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https://www.readbyqxmd.com/read/28454481/aln-surface-passivation-of-gan-based-high-electron-mobility-transistors-by-plasma-enhanced-atomic-layer-deposition
#1
An-Jye Tzou, Kuo-Hsiung Chu, I-Feng Lin, Erik Østreng, Yung-Sheng Fang, Xiao-Peng Wu, Bo-Wei Wu, Chang-Hong Shen, Jia-Ming Shieh, Wen-Kuan Yeh, Chun-Yen Chang, Hao-Chung Kuo
We report a low current collapse GaN-based high electron mobility transistor (HEMT) with an excellent thermal stability at 150 °C. The AlN was grown by N2-based plasma enhanced atomic layer deposition (PEALD) and shown a refractive index of 1.94 at 633 nm of wavelength. Prior to deposit AlN on III-nitrides, the H2/NH3 plasma pre-treatment led to remove the native gallium oxide. The X-ray photoelectron spectroscopy (XPS) spectroscopy confirmed that the native oxide can be effectively decomposed by hydrogen plasma...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454478/enhanced-mri-t-2-relaxivity-in-contrast-probed-anchor-free-pegylated-iron-oxide-nanoparticles
#2
Bibek Thapa, Daysi Diaz-Diestra, Juan Beltran-Huarac, Brad R Weiner, Gerardo Morell
Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit a spin-spin relaxivity of 123 ± 6 mM(-1)s(-1), which is higher than those of PEG-SPIONs anchored with intermediate biomolecules, iron oxide nanoworms, or Feridex...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454469/regulation-of-cytotoxicity-and-apoptosis-associated-pathways-contributes-to-the-enhancement-of-efficacy-of-cisplatin-by-baicalein-adjuvant-in-human-a549-lung-cancer-cells
#3
Suparata Kiartivich, Ying Wei, Jiaqi Liu, Rungtip Soiampornkul, Mihui Li, Hongying Zhang, Jingcheng Dong
Scutellaria baicalensis (SB; Chinese name, huangqin) is widely used in Chinese medicine as a traditional adjuvant in the chemotherapy of lung and liver cancer. Baicalein is one of the bioactive flavonoid components isolated from the root of SB. The present study aimed to observe the effect of baicalein, in combination with platin-based systemic chemotherapy (cisplatin), on cytotoxicity and apoptosis of human A549 lung cancer cells. The cell cultures were treated with baicalein, cisplatin, or a combination of the two...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454468/ethanolic-extract-of-thevetia-peruviana-flowers-enhances-tnf-%C3%AE-and-trail-induced-apoptosis-of-human-cervical-cancer-cells-via-intrinsic-and-extrinsic-pathways
#4
Chittima Managit, Hiroaki Sakurai, Ikuo Saiki
Tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) are promising candidates for cancer treatment due to their ability to induce apoptosis through death receptor stimulation. However, their usage may be limited due to the resistance of cancer cells to TNF-α- and TRAIL-induced apoptosis. Currently, there is interest in screening for natural products that can sensitize cancer cells to TNF-α- and TRAIL-induced apoptosis for their use in combination with TNF-α or TRAIL. It was previously reported that the bark extract of Thevetia peruviana showed a reversal effect on TRAIL-resistance in human gastric adenocarcinoma cell lines...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454463/reduced-ebp50-expression-levels-are-correlated-with-unfavorable-clinicopathological-features-of-extrahepatic-bile-duct-carcinoma-and-promote-the-proliferation-and-migration-of-qbc939-cells
#5
Duiping Feng, Ying Xiong, Zhiqiang Peng, Qiang Ma, Tao Tao, Hua Liu, Jianfang Liang, Zhigang Wei, Junfang Zheng, Lei Wang, Hui Zhang
The present study aimed to clarify the association between ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) expression level and the tumor phenotype and clinicopathological features of extrahepatic bile duct carcinoma. Tissue samples from patients with extrahepatic bile duct carcinoma (54 cases) and patients with normal bile duct epithelia from gallbladder of cholecystitis (20 cases) were collected, and immunohistochemical staining was used to detect the expression levels of EBP50 in these tissues. In addition, small interfering (si)RNA-EBP50 was used to knock down the expression of EBP50 in the QBC939 human cholangiocarcinoma (CC) cell line...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454447/inhibitory-effect-and-mechanism-of-exogenous-mammalian-sterile-20-like-kinase-1-on-the-growth-of-human-colorectal-cancer
#6
Jian Wu, Xiaohong Yang, Hongfei Lu, Liqiao Liu, Baohua Xu, Shuangyan Zheng, Bo Yu, Kemin Jie, Fusheng Wan
The present study aimed to observe the inhibitory effect and preliminary mechanism of exogenous mammalian sterile 20-like kinase 1 (MST1) on the growth of colorectal cancer SW480 cells. The SW480 cells were randomly divided into the following groups: Control, empty enhanced green fluorescent protein (EGFP) plasmid (pEGFP-N1), MST1 EGFP plasmid (pEGFP-MST1), 20 µmol/l fluorouracil (5-FU) and pEGFP-MST1 + 5-FU. An MTS colorimetric assay was used to detect cell viability, Hoechst 33342 staining was used to observe cell apoptosis, and western blotting and immunohistochemistry were used to detect the levels of the proteins MST1, yes-associated protein (YAP), phospho-YAP1 (Ser127), p53 and p53 upregulated modulator of apoptosis (PUMA)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454439/oct4-induces-emt-through-lef1-%C3%AE-catenin-dependent-wnt-signaling-pathway-in-hepatocellular-carcinoma
#7
Lu Sun, Tianhua Liu, Shu Zhang, Kun Guo, Yinkun Liu
Octamer 4 (Oct4), a member of the Pit-Oct-Unc transcription factor family required to maintain self-renewal and pluripotency of embryonic stem cells, has been previously identified to be associated with tumorigenesis and malignant transformation of numerous types of cancer including hepatocellular carcinoma (HCC). The present data shows that Oct4 enhances cancer stem cell properties and increases invasion ability in the Huh7 cell line. To increase understanding of the role of Oct4 in HCC, the present study used a functional genomics approach and analyzed the resulting transcriptional profiles to identify Oct4-dependent genes in Huh7...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454437/polycomb-group-expression-signatures-in-the-malignant-progression-of-gliomas
#8
Qi Hu, Weining Wu, Ailiang Zeng, Tianfu Yu, Feng Shen, Er Nie, Yingyi Wang, Ning Liu, Junxia Zhang, Yongping You
Polycomb group (PcG) proteins form at least two key complexes, namely polycomb repressive complex 1 and polycomb repressive complex 2. These complexes are involved in the progression of various cancers. Systematic research has not been conducted on the aberrant expression of PcG members in gliomas. Using the Chinese Glioma Genome Atlas data set, PcG expression patterns between normal brain tissues and glioma samples were analyzed, and a PcG-based classifier was then developed using BRB Cox regression and risk-score model...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454417/mir-185-enhances-the-inhibition-of-proliferation-and-migration-induced-by-ionizing-radiation-in-melanoma
#9
Jinpeng He, Ning Tian, Yanli Yang, Liangliang Jin, Xiu Feng, Junrui Hua, Sulan Lin, Bing Wang, He Li, Jufang Wang
Melanoma is an aggressive malignancy that is increasingly common and exhibits a poor patient survival rate. Radiotherapy is the primary option for patients with melanoma, particularly those who are not candidates for surgery; however, the therapeutic effect is limited due to the relative radioresistance of melanoma to ionizing radiation (IR). It has been reported that microRNAs (miRNAs) serve a vital role in determining the radiosensitivity of tumors; however, little is known concerning the radiosensitization of melanoma using miRNA...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454413/na7crcuw11o39-16h2o-induces-apoptosis-in-human-ovarian-cancer-skov3-cells-through-the-p38-signaling-pathway
#10
Hai-Ying Liu, Xiu-Li Pan, Jia-Nan Tian, Hui Sun, Qing Huan, Yu-Ling Huang, Jian-Qiao Liu
Ovarian carcinoma is a common malignant disease worldwide with a poor therapeutic response. The present study investigated the effects of Na7CrCuW11O39.16H2O (CrCuW11) on ovarian cancer cell growth and investigated the mechanisms underlying its actions. The effects of CrCuW11 on cell viability and apoptosis were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, acridine orange/ethidium bromide staining and electron microscopy in human ovarian cancer SKOV3 cells. The expression of bcl-2-like protein 4 (Bax), B-cell lymphoma 2 (Bcl-2), cytochrome c, phosphorylated (p)-p38 and p38 was determined by western blot analysis...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454401/safety-and-effectiveness-of-localized-lung-resection-combined-with-neoadjuvant-chemotherapy-in-the-treatment-of-stage-i-ii-non-small-cell-lung-cancer
#11
Bing Zhu, Jianru Yang, Pei Zhang, Lin Shen, Xiaolong Li, Jing Li
This study was conducted to evaluate the safety and effectiveness of localized lung resection combined with neoadjuvant chemotherapy in the treatment of stage I-II non-small cell lung cancer (NSCLC). A total of 88 patients, who were admitted to our hospital for first diagnosis and treatment, were selected. The patients were divided into control group (n=40 cases) and observation group (n=48 cases) according to the last digit of the admission number. The control group was treated with minimally invasive localized lung resection by thoracoscope...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454393/diagnosing-and-discriminating-between-primary-and-secondary-aneurysmal-bone-cysts
#12
Hiromi Sasaki, Satoshi Nagano, Hirofumi Shimada, Masahiro Yokouchi, Takao Setoguchi, Yasuhiro Ishidou, Osamu Kunigou, Kosuke Maehara, Setsuro Komiya
Aneurysmal bone cysts (ABCs) are benign bony lesions frequently accompanied by multiple cystic lesions and aggressive bone destruction. They are relatively rare lesions, representing only 1% of bone tumors. The pathogenesis of ABCs has yet to be elucidated. In the present study, a series of 22 cases of primary and secondary ABC from patients treated in Department of Orthopedic Surgery, Kagoshima University Hospital (Kagoshima, Japan) from 2001-2015 were retrospectively analyzed. The average age at the time of diagnosis of primary ABC was 17...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454389/notch-signaling-is-important-for-epithelial-mesenchymal-transition-induced-by-low-concentrations-of-doxorubicin-in-osteosarcoma-cell-lines
#13
Jian Yang, Weichun Guo, Lu Wang, Ling Yu, Hongjun Mei, Shuo Fang, Anyuan Chen, Yang Liu, Kezhou Xia, Gaiwei Liu
Osteosarcoma is an aggressive pediatric tumor affecting growing bones that typically occurs in adolescents and young adults. Although advances in treatment have been made in recent years, a high proportion of patients relapse due to metastases, which are frequently resistant to chemotherapy and pose a significant threat to long-term survival. Previous studies have demonstrated that the epithelial-mesenchymal transition (EMT) is associated with cancer occurrence and metastasis, and our previous study demonstrated the occurrence of EMT in osteosarcoma...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454379/characterization-of-single-lesion-nonfunctioning-pancreatic-neuroendocrine-carcinoma-via-computed-tomography
#14
Jibo Hu, Qunhui Hu, Hongjie Hu
Nonfunctioning pancreatic neuroendocrine carcinoma (NPNEC) is a poorly differentiated neuroendocrine carcinoma and a rare type of pancreatic cancer. Computed tomography (CT)-based imaging is currently the most effective method for diagnosing and classifying NPNEC. The present study investigated the clinical features and CT manifestations of this disease. The CT manifestations and clinical data of 13 patients with NPNEC, confirmed by surgery or needle biopsy, were retrospectively analyzed. None of the 13 patients exhibited endocrine-related symptoms and a single lesion with a variable position in the pancreatic was observed in all patients...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454374/arsenic-trioxide-inhibits-tumor-induced-myeloid-derived-suppressor-cells-and-enhances-t-cell-activity
#15
Qingmin Gao, Jingwei Jiang, Zhaohui Chu, Hao Lin, Xinli Zhou, Xiaohua Liang
Myeloid-derived suppressor cells (MDSCs), one of the major orchestrators of the immunosuppressive network, are associated with immune suppression and considered a prime target for cancer immunotherapy. At present, various strategies have been explored to deplete and/or inactivate MDSCs in vivo. In this study, we investigated the effect of arsenic trioxide (ATO) on MDSCs derived from tumor-bearing mice. This study examined the in vitro and in vivo effects of ATO administration on MDSCs from C57/j mice bearing either the B16 or H22 tumor...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454371/synergistic-effects-of-a-novel-lipid-soluble-extract-from-pinellia-pedatisecta-schott-and-cisplatin-on-human-cervical-carcinoma-cell-lines-through-the-regulation-of-dna-damage-response-signaling-pathway
#16
Mingxing Zhang, Hongwei Zhang, Yi Yu, Haixia Huang, Guiling Li, Congjian Xu
Herbal medicines have been recognized as an attractive approach for cancer therapy with minimal side effects. The present study investigated the type of interaction between a novel lipid-soluble extract from Pinellia pedatisecta Schott (PE) and cisplatin (CDDP) on human cervical cancer SiHa and CaSki cell lines in vitro. The mechanism of this combination was studied using cell proliferation, invasion and apoptosis assays, and by analyzing cell cycle distribution and protein expression, with a focus on DNA damage response (DDR) activation...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454363/microrna-124-regulates-the-radiosensitivity-of-non-small-cell-lung-cancer-cells-by-targeting-txnrd1
#17
Chuncheng Hao, Xiangying Xu, Jia Ma, Jun Xia, Bingbing Dai, Lili Liu, Yuyan Ma
Radiation treatment remains one of the major modalities in the treatment of lung cancer. Although the majority of patients initially respond to treatment with radiation, resistance inevitably develops and leads to treatment failure. Therefore, the identification of the underlying molecular mechanisms of radiation resistance may facilitate the development of novel approaches for overcoming resistance, and enhance the efficacy of treatment with radiation in lung and other types of cancer. In the present study we established three radiation-resistant sub-cell lines derived from the radiation-sensitive lung cancer cell line HCC827...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454344/galectin-7-promotes-the-invasiveness-of-human-oral-squamous-cell-carcinoma-cells-via-activation-of-erk-and-jnk-signaling
#18
Jia-Ping Guo, Xiao-Guang Li
Galectin-7 is a member of the β-galactoside-binding protein family, and is highly expressed in oral squamous cell carcinoma (OSCC). The aim of the present study was to investigate the effects of manipulating galectin-7 expression on the biological phenotype of human OSCC cells and the associated molecular mechanisms. Knockdown of endogenous galectin-7 via small interfering RNA (siRNA) was performed and cell proliferation, apoptosis, migration, and invasion were subsequently assessed. The data indicated that galectin-7 silencing had no impact on the proliferation or apoptosis of OSCC cells...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454333/a-polysaccharide-component-from-strongylocentrotus-nudus-eggs-inhibited-hepatocellular-carcinoma-in-mice-by-activating-t-lymphocytes
#19
Min Zhang, Yang Liu, Jingwen Li, Mengyun Ke, Jie Yu, Jie Dou, Hui Wang, Changlin Zhou
A component purified from Strongylocentrotus nudus eggs on a diethylaminoethyl cellulose-52 chromatography column and eluted using a NaCl solution gradient (SEP-S), is a homogeneous polysaccharide of α-D-glucan with a reduced molecular weight of 9.33×10(5) Da, compared with that of S. nudus egg polysaccharide (SEP). In an in vivo antitumor assay of histocompatibility-22 hepatocellular carcinoma in tumor-bearing mice, the inhibitory rates at SEP-S doses of 5, 10 and 20 mg/kg/day were 38.8, 50.7 and 70.3%, respectively...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454322/accumulation-of-low-dose-bix01294-promotes-metastatic-potential-of-u251-glioblastoma-cells
#20
Min Young Kim, Shin-Ji Park, Jae Woong Shim, Yu Jin Song, Kwangmo Yang, Seong-Joon Park, Kyu Heo
BIX01294 (Bix) is known to be a euchromatic histone-lysine N-methyltransferase 2 inhibitor and treatment with Bix suppresses cancer cell survival and proliferation. In the present study, it was observed that sequential treatment with low-dose Bix notably increases glioblastoma cell migration and metastasis. It was demonstrated that U251 cells sequentially treated with low-dose Bix exhibited induced characteristic changes in critical epithelial-mesenchymal transition (EMT) markers, including E-cadherin, N-cadherin, β-catenin and zinc finger protein SNAI2...
March 2017: Oncology Letters
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