Hiroki Iida, Takashi Onuma, Daiki Nakashima, Daisuke Mizutani, Takamitsu Hori, Kyohei Ueda, Tomoyuki Hioki, Woo Kim, Yukiko Enomoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Shinobu Yamaguchi, Junko Tachi, Kumiko Tanabe, Shinji Ogura, Toru Iwama, Osamu Kozawa, Haruhiko Tokuda
Tramadol is a useful analgesic which acts as a serotonin and noradrenaline reuptake inhibitor in addition to μ-opioid receptor agonist. Cytoplasmic serotonin modulates the small GTPase activity through serotonylation, which is closely related to the human platelet activation. We recently reported that the combination of subthreshold collagen and CXCL12 synergistically activates human platelets. We herein investigated the effect and the mechanism of tramadol on the synergistic effect. Tramadol attenuated the synergistically stimulated platelet aggregation (300 μM of tramadol, 64...
2023: PloS One