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Transcranial doppler

Jessica C Hodgson, Rebecca J Hirst, John M Hudson
Commonly displayed functional asymmetries such as hand dominance and hemispheric speech lateralisation are well researched in adults. However there is debate about when such functions become lateralised in the typically developing brain. This study examined whether patterns of speech laterality and hand dominance were related and whether they varied with age in typically developing children. 148 children aged 3-10 years performed an electronic pegboard task to determine hand dominance; a subset of 38 of these children also underwent functional Transcranial Doppler (fTCD) imaging to derive a lateralisation index (LI) for hemispheric activation during speech production using an animation description paradigm...
September 29, 2016: Developmental Cognitive Neuroscience
Laurence Ducharme-Crevier, Michele G Mills, Priya M Mehta, Craig M Smith, Mark S Wainwright
BACKGROUND: The primary objective of this study was to characterize changes in cerebral blood flow measured using transcranial Doppler in children with central nervous system infections. We hypothesized that children with central nervous system infections have abnormal cerebral blood flow, associated with a greater frequency of complications and poor neurological outcome. METHODS: We conducted a single-center, retrospective study of children admitted to the neonatal or pediatric intensive care unit with central nervous system infection and undergoing transcranial Doppler as part of routine care between March 2011 and July 2015...
September 4, 2016: Pediatric Neurology
Verónica V Olavarría, Hisatomi Arima, Craig S Anderson, Alejandro Brunser, Paula Muñoz-Venturelli, Laurent Billot, Pablo M Lavados
BACKGROUND: The HEADPOST Pilot is a proof-of-concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat head position initiated in patients within 12 h of onset of acute ischemic stroke involving the anterior circulation increases cerebral blood flow in the middle cerebral arteries, as measured by transcranial Doppler. The study will also assess the safety and feasibility of patients lying flat for ≥24 h...
October 14, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Charles L Francoeur, Stephan A Mayer
For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed cerebral ischemia (DCI) is one of the most important causes of mortality and poor neurological outcome. New insights in the last decade have led to an important paradigm shift in the understanding of DCI pathogenesis. Large-vessel cerebral vasospasm has been challenged as the sole causal mechanism; new hypotheses now focus on the early brain injury, microcirculatory dysfunction, impaired autoregulation, and spreading depolarization...
October 14, 2016: Critical Care: the Official Journal of the Critical Care Forum
Laura Llull, Steffen Thiel, Sergio Amaro, Álvaro Cervera, Anna M Planas, Ángel Chamorro
Activation of the inflammatory generating complement system might play a pathogenic role in spontaneous subarachnoid hemorrhage (SAH). We studied whether plasma and cerebrospinal fluid (CSF) levels of complement proteins were associated with angiographic vasospasm and cerebral ischemic lesions after SAH. Ficolin-1 (M-ficolin), ficolin-3 (H-ficolin), mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2), MASP-3, and MAp44 were analyzed in plasma of 45 SAH patients at 24 h after bleeding. Additionally, ficolin-1 levels were measured in cerebrospinal fluid (CSF) samples obtained 24 h after bleeding in 19 patients with external ventricular drainage placement...
October 12, 2016: Molecular Neurobiology
Mei-Ling Sharon Tai, Vijay K Sharma
BACKGROUND: Vascular complications are important causes of cerebral infarction in tuberculous meningitis (TBM).Transcranial Doppler ultrasonography (TCD) is a non-invasive tool that can provide real-time information about cerebral hemodynamics. However, the literature on the role of TCD in the diagnosis or monitoring of vasculopathy associated with TBM is scarce. We explored the role of TCD in the diagnosis and monitoring of TBM-related vasculopathy of the major intracranial arteries...
2016: PloS One
Elisabeth B Marsh, Wendy C Ziai, Rafael H Llinas
INTRODUCTION: Reversible cerebral vasoconstriction syndrome (RCVS) typically affects young patients and left untreated can result in hemorrhage or ischemic stroke. Though the disorder has been well characterized in the literature, the most appropriate way to diagnose, treat, and evaluate therapeutic response remains unclear. In previous studies, transcranial Doppler ultrasound (TCD) has shown elevated velocities indicative of vasospasm. This imaging modality is noninvasive and inexpensive; an attractive option for diagnosis and therapeutic monitoring if it is sensitive enough to detect changes in the acute setting given that RCVS often affects the distal vessels early in the course of disease...
May 2016: Case Reports in Neurology
Emily Riehm Meier, Angeli Rampersad
Once a fatal disease of childhood, more than 95% of patients born today with sickle cell disease (SCD) in developed countries are expected to survive into adulthood, largely because of improvements in supportive and preventive care (newborn screening, penicillin prophylaxis, transcranial Doppler (TCD) screening). Hydroxyurea (HU) therapy, the only oral medication currently available to prevent SCD complications, has become more widespread over the past 20 years. The NHLBI recommends that HU be offered to all patients with HbSS beginning at nine months of age, and the recently published Abnormal TCD with Transfusions Changing to HU (TWiTCH) trial has shown HU as an acceptable alternative to transfusion therapy for patients at high risk of stroke...
October 5, 2016: Pediatric Research
William K Karlsson, Caspar G Sørensen, Christina Kruuse
Endothelial dysfunction (ED), in particular cerebral ED, may be an essential biomarker for ischemic cerebrovascular disease. However, there is no consensus on methods to best estimate cerebral ED. In this systematic review, we evaluate the use of L-arginine and N(G) -monomethyl-L-arginine (L-NMMA) for assessment of cerebral ED. A systematic search of PubMed, EMBASE and the Cochrane Library was done. We included studies investigating cerebrovascular response to L-arginine or L-NMMA in human subjects with vascular risk factors or ischemic cerebrovascular disease...
October 5, 2016: Clinical and Experimental Pharmacology & Physiology
Masoud Hatefi, Someyeh Behzadi, Masoud Moghadas Dastjerdi, Alireza Abootalebi Ghahnavieh, Asghar Rahmani, Fatemeh Madizadeh, Mohammad Reza Hafezi Ahmadi, Khairollah Asadollahi
OBJECTIVE: This study aimed to assess any correlation between serum levels of homocysteine (Hcy) with markers of cerebral hemodynamic, endothelial dysfunction and cognition impairment in patients with traumatic brain injury (TBI). METHODS: By a cross-sectional study, all clinical data and serum levels of homocysteine of 85 TBI patients were collected. The pulsatility indices (PI) of the middle cerebral artery (MCA) were recorded by transcranial color-coded doppler ultrasonography (TCD) and cereberovascular reactivity (CVR)...
September 29, 2016: World Neurosurgery
Chuanyuan Tao, Jiajing Wang, Yuekang Zhang, Shirong Qi, Fan Liu, Chao You
OBJECTIVE: Cerebral vasospasm can occur after skull base tumor removal. Few studies concentrated on the posterior circulation vasospasm after tumor resection in the posterior fossa. We aimed to identify the risk factors associated with postoperative vertebrobasilar vasospasm after tumor resection in the foramen magnum. METHODS: We retrospectively reviewed the data of 62 patients with tumors in the foramen magnum at our institution from January 2010 to January 2015...
2016: PloS One
Thomas Sauvigny, Katja Brückner, Lasse Dührsen, Oliver Heese, Manfred Westphal, Stefan R G Stodieck, Tobias Martens
OBJECTIVE: Selective amygdalohippocampectomy (sAHE) is a well-established treatment for temporal lobe epilepsy, commonly with favorable neuropsychological outcome. Yet, it is still unknown if subsequent resection of the anteromesial temporal lobe (AMTLR), when necessary, deteriorates neuropsychological performance in this selected group of patients. Thus, we evaluated the clinical and neuropsychological data of patients who, due to insufficient seizure control after sAHE, received a subsequent ipsilateral AMTLR and compared these findings with patients who did not receive a second resection (control group)...
September 28, 2016: Epilepsia
Misaki Kohama, Shinichiro Sugiyama, Kenichi Sato, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Makoto Ohta, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga
BACKGROUND: Transcranial Doppler (TCD) is used to monitor cerebral vasospasm after subarachnoid hemorrhage (SAH), but its diagnostic ability is reported to be limited. Therefore, the purpose of this study was to investigate the relationship between the diagnosability of TCD and the localization of the vasospasm. METHODS: This retrospective study included 20 patients who presented with symptomatic vasospasm after SAH. All 20 patients underwent daily TCD examinations and cerebral angiography after the onset of delayed cerebral ischemia...
2016: Cerebrovascular Diseases Extra
Daniel Schuepbach, Stephan T Egger, Heinz Boeker, Stefan Duschek, Stefan Vetter, Erich Seifritz, Sabine C Herpertz
Patients with schizophrenia show deficits in cognitive functioning, and studies on cerebral hemodynamics have revealed aberrant patterns of mean cerebral blood flow velocity (MFV), an equivalent of cerebral blood flow (CBF). Therefore, we carried out a controlled study that assessed MFV in schizophrenia during a well-known neuropsychological task, the Trail Making Test (TMT). We measured MFV in the middle cerebral arteries using functional transcranial Doppler sonography in 15 schizophrenia patients and 15 healthy subjects...
September 17, 2016: Brain and Cognition
Abdolhamid Shariat, Leila Niknam, Sadegh Izadi, Alireza Salehi
BACKGROUND: The aim of this study is to determine the frequency of intracranial artery stenosis in patients with acute ischemic stroke in Iran. METHODS: A total of 169 patients with acute ischemic stroke were eligible to participate and were enrolled in this study from January 2012 to February 2013. All the patients were admitted to the Nemazee ‎Hospital, affiliated to Shiraz University of Medical Sciences, Iran. They underwent transcranial Doppler (TCD) ultrasonography...
July 6, 2016: Iranian Journal of Neurology
Tatiana Ripp, Victor Mordobin, Evgeny Ripp, Galina Semke, Alla Falkovskaya, Ludmila Fedorova, Sergey Popov
OBJECTIVE: The aim of the study was to develop the new technology and to classify changes of arterial reactivity (AR) after metabolic stress tests in patients with hypertension. DESIGN AND METHOD: All participants of research have given the informed agreement. We used new special portative apparatus with metering rate during hypercapnia (inhalation 2 min 4% mixture of carbonic gas with air (gipercapnia) or hyperoxia - 100% oxygen (giperoxia) and in periods of recovery (rec) (air-inhalation 2 min) of 264 patients (age 52...
September 2016: Journal of Hypertension
Rachel Wong, Rhenan Nealon, Daniel Raederstorff, Peter Howe
OBJECTIVE: Having shown that resveratrol consumption can improve flow mediated dilation of the brachial artery, we tested its effects on CVR to hypercapnia in adults with T2DM, a risk population for cerebrovascular disease and cognitive impairments. DESIGN AND METHOD: In a double-blind crossover trial, 34 adults with T2DM consumed 0, 75, 150 and 300 mg of synthetic trans-resveratrol (one dose per week in random order). Before and 1-2 hr after dosing, transcranial Doppler ultrasound was used to assess CVR to a hypercapnic stimulus (breathing Carbogen gas for 3 min) in the middle (MCA) and posterior (PCA) cerebral arteries...
September 2016: Journal of Hypertension
Jian Wang, Weici Wang, Bi Jin, Yanrong Zhang, Ping Xu, Feixiang Xiang, Yi Zheng, Juan Chen, Shi Sheng, Chenxi Ouyang, Yiqing Li
Purpose. To investigate the alternation in cerebral and ocular blood flow velocity (BFV) in patients of carotid stenosis (CS) with or without contralateral carotid occlusion (CO) early after carotid endarterectomy (CEA). Patients and Methods. Nineteen patients underwent CEA for ≥50% CS. Fourteen patients had the unilateral CS, and five patients had the ipsilateral CS and the contralateral CO. Transcranial Doppler (TCD) and Color Doppler Imaging (CDI) were performed before and early after CEA. Results. In patients with unilateral CS, significant improvements in BFV were observed in anterior cerebral artery (ACA) and middle cerebral artery (MCA) on the ipsilateral side after CEA...
2016: BioMed Research International
Matheus Fernandes de Oliveira, Manoel Jacobsen Teixeira, Marcelo de Lima Oliveira, Edson Bor Seng-Shu, Karen Andrade Norremose, Fernando Campos Gomes Pinto
INTRODUCTION: Hydrocephalus is a prevalent condition among infants. Retrograde ventriculosinus shunt (RVSS) proposes a feasible option to treat hydrocephalus according to the principles presented by El-Shafei. In this essay, we analyze nuances and application of transcranial Doppler (TCD) in patients submitted to RVSS. METHODS: We consecutively enrolled patients diagnosed with hydrocephalus after surgical repair of myelomeningocele from January 2010 to January 2012, users of Hospital das Clinicas, University of Sao Paulo...
September 14, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
J Strouse
Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a mutation in the sixth amino acid of the β-globin gene (HBB). It is the most common serious genetic diseases in childhood, affecting approximately 1 in 2500 births and 100 000 individuals in the USA, in addition to 300 000 new cases globally each year. Central nervous system injury is the most debilitating frequent complication of SCD and includes stroke, silent cerebral infarct (SCI), and cognitive impairment. Among children with sickle cell anemia (HbSS), 11% had a stroke by age 18 years before the implementation of transcranial Doppler screening...
2016: Handbook of Clinical Neurology
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