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https://www.readbyqxmd.com/read/29045046/a-novel-mouse-cre-driver-line-targeting-perilipin-2-expressing-cells-in-the-neonatal-lung
#1
Aglaia Ntokou, Marten Szibor, José Alberto Rodríguez-Castillo, Jennifer Quantius, Susanne Herold, Elie El Agha, Saverio Bellusci, Isabelle Salwig, Thomas Braun, Robert Voswinckel, Werner Seeger, Rory E Morty, Katrin Ahlbrecht
Pulmonary diseases such as chronic obstructive pulmonary disease, lung fibrosis, and bronchopulmonary dysplasia are characterized by the destruction or malformation of the alveolar regions of the lung. The underlying pathomechanisms at play are an area of intense interest since these mechanisms may reveal pathways suitable for interventions to drive reparative processes. Lipid-laden fibroblasts (lipofibroblasts) express the Perilipin 2 (Plin2) gene-product, PLIN2, commonly called adipose-differentiation related protein (ADRP) These cells are also thought to play a role in alveolarization and repair after injury to the alveolus...
October 16, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29040909/treatment-with-fenofibrate-plus-a-low-dose-of-benznidazole-attenuates-cardiac-dysfunction-in-experimental-chagas-disease
#2
Ágata C Cevey, Gerardo A Mirkin, Martín Donato, María J Rada, Federico N Penas, Ricardo J Gelpi, Nora B Goren
Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from the beginning of infection, is critical for the control of parasite proliferation and evolution of Chagas disease. Peroxisome proliferator-activated receptors (PPAR)-α, are known to modulate inflammation. In this study we investigated whether a PPAR-α agonist, Fenofibrate, improves cardiac function and inflammatory parameters in a murine model of T. cruzi infection. BALB/c mice were sequentially infected with two T...
October 7, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29039840/-use-of-loop-diuretics-in-heart-failure-current-aspects
#3
N V Kurlykina, E M Seredenina, Yа A Orlova
Loop diuretics take the lead in the treatment of patients with symptomatic heart failure. Torasemide is the most effective and safe loop diuretic with the optimal pharmacokinetic profile, the additional properties associated with simultaneous blockade of the renin-angiotensin-aldosterone system and with the antiadrenergic effects of the drug, its positive impact on myocardial fibrosis and minimal severe potential negative effects. Sustained-release torasemide provides a more comfortable removal of excess liquid and does not deteriorate quality of life...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29039471/hydrogen-sulfide-alleviates-myocardial-fibrosis-in-mice-with-alcoholic-cardiomyopathy-by-downregulating-autophagy
#4
Biao Liang, Ting Xiao, Junrong Long, Maojun Liu, Zining Li, Shengquan Liu, Jun Yang
Myocardial fibrosis is one of the most important pathological features of alcoholic cardiomyopathy (ACM). Hydrogen sulfide (H2S) exerts protective effects in various types of cardiovascular disease, which has been demonstrated by many previous studies. However, there is a lack of adequate research on the effect of H2S on myocardial fibrosis in ACM. The present study aimed to investigate the etiopathogenic role of H2S in myocardial fibrosis induced by chronic alcohol intake. An ACM mouse model was induced by consumption of 4% ethanol solution in drinking water for 12 weeks...
October 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038991/pathophysiological-and-therapeutic-implications-in-patients-with-atrial-fibrillation-and-heart-failure
#5
REVIEW
Felix Hohendanner, F R Heinzel, F Blaschke, B M Pieske, W Haverkamp, H L Boldt, A S Parwani
Heart failure and atrial fibrillation are common and responsible for significant mortality of patients. Both share the same risk factors like hypertension, ischemic heart disease, diabetes, obesity, arteriosclerosis, and age. A variety of microscopic and macroscopic changes favor the genesis of atrial fibrillation in patients with preexisting heart failure, altered subcellular Ca(2+) homeostasis leading to increased cellular automaticity as well as concomitant fibrosis that are induced by pressure/volume overload and altered neurohumoral states...
October 16, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/29037258/transplantation-of-isl1-cardiac-progenitor-cells-in-small-intestinal-submucosa-improves-infarcted-heart-function
#6
Lingjun Wang, Elizabeth M Meier, Shuo Tian, Ienglam Lei, Liu Liu, Shaoxiang Xian, Mai T Lam, Zhong Wang
BACKGROUND: Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. METHODS: In this study, we seeded Isl1(+) embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1(+) CPCs and the biocompatibility of SIS-ECM with these cells...
October 16, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29034264/reducing-cardiac-fibrosis-na-k-atpase-signaling-complex-as-a-novel-target
#7
X Fan, J Xie, J Tian
Cardiac fibrosis is a common pathological process in cardiac disease and may lead to heart failure. It can also cause sudden death even in those without cardiac symptoms. Tissue fibrosis can be categorized into two categories: replacement fibrosis (also called reparative fibrosis) and reactive fibrosis. In replacement fibrosis, infiltration of inflammatory cells and accumulation of Extracellular Matrix (ECM) proteins are the initial steps in forming scarlike fibrotic tissue after acute cardiac injury and cardiac cell necrosis...
2017: Cardiovascular Pharmacology: Open Access
https://www.readbyqxmd.com/read/29034087/spironolactone-in-cardiovascular-disease-an-expanding-universe
#8
REVIEW
John W Funder
Spironolactone has been marketed for over half a century as a 'potassium-sparing diuretic', used primarily in patients with ascites. With the realization that primary aldosteronism is the most common (5-13%) form of secondary hypertension, it has become widely used as a mineralocorticoid receptor antagonist. More recently, in the wake of the RALES trial, spironolactone in addition to standard therapy has been shown to be very beneficial in heart failure with a reduced ejection fraction. Despite the failure of the TOPCAT trial, spironolactone is being increasingly used in diastolic heart failure (i...
2017: F1000Research
https://www.readbyqxmd.com/read/29032244/the-impact-of-sparc-on-age-related-cardiac-dysfunction-and-fibrosis-in-drosophila
#9
Leigh Vaughan, Richard Marley, Sara Miellet, Paul S Hartley
Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as well as collagen deposition; however it is unclear whether collagen accumulates in the ageing Drosophila heart. This work examined collagen deposition and cardiac function in ageing Drosophila, in the context of reduced expression of collagen-interacting protein SPARC (Secreted Protein Acidic and Rich in Cysteine) an evolutionarily conserved protein linked with fibrosis...
October 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29032136/a-multicenter-randomized-double-blind-placebo-controlled-trial-of-the-efficacy%C3%A2-and-safety-of-the-oral-soluble-guanylate-cyclase-stimulator-the-victoria-trial
#10
REVIEW
Paul W Armstrong, Lothar Roessig, Mahesh J Patel, Kevin J Anstrom, Javed Butler, Adriaan A Voors, Carolyn S P Lam, Piotr Ponikowski, Tracy Temple, Burkert Pieske, Justin Ezekowitz, Adrian F Hernandez, Joerg Koglin, Christopher M O'Connor
This trial sought to evaluate whether vericiguat, a novel oral soluble guanylate cyclase (sGC) stimulator, was superior to placebo, on a background of standard of care, in increasing the time to the first occurrence of the composite endpoints of cardiovascular (CV) death and heart failure (HF) hospitalization in patients with HF with reduced ejection fraction (HFrEF). Deficiency in sGC-derived cyclic guanosine monophosphate (cGMP) causes both myocardial dysfunction and impaired endothelium-dependent vasomotor regulation that includes the myocardial microcirculation...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29029396/activation-of-cannabinoid-receptor-type-ii-by-am1241-protects-adipose-derived-mesenchymal-stem-cells-from-oxidative-damage-and-enhances-their-therapeutic-efficacy-in-myocardial-infarction-mice-via-stat3-activation
#11
Dong Han, Xiang Li, Wen-Si Fan, Jiang-Wei Chen, Tian-Tian Gou, Tao Su, Miao-Miao Fan, Meng-Qi Xu, Ya-Bin Wang, Sai Ma, Ya Qiu, Feng Cao
The poor survival of cells in ischemic sites diminishes the therapeutic efficacy of stem cell therapy. Previously we and others have reported that Cannabinoid receptor type II (CB2) is protective during heart ischemic injury for its anti-oxidative activity. However, whether CB2 activation could improve the survival and therapeutic efficacy of stem cells in ischemic myocardium and the underlying mechanisms remain elusive. Here, we showed evidence that CB2 agonist AM1241 treatment could improve the functional survival of adipose-derived mesenchymal stem cells (AD-MSCs) in vitro as well as in vivo...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029392/spermine-and-spermidine-reversed-age-related-cardiac-deterioration-in-rats
#12
Hao Zhang, Junying Wang, Lingxu Li, Nannan Chai, Yuhan Chen, Feixiang Wu, Weihua Zhang, Lina Wang, Sa Shi, Li Zhang, Shuling Bian, Changqing Xu, Ye Tian, Yajun Zhao
Aging is the most important risk factor for cardiovascular disease (CVD). Slowing or reversing the physiological impact of heart aging may reduce morbidity and mortality associated with age-related CVD. The polyamines, spermine (SP) and spermidine (SPD) are essential for cell growth, differentiation and apoptosis, and levels of both decline with age. To explore the effects of these polyamines on heart aging, we administered SP or SPD intraperitoneally to 22- to 24-month-old rats for 6 weeks. Both treatments reversed and inhibited age-related myocardial morphology alterations, myocardial fibrosis, and cell apoptosis...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027210/oedema-fibrosis-in-duchenne-muscular-dystrophy-role-of-cardiovascular-magnetic-resonance-imaging
#13
REVIEW
Sophie Mavrogeni, Antigoni Papavasiliou, Katerina Giannakopoulou, George Markousis-Mavrogenis, Maria Roser Pons, Evangelos Karanasios, Ioannis Nikas, George Papadopoulos, Genovefa Kolovou, George P Chrousos
Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by progressive, irreversible loss of cardiac and skeletal muscular function. Muscular enlargement in DMD is attributed to oedema, due to the increased cytoplasmic Na+ concentration. The aim in this review is to present the current experience and emphasize the role of cardiovascular magnetic resonance (CMR) in the diagnosis of this condition. DMD patients' survival depends on ventilatory assistance, as respiratory muscle dysfunction was the most common cause of death in the past...
October 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29026304/prevention-of-doxorubicin-induced-cardiomyopathy-using-targeted-mafgf-mediated-by-nanoparticles-combined-with-ultrasound-targeted-mb-destruction
#14
Xin-Qiao Tian, Xian-Wei Ni, He-Lin Xu, Lei Zheng, De-Li ZhuGe, Bin Chen, Cui-Tao Lu, Jian-Jun Yuan, Ying-Zheng Zhao
The present study seeks to observe the preventive effects of doxorubicin-induced cardiomyopathy (DOX-CM) in rats using targeted non-mitogenic acidic fibroblast growth factor (MaFGF) mediated by nanoparticles (NP) combined with ultrasound-targeted MB destruction (UTMD). DOX-CM rats were induced by intraperitoneally injected doxorubicin. Six weeks after intervention, the indices from the transthoracic echocardiography and velocity vector imaging showed that the left ventricular function in the MaFGF-loaded NP (MaFGF-NP) + UTMD group was significantly improved compared with the DOX-CM group...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29025547/contemporary-techniques-of-pericardiectomy-for-pericardial-disease
#15
REVIEW
Pouya Hemmati, Kevin L Greason, Hartzell V Schaff
Pericardiectomy is a potentially curative treatment for constrictive pericarditis. We use a median sternotomy and believe that adequate resection involves removal of the diaphragmatic pericardium and the anterior pericardium. Late outcomes depend on severity of right-sided heart failure preoperatively, the etiology of constrictive pericarditis, and adequate pericardial resection. Late results are excellent in patients with idiopathic disease or those with pericarditis secondary to prior cardiac operations. However, survival is reduced in those with radiation-induced constrictive pericarditis, primarily owing to additional secondary effects of radiation on cardiac valves, epicardial coronary arteries, and ventricular myocardium where fibrosis may cause associated restrictive cardiomyopathy...
November 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/29024319/prognostic-significance-of-glasgow-prognostic-score-in-patients-with-acute-exacerbation-of-idiopathic-pulmonary-fibrosis
#16
Hye S Kang, Kang W Cho, Soon S Kwon, Yong H Kim
BACKGROUND AND OBJECTIVE: The Glasgow prognostic score (GPS) reflects the host systemic inflammatory response and is a validated independent prognostic factor in lung cancer. We investigated GPS as a potential predictive factor of clinical outcomes in idiopathic pulmonary fibrosis (IPF) patients with acute exacerbation (AE). METHODS: This was a retrospective study performed between January 2006 and March 2016 in Bucheon St. Mary's Hospital, The Catholic University of Korea...
October 12, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29022267/cardiac-fibrosis-the-beneficial-effects-of-exercise-in-cardiac-fibrosis
#17
Jan Kyselovič, John J Leddy
Numerous scientific findings have concluded that individuals who are active tend to develop less cardiovascular disease than those who enjoy more sedentary lifestyles. Animal models have further demonstrated that the beneficial effects of training on the heart effects of training are related to the signaling pathways of myocardial hypertrophy and fibrosis. As such, fibroblasts represent a very important population of cells within the myocardium as they play a crucial role in both cardiac development and response to injury...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022265/exercise-amaliorates-metabolic-disturbances-and-oxidative-stress-in-diabetic-cardiomyopathy-possible-underlying-mechanisms
#18
Ayman M Mahmoud
Cardiomyopathy is a serious complication of diabetes mellitus and occurs independently of coronary artery disease or hypertension. It manifests as systolic/diastolic dysfunction and hypertrophy of the left ventricle and can lead to heart failure. Hyperglycemia can trigger a series of maladaptive stimuli and result in cardiac hypertrophy, fibrosis and reduced performance and contractility. The pathogenesis of diabetic cardiomyopathy is a multifactorial process that includes metabolic derangements such as increased oxidative stress, and altered non-oxidative glucose pathways and lipid metabolism...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022261/the-non-cardiomyocyte-cells-of-the-heart-their-possible-roles-in-exercise-induced-cardiac-regeneration-and-remodeling
#19
Ivan Varga, Jan Kyselovič, Paulina Galfiova, Lubos Danisovic
The non-cardiomyocyte cellular microenvironment of the heart includes diverse types of cells of mesenchymal origin. During development, the majority of these cells derive from the epicardium, while a subset derives from the endothelium/endocardium and neural crest derived mesenchyme. This subset includes cardiac fibroblasts and telocytes, the latter of which are a controversial type of "connecting cell" that support resident cardiac progenitors in the postnatal heart. Smooth muscle cells, pericytes, and endothelial cells are also present, in addition to adipocytes, which accumulate as epicardial adipose connective tissue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29021775/cardiac-findings-in-amyotrophic-lateral-sclerosis-a-magnetic-resonance-imaging-study
#20
Angela Rosenbohm, Benjamin Schmid, Dominik Buckert, Wolfgang Rottbauer, Jan Kassubek, Albert C Ludolph, Peter Bernhardt
The objective of this study was to investigate the potential involvement of cardiac structure and function by cardiac magnetic resonance (CMR) imaging in amyotrophic lateral sclerosis (ALS) patients. Our study included 35 patients with ALS without a history of cardiac disease and an age- and gender-matched healthy control group (n = 34). All subjects received a CMR in a 1.5-T whole-body scanner. Patients were also screened with Holter monitoring, echocardiography, and a blood test of cardiac markers. Myocardial mass in ALS hearts was reduced compared to the control group, and ejection volumes in the left and right heart were severely decreased in ALS patients, as shown by echocardiography and CMR...
2017: Frontiers in Neurology
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