Sydney J Conner, Justinne R Guarin, Thanh T Le, Jackson P Fatherree, Charlotte Kelley, Samantha L Payne, Savannah R Parker, Hanan Bloomer, Crystal Zhang, Kenneth Salhany, Rachel A McGinn, Emily Henrich, Anna Yui, Deepti Srinivasan, Hannah Borges, Madeleine J Oudin
BACKGROUND: Metastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade locally, intravasate, and colonize distant tissues and organs, all steps that require tumor cell migration. The majority of studies on invasion and metastasis rely on human breast cancer cell lines. While it is known that these cells have different properties and abilities for growth and metastasis, the in vitro morphological, proliferative, migratory, and invasive behavior of these cell lines and their correlation to in vivo behavior is poorly understood...
March 11, 2024: Breast Cancer Research: BCR