Xiaozhou Xie, Yulong Zhao, Fengying Du, Baoshan Cai, Zhen Fang, Yuan Liu, Yaodong Sang, Chenghao Ma, Zhaodong Liu, Xinshuai Yu, Chi Zhang, Jiayu Jiang, Zi Gao, Yan Liu, Xiaoyan Lin, Haiyan Jing, Xiuming Zhong, Lei Cong, Honghai Dai, Dan Sha, Na Shao, Hong Feng, Leping Li, Jin Liu, Liang Shang
Monoubiquitination of FANCD2 is a central step in the activation of the Fanconi anemia (FA) pathway after DNA damage. Defects in the FA pathway centered around FANCD2 not only lead to genomic instability but also induce tumorigenesis. At present, few studies have investigated FANCD2 in tumors, and no pan-cancer research on FANCD2 has been conducted. We conducted a comprehensive analysis of the role of FANCD2 in cancer using public databases and other published studies. Moreover, we evaluated the role of FANCD2 in the proliferation, migration and invasion of lung adenocarcinoma cells through in vitro and in vivo experiments, and explored the role of FANCD2 in cisplatin chemoresistance...
December 15, 2023: Genomics