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https://www.readbyqxmd.com/read/29471495/arginine-methylation-of-the-c-terminus-rgg-motif-promotes-top3b-topoisomerase-activity-and-stress-granule-localization
#1
Lifeng Huang, Zhihao Wang, Nithya Narayanan, Yanzhong Yang
DNA topoisomerase 3B (TOP3B) is unique among all mammalian topoisomerases for its dual activities that resolve both DNA and RNA topological entanglements to facilitate transcription and translation. However, the mechanism by which TOP3B activity is regulated is still elusive. Here, we have identified arginine methylation as an important post-translational modification (PTM) for TOP3B activity. Protein arginine methyltransferase (PRMT) 1, PRMT3 and PRMT6 all methylate TOP3B in vitro at its C-terminal arginine (R) and glycine (G)-rich motif...
February 19, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29471430/gwas-identifies-two-novel-colorectal-cancer-loci-at-16q24-1-and-20q13-12
#2
Chizu Tanikawa, Yoichiro Kamatani, Atsushi Takahashi, Yukihide Momozawa, Karine Leveque, Satoshi Nagayama, Koshi Mimori, Masaki Mori, Hideshi Ishii, Johji Inazawa, Jun Yasuda, Akito Tsuboi, Atsushi Shimizu, Makoto Sasaki, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Mariko Naito, Kenji Wakai, Teruhide Koyama, Toshiro Takezaki, Koichiro Yuji, Yoshinori Murakami, Yusuke Nakamura, Michiaki Kubo, Koichi Matsuda
Colorectal cancer is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 colorectal cancer loci. However, most of the previous studies were conducted in European populations, and host genetic factors among Japanese population are largely remained to be identified. To identify novel loci in the Japanese population, here, we performed a large-scale GWAS using 6,692 cases and 27,178 controls followed by a replication analysis using more than 11,000 case-control samples...
February 17, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29471413/combined-cistrome-and-transcriptome-analysis-of-ski-in-aml-cells-identifies-ski-as-a-co-repressor-for-runx1
#3
Christine Feld, Peeyush Sahu, Miriam Frech, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Uta-Maria Bauer, Andreas Neubauer
SKI is a transcriptional co-regulator and overexpressed in various human tumors, for example in acute myeloid leukemia (AML). SKI contributes to the origin and maintenance of the leukemic phenotype. Here, we use ChIP-seq and RNA-seq analysis to identify the epigenetic alterations induced by SKI overexpression in AML cells. We show that approximately two thirds of differentially expressed genes are up-regulated upon SKI deletion, of which >40% harbor SKI binding sites in their proximity, primarily in enhancer regions...
February 20, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29471396/involvement-of-epigenetic-modifications-of-gabaergic-interneurons-in-basolateral-amygdala-in-anxiety-like-phenotype-of-prenatally-stressed-mice
#4
Chunting Zhu, Min Liang, Yingchun Li, Xuejiao Feng, Juan Hong, Rong Zhou
Background: Prenatal stress is considered a risk factor for anxiety disorder. Downregulation in the expression of GABAergic gene, that is, glutamic acid decarboxylase 67, associated with DNA methyltransferase overexpression in GABAergic neurons has been regarded as a characteristic component of anxiety disorder. Prenatal stress has an adverse effect on the development of the basolateral amygdala, which is a key region in anxiety regulation. The aim of this study is to analyze the possibility of epigenetic alterations of GABAergic neurons in the basolateral amygdala participating in prenatal stress-induced anxiety...
February 20, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29471367/evolution-of-genes-associated-with-gynoecium-patterning-and-fruit-development-in-solanaceae
#5
Clara Inés Ortiz-Ramírez, Sayonara Plata-Arboleda, Natalia Pabón-Mora
Background and Aims: The genetic basis of fruit development has been extensively studied in Arabidopsis, where major transcription factors controlling valve identity (i.e. FRUITFULL), replum development (i.e. REPLUMLESS) and the differentiation of the dehiscence zones (i.e. SHATTERPROOF, INDEHISCENT and ALCATRAZ) have been identified. This gene regulatory network in other flowering plants is influenced by duplication events during angiosperm diversification. Here we aim to characterize candidate fruit development genes in the Solanaceae and compare them with those of Brassicaceae...
February 17, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29471365/integrator-subunit-4-is-a-symplekin-like-scaffold-that-associates-with-ints9-11-to-form-the-integrator-cleavage-module
#6
Todd R Albrecht, Sergey P Shevtsov, Yixuan Wu, Lauren G Mascibroda, Natoya J Peart, Kai-Lieh Huang, Iain A Sawyer, Liang Tong, Miroslav Dundr, Eric J Wagner
Integrator (INT) is a transcriptional regulatory complex associated with RNA polymerase II that is required for the 3'-end processing of both UsnRNAs and enhancer RNAs. Integrator subunits 9 (INTS9) and INTS11 constitute the catalytic core of INT and are paralogues of the cleavage and polyadenylation specificity factors CPSF100 and CPSF73. While CPSF73/100 are known to associate with a third protein called Symplekin, there is no paralog of Symplekin within INT raising the question of how INTS9/11 associate with the other INT subunits...
February 20, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29471285/effects-of-docosahexanoic-acid-supplementation-on-inflammatory-and-subcutaneous-adipose-tissue-gene-expression-in-hiv-infected-patients-on-combination-antiretroviral-therapy-cart-a-sub-study-of-a-randomized-double-blind-placebo-controlled-study
#7
Pere Domingo, José Miguel Gallego-Escuredo, Irene Fernández, Joan Villarroya, Ferran Torres, María Del Mar Gutierrez, María Gracia Mateo, Francesc Villarroya, Francesc Vidal, Marta Giralt, Joan Carles Domingo
BACKGROUND: Omega-3 fatty acids have the potential to decrease inflammation and modify gene transcription. Whether docosahexanoic acid (DHA) supplementation can modify systemic inflammatory and subcutaneous adipose tissue (SAT) gene expression in HIV-infected patients is unknown. METHODS: A randomized, double-blind, placebo-controlled trial that enrolled 84 antiretroviral-treated patients who had fasting TG levels from 2.26 to 5.65 mmol/l and received DHA or placebo for 48 weeks was performed (ClinicalTrials...
February 19, 2018: Cytokine
https://www.readbyqxmd.com/read/29471265/role-of-rpos-in-stress-resistance-quorum-sensing-and-spoilage-potential-of-pseudomonas-fluorescens
#8
Xiaoxiang Liu, Lei Ji, Xu Wang, Jianrong Li, Junli Zhu, Aihua Sun
Microorganism activities are considered the main cause of most food spoilage, leading to great economic losses. Pseudomonas fluorescens is a Gram-negative bacterium that is widely found in food and has high spoilage activity. RpoS is considered an important global regulator involved in stress survival and virulence in many pathogens. Thus, it is very possible that RpoS plays an important role in spoilage regulation in P. fluorescens. In this study an in-frame deletion mutation of rpoS was constructed to explore its function in P...
February 14, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29471264/collective-transcriptomic-deregulation-of-hypertrophic-and-dilated-cardiomyopathy-importance-of-fibrotic-mechanism-in-heart-failure
#9
Beutline Malgija, Nachimuthu Senthil Kumar, Shanmughavel Piramanayagam
Myocardial fibrosis reside a common pathological feature in hypertrophic and dilated cardiomyopathy that results in ventricular dysfunction leading to heart failure. Though several studies reported the role of fibrosis in cardiac diseases, their pathologic mechanisms leading to heart failure remains unclear. A few studies have proposed integrated analysis of microarray information and protein-protein interaction (PPI) systems to discover subnetwork markers related to diagnosis and prognosis of the disease. In addition to PPI networks, we incorporated miRNAs and transcription factors to find the putative miRNAs and transcription factors that might regulate the pathological process and progression of cardiomyopathy and their further progression to heart failure...
February 10, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29471061/effects-of-dietary-inulin-and-mannan-oligosaccharide-on-immune-related-genes-expression-and-disease-resistance-of-pacific-white-shrimp-litopenaeus-vannamei
#10
Yun Li, Hong Liu, Xilin Dai, Jingjing Li, Fujiang Ding
The effects of inulin and mannan oligosaccharide (MOS) at different doses (2.5, 4 and 10 mg/g) in singular or combined diet on growth rate, immune related genes expression, and resistance to white spot syndrome virus (WSSV) and Vibrio alginolyticus in Pacific white shrimp (Litopenaeus vannamei) were investigated. At the end of 28-day singular feeding experiment, the highest values of specific growth rate (SGR) and the expression of toll-like receptor1, 2 and 3 (TLR1, 2, 3), signal transducer and activator of transcription (STAT), crustin, anti-lipopolysaccharide factor (ALF) as well as prophenoloxidase (proPO) were observed in shrimp individually fed with 5 mg/g dietary inulin or MOS, respectively...
February 19, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29471045/prdm14-a-putative-histone-methyl-transferase-interacts-with-and-decreases-the-stability-and-activity-of-the-hoxa1-transcription-factor
#11
Amandine Draime, Laure Bridoux, Magali Belpaire, Tamara Pringels, Janne Tys, René Rezsohazy
Understanding how the activity of transcription factors like HOX proteins is regulated remains a widely open question. In a recent screen for proteins interacting with HOXA1, we identified a PRDM protein family member, PRDM14, which is known to be transiently co-expressed with HOXA1 in epiblast cells before their specification towards somatic versus germ cell fate. Here, we confirm PRDM14 is an interactor of HOXA1 and we identify the homeodomain of HOXA1 as well as the PR domain and Zinc fingers of PRDM14 to be required for the interaction...
February 19, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29471006/astilbin-ameliorates-cisplatin-induced-nephrotoxicity-through-reducing-oxidative-stress-and-inflammation
#12
Si-Wei Wang, Yi Xu, Yuan-Yuan Weng, Xue-Yu Fan, Yong-Feng Bai, Xiao-Yan Zheng, Li-Jun Lou, Feng Zhang
Oxidative stress and inflammation are considered to be the main pathogenesis of cisplatin nephrotoxicity. Astilbin, a flavonoid with anti-oxidation and anti-inflammation function, has been used to treat heavy metal induced kidney injury. In this study, we investigated the protective effects of astilbin on cisplatin-induced nephrotoxicity and its underlying mechanisms. Our results showed that astilbin markedly inhibited cisplatin-induced cell apoptosis and recovered cell growth. Astilbin significantly decreased reactive oxygen species (ROS) accumulation and alleviated ROS-induced activation of p53, MAPKs and AKT signaling cascades, which in turn attenuated cisplatin-induced HEK-293 cell apoptosis...
February 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29471005/mir-155-5p-controls-colon-cancer-cell-migration-via-post-transcriptional-regulation-of-human-antigen-r-hur
#13
Amr Al-Haidari, Anwar Algaber, Raed Madhi, Ingvar Syk, Henrik Thorlacius
Colorectal cancer (CRC) is the third most common cancer and a significant cause of cancer-related deaths worldwide. Metastasis is the worst prognostic factor for patients with CRC. HuR (ELAVL1) is overexpressed in CRC and has been reported to promote colon cancer growth by targeting RNA in the cell cytoplasm. Herein, the role of miR-155-5p in regulating HuR expression and cell migration was examined in colon cancer cells. MiR-155-5p knockdown in serum-starved colon cancer cells decreased both colon cancer cell chemotaxis and cytoplasmic expression of HuR...
February 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29470977/the-unfolded-protein-response-in-ischemic-heart-disease
#14
REVIEW
Xiaoding Wang, Lin Xu, Thomas G Gillette, Xuejun Jiang, Zhao V Wang
Ischemic heart disease is a severe stress condition that causes extensive pathological alterations and triggers cardiac cell death. Accumulating evidence suggests that the unfolded protein response (UPR) is strongly induced by myocardial ischemia. The UPR is an evolutionarily conserved cellular response to cope with protein-folding stress, from yeast to mammals. Endoplasmic reticulum (ER) transmembrane sensors detect the accumulation of unfolded proteins and stimulate a signaling network to accommodate unfolded and misfolded proteins...
February 19, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29470957/kaempferol-7-o-%C3%AE-d-glucoside-isolated-from-the-leaves-of-cudrania-tricuspidata-inhibits-lps-induced-expression-of-pro-inflammatory-mediators-through-inactivation-of-nf-%C3%AE%C2%BAb-ap-1-and-jak-stat-in-raw-264-7-macrophages
#15
Seung-Bin Lee, Ji-Sun Shin, Hee-Soo Han, Hwi-Ho Lee, Jong Cheol Park, Kyung-Tae Lee
Kaempferol 7-O-β-D-glucoside (KPG), a natural flavonol isolated from Cudrania tricuspidata, has been reported to exert anti-cancer effects; however, its anti-inflammatory effects have not yet been reported. In this study, we demonstrate the suppressive effect of KPG on the production of nitric oxide (NO), prostaglandin E2 (PGE2 ), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and mouse bone marrow-derived macrophages...
February 19, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29470917/theoretical-studies-on-the-photophysics-and-photochemistry-of-5-formylcytosine-and-5-carboxylcytosine-the-oxidative-products-of-epigenetic-modification-of-cytosine-in-dna
#16
Jinlu Xing, Yuejie Ai, Yang Liu, Jia Du, Weiqiang Chen, Zhanhui Lu, Xiangke Wang
Cytosine methylation and demethylation play crucial roles in understanding the genomic DNA expression regulation. The epigenetic modification of cytosine and its continuous oxidative products-the "new four bases of DNA" including 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxylcytosine (5caC). However, compared to the abundant studies on the classical DNA bases, the photophysical and photochemical properties of those new bases have not yet aroused people's excessive attention...
February 22, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29470850/identification-and-functional-analysis-of-a-novel-g310d-variant-in-the-insulin-like-growth-factor-1-receptor-igf1r-gene-that-associates-with-type-2-diabetes-in-american-indians
#17
Yunhua L Muller, Graham Skelton, Paolo Piaggi, Peng Chen, Anup Nair, Sayuko Kobes, Wen-Chi Hsueh, William C Knowler, Robert L Hanson, Leslie J Baier, Clifton Bogardus
AIMS: Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analyzed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS: Whole genome sequence data from 335 American Indians identified 3 novel missense variants in IGF1R. The associations of IGF1R variants with T2D, age of T2D onset and birth weight were analyzed in a population based sample of 7701 American Indians...
February 22, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29470839/embryonic-neurogenesis-in-echinoderms
#18
REVIEW
Veronica F Hinman, Robert D Burke
The phylogenetic position of echinoderms is well suited to revealing shared features of deuterostomes that distinguish them from other bilaterians. Although echinoderm neurobiology remains understudied, genomic resources, molecular methods, and systems approaches have enabled progress in understanding mechanisms of embryonic neurogenesis. Even though the morphology of echinoderm larvae is diverse, larval nervous systems, which arise during gastrulation, have numerous similarities in their organization. Diverse neural subtypes and specialized sensory neurons have been identified and details of neuroanatomy using neuron-specific labels provide hypotheses for neural function...
February 22, 2018: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/29470798/nr4a1-contributes-to-high-fat-associated-endothelial-dysfunction-by-promoting-camkii-parkin-mitophagy-pathways
#19
Pei Li, Yuzhi Bai, Xia Zhao, Tian Tian, Liying Tang, Jing Ru, Yun An, Jing Wang
Parkin-related mitophagy is vital for endothelial cell viability and the development of atherosclerosis, although the upstream regulatory factor underlying Parkin-mediated mitophagy in endothelial apoptosis and atherosclerosis progression remains unknown. In the present study, we demonstrated that nuclear receptor subfamily 4 group A member 1 (NR4A1) is actually expressed in aortic endothelial cells (AECs) under oxidized low-density lipoprotein (ox-LDL) treatment in vitro or isolated from high-fat treated mice in vivo...
February 22, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29470695/a-banana-nac-transcription-factor-musasnac1-impart-drought-tolerance-by-modulating-stomatal-closure-and-h-2-o-2-content
#20
Sanjana Negi, Himanshu Tak, T R Ganapathi
MusaSNAC1 function in H2 O2 mediated stomatal closure and promote drought tolerance by directly binding to CGT[A/G] motif in regulatory region of multiple stress-related genes. Drought is a abiotic stress-condition, causing reduced plant growth and diminished crop yield. Guard cells of the stomata control photosynthesis and transpiration by regulating CO2 exchange and water loss, thus affecting growth and crop yield. Roles of NAC (NAM, ATAF1/2 and CUC2) protein in regulation of stress-conditions has been well documented however, their control over stomatal aperture is largely unknown...
February 22, 2018: Plant Molecular Biology
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