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https://www.readbyqxmd.com/read/27913589/integrin-linked-kinase-ilk-deletion-disrupts-oligodendrocyte-development-by-altering-cell-cycle
#1
Rashad Hussain, Wendy B Macklin
: During development, oligodendrocytes are initially specified, after which oligodendrocyte precursor cells (OPCs) migrate and proliferate before differentiating into myelinating cells. Lineage specific programming of oligodendrocytes results from sensing environmental cues through membrane-bound receptors and related intracellular signaling molecules. Integrin linked kinase (ILK) is an important protein expressed at the inner margins of the plasma membrane, which can mediate some of these signals...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27888476/histological-detection-of-dynamic-glial-responses-in-the-dysmyelinating-tabby-jimpy-mutant-brain
#2
Masanao Ikeda, M Ibrahim Hossain, Li Zhou, Masao Horie, Kazuhiro Ikenaka, Arata Horii, Hirohide Takebayashi
Oligodendrocytes (OLs) are glial cells that form myelin sheaths surrounding the axons in the central nervous system (CNS). Jimpy (jp) mutant mice are dysmyelinating disease models that show developmental abnormalities in myelinated OLs in the CNS. The causative gene in jp mice is the proteolipid protein (PLP) located on the X chromosome. Mutations in the jp allele result in exon 5 skipping and expression of abnormal PLP containing a C-terminal frame shift. Many lines of evidence suggest that abnormal PLP in OLs results in endoplasmic reticulum (ER) stress and cell death...
November 25, 2016: Anatomical Science International
https://www.readbyqxmd.com/read/27705795/myt1-counteracts-the-neural-progenitor-program-to-promote-vertebrate-neurogenesis
#3
Francisca F Vasconcelos, Alessandro Sessa, Cátia Laranjeira, Alexandre A S F Raposo, Vera Teixeira, Daniel W Hagey, Diogo M Tomaz, Jonas Muhr, Vania Broccoli, Diogo S Castro
The generation of neurons from neural stem cells requires large-scale changes in gene expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. While recent studies have characterized the differentiation genes activated by proneural factors, less is known on the mechanisms that suppress progenitor cell identity. Here, we show that Ascl1 induces the transcription factor MyT1 while promoting neuronal differentiation. We combined functional studies of MyT1 during neurogenesis with the characterization of its transcriptional program...
October 4, 2016: Cell Reports
https://www.readbyqxmd.com/read/27474686/increased-mrna-expression-of-peripheral-glial-cell-markers-in-bipolar-disorder-the-effect-of-long-term-lithium-treatment
#4
Ewa Ferensztajn-Rochowiak, Maciej Tarnowski, Jerzy Samochowiec, Michal Michalak, Mariusz Z Ratajczak, Janusz K Rybakowski
Neuroinflammation, with microglial activation as an important element, plays a role in the pathogenesis of bipolar disorder (BD). Also, in mood disorders, pathological changes have been demonstrated in macroglial cells, such as astrocyctes and oligodendrocytes. Postmortem brain studies of BD patients to assess glial cells, such as astrocytes and oligodendrocytes and their markers such as glial fibrillary acidic protein (GFAP), Olig1 and Olig2, produced controversial results. On the other hand, investigation of these markers in the peripheral blood of such patients has not been performed so far...
September 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27469598/olig2-regulates-purkinje-cell-generation-in-the-early-developing-mouse-cerebellum
#5
Jun Ju, Qian Liu, Yang Zhang, Yuanxiu Liu, Mei Jiang, Liguo Zhang, Xuelian He, Chenchen Peng, Tao Zheng, Q Richard Lu, Hedong Li
The oligodendrocyte transcription factor Olig2 plays a crucial role in the neurogenesis of both spinal cord and brain. In the cerebellum, deletion of both Olig2 and Olig1 results in impaired genesis of Purkinje cells (PCs) and Pax2(+) interneurons. Here, we perform an independent study to show that Olig2 protein is transiently expressed in the cerebellar ventricular zone (VZ) during a period when PCs are specified. Further analyses demonstrate that Olig2 is expressed in both cerebellar VZ progenitors and early-born neurons...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27313623/clonal-heterogeneity-in-the-neuronal-and-glial-differentiation-of-dental-pulp-stem-progenitor-cells
#6
Fraser I Young, Vsevolod Telezhkin, Sarah J Youde, Martin S Langley, Maria Stack, Paul J Kemp, Rachel J Waddington, Alastair J Sloan, Bing Song
Cellular heterogeneity presents an important challenge to the development of cell-based therapies where there is a fundamental requirement for predictable and reproducible outcomes. Transplanted Dental Pulp Stem/Progenitor Cells (DPSCs) have demonstrated early promise in experimental models of spinal cord injury and stroke, despite limited evidence of neuronal and glial-like differentiation after transplantation. Here, we report, for the first time, on the ability of single cell-derived clonal cultures of murine DPSCs to differentiate in vitro into immature neuronal-like and oligodendrocyte-like cells...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27143892/olig1-expression-pattern-in-neural-cells-during-rat-spinal-cord-development
#7
Qi Qi, Yuxin Zhang, Lin Shen, Rui Wang, Jiansheng Zhou, Hezuo Lü, Jianguo Hu
PURPOSE: Our purpose was to systematically investigate the expression pattern and role of Olig1 in neural cells during rat spinal cord development. ANIMALS AND METHODS: Spinal cord tissues were dissected from Sprague-Dawley rats at embryonic day 14.5 (E14.5) and E18.5, postnatal day 0 (P0), P3, P7, postnatal 2 weeks (P2W), P4W, and adults (more than 2 months after birth), respectively. The expression of Olig1 was determined by Western blot and immunostaining. To observe expression of Olig1 in different neural cell types, a double immunohistochemical staining was performed using antibodies against Olig1 with O4, β-tubulin, glial fibrillary acidic protein (GFAP), and myelin basic protein, respectively...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27084689/predominant-neuronal-differentiation-of-olig1-neural-progenitors-in-forebrain-cortex-biased-by-%C3%AE-catenin-over-expression
#8
Jialei Yang, Xunyuan Liu, Xiufen Zhang, Xianghui Zhao, Yuanhang Pan, Mengsheng Qiu, Shengxi Wu, Gang Zhao, Ya-Zhou Wang
Proper neuron-glia ratio is essential for normal brain development and function. Olig1 is a basic helix-loop-helix (bHLH) transcription factor generally used as a lineage tool for oligodendrocyte research in spinal cord. Recent studies have revealed a property of Olig1-positive cells as the common progenitors of GABAergic neurons and oligodendrocytes in the forebrain during embryogenesis, and a stage-dependent regulatory role of Wnt/β-catenin signaling in the differentiation of oligodendrocytes in spinal cord...
May 27, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27067589/resveratrol-promotes-remyelination-in-cuprizone-model-of-multiple-sclerosis-biochemical-and-histological-study
#9
Heba R Ghaiad, Mohammed M Nooh, Maha M El-Sawalhi, Amira A Shaheen
Multiple sclerosis (MS) is a demyelinating neurodegenerative disease, representing a major cause of neurological disability in young adults. Resveratrol is a stilbenoid polyphenol, known to pass blood brain barrier and exhibit antioxidant, anti-inflammatory, and neuroprotective effects in several brain injuries. Cuprizone model of MS is particularly beneficial in studying demyelination/remyelination. Our study examined the potential neuroprotective and pro-remyelination effects of resveratrol in cuprizone-intoxicated C57Bl/6 mice...
April 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27065804/oligodendrocyte-and-interneuron-density-in-hippocampal-subfields-in-schizophrenia-and-association-of-oligodendrocyte-number-with-cognitive-deficits
#10
Peter Falkai, Johann Steiner, Berend Malchow, Jawid Shariati, Andreas Knaus, Hans-Gert Bernstein, Thomas Schneider-Axmann, Theo Kraus, Alkomiet Hasan, Bernhard Bogerts, Andrea Schmitt
In schizophrenia, previous stereological post-mortem investigations of anterior, posterior, and total hippocampal subfields showed no alterations in total neuron number but did show decreased oligodendrocyte numbers in CA4, an area that corresponds to the polymorph layer of the dentate gyrus (DG). However, these investigations identified oligodendrocytes only on the basis of morphological criteria in Nissl staining and did not assess alterations of interneurons with immunohistochemical markers. Moreover, the association of findings in the posterior hippocampus with cognitive deficits remains unknown...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/26919831/effect-of-bushen-yisui-capsule-on-oligodendrocyte-lineage-genes-1-and-2-in-mice-with-experimental-autoimmune-encephalomyelitis
#11
Tao Yang, Qi Zheng, Hui Zhao, Qiu-Xia Zhang, Ming Li, Fang Qi, Kang-Ning Li, Ling Fang, Lei Wang, Yong-Ping Fan
OBJECTIVE: To study the effects of Bushen Yisui Capsule (, BSYSC) on the oligodendrocyte lineage genes (Olig) 1 and Olig2 in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE) in order to explore the remyelination effect of BSYSC. METHODS: The mice were randomly divided into normal control (NC), EAE model (EAE-M), prednisone acetate (PA, 6 mg/kg), BSYSC high-dose (3.02 g/kg) and BSYSC low-dose (1.51 g/kg) groups. The mice were induced by immunization with myelin oligodendrocyte glycoprotein (MOG) 35-55...
February 26, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/26678483/il-1%C3%AE-induces-hypomyelination-in-the-periventricular-white-matter-through-inhibition-of-oligodendrocyte-progenitor-cell-maturation-via-fyn-mek-erk-signaling-pathway-in-septic-neonatal-rats
#12
Di Xie, Fengcai Shen, Shaoru He, Mengmeng Chen, Qianpeng Han, Ming Fang, Hongke Zeng, Chunbo Chen, Yiyu Deng
Neuroinflammation elicited by microglia plays a key role in periventricular white matter (PWM) damage (PWMD) induced by infectious exposure. This study aimed to determine if microglia-derived interleukin-1β (IL-1β) would induce hypomyelination through suppression of maturation of oligodendrocyte progenitor cells (OPCs) in the developing PWM. Sprague-Dawley rats (1-day old) were injected with lipopolysaccharide (LPS) (1 mg/kg) intraperitoneally, following which upregulated expression of IL-1β and IL-1 receptor 1 (IL-1R1 ) was observed...
April 2016: Glia
https://www.readbyqxmd.com/read/26631469/olig1-acetylation-and-nuclear-export-mediate-oligodendrocyte-development
#13
Jinxiang Dai, Kathryn K Bercury, Weilin Jin, Wendy B Macklin
The oligodendrocyte transcription factor Olig1 is critical for both oligodendrocyte development and remyelination in mice. Nuclear to cytoplasmic translocation of Olig1 protein occurs during brain development and in multiple sclerosis, but the detailed molecular mechanism of this translocation remains elusive. Here, we report that Olig1 acetylation and deacetylation drive its active translocation between the nucleus and the cytoplasm in both mouse and rat oligodendrocytes. We identified three functional nuclear export sequences (NES) localized in the basic helix-loop-helix domain and one specific acetylation site at Lys 150 (human Olig1) in NES1...
December 2, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26620201/a-simple-histological-technique-to-improve-immunostaining-when-using-dna-denaturation-for-brdu-labelling
#14
Jenna J Boulanger, William A Staines, Véronique LeBlanc, Eve-Ling Khoo, Jacky Liang, Claude Messier
The typical immunohistochemistry technique used to reveal 5-bromo-2'-deoxyuridine (BrdU) incorporation requires denaturation of the DNA by heat and acid to permeabilize the cell nucleus. This treatment can damage tissue and reduce the antigenicity of several proteins, which then leads to weak immunostaining and/or false negatives. We show that an overnight post-fixation step following immunohistochemistry for antigens of interest protects immunostaining during the acid/heat denaturation treatment for subsequent BrdU staining...
February 1, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/26584621/motor-neurons-and-oligodendrocytes-arise-from-distinct-cell-lineages-by-progenitor-recruitment
#15
Andrew M Ravanelli, Bruce Appel
During spinal cord development, ventral neural progenitor cells that express the transcription factors Olig1 and Olig2, called pMN progenitors, produce motor neurons and then oligodendrocytes. Whether motor neurons and oligodendrocytes arise from common or distinct progenitors in vivo is not known. Using zebrafish, we found that motor neurons and oligodendrocytes are produced sequentially by distinct progenitors that have distinct origins. When olig2(+) cells were tracked during the peak period of motor neuron formation, most differentiated as motor neurons without further cell division...
December 1, 2015: Genes & Development
https://www.readbyqxmd.com/read/26474911/evolution-of-the-cns-myelin-gene-regulatory-program
#16
REVIEW
Huiliang Li, William D Richardson
Myelin is a specialized subcellular structure that evolved uniquely in vertebrates. A myelinated axon conducts action potentials many times faster than an unmyelinated axon of the same diameter; for the same conduction speed, the unmyelinated axon would need a much larger diameter and volume than its myelinated counterpart. Hence myelin speeds information transfer and saves space, allowing the evolution of a powerful yet portable brain. Myelination in the central nervous system (CNS) is controlled by a gene regulatory program that features a number of master transcriptional regulators including Olig1, Olig2 and Myrf...
June 15, 2016: Brain Research
https://www.readbyqxmd.com/read/26306918/retracted-article-identification-of-the-interaction-between-the-human-homologue-of-the-arabidopsis-cop9-signalosome-subunit-7a-and-olig1
#17
Jiazhen Zhou, Yuanyuan Li, Cheng He
No abstract text is available yet for this article.
May 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/26189831/up-regulation-of-oligodendrocyte-lineage-markers-in-the-cerebellum-of-autistic-patients-evidence-from-network-analysis-of-gene-expression
#18
Fares Zeidán-Chuliá, Ben-Hur Neves de Oliveira, Manuel F Casanova, Emily L Casanova, Mami Noda, Alla B Salmina, Alexei Verkhratsky
Autism is a neurodevelopmental disorder manifested by impaired social interaction, deficits in communication skills, restricted interests, and repetitive behaviors. In neurodevelopmental, neurodegenerative, and psychiatric disorders, glial cells undergo morphological, biochemical, and functional rearrangements, which are critical for neuronal development, neurotransmission, and synaptic connectivity. Cerebellar function is not limited to motor coordination but also contributes to cognition and may be affected in autism...
August 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26123132/pluripotent-stem-cell-derived-radial-glia-like-cells-as-stable-intermediate-for-efficient-generation-of-human-oligodendrocytes
#19
Raphaela Gorris, Julia Fischer, Kim Lina Erwes, Jaideep Kesavan, Daniel A Peterson, Michael Alexander, Markus M Nöthen, Michael Peitz, Tamara Quandel, Michael Karus, Oliver Brüstle
Neural precursor cells (NPCs) derived from human pluripotent stem cells (hPSCs) represent an attractive tool for the in vitro generation of various neural cell types. However, the developmentally early NPCs emerging during hPSC differentiation typically show a strong propensity for neuronal differentiation, with more limited potential for generating astrocytes and, in particular, for generating oligodendrocytes. This phenomenon corresponds well to the consecutive and protracted generation of neurons and GLIA during normal human development...
December 2015: Glia
https://www.readbyqxmd.com/read/25950478/the-p38%C3%AE-mitogen-activated-protein-kinase-is-a-key-regulator-of-myelination-and-remyelination-in-the-cns
#20
S-H Chung, S Biswas, V Selvaraj, X-B Liu, J Sohn, P Jiang, C Chen, F Chmilewsky, H Marzban, M Horiuchi, D E Pleasure, W Deng
The p38α mitogen-activated protein kinase (MAPK) is one of the serine/threonine kinases regulating a variety of biological processes, including cell-type specification, differentiation and migration. Previous in vitro studies using pharmacological inhibitors suggested that p38 MAPK is essential for oligodendrocyte (OL) differentiation and myelination. To investigate the specific roles of p38α MAPK in OL development and myelination in vivo, we generated p38α conditional knockout (CKO) mice under the PLP and nerve/glial antigen 2 (NG2) gene promoters, as these genes are specifically expressed in OL progenitor cells (OPCs)...
2015: Cell Death & Disease
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