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https://www.readbyqxmd.com/read/28550795/thrombocytopenia-associated-with-tavi-the-summary-of-possible-causes
#1
REVIEW
Maciej Mitrosz, Malgorzata Chlabicz, Katarzyna Hapaniuk, Karol A Kaminski, Bozena Sobkowicz, Jaroslaw Piszcz, Slawomir Dobrzycki, Wlodzimierz J Musial, Tomasz Hirnle, Agnieszka M Tycinska
Thrombocytopenia (TP) following transcatheter aortic valve implantation (TAVI) procedure is a common phenomenon but the underlying mechanisms are neither well known nor described. Postinterventional severe TP is related to worse early and late outcome. Moreover, the statement of enhanced platelet and coagulation activation might justify even stronger antiplatelet and anticoagulation therapy following TAVI procedure. Thus, the examination of the pathomechanisms responsible for TP post TAVI seems to be crucial...
May 24, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28550101/a-novel-experimental-rat-model-of-peripheral-nerve-scarring-reliably-mimicking-post-surgical-complications-and-recurring-adhesions
#2
Angela Lemke, Carina Penzenstadler, James Ferguson, Dominika Lidinsky, Rudolf Hopf, Monika Bradl, Heinz Redl, Susanne Wolbank, Thomas Hausner
Inflammation, fibrosis and perineural adhesions with the surrounding tissue are common pathological processes following nerve injury and surgical interventions on peripheral nerves in human patients. Furthermore, these signs can reoccur following external neurolysis, currently the most common surgical treatment, thus leading to renewed nerve function impairment and chronic pain. To enable a successful evaluation of new therapeutic approaches, it is crucial to use a reproducible animal model that mimics the main clinical symptoms occurring in human patients...
May 26, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28549804/the-efficient-clade-lactic-acid-bacteria-for-industrial-chemical-production
#3
REVIEW
Michael Sauer, Hannes Russmayer, Reingard Grabherr, Clemens K Peterbauer, Hans Marx
Lactic acid bacteria are well known to be beneficial for food production and, as probiotics, they are relevant for many aspects of health. However, their potential as cell factories for the chemical industry is only emerging. Many physiological traits of these microorganisms, evolved for optimal growth in their niche, are also valuable in an industrial context. Here, we illuminate these features and describe why the distinctive adaptation of lactic acid bacteria is particularly useful when developing a microbial process for chemical production from renewable resources...
May 23, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28549626/cell-biology-metabolic-crosstalk-in-glioma
#4
REVIEW
Alison Colquhoun
The renewed interest in cancer metabolism in recent years has been fuelled by the identification of the involvement of key oncogenes and tumour suppressor genes in the control of metabolic pathways. Many of these alterations lead to dramatic changes in bioenergetics, biosynthesis and redox balance within tumour cells. The complex relationship between tumour cell metabolism and the tumour microenvironment has turned this field of biochemistry and cell biology into a challenging and exciting area for study. In the case of gliomas the involvement of altered metabolic pathways including glycolysis, oxidative phosphorylation and glutaminolysis are pointing the way to new possibilities for treatment...
May 23, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28549559/the-novel-indole-3-formaldehyde-2-aitfei-3-f-is-involved-in-processes-of-apoptosis-induction
#5
Mojgan Noroozi Karimabad, Mehdi Mahmoodi, Abdollah Jafarzadeh, Ali Darehkordi, Mohammad Reza Hajizadeh, Hossein Khorramdelazad, Soudeh Khanamani Falahati-Pour, Gholamhossein Hassanshahi
AIM AND OBJECTIVES: Balancing between Bax and Bcl-2 plays critical roles in both proliferation and self-renewal activation of cancer cells. Indole-3-formaldehyde derivatives limit the growth and facilitate cell death in different cell systems. In this study, we introduced a novel indole derivative (2-AITFEI-3-F) with tendency to facilitate apoptosis in NB4 line in comparison to basal Indole-3-formaldehyde (I3F). METHODS: The NB4 cells were cultured in RPMI1640 medium contained 2-AITFEI-3-F and I3F (15...
May 23, 2017: Life Sciences
https://www.readbyqxmd.com/read/28549413/external-magnetic-field-promotes-homing-of-magnetized-stem-cells-following-subcutaneous-injection
#6
Yu Meng, Changzhen Shi, Bo Hu, Jian Gong, Xing Zhong, Xueyin Lin, Xinju Zhang, Jun Liu, Cong Liu, Hao Xu
BACKGROUND: Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to self-renew and migrate to sites of pathology. In vivo tracking of MSCs provides insights into both, the underlying mechanisms of MSC transformation and their potential as gene delivery vehicles. The aim of our study was to assess the ability of superparamagnetic iron oxide nanoparticles (SPIONs)-labeled Wharton's Jelly of the human umbilical cord-derived MSCs (WJ-MSCs) to carry the green fluorescent protein (GFP) gene to cutaneous injury sites in a murine model...
May 26, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28549373/production-of-a-potential-liquid-plant-bio-stimulant-by-immobilized-piriformospora-indica-in-repeated-batch-fermentation-process
#7
Nikolay Vassilev, Bettina Eichler-Löbermann, Elena Flor-Peregrin, Vanessa Martos, Antonia Reyes, Maria Vassileva
Piriformospora indica, a mycorrhizal-like fungus able to establish associations with roots of a wide range of plants, supporting plant nutrition and increasing plant resistance and tolerance to stress, was shown to solubilise phosphate applied in the form of animal bone char (HABO) in fermentation systems. The process of P solubilisation was caused most likely by proton extrusion and medium pH lowering. The fungal mycelium was successfully immobilized/retained in a polyurethane foam carrier. Further employment of the immobilized mycelium in repeated-batch fermentation process resulted in at least 5 cycles of P solubilization...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28549280/protocols-for-the-analytical-characterization-of-therapeutic-monoclonal-antibodies-i-non-denaturing-chromatographic-techniques
#8
Alexandre Goyon, Valentina D'Atri, Balazs Bobaly, Elsa Wagner-Rousset, Alain Beck, Szabolcs Fekete, Davy Guillarme
Size-, charge- and hydrophobicity-related variants of a biopharmaceutical product have to be deeply characterized for batch consistency and for the assessment of immunogenicity and safety effects. Size exclusion chromatography (SEC) and ion exchange chromatography (IEX) are considered as the gold standard for the analysis of high molecular weight species (HMWS) and charge-related variants, respectively. Hydrophobic interaction chromatography (HIC) has drawn renewed attention to monitor the small drug payload distribution in the cysteine-linked antibody-drug conjugates (ADC)...
May 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28549210/selecting-sugarcane-genotypes-by-the-selection-index-reveals-high-gain-for-technological-quality-traits
#9
L A Silva, P E Teodoro, L A Peixoto, C Assis, K Gasparini, M H P Barbosa, L L Bhering
Sugarcane (Saccharum sp) is one of the most promising crops and researchers have sought for renewable alternative energy sources to reduce CO2 emission. The study of strategies, which allow breeders in the selection of superior genotypes for many traits simultaneously, is important. Therefore, the objectives of this study were: i) to apply path analysis to better understand the relationship between the lignocellulosic traits and technological quality traits with total recoverable sugars (TRS) and ii) to use several multivariate selection indexes to predict the genetic gain and to select superior genotypes in the sugarcane breeding...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28548937/nac1-promotes-self-renewal-of-embryonic-stem-cells-through-direct-transcriptional-regulation-of-c-myc
#10
Yan Ruan, Jianrong He, Wei Wu, Ping He, Yanping Tian, Lan Xiao, Gaoke Liu, Jiali Wang, Yuda Cheng, Shuo Zhang, Yi Yang, Jiaxiang Xiong, Ke Zhao, Ying Wan, He Huang, Junlei Zhang, Rui Jian
The pluripotency transcriptional network in embryonic stem cells (ESCs) is composed of distinct functional units including the core and Myc units. It is hoped that dissection of the cellular functions and interconnections of network factors will aid our understanding of ESC and cancer biology. Proteomic and genomic approaches have identified Nac1 as a member of the core pluripotency network. However, previous studies have predominantly focused on the role of Nac1 in psychomotor stimulant response and cancer pathogenesis...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548175/the-water-based-synthesis-of-chemically-stable-zr-based-mofs-using-pyridine-containing-ligands-and-their-exceptionally-high-adsorption-capacity-for-iodine
#11
Zhe Wang, Ying Huang, Jian Yang, Yongsheng Li, Qixin Zhuang, Jinlou Gu
The primary pollutant, radioactive iodine (I2), has become a worldwide concern due to its serious ill effects of radiotoxicity on human health. Therefore, it is of great significance to develop novel adsorbents for effectively eliminating I2 from nuclear waste. Herein, we reported a Zr-based MOF adsorbent constructed by utilizing pyridine-containing pyridine-dicarboxylic acid (PYDC) as organic ligands (UiO-66-PYDC) as well as active sites for the efficient removal of I2. UiO-66-PYDC MOFs were synthesized by a hydrothermal strategy and featured good chemical and thermal stabilities, endowing them with the ability to work in harsh environments...
May 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28548166/biomass-involved-synthesis-of-n-substituted-benzofuro-2-3-d-pyrimidine-4-amines-and-biological-evaluation-as-novel-egfr-tyrosine-kinase-inhibitors
#12
Jianfei Sheng, Zhihong Liu, Ming Yan, Xuejing Zhang, Dejian Wang, Jun Xu, Ensheng Zhang, Yong Zou
Shikimic acid (1) is a renewable biomass which could be obtained sustainably through natural product isolation or metabolic engineering. Owing to its great potential in chemical conversion, the value-added utilization of this non-grain biomass has received much attention in recent years. Based on the established transformation route from shikimic acid (1) to methyl 3-dehydroshikimate (3-MDHS, 2) and to the multi-functionalized methyl 2-amino-3-cyanobenzofuran-5-carboxylate (3), we disclose a facile and transition metal-free method to access a series of N-substituted benzofuro[2,3-d]pyrimidine-4-amines in 63%-90% yields...
May 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28548046/large-area-snow-like-mose2-monolayers-synthesis-growth-mechanism-and-efficient-electrocatalyst-application
#13
JingWen Huang, Huiqiang Liu, Bo Jin, Min Liu, Qingchun Zhang, Liqiong Luo, Shijin Chu, Sheng Chu, Rufang Peng
This study explores the large-area synthesis of controllable morphology, uniform, and high-quality monolayer. MoSe2 is essential for its potential application in optoelectronics, photocatalysis, and renewable energy sources. In this study, we successfully synthesized snow-like MoSe2 monolayers using a simple chemical vapor deposition method. Results reveal that snow-like MoSe2 is a single crystal with a hexagonal structure, a thickness of ~0.9 nm, and a lateral dimension of up to 20 μm. The peak position of the photoluminescence spectra is ~1...
May 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28546906/recent-progress-in-energy-driven-water-splitting
#14
REVIEW
Si Yin Tee, Khin Yin Win, Wee Siang Teo, Leng-Duei Koh, Shuhua Liu, Choon Peng Teng, Ming-Yong Han
Hydrogen is readily obtained from renewable and non-renewable resources via water splitting by using thermal, electrical, photonic and biochemical energy. The major hydrogen production is generated from thermal energy through steam reforming/gasification of fossil fuel. As the commonly used non-renewable resources will be depleted in the long run, there is great demand to utilize renewable energy resources for hydrogen production. Most of the renewable resources may be used to produce electricity for driving water splitting while challenges remain to improve cost-effectiveness...
May 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28545844/rise-and-fall-of-the-two-visual-systems-theory
#15
Yves Rossetti, Laure Pisella, Robert D McIntosh
Among the many dissociations describing the visual system, the dual theory of two visual systems, respectively dedicated to perception and action, has yielded a lot of support. There are psychophysical, anatomical and neuropsychological arguments in favor of this theory. Several behavioral studies that used sensory and motor psychophysical parameters observed differences between perceptive and motor responses. The anatomical network of the visual system in the non-human primate was very readily organized according to two major pathways, dorsal and ventral...
May 22, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28545668/phenethyl-isothiocyanate-suppresses-cancer-stem-cell-properties-in-vitro-and-in-a-xenograft-model
#16
Ji Ho Yun, Kyung-A Kim, Gyhye Yoo, Sun Young Kim, Ji Min Shin, Jung Hoon Kim, Sang Hoon Jung, Jungho Kim, Chu Won Nho
BACKGROUND: Cancer stem cells (CSCs) are a subset of cells within the bulk of a tumor that have the ability to self-renew and differentiate, and are thus associated with cancer invasion, metastasis, and recurrence. Phenethyl isothiocyanate (PEITC) is a natural compound found in cruciferous vegetables such as broccoli and is used as a cancer chemopreventive agent; however, its effects on CSCs are little known. PURPOSE: To evaluate the effect of PEITC on CSCs in this study by examining CSC properties...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28545541/mal-gene-overexpression-as-a-marker-of-high-grade-serous-ovarian-carcinoma-stem-like-cells-that-predicts-chemoresistance-and-poor-prognosis
#17
Laura Zanotti, Chiara Romani, Laura Tassone, Paola Todeschini, Renata Alessandra Tassi, Elisabetta Bandiera, Giovanna Damia, Francesca Ricci, Laura Ardighieri, Stefano Calza, Sergio Marchini, Luca Beltrame, Germana Tognon, Maurizio D'Incalci, Sergio Pecorelli, Enrico Sartori, Franco Odicino, Antonella Ravaggi, Eliana Bignotti
BACKGROUND: The existence of cancer stem cells (CSCs) within a tumor bulk has been demonstrated for many solid tumors including epithelial ovarian carcinoma (EOC). CSCs have been associated to tumor invasion, metastasis and development of chemoresistant recurrences. In this context, we aim to characterize EOC CSCs from the molecular point of view in order to identify potential biomarkers associated with chemoresistance. METHODS: We isolated a population of cells with stem-like characteristics (OVA-BS4 spheroids) from a primary human EOC cell line under selective conditions...
May 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28545378/piperine-as-a-potential-anti-cancer-agent-a-review-on-preclinical-studies
#18
Azadeh Manayi, Seyed Mohammad Nabavi, William N Setzer, Samineh Jafari
Recently many studies showed anticancer activities of piperine, a pungent alkaloid found in black pepper and some other Piper species. We attempted to summarize acquired data that support anticancer potential of this natural agent. Piperine has been reported to possess effective chemopreventive activity. It has been studied to affect several mechanisms of action, in brief enhancing antioxidant system, increasing level and activity of detoxifying enzymes and suppressing stem cell self-renewal. Moreover, piperine has been found to inhibit proliferation and survival of various cancerous cell lines via modulating cell cycle progression and exhibiting anti-apoptotic activity, respectively...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28545367/targeting-dna-minor-groove-by-hybrid-molecules-as-anticancer-agents
#19
Shalini Nekkanti, Ramya Tokala, Nagula Shankaraiah
Agents which can recognize and bind specific sequences of DNA offer selective therapy through the modulation of specific transcription factors or genes. Recently, there has been renewed interest in the field of anticancer minor groove binders. This may be attributed to the fact that many compounds of this class have demonstrated significant antitumor activity against a wide variety of cancers in recent clinical trials. This review will discuss the recent efforts to overcome the drawbacks of existing minor groove binding anticancer agents through rational drug design based on scaffolds with known antitumor activity...
May 22, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28545230/nanog-plays-a-hierarchical-role-in-the-transcription-network-regulating-the-pluripotency-and-plasticity-of-adipose-tissue-derived-stem-cells
#20
Maria Pitrone, Giuseppe Pizzolanti, Laura Tomasello, Antonina Coppola, Lorenzo Morini, Gianni Pantuso, Romina Ficarella, Valentina Guarnotta, Sebastio Perrini, Francesco Giorgino, Carla Giordano
The stromal vascular cell fraction (SVF) of visceral and subcutaneous adipose tissue (VAT and SAT) has increasingly come into focus in stem cell research, since these compartments represent a rich source of multipotent adipose-derived stem cells (ASCs). ASCs exhibit a self-renewal potential and differentiation capacity. Our aim was to study the different expression of the embryonic stem cell markers NANOG (homeobox protein NANOG), SOX2 (SRY (sex determining region Y)-box 2) and OCT4 (octamer-binding transcription factor 4) and to evaluate if there exists a hierarchal role in this network in ASCs derived from both SAT and VAT...
May 23, 2017: International Journal of Molecular Sciences
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