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Heterogeneity breast metastasis

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https://www.readbyqxmd.com/read/29755619/molecularly-targeted-therapy-for-the-oral-cancer-stem-cells
#1
REVIEW
Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro Nakajima
Human cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the underlying mechanisms remain unclear. Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR)/ErbB2, has antiproliferative effects and is used to treat patients with ErbB2-positive metastatic breast cancer...
May 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29753955/the-diagnostic-value-of-one-step-nucleic-acid-amplification-osna-in-differentiating-lymph-node-metastasis-of-tumors-a-systematic-review-and-meta-analysis
#2
REVIEW
Min Zhou, Xuzhen Wang, Liping Jiang, Xu Chen, Xin Bao, Xiang Chen
BACKGROUND: The aim of this study was clarify the diagnostic accuracy of one step nucleic acid amplification (OSNA) for differentiating metastatic lymph nodes from non-metastatic ones in patients with tumors (not including breast cancer). METHODS: A systematic literature search for original diagnostic studies was performed in PubMed. Findings were pooled by using combined effect models and hierarchic summary receiver operating characteristic curve models. Meta-regression analysis and threshold effect evaluating were performed to explore the sources of heterogeneity affected classification accuracy...
May 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29750999/modeling-triple-negative-breast-cancer-heterogeneity-effects-of-stromal-macrophages-fibroblasts-and-tumor-vasculature
#3
Kerri-Ann Norton, Kideok Jin, Aleksander S Popel
A hallmark of breast tumors is its spatial heterogeneity that includes its distribution of cancer stem cells and progenitor cells, but also heterogeneity in the tumor microenvironment. In this study we focus on the contributions of stromal cells, specifically macrophages, fibroblasts, and endothelial cells on tumor progression. We develop a computational model of triple-negative breast cancer based on our previous work and expand it to include macrophage infiltration, fibroblasts, and angiogenesis. In vitro studies have shown that the secretomes of tumor-educated macrophages and fibroblasts increase both the migration and proliferation rates of triple-negative breast cancer cells...
May 8, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29722493/-oligometastatic-breast-cancer-therapeutic-implications-of-a-new-paradigm
#4
B Méry, G Moriceau, A Vallard, J P Jacquin, N Magné
INTRODUCTION: Oligometastatic breast cancer incidence is recently increasing thanks to screening and imaging improvements. Unlike patients with metastatic disease, a small number of oligometastatic patients may expect a definitive remission, in case of aggressive management performed with intent to cure. We report the atypical evolution of an oligometastatic breast cancer patient, who lately relapsed with a different Her2 status. RESULTS: A 46 year old women was treated for an infiltrating duct breast carcinoma, initially diagnosed with oligometastases and an Her2- negative status...
2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29702311/initial-experience-with-intraoperative-phosphorous-32-brachytherapy-during-resection-of-malignant-spinal-tumors
#5
Cecilia L Dalle Ore, Christopher P Ames, Stephen T Magill, Vedat Deviren, Manish K Aghi, Darryl Lau
INTRODUCTION: Brachytherapy is a major adjuvant modality for neoplasms, but few have trialed its use for spinal tumors. This study examines perioperative and oncological outcomes of malignant spinal tumor patients who underwent resection with intraoperative phosphorous-32 (P32) brachytherapy. METHODS: Consecutive adult patients who underwent P32 brachytherapy during malignant spinal tumor resection were retrospectively identified from 2014 to 2015. Complications, tumor recurrence, and survival were reviewed...
April 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29698064/intracranial-meningioma-with-carcinoma-tumor-to-tumor-metastasis-two-case-reports
#6
Jason T Pham, Ronald C Kim, Anna Nguyen, Daniela Bota, Xiao-Tang Kong, Sumeet Vadera, Frank Hsu, Jose A Carrillo
Meningiomas have been implicated as the most common primary intracranial tumor to contain tumor-to-tumor metastasis. In the following two case reports, we describe cases of adenocarcinoma and breast carcinoma that metastasized into an intracranial meningioma. The first patient was a 64-year-old man presenting to the emergency department with seizures and loss of consciousness. After a left frontal mass resection, pathology reported a heterogeneous mass consisting of a meningioma and a metastatic adenocarcinoma component...
April 26, 2018: CNS Oncology
https://www.readbyqxmd.com/read/29675884/specific-breast-cancer-prognosis-subtype-distinctions-based-on-dna-methylation-patterns
#7
Shumei Zhang, Yihan Wang, Yue Gu, Jiang Zhu, Ce Ci, Zhongfu Guo, Chuangeng Chen, Yanjun Wei, Wenhua Lv, Hongbo Liu, Dongwei Zhang, Yan Zhang
Tumor heterogeneity is an obstacle to effective breast cancer diagnosis and therapy. DNA methylation is an important regulator of gene expression, thus characterizing tumor heterogeneity by epigenetic features can be clinically informative. In this study, we explored specific prognosis-subtypes based on DNA methylation status using 669 breast cancers from TCGA database. Nine subgroups were distinguished by consensus clustering using 3869 CpGs that significantly influenced survival. The specific DNA methylation patterns were reflected by different races, ages, tumor stages, receptor status, histological types, metastasis status and prognosis...
April 19, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29660692/aggressive-phenotype-of-cells-disseminated-via-hematogenous-and-lymphatic-route-in-breast-cancer-patients
#8
Aleksandra Markiewicz, Anna Nagel, Jolanta Szade, Hanna Majewska, Jaroslaw Skokowski, Barbara Seroczynska, Tomasz Stokowy, Marzena Welnicka-Jaskiewicz, Anna J Zaczek
Intratumoral heterogeneity of breast cancer remains a major challenge in successful treatment. Failure of cancer therapies can also be accredited to inability to systemically eradicate cancer stem cells (CSCs). Recent evidence points to the role of epithelial-mesenchymal transition (EMT) in expanding the pool of tumor cells with CSCs features. Thus, we assessed expression level as well as heterogeneity of CSCs markers in primary tumors (PT), lymph node metastasis (LNM), and circulating tumor cells (CTCs)-enriched blood fractions in order to correlate them with signs of EMT activation as well as clinicopathological data of breast cancer patients...
April 13, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29620124/precise-targeting-of-cancer-metastasis-using-multi-ligand-nanoparticles-incorporating-four-different-ligands
#9
P M Peiris, F He, G Covarrubias, S Raghunathan, O Turan, M Lorkowski, B Gnanasambandam, C Wu, W P Schiemann, E Karathanasis
Metastasis displays a highly heterogeneous cellular population with cancer cells continuously evolving. As a result, a single-ligand nanoparticle cannot account for the continuously changing expression of targetable biomarkers over time and space. To effectively direct nanoparticles to metastasis, we developed a multi-ligand nanoparticle by using four different types of ligands on the same nanoparticle that target biomarkers on the endothelium associated with metastatic disease. These vascular targets included αvβ3 integrin, P-selectin, EGFR and fibronectin...
April 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29602822/-18-f-fluoroestradiol-tumor-uptake-is-heterogeneous-and-influenced-by-site-of-metastasis-in-breast-cancer-patients
#10
Hilde H Nienhuis, Michel van Kruchten, Sjoerd G Elias, Andor W J M Glaudemans, Erik F J de Vries, Alfons H H Bongaerts, Carolien P Schröder, Elisabeth G E de Vries, Geke A P Hospers
Heterogeneity of estrogen receptor (ER) expression in breast cancer is recognized. However, knowledge about varying expression across metastases and surrounding normal tissue in patients is scarce. We therefore analyzed 16α-[18 F]-fluoro-17β-estradiol (18 F-FES) positron emission tomography (PET) to assess ER expression heterogeneity. Methods: 18 F-FES-PET on EARL accredited PET-CT camera systems performed in patients with ER positive metastatic breast cancer November 2009- December 2014 were analyzed. Lesions with maximum absolute standardized uptake value (SUVmax ) ≥ 1...
March 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29521203/involvement-of-breast-cancer-associated-fibroblasts-in-tumor-development-therapy-resistance-and-evaluation-of-potential-therapeutic-strategies
#11
Maria Rosaria Ruocco, Angelica Avagliano, Giuseppina Granato, Valeria Imparato, Stefania Masone, Mariorosario Masullo, Rosarita Nasso, Stefania Montagnani, Alessandro Arcucci
Breast cancer is the most common cancer in women, which incidence has increased in recent years. It is constituted by very heterogeneous tissue characterized by an abnormal microenvironment regulating tumor progression and providing evasion from cancer therapies. Breast cancer associated fibroblasts (BCAFs) are the main cell type of breast cancer microenvironment and can represent up to 80 % of the tumor mass. In particular, BCAFs induce cancer initiation, proliferation, invasion and metastasis by undergoing an irreversible activation process associated with secretion of growth factors, cytokines, and paracrine interactions...
March 9, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29520340/molecular-mechanisms-and-emerging-therapeutic-targets-of-triple-negative-breast-cancer-metastasis
#12
REVIEW
Christiana Neophytou, Panagiotis Boutsikos, Panagiotis Papageorgis
Breast cancer represents a highly heterogeneous disease comprised by several subtypes with distinct histological features, underlying molecular etiology and clinical behaviors. It is widely accepted that triple-negative breast cancer (TNBC) is one of the most aggressive subtypes, often associated with poor patient outcome due to the development of metastases in secondary organs, such as the lungs, brain, and bone. The molecular complexity of the metastatic process in combination with the lack of effective targeted therapies for TNBC metastasis have fostered significant research efforts during the past few years to identify molecular "drivers" of this lethal cascade...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29516917/upregulation-of-cxc-chemokine-receptor-4-cxc-chemokine-ligand-12-axis-ininvasive-breast-carcinoma-a-potent-biomarker-predicting-lymph-node-metastasis
#13
Reza Dayer, Sadegh Babashah, Shirin Jamshidi, Majid Sadeghizadeh
Objective: Breast cancer is considered as a heterogeneous disease, characterized by different biological and phenotypic features which make its diagnosis and treatment challenging. The CXC chemokine receptor 4 (CXCR4) expression was found to be correlated with poor overall survival in invasive breast carcinoma patients. Here, we sought to investigate the expression levels of the CXCR4-CXC chemokine ligand 12 (CXCL12) chemokine axis and their association with clinicopathologic features and lymph node metastasis in invasive breast carcinoma...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29483489/genome-wide-association-study-of-loss-of-heterozygosity-and-metastasis-free-survival-in-breast-cancer-patients
#14
I V Deryusheva, M Tsyganov, E Y Garbukov, M K Ibragimova, Ju G Kzhyshkovska, E Slonimskaya, N V Cherdyntseva, N V Litviakov
One of the factors providing the diversity and heterogeneity of malignant tumors, particularly breast cancer, are genetic variations, due to gene polymorphism, and, especially, the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker. AIM: To perform genome-wide study on LOH in association with metastasis-free survival in breast cancer. MATERIALS AND METHODS: The study involved 68 patients with breast cancer...
July 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29480819/integrated-rna-and-dna-sequencing-reveals-early-drivers-of-metastatic-breast-cancer
#15
Marni B Siegel, Xiaping He, Katherine A Hoadley, Alan Hoyle, Julia B Pearce, Amy L Garrett, Sunil Kumar, Vincent J Moylan, Claudia M Brady, Amanda Ed Van Swearingen, David Marron, Gaorav P Gupta, Leigh B Thorne, Niamh Kieran, Chad Livasy, Elaine R Mardis, Joel S Parker, Mengjie Chen, Carey K Anders, Lisa A Carey, Charles M Perou
Breast cancer metastasis remains a clinical challenge, even within a single patient across multiple sites of the disease. Genome-wide comparisons of both the DNA and gene expression of primary tumors and metastases in multiple patients could help elucidate the underlying mechanisms that cause breast cancer metastasis. To address this issue, we performed DNA exome and RNA sequencing of matched primary tumors and multiple metastases from 16 patients, totaling 83 distinct specimens. We identified tumor-specific drivers by integrating known protein-protein network information with RNA expression and somatic DNA alterations and found that genetic drivers were predominantly established in the primary tumor and maintained through metastatic spreading...
April 2, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29462553/light-activated-core-shell-nanoparticles-for-spatiotemporally-specific-treatment-of-metastatic-triple-negative-breast-cancer
#16
Qingshuo Meng, Jia Meng, Wei Ran, Junyang Wang, Yihui Zhai, Pengcheng Zhang, Yaping Li
Triple-negative breast cancer (TNBC) tumors are heterogeneous, with mesenchymal-like cells at their core and fast proliferating cells on the periphery. It is desirable and beneficial to treat TNBC cells of different phenotypes with the most appropriate drugs. Here, we report a 78 nm, chlorin e6-, docetaxel-, and anti-Twist siRNA-containing polymeric nanoparticle (CDTN) with spatiotemporally specific activity when irradiated by light. Under conditions mimicking superficial tumor tissue with sufficient light input, TNBC cells are mainly killed by the photodynamic therapy (PDT) function of CDTNs...
March 27, 2018: ACS Nano
https://www.readbyqxmd.com/read/29439457/immune-landscape-of-breast-cancers
#17
REVIEW
Divya Nagarajan, Stephanie E B McArdle
Breast cancer is a very heterogeneous disease, both at a molecular and a histological level. Five intrinsic subtypes were initially identified-Luminal-A, Luminal-B, HER2⁺, Triple negative/basal like (TNBC) and normal like-subsequently expanded to seven (Basal-like-1 and 2, mesenchymal, mesenchymal stem-like, luminal androgen receptor, immuno-modulatory and unstable). Although genetic and epigenetic changes are key pathogenic events, the immune system plays a substantial role in promoting progression and metastasis...
February 11, 2018: Biomedicines
https://www.readbyqxmd.com/read/29437708/expression-of-adipocyte-macrophage-fatty-acid-binding-protein-in-tumor-associated-macrophages-promotes-breast-cancer-progression
#18
Jiaqing Hao, Fei Yan, Yuwen Zhang, Ashley Triplett, Ying Zhang, Debra A Schultz, Yanwen Sun, Jun Zeng, Kevin A T Silverstein, Qi Zheng, David A Bernlohr, Margot P Cleary, Nejat K Egilmez, Edward Sauter, Shujun Liu, Jill Suttles, Bing Li
Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid-binding protein (A-FABP) in TAM promotes breast cancer progression. Although upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis...
May 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29433456/exome-sequencing-of-primary-breast-cancers-with-paired-metastatic-lesions-reveals-metastasis-enriched-mutations-in-the-a-kinase-anchoring-protein-family-akaps
#19
Una Kjällquist, Rikard Erlandsson, Nicholas P Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh
BACKGROUND: Tumor heterogeneity in breast cancer tumors is today widely recognized. Most of the available knowledge in genetic variation however, relates to the primary tumor while metastatic lesions are much less studied. Many studies have revealed marked alterations of standard prognostic and predictive factors during tumor progression. Characterization of paired primary- and metastatic tissues should therefore be fundamental in order to understand mechanisms of tumor progression, clonal relationship to tumor evolution as well as the therapeutic aspects of systemic disease...
February 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29430386/tumor-microenvironment-heterogeneity-challenges-and-opportunities
#20
F Runa, S Hamalian, K Meade, P Shisgal, P C Gray, J A Kelber
The tumor microenvironment (TME) has been recognized as an integral component of malignancies in breast and prostate tissues, contributing in confounding ways to tumor progression, metastasis, therapy resistance and disease recurrence. Major components of the TME are immune cells, fibroblasts, pericytes, endothelial cells, mesenchymal stroma/stem cells (MSCs), and extracellular matrix (ECM) components. Herein, we discuss the molecular and cellular heterogeneity within the TME and how this presents unique challenges and opportunities for treating breast and prostate cancers...
December 2017: Current Molecular Biology Reports
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