drain, Lehana Thabane
Introduction: The World Health Organization advocates for increased accessibility of HIV-related point-of-care (POC) diagnostics in settings that lack laboratory infrastructure. The aim of this study is to assess the impact of POC diagnostics on maternal health outcomes in HIV-infected women. Methods: A systematic literature review used multiple data sources as follows: Cochrane Infectious Disease Group Specialized Register; Cochrane Central Register of Control Trials, published in The Cochrane Library; PubMed; EBSCOhost and LILACS from January 2000 to October 2015...
June 2017: Point of Care
https://www.readbyqxmd.com/read/29242521/surveillance-of-live-poultry-markets-for-low-pathogenic-avian-influenza-viruses-in-guangxi-province-southern-china-from-2012-2015
#16
Sisi Luo, Zhixun Xie, Zhiqin Xie, Liji Xie, Li Huang, Jiaoling Huang, Xianwen Deng, Tingting Zeng, Sheng Wang, Yanfang Zhang, Jiabo Liu
Infections with low pathogenic avian influenza viruses (LPAIVs) can be mild or asymptomatic in poultry; however, in humans, LPAIVs can cause severe infections and death, as demonstrated by the H7N9 and H10N8 human infection outbreaks in 2013 in China. In this study, we conducted an epidemiological survey of LPAIVs at live poultry markets (LPMs) in Guangxi Province, Southern China, which is near several Southeast Asian countries. From January 2012 to December 2015, we collected 3,813 swab samples from poultry at LPMs in Guangxi...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242191/the-inducible-microrna-203-in-fish-represses-the-inflammatory-responses-to-gram-negative%C3%A2-bacteria-by-targeting-il-1-receptor-associated-kinase-4
#17
Tianjun Xu, Qing Chu, Junxia Cui, Xueyan Zhao
Innate immune responses are the first defense against pathogenic invaders. Activation and termination of these immune responses are regulated by several mechanisms. MicroRNAs (miRNAs), a group of small non-coding RNAs, have been implicated in the regulation of a spectrum of both physiological and pathological conditions, including immune responses. Although immune regulatory miRNAs networks in higher vertebrates have been well described, regulation of these responses in fish species is poorly understood in fish species...
December 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29242141/molecular-and-epidemiological-evidence-of-patient-to-patient-hepatitis-c-virus-transmission-in-a-scottish-emergency-department
#18
I Johannessen, J Danial, D B Smith, J Richards, L Imrie, A Rankin, L J Willocks, C Evans, C Leen, P Gibson, P Simmonds, D Goldberg, A McCallum, K Roy
BACKGROUND: Transmission of hepatitis C virus (HCV) in the health care setting is rare. Routine infection prevention and control (IPC) measures mean this should be a preventable never event. This paper investigates the diagnosis of acute healthcare associated HCV infection. METHODS: Epidemiological and molecular investigation of a case of acute HCV infection associated with nosocomial exposure. RESULTS: Detailed investigation of the treatment history of a patient with acute HCV infection identified transmission from a co-attending patient in an Emergency Department as the likely source; this possibility was confirmed by virus sequence analysis...
December 11, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29241815/litigation-in-orthopedic-surgery-what-can-we-do-to-prevent-it-systematic-analysis-of-126-legal-actions-involving-four-university-hospitals-in-france
#19
J Mouton, R Gauthé, M Ould-Slimane, S Bertiaux, S Putman, F Dujardin
INTRODUCTION: Orthopedic surgery produces 20% of medical malpractice claims. However only a few studies have examined the reasons for and consequences of these disputes, and they have usually been limited to a single hospital. This led us to perform a retrospective analysis of the claims at four teaching hospitals in northwestern France. The goals were 1) to describe the circumstances that led to these claims and recommend ways to prevent them, and 2) to describe the conduct of the proceedings and their financial and social outcomes...
December 11, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29241768/zika-virus-the-transboundary-pathogen-from-mosquito-and-updates
#20
REVIEW
Weili Kong, Jian Zhu
Zika virus (ZIKV) is a mosquito-borne flavivirus that was relatively obscure until outbreaks started in 2013. ZIKV is associated with neurological manifestations such as Guillan-Barrè Syndrome in adult and microcephaly in the newborn population. Although the majority of disease mechanisms of ZIKV is unclear, some information was updated with new scientific evidence. Currently, there are no approved drugs or vaccine that can be used for therapy during ZIKV infection. Based on the transmission mechanism of ZIKV, vector control and safe sex seem to be the most effective available preventive measures against ZIKV spread...
December 11, 2017: Microbial Pathogenesis
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