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Cardiac strain

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https://www.readbyqxmd.com/read/28319168/targeting-chronic-cardiac-remodeling-with-cardiac-progenitor-cells-in-a-murine-model-of-ischemia-reperfusion-injury
#1
Janine C Deddens, Dries A Feyen, Peter-Paul Zwetsloot, Maike A Brans, Sailay Siddiqi, Linda W van Laake, Pieter A Doevendans, Joost P Sluijter
BACKGROUND: Translational failure for cardiovascular disease is a substantial problem involving both high research costs and an ongoing lack of novel treatment modalities. Despite the progress already made, cell therapy for chronic heart failure in the clinical setting is still hampered by poor translation. We used a murine model of chronic ischemia/reperfusion injury to examine the effect of minimally invasive application of cardiac progenitor cells (CPC) in cardiac remodeling and to improve clinical translation...
2017: PloS One
https://www.readbyqxmd.com/read/28317398/cardiac-transplantation-towards-a-new-noninvasive-approach-of-cardiac-allograft-rejection
#2
Sophie I Mavrogeni, George Athanasopoulos, Aggeliki Gouziouta, Evangelos Leontiadis, Stamatis Adamopoulos, Genovefa Kolovou
Cardiac allograft rejection (CAR) may occur after transplantation and remains silent, until hemodynamic deterioration takes place. Endomyocardial biopsy (EMB) is applied to early detect CAR. Although, flexible bioptoms have decreased the incidence of lethal complications, EMB remains an invasive procedure carrying risk of tamponade and permanent heart block. Therefore, a new non-invasive approach is needed. Areas covered: AlloMap molecular expression testing and graft-derived cell-free DNA (GcfDNA) test can be used as blood indices of acute and chronic CAR, respectively...
March 20, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28315522/human-cardiac-fibroblasts-adaptive-responses-to-controlled-combined-mechanical-strain-and-oxygen-changes-in-vitro
#3
Giovanni Stefano Ugolini, Andrea Pavesi, Marco Rasponi, Gianfranco Beniamino Fiore, Roger Kamm, Monica Soncini
Upon cardiac pathological conditions such as ischemia, microenvironmental changes instruct a series of cellular responses that trigger cardiac fibroblasts-mediated tissue adaptation and inflammation. A comprehensive model of how early environmental changes may induce cardiac fibroblasts (CF) pathological responses is far from being elucidated, partly due to the lack of approaches involving complex and simultaneous environmental stimulation. Here, we provide a first analysis of human primary CF behavior by means of a multi-stimulus microdevice for combined application of cyclic mechanical strain and controlled oxygen tension...
March 18, 2017: ELife
https://www.readbyqxmd.com/read/28314836/safe-heart-rationale-and-design-of-a-pilot-study-investigating-cardiac-safety-of-her2-targeted-therapy-in-patients-with-her2-positive-breast-cancer-and-reduced-left-ventricular-function
#4
Filipa Lynce, Ana Barac, Ming T Tan, Federico M Asch, Karen L Smith, Chau Dang, Claudine Isaacs, Sandra M Swain
BACKGROUND: Human epidermal growth receptor 2 (HER2) targeted therapies have survival benefit in adjuvant and metastatic HER2 positive breast cancer but are associated with cardiac dysfunction. Current U.S. Food and Drug Administration recommendations limit the use of HER2 targeted agents to patients with normal left ventricular (LV) systolic function. METHODS: The objective of the SAFE-HEaRt study is to evaluate the cardiac safety of HER2 targeted therapy in patients with HER2 positive breast cancer and mildly reduced left ventricular ejection fraction (LVEF) with optimized cardiac therapy...
March 17, 2017: Oncologist
https://www.readbyqxmd.com/read/28314078/high-physical-fitness-is-associated-with-reduction-in-basal-and-exercise-induced-inflammation
#5
Øyunn Kleiven, Magnus Bjørkavoll-Bergseth, Tor Melberg, Øyvind Skadberg, Rolf Bergseth, Jone Selvåg, Bjørn Auestad, Pål Aukrust, Torbjørn Aarsland, Stein Ørn
C-reactive protein (CRP) increases after strenuous exercise. It has been a concern that prolonged strenuous exercise may be harmful, and induce a deleterious inflammatory response. The purpose of this study was to 1) Assess and quantify the magnitude of CRP response following an endurance cycling competition in healthy middle-aged recreational cyclists. 2) Identify important determinants of this response. 3) Identify the relationship between CRP, myocardial damage (cardiac Troponin I (cTnI)) and myocardial strain (B-type natriuretic peptide (BNP))...
March 17, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28302557/prevalence-and-prognostic-features-of-ecg-abnormalities-in-acute-stroke-findings-from-the-siren-study-among-africans
#6
Abiodun M Adeoye, Okechukwu S Ogah, Bruce Ovbiagele, Rufus Akinyemi, Vincent Shidali, Francis Agyekum, Akinyemi Aje, Oladimeji Adebayo, Joshua O Akinyemi, Philip Kolo, Lambert Tetteh Appiah, Henry Iheonye, Uwanuruochi Kelechukwu, Amusa Ganiyu, Taiwo O Olunuga, Onoja Akpa, Ojo Olakanmi Olagoke, Fred Stephen Sarfo, Kolawole Wahab, Samuel Olowookere, Adekunle Fakunle, Albert Akpalu, Philip B Adebayo, Kwadwo Nkromah, Joseph Yaria, Philip Ibinaiye, Godwin Ogbole, Aridegbe Olumayowa, Sulaiman Lakoh, Benedict Calys-Tagoe, Paul Olowoyo, Chukwuonye Innocent, Hemant K Tiwari, Donna Arnett, Osaigbovo Godwin, Bisi Ayotunde, Josephine Akpalu, Okeke Obiora, Odo Joseph, Adeleye Omisore, Carolyn Jenkins, Daniel Lackland, Lukman Owolabi, Suleiman Isah, Abdu H Dambatta, Morenikeji Komolafe, Andrew Bock-Oruma, Ezinne Sylvia Melikam, Lucius Chidiebere Imoh, Taofiki Sunmonu, Mulugeta Gebregziabher, Oluyemisi Olabisi, Kevin Armstrong, Ugochukwu U Onyeonoro, Emmanuel Sanya, Atinuke M Agunloye, Luqman Ogunjimi, Oyedunni Arulogun, Temitope H Farombi, Olugbo Obiabo, Reginald Obiako, Mayowa Owolabi
BACKGROUND: Africa has a growing burden of stroke with associated high morbidity and a 3-year fatality rate of 84%. Cardiac disease contributes to stroke occurrence and outcomes, but the precise relationship of abnormalities as noted on a cheap and widely available test, the electrocardiogram (ECG), and acute stroke outcomes have not been previously characterized in Africans. OBJECTIVES: The study assessed the prevalence and prognoses of various ECG abnormalities among African acute stroke patients encountered in a multisite, cross-national epidemiologic study...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28302319/high-sensitivity-cardiac-troponin-t-and-systemic-right-ventricular-function-in-adults-with-congenitally-corrected-transposition-of-the-great-arteries
#7
Ewa Kowalik, Anna Klisiewicz, Justyna Rybicka, Elżbieta K Biernacka, Piotr Hoffman
BACKGROUND: High sensitive troponin T (hsTnT), a marker of myocardial injury, appears to be a promising diagnostic tool in patients with congenital heart disease. However, little is known about its distribution among adults with systemic right ventricle (sRV). We aimed to assess the distribution of hsTnT concentrations in patients with congenitally corrected transposition of the great arteries (ccTGA) and to evaluate its relationship with sRV function and NT-proBNP. METHODS: A cross-sectional study of adults with ccTGA was conducted...
March 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28298286/echo-parameters-for-differential-diagnosis-in-cardiac-amyloidosis-a-head-to-head-comparison-of-deformation-and-nondeformation-parameters
#8
Efstathios D Pagourelias, Oana Mirea, Jürgen Duchenne, Johan Van Cleemput, Michel Delforge, Jan Bogaert, Tatyana Kuznetsova, Jens-Uwe Voigt
BACKGROUND: A plethora of echo parameters has been suggested for distinguishing cardiac amyloidosis (CA) from other causes of myocardial thickening with, however, scarce data on their head-to-head comparison. This study aimed at comparing the diagnostic accuracy of various deformation and conventional echo parameters in differentiating CA from other hypertrophic substrates, especially in the gray zone of mild hypertrophy (maximum wall thickness ≤16 mm) or normal ejection fraction (EF)...
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28294407/assessment-of-cardiac-allograft-systolic-function-by-global-longitudinal-strain-from-donor-to-recipient
#9
Adam D DeVore, Fawaz Alenezi, Arun Krishnamoorthy, Mads Ersboll, Marc D Samsky, Phillip J Schulte, Chetan B Patel, Joseph G Rogers, Carmelo A Milano, Eric J Velazquez, Michel G Khouri
BACKGROUND: Cardiac allografts are routinely evaluated by left ventricular ejection fraction (LVEF) before and after transplantation. However, myocardial deformation analyses with LV global longitudinal strain (GLS) are more sensitive for detecting impaired LV myocardial systolic performance compared with LVEF. METHODS: We analyzed echocardiograms in 34 heart donor-recipient pairs transplanted at Duke University from 2000-2013. Assessments of allograft LV systolic function by LVEF and/or LV GLS were performed on echocardiograms obtained pre-explanation in donors and serially in corresponding recipients...
March 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28293551/timely-pulmonary-valve-replacement-may-allow-preservation-of-left-ventricular-circumferential-strain-in-patients-with-tetralogy-of-fallot
#10
Barbara E U Burkhardt, Marí Nieves Velasco Forte, Saravanan Durairaj, Isma Rafiq, Israel Valverde, Animesh Tandon, John Simpson, Tarique Hussain
INTRODUCTION: Patients with Tetralogy of Fallot (TOF) and pulmonary insufficiency and a dilated right ventricle (RV) may suffer from a reduction in left ventricular (LV) performance. It is not clear whether timely pulmonary valve replacement (PVR) preserves LV mechanics. METHODS: Ten TOF patients who underwent PVR were identified from hospital records, and pre- and postoperative cardiac magnetic resonance images were post-processed with a semi-automatic tissue tracking software...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28292971/selective-replacement-of-mitochondrial-dna-increases-cardioprotective-effect-of-chronic-continuous-hypoxia-in-spontaneously-hypertensive-rats
#11
Jan Neckar, Anna Svatonova, Romana Weissova, Zdenek Drahota, Pavlina Zajickova, Iveta Brabcova, David Kolar, Petra Alanova, Jana Vasinova, Jan Silhavy, Marketa Hlavackova, Katerina Tauchmannova, Marie Milerova, Bohuslav Ostadal, Ludek Cervenka, Jitka Zurmanova, Martin Kalous, Olga Novakova, Jiri Novotny, Michal Pravenec, Frantisek Kolar
Mitochondria play an essential role in improved cardiac ischemic tolerance conferred by adaptation to chronic hypoxia. In the present study, we analyzed effects of continuous normobaric hypoxia (CNH) on mitochondrial functions, including the sensitivity of mitochondrial permeability transition pore (MPTP) to opening, and infarct size in hearts of spontaneously hypertensive rats (SHR) and in conplastic SHR-mtBN strain characterized by the selective replacement of the mitochondrial genome of SHR with that of more ischemia-resistant Brown Norway (BN) strain...
March 14, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28285896/perinatal-changes-in-fetal-ventricular-geometry-myocardial-performance-and-cardiac-function-in-normal-term-pregnancies
#12
Olga Patey, Michael A Gatzoulis, Basky Thilaganathan, Julene S Carvalho
BACKGROUND: The fetal heart at term is exposed to an increase in hemodynamic work as a consequence of fetal growth, increased circulating volume, and alteration in loading patterns due to maturational changes in fetoplacental circulation. The extent to which these cardiovascular changes influence human fetal and neonatal cardiac adaptation has not been fully elucidated. The aim of this study was to evaluate perinatal cardiovascular changes in ventricular geometry and myocardial performance in normal term fetuses...
March 9, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28285119/fitness-in-young-adulthood-and-long-term-cardiac-structure-and-function-the-cardia-study
#13
Ambarish Pandey, Norrina B Allen, Colby Ayers, Jared P Reis, Henrique T Moreira, Stephen Sidney, Jamal S Rana, David R Jacobs, Lisa S Chow, James A de Lemos, Mercedes Carnethon, Jarett D Berry
OBJECTIVES: This study sought to evaluate the association between early-life cardiorespiratory fitness (CRF) and measures of left ventricular (LV) structure and function in midlife. BACKGROUND: Low CRF in midlife is associated with a higher risk of heart failure. However, the unique contributions of early-life CRF toward measures of LV structure and function in middle age are not known. METHODS: CARDIA (Coronary Artery Risk Development in Young Adults) study participants with a baseline maximal treadmill test and an echocardiogram at year 25 were included...
March 5, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28284461/right-ventricular-systolic-dysfunction-in-chagas-disease-defined-by-speckle-tracking-echocardiography-a-comparative-study-with-cardiac-magnetic-resonance-imaging
#14
Henrique T Moreira, Gustavo J Volpe, José A Marin-Neto, Chike C Nwabuo, Bharath Ambale-Venkatesh, Luis G Gali, Oswaldo C Almeida-Filho, Minna M D Romano, Antonio Pazin-Filho, Benedito C Maciel, João A C Lima, André Schmidt
BACKGROUND: Chagas disease leads to biventricular heart failure, usually with prominent systemic congestion. Although echocardiography is widely used in clinical routine, the utility of echocardiographic parameters to detect right ventricular (RV) systolic dysfunction in patients with Chagas disease is unknown. We sought to study the diagnostic value of echocardiography, including speckle-tracking parameters, to distinguish individuals with RV systolic dysfunction from those with normal RV systolic function in Chagas disease using cardiac magnetic resonance (CMR) as the reference method...
March 8, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28284183/multiparametric-cardiac-magnetic-resonance-imaging-cmr-for-the-diagnosis-of-loeffler-s-endocarditis-a-case-report
#15
Mareike Gastl, Patrick Behm, Christoph Jacoby, Malte Kelm, Florian Bönner
BACKGROUND: Endocarditis parietalis fibroplastica Löfflein (EPF) is a rare form of primary restrictive cardiomyopathy with poor prognosis. It is generally caused by hypereosinophilic syndrome with eosinophilic penetration of the heart. This leads to congestive heart failure in three different stages. As a frequent manifestation of neoplastic diseases, cardiac involvement means poor prognosis. CASE PRESENTATION: The present report deals with a case of EPF caused by non-specified T-cell lymphoma (T-NOS)...
March 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28283942/comparison-of-blood-viscoelasticity-in-pediatric-and-adult-cardiac-patients
#16
M Keith Sharp, Mary Gregg, Guy Brock, Neema Nair, Sarina Sahetya, Erle H Austin, Christopher Mascio, Mark D Slaughter, George M Pantalos
Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood viscoelasticity. Thus, to better understand the challenges to providing circulatory support and surgical therapies for pediatric and adult patients, viscous and elastic components of complex blood viscoelasticity of 31 pediatric patients were compared to those of 29 adult patients with a Vilastic-3 rheometer. A random effects model with categorical age covariates found statistically significant differences between pediatric and adult patients for log viscosity (p = 0...
March 10, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28283244/left-atrial-mechanics-in-patients-with-acute-stemi-and-secondary-mitral-regurgitation-a-prospective-pilot-cmr-feature-tracking-study
#17
Tomas Lapinskas, Paulius Bučius, Laura Urbonaitė, Agnieta Stabinskaitė, Živilė Valuckienė, Lina Jankauskaitė, Rimantas Benetis, Remigijus Žaliūnas
BACKGROUND AND OBJECTIVE: Left atrium (LA) is an important biomarker of adverse cardiovascular outcomes and cerebrovascular events. This study aimed to evaluate LA myocardial deformation using cardiac magnetic resonance feature tracking (CMR-FT) in patients with acute ST-segment elevation myocardial infarction (STEMI) and secondary mitral regurgitation (MR). Additionally, to assess interobserver and intraobserver variability of the technique. MATERIALS AND METHODS: Twenty patients with STEMI underwent CMR with a 1...
March 1, 2017: Medicina
https://www.readbyqxmd.com/read/28283005/-comparison-of-maldi-tof-and-16s-rrna-methods-in-identification-of-viridans-group-streptococci
#18
Serap Süzük Yıldız, Banu Kaşkatepe, Salih Altınok, Mustafa Çetin, Alper Karagöz, Sümeyra Savaş
Accurate identification of viridans group streptococci (VGS) frequently encountered as a causative agent of infective endocarditis is always a challenge for the clinical microbiology laboratory. Clinical microbiology laboratories generally use semi automatic/full automatic systems, molecular methods and also conventional methods for the identification of these bacteria. There are recent published studies that have used MALDI-TOF (Matrix Assisted Laser Ionization Mass Spectrometry-Time of Flight) systems in the identification of VGS...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28275864/longitudinal-assessment-of-myocardial-function-in-childhood-chronic-kidney-disease-during-dialysis-and-following-kidney-transplantation
#19
Rawan K Rumman, Ronand Ramroop, Rahul Chanchlani, Mikaeel Ghany, Diane Hebert, Elizabeth A Harvey, Rulan S Parekh, Luc Mertens, Michael Grattan
BACKGROUND: Childhood chronic kidney disease (CKD) and dialysis are associated with increased long-term cardiovascular risk. We examined subclinical alterations in myocardial mechanics longitudinally in children with CKD, during dialysis, and following renal transplantation. METHODS: Forty-eight children with CKD (stage III or higher) who received kidney transplants from 2008 to 2014 were included in a retrospective study and compared to 192 age- and sex-matched healthy children...
March 8, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28275592/model-of-human-fetal-growth-in-hypoplastic-left-heart-syndrome-reduced-ventricular-growth-due-to-decreased-ventricular-filling-and-altered-shape
#20
Sukriti Dewan, Adarsh Krishnamurthy, Devleena Kole, Giulia Conca, Roy Kerckhoffs, Michael D Puchalski, Jeffrey H Omens, Heather Sun, Vishal Nigam, Andrew D McCulloch
INTRODUCTION: Hypoplastic left heart syndrome (HLHS) is a congenital condition with an underdeveloped left ventricle (LV) that provides inadequate systemic blood flow postnatally. The development of HLHS is postulated to be due to altered biomechanical stimuli during gestation. Predicting LV size at birth using mid-gestation fetal echocardiography is a clinical challenge critical to prognostic counseling. HYPOTHESIS: We hypothesized that decreased ventricular filling in utero due to mitral stenosis may reduce LV growth in the fetal heart via mechanical growth signaling...
2017: Frontiers in Pediatrics
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