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https://www.readbyqxmd.com/read/29580444/medical-simulation-as-a-vital-adjunct-to-identifying-clinical-life-threatening-gaps-in-austere-environments
#1
Adaora M Chima, Rahul Koka, Benjamin Lee, Tina Tran, Onyebuchi U Ogbuagu, Howard Nelson-Williams, Michael Rosen, Michael Koroma, John B Sampson
BACKGROUND: Maternal mortality and morbidity are major causes of death in low-resource countries, especially those in Sub-Saharan Africa. Healthcare workforce scarcities present in these locations result in poor perioperative care access and quality. These scarcities also limit the capacity for progressive development and enhancement of workforce training, and skills through continuing medical education. Newly available low-cost, in-situ simulation systems make it possible for a small cadre of trainers to use simulation to identify areas needing improvement and to rehearse best practice approaches, relevant to the context of target environments...
April 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29573142/development-of-an-unbiased-semi-automated-approach-for-classifying-plasma-cell-immunophenotype-following-multicolor-flow-cytometry-of-bone-marrow-aspirates
#2
Steven R Post, Ginell R Post, Dejan Nikolic, Rebecca Owens, Giovanni Insuasti-Beltran
BACKGROUND: Despite increased usage of multiparameter flow cytometry (MFC) to assess diagnosis, prognosis, and therapeutic efficacy (minimal residual disease, MRD) in plasma cell neoplasms (PCNs), standardization of methodology and data analysis is suboptimal. We investigated the utility of using the mean and median fluorescence intensities (FI) obtained from MFC to objectively describe parameters that distinguish plasma cell (PC) phenotypes. METHODS: In this retrospective study, flow cytometry results from bone marrow aspirate specimens from 570 patients referred to the Myeloma Institute at UAMS were evaluated...
March 24, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29476852/comparative-study-on-the-physicochemical-and-functional-properties-of-the-mucilage-in-the-carpel-of-nymphaea-odorata-using-ultrasonic-and-classical-heating-extractions
#3
WeiZhi Wu, ChinWei Tu, WenJen Yang, HengLong Wang, ChaoLin Chang, JengDer Chung, MeiKuang Lu, WeiTung Liao
The cooked carpel of Nymphaea odorata has a large amount of transparent mucilage; however, the basic characteristics of this mucilage have not yet been reported. This study compared the physicochemical and functional properties of this mucilage obtained using conventional hot water extraction (HWM) and ultrasonic-assisted extraction (UAM). Neither HWM nor UAM affected the viability of mouse skin fibroblasts (NIH/3T3) below 100 μg/mL. UAM had a higher yield production, phenol concentration, and in vitro antioxidant activity, but lower viscosity and water-holding capacity than for HWM...
February 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29470350/analysis-of-luminex-based-algorithms-to-define-unacceptable-hla-antibodies-in-cdc-crossmatch-negative-kidney-transplant-recipients
#4
Daniel Zecher, Christian Bach, Adrian Preiss, Christoph Staudner, Kirsten Utpatel, Matthias Evert, Bettina Jung, Tobias Bergler, Carsten A Böger, Bernd M Spriewald, Bernhard Banas
BACKGROUND: HLA-specific antibodies detected by solid phase assays are increasingly used to define unacceptable HLA antigen mismatches (UAM) prior to renal transplantation. The accuracy of this approach is unclear. METHODS: Day of transplant sera from 211 CDC-crossmatch-negative patients were retrospectively analyzed for donor-specific anti-HLA antibodies (DSA) using Luminex technology. HLA were defined as UAM if DSA had mean fluorescence intensity above (I) 3000 (patients retransplanted and those with DSA against HLA class I and II) or 5000 (all other patients), (II) 5000 for HLA A, B and DR and 10,000 for HLA DQ or (III) 10,000 (all HLA)...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29465808/investigating-the-potential-barrier-function-of-nanostructured-materials-formed-in-engineered-barrier-systems-ebs-designed-for-nuclear-waste-isolation
#5
REVIEW
Jaime Cuevas, Ana Isabel Ruiz, Raúl Fernández
Clay and cement are known nano-colloids originating from natural processes or traditional materials technology. Currently, they are used together as part of the engineered barrier system (EBS) to isolate high-level nuclear waste (HLW) metallic containers in deep geological repositories (DGR). The EBS should prevent radionuclide (RN) migration into the biosphere until the canisters fail, which is not expected for approximately 103 years. The interactions of cementitious materials with bentonite swelling clay have been the scope of our research team at the Autonomous University of Madrid (UAM) with participation in several European Union (EU) projects from 1998 up to now...
February 21, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29459837/effects-of-relaxing-and-arousing-music-during-imagery-training-on-dart-throwing-performance-physiological-arousal-indices-and-competitive-state-anxiety
#6
Garry Kuan, Tony Morris, Yee Cheng Kueh, Peter C Terry
Music that is carefully selected to match the requirements of activities and the characteristics of individuals has been shown to produce significant impacts on performance enhancement (Priest et al., 2004). There is also evidence that music can enhance imagery (Grocke and Wigram, 2007), although few studies have investigated the effects of music on imagery in the context of sport skills. In the present study, the effects of relaxing and arousing music during imagery on dart-throwing performance, physiological arousal indices, and competitive state anxiety, were investigated among 63 novice dart throwers...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29393221/the-synergy-of-endotoxin-and-1%C3%A2-3-%C3%AE-d-glucan-from-gut-translocation-worsens-sepsis-severity-in-a-lupus-model-of-fc-gamma-receptor-iib-deficient-mice
#7
Jiraphorn Issara-Amphorn, Saowapha Surawut, Navaporn Worasilchai, Arthid Thim-Uam, Malcolm Finkelman, Ariya Chindamporn, Tanapat Palaga, Nattiya Hirankarn, Prapaporn Pisitkun, Asada Leelahavanichkul
We investigated the influence of spontaneous gut leakage upon polymicrobial sepsis in a lupus model with Fc gamma receptor IIb-deficient (FcGRIIb-/-) mice aged 8 and 40 weeks, as representing asymptomatic and symptomatic lupus, respectively. Spontaneous gut leakage, determined by (i) the presence of FITC-dextran, (ii) elevated serum endotoxin, and (iii) elevated serum (1→3)-β-D-glucan (BG), was demonstrated in symptomatic lupus but not in the asymptomatic group. In parallel, spontaneous gut leakage, detected by elevated serum BG without fungal infection, was demonstrated in patients with active lupus nephritis...
January 31, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29384744/the-age-estimation-practice-related-to-illegal-unaccompanied-minors-immigration-in-italy
#8
F Pradella, V Pinchi, M Focardi, R Grifoni, M Palandri, G A Norelli
The migrants arrived to the Italian coasts in 2016 were 181.436, 18% more than the previous year and 6% more than the highest number ever since. An "unaccompanied minor" (UAM) is a third-country national or a stateless person under eighteen years of age, who arrives on the territory of the Member State unaccompanied by an adult responsible for him/her whether by law or by the practice of the Member State concerned, and for as long as he or she is not effectively taken into the care of such a person; it includes a minor who is left unaccompanied after he/she entered the territory of the Member States...
December 1, 2017: Journal of Forensic Odonto-stomatology
https://www.readbyqxmd.com/read/29297289/dbbqs-database-of-bacterial-quality-scores
#9
Visanu Wanchai, Preecha Patumcharoenpol, Intawat Nookaew, David Ussery
BACKGROUND: It is well-known that genome sequencing technologies are becoming significantly cheaper and faster. As a result of this, the exponential growth in sequencing data in public databases allows us to explore ever growing large collections of genome sequences. However, it is less known that the majority of available sequenced genome sequences in public databases are not complete, drafts of varying qualities. We have calculated quality scores for around 100,000 bacterial genomes from all major genome repositories and put them in a fast and easy-to-use database...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29276696/characterization-of-scenedesmus-obtusiusculus-at-uam-for-high-energy-molecules-accumulation-deeper-insight-into-biotechnological-potential-of-strains-of-the-same-species
#10
Alma Toledo-Cervantes, Gloria Garduño Solórzano, Jorge E Campos, Martha Martínez-García, Marcia Morales
Scenedesmus obtusiusculus AT-UAM, isolated from Cuatro Ciénegas wetlands in Mexico was taxonomically, molecularly and biochemically compared to S. obtusiusculus CCAP 276/25 (Culture Collection of Algae and Protozoa, Scotland, UK). Analysis of Internal Transcribed Spacer 2 (ITS2) secondary structures confirmed that the mexican strain belongs to S. obtusiusculus with one change in the ITS2 nucleotide sequence. However, both strains exhibited different biochemical and fatty acid profiles and therefore biotechnological potential, emphasizing the need for deeper studies among strains of the same species...
March 2018: Biotechnology Reports
https://www.readbyqxmd.com/read/29226282/feasibility-of-conducting-a-6-month-long-home-based-exercise-program-with-protein-supplementation-in-elderly-community-dwelling-individuals-with-heart-failure
#11
Masil George, Gohar Azhar, Amanda Pangle, Eric Peeler, Amanda Dawson, Robert Coker, Kellie S Coleman, Amy Schrader, Jeanne Wei
Objective: Cardiac cachexia is a condition associated with heart failure, particularly in the elderly, and is characterized by loss of muscle mass with or without the loss of fat mass. Approximately 15% of elderly heart failure patients will eventually develop cardiac cachexia; such a diagnosis is closely associated with high morbidity and increased mortality. While the mechanism(s) involved in the progression of cardiac cachexia is incompletely established, certain factors appear to be contributory...
2017: Journal of Physiotherapy & Physical Rehabilitation
https://www.readbyqxmd.com/read/29110079/old-and-emerging-concepts-on-adrenal-chromaffin-cell-stimulus-secretion-coupling
#12
EDITORIAL
Ricardo Borges, Luis Gandía, Emilio Carbone
The chromaffin cells (CCs) of the adrenal medulla play a key role in the control of circulating catecholamines to adapt our body function to stressful conditions. A huge research effort over the last 35 years has converted these cells into the Escherichia coli of neurobiology. CCs have been the testing bench for the development of patch-clamp and amperometric recording techniques and helped clarify most of the known molecular mechanisms that regulate cell excitability, Ca2+ signals associated with secretion, and the molecular apparatus that regulates vesicle fusion...
January 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29104251/influence-of-glycine-and-arginine-on-cylindrospermopsin-production-and-aoa-gene-expression-in-aphanizomenon-ovalisporum
#13
Ángel Barón-Sola, Francisca Fernández Del Campo, Soledad Sanz-Alférez
Arginine (Arg) and glycine (Gly) seem to be the only substrates accepted by the amidinotransferase that catalyze the first step of the synthesis pathway of the cyanotoxin cylindrospermopsin (CYN), leading to guanidinoacetate (GAA). Here, the effect of these amino acids on the production of CYN in cultures of the cylindrospermopsin-producing strain, Aphanizomenon ovalisporum UAM-MAO, has been studied. Arg clearly increased CYN content, the increment appearing triphasic along the culture. On the contrary, Gly caused a decrease of CYN, observable from the first day on...
November 1, 2017: Toxins
https://www.readbyqxmd.com/read/29077700/electroencephalographic-indicators-in-default-mode-habituation-and-visual-motor-association-in-female-college-students
#14
Héctor Brust-Carmona, Yessica Martínez-Serrato, Ana Sánchez-Quezada, Blanca Flores-Avalos, Javier Alducin-Castillo, Oscar Yáñez-Suarez
BACKGROUND: Oscillations, action, and postsynaptic potentials in glial-neuronal ensembles integrate the spectral power (SP) of electroencephalographic (EEG). Our objective is to propose SP indicators of healthy brains (control groups) based on the default mode and their modifications by habituation and visual-motor association (VM-asso), to support diagnostic and rehabilitation processes. However, important differences seem to exist between men and women. Therefore, we aim to analyze EEG characteristics in a female sample...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29056625/the-development-of-a-community-engagement-workshop-a-community-led-approach-for-building-researcher-capacity
#15
Jake Coffey, Anna Huff-Davis, Christie Lindsey, Onie Norman, Henryetter Curtis, Calvin Criner, M Kathryn Stewart
BACKGROUND: Although community-engaged research (CEnR) is increasingly promoted in the literature, academic programs often fail to prepare researchers for the critical, ethical, and power issues involved in CEnR. This article documents a community-created and led workshop for CEnR researchers. OBJECTIVES: The workshop's main objective is to increase researchers' knowledge and felt experience of the "dos and don'ts" of CEnR in three research domains: entering the community, accommodating the realities and constraints of community-based organizations, and dissemination...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29056624/community-health-warriors-marshallese-community-health-workers-perceptions-and-experiences-with-cbpr-and-community-engagement
#16
Rachel S Purvis, Williamina Ioanna Bing, Christopher J Jacob, Sharlynn Lang, Sammie Mamis, Mandy Ritok, Jellesen Rubon-Chutaro, Pearl Anna McElfish
Our manuscript highlights the viewpoints and reflections of the native Marshallese community health workers (CHWs) engaged in research with the local Marshallese community in Northwest Arkansas. In particular, this paper documents the vital role Marshallese CHWs play in the success of programs and research efforts. The negative health effects of nuclear testing in the Marshall Islands has been passed down through many generations, along with unfavorable attitudes toward the U.S. government and researchers. However, the community-based participatory research (CBPR) approach used by the University of Arkansas for Medical Sciences (UAMS) has allowed the native Marshallese CHWs to become advocates for the Marshallese community...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29052022/udp-arabinopyranose-mutase-gene-expressions-are-required-for-the-biosynthesis-of-the-arabinose-side-chain-of-both-pectin-and-arabinoxyloglucan-and-normal-leaf-expansion-in-nicotiana-tabacum
#17
Hideyuki Honta, Takuya Inamura, Teruko Konishi, Shinobu Satoh, Hiroaki Iwai
Plant cell walls are composed of polysaccharides such as cellulose, hemicelluloses, and pectins, whose location and function differ depending on plant type. Arabinose is a constituent of many different cell wall components, including pectic rhamnogalacturonan I (RG-I) and II (RG-II), glucuronoarabinoxylans (GAX), and arabinoxyloglucan (AXG). Arabinose is found predominantly in the furanose rather than in the thermodynamically more stable pyranose form. The UDP-arabinopyranose mutases (UAMs) have been demonstrated to convert UDP-arabinopyranose (UDP-Arap) to UDP-arabinofuranose (UDP-Araf) in rice (Oryza sativa L...
October 19, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/29048486/cancer-progression-models-and-fitness-landscapes-a-many-to-many-relationship
#18
Ramon Diaz-Uriarte
Motivation: The identification of constraints, due to gene interactions, in the order of accumulation of mutations during cancer progression can allow us to single out therapeutic targets. Cancer progression models (CPMs) use genotype frequency data from cross-sectional samples to identify these constraints, and return Directed Acyclic Graphs (DAGs) of restrictions where arrows indicate dependencies or constraints. On the other hand, fitness landscapes, which map genotypes to fitness, contain all possible paths of tumor progression...
October 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28946440/in-situ-development-of-highly-photocatalytic-multifunctional-nanocomposites-by-ultrasonic-acoustic-method
#19
Muhammad Tayyab Noman, Jakub Wiener, Jana Saskova, Muhammad Azeem Ashraf, Martina Vikova, Hafsa Jamshaid, Pavel Kejzlar
Cotton-titania nanocomposites with multifunctional properties were synthesized through ultrasonic acoustic method (UAM). Ultrasonic irradiations were used as a potential tool to develop cotton-titania (CT) nanocomposites at low temperature in the presence of titanium tetrachloride and isopropanol. The synthesized samples were characterized by XRD, SEM, EDX and ICP-OES methods. Functional properties i.e. Ultraviolet protection factor (UPF), self-cleaning, washing durability, antimicrobial and tensile strength of the CT nanocomposites were evaluated by different methods...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28872535/the-opportunity-awaits-to-lead-orthopaedic-telehealth-innovation-aoa-critical-issues
#20
Montri D Wongworawat, Gary Capistrant, John M Stephenson
Telehealth is a way to provide health-care services to a patient from a provider who is at another location. The most common methods include a live interactive visit with the patient, interpretation of imaging, and monitoring of patient progress. Principally, telehealth is a way of providing a service rather than a type of service. It is about patient care, not data care.Examples of orthopaedic applications include conducting patient examinations, interpreting imaging studies, and providing postoperative care...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
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