Tobias Di Marco, Ina Djonlagic, Yves Dauvilliers, Kolia Sadeghi, David Little, Alexandre N Datta, Jeffrey Hubbard, Göran Hajak, Andrew Krystal, Antonio Olivieri, Liborio Parrino, Corey B Puryear, Gary Zammit, Jacob Donoghue, Thomas E Scammell
STUDY OBJECTIVES: Post-hoc analysis to evaluate the effect of daridorexant on sleep architecture in people with insomnia, focusing on features associated with hyperarousal. METHODS: We studied sleep architecture in adults with chronic insomnia disorder from two randomized Phase 3 clinical studies (Clinicaltrials.gov: NCT03545191 and NCT03575104) investigating 3 months of daridorexant treatment (placebo, daridorexant 25 mg, daridorexant 50 mg). We analyzed sleep-wake transition probabilities, EEG spectra and sleep spindle properties including density, dispersion, and slow oscillation phase coupling...
April 22, 2024: Sleep