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https://www.readbyqxmd.com/read/28230179/crowdsourcing-scoring-of-immunohistochemistry-images-evaluating-performance-of-the-crowd-and-an-automated-computational-method
#1
Humayun Irshad, Eun-Yeong Oh, Daniel Schmolze, Liza M Quintana, Laura Collins, Rulla M Tamimi, Andrew H Beck
The assessment of protein expression in immunohistochemistry (IHC) images provides important diagnostic, prognostic and predictive information for guiding cancer diagnosis and therapy. Manual scoring of IHC images represents a logistical challenge, as the process is labor intensive and time consuming. Since the last decade, computational methods have been developed to enable the application of quantitative methods for the analysis and interpretation of protein expression in IHC images. These methods have not yet replaced manual scoring for the assessment of IHC in the majority of diagnostic laboratories and in many large-scale research studies...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229931/modulation-of-the-sensorimotor-system-by-sustained-manual-pressure-stimulation
#2
Pavel Hok, Jaroslav Opavský, Miroslav Kutín, Zbyněk Tüdös, Petr Kaňovský, Petr Hluštík
In Vojta physiotherapy, also known as reflex locomotion therapy, prolonged peripheral pressure stimulation induces complex generalized involuntary motor responses and modifies subsequent behavior, but its neurobiological basis remains unknown. We hypothesized that the stimulation would induce sensorimotor activation changes in functional magnetic resonance imaging (fMRI) during sequential finger opposition. Thirty healthy volunteers (mean age 24.2) underwent two randomized fMRI sessions involving manual pressure stimulation applied either at the right lateral heel according to Vojta, or at the right lateral ankle (control site)...
February 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28229515/treatment-integrity-of-elaborated-semantic-feature-analysis-aphasia-therapy-delivered-in-individual-and-group-settings
#3
Vasiliki Kladouchou, Ilias Papathanasiou, Eva A Efstratiadou, Vasiliki Christaki, Katerina Hilari
BACKGROUND & AIMS: This study ran within the framework of the Thales Aphasia Project that investigated the efficacy of elaborated semantic feature analysis (ESFA). We evaluated the treatment integrity (TI) of ESFA, i.e., the degree to which therapists implemented treatment as intended by the treatment protocol, in two different formats: individual and group therapy. METHODS & PROCEDURES: Based on the ESFA manual, observation of therapy videos and TI literature, we developed two ESFA integrity checklists, for individual and group therapy, and used them to rate 15 videos of therapy sessions, delivered by three speech-language therapists (SLTs)...
February 23, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/28228695/accessory-joint-and-neural-mobilizations-for-shoulder-range-of-motion-restriction-after-breast-cancer-surgery-a-pilot-randomized-clinical-trial
#4
Irene de la Rosa Díaz, María Torres Lacomba, Ester Cerezo Téllez, Cristina Díaz Del Campo Gómez-Rico, Carlos Gutiérrez Ortega
OBJECTIVE: The aim of this study was to assess the methods to conduct a substantive clinical trial to evaluate the effects of accessory joint mobilization (AJM) vs neural mobilization (NM) techniques for shoulder motion restriction after breast cancer surgery. METHODS: This pilot study was a prospective randomized and double-blind clinical trial in which 18 women who underwent unilateral breast cancer surgery and axillary lymph node dissection participated. The study was conducted at the Women's Health Research Group at the Physical Therapy Department of Alcalá University, Madrid, Spain...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28226732/lung-tumor-boundary-tracking-in-mri-with-moving-mesh-correspondences-for-adaptive-radio-therapy
#5
Nazanin Tahmasebi, Pierre Boulanger, Kumaradevan Punithakumar, Nazanin Tahmasebi, Pierre Boulanger, Kumaradevan Punithakumar, Kumaradevan Punithakumar, Pierre Boulanger, Nazanin Tahmasebi
Delineation of lung tumor regions from magnetic resonance imaging (MRI) poses many difficulties due to MR signal similarities of the region of interest and surrounding area as well as the influence of respiration. However, accurate segmentation of the tumor region is of utmost importance in planning a radiation therapy since a small error can result in some healthy tissues to receive excessive radiation. This study presents a semi-automated method to delineate lung tumor regions from a sequence of MRIs. The proposed method uses a non-rigid image registration framework to propagate the boundaries of the tumor region in MRI acquired during a radiation treatment stage, given manual segmentation on frames acquired during pretreatment stage...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226351/-significance-and-contemplation-of-clinical-diagnosis-and-therapy-on-the-renewal-of-the-eighth-edition-of-gastric-cancer-tnm-staging-system
#6
Hongqing Xi, Kecheng Zhang, Bo Wei, Lin Chen
TNM staging is essential for clinical decision-making and prognostic prediction for patients with gastric cancer. The 7th TNM staging manual was formulated in 2009 and implemented in 2010. However, it was published that there were some deficiencies of the 7th edition of gastric cancer TNM staging system in clinical application process, and this old staging system could not meet the clinical needs. With the cooperation and promotion of the American Joint Committee on Cancer (AJCC), the International Union for Cancer Control (UICC) and the International Gastric Cancer Association (IGCA), and through the accumulation and analysis of gastric cancer big data, the 8th TNM staging system was published at the end of 2016...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28225717/mobility-and-clinic-switching-among-postpartum-women-considered-lost-to-hiv-care-in-south-africa
#7
Kate Clouse, Sten H Vermund, Mhairi Maskew, Mark N Lurie, William MacLeod, Given Malete, Sergio Carmona, Gayle Sherman, Matthew P Fox
OBJECTIVE: Retention in HIV care, particularly among postpartum women, is a challenge to national antiretroviral therapy programs. Retention estimates may be underestimated because of unreported transfers. We explored mobility and clinic switching among patients considered lost to follow-up (LTFU). DESIGN: Observational cohort study. METHODS: Of 788 women initiating antiretroviral therapy during pregnancy at 6 public clinics in Johannesburg, South Africa, 300 (38...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28222571/the-edurep-approach-plus-manual-therapy-for-the-management-of-insertional-achilles-tendinopathy-a-case-report
#8
Francesco Sartorio, Anna Zanetta, Giorgio Ferriero, Elisabetta Bravini, Stefano Vercelli
BACKGROUND: Insertional Achilles tendinopathy (IAT) is a challenging overuse disorder. The aim of this case report was to study the feasibility of a comprehensive rehabilitative approach according to the Education, Unloading, Reloading, and Prevention (EdUReP) framework combined with Instrument-Augmented Soft Tissue Mobilization (I-ASTM). METHODS: An active 51-year-old man patient with chronic IAT was studied. Clinical assessment battery was composed by visual analogue scale for pain during the Achilles tendon palpation test, passive straight leg raise test, single leg hop test, Patient-Specific Functional Scale, and Foot and Ankle Ability Measure...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28221062/habituation-of-distress-and-craving-during-treatment-as-predictors-of-change-in-ptsd-symptoms-and-substance-use-severity
#9
Christal L Badour, Julianne C Flanagan, Daniel F Gros, Therese Killeen, Irene Pericot-Valverde, Kristina J Korte, Nicholas P Allan, Sudie E Back
OBJECTIVE: Increasing evidence supports the efficacy of trauma-focused exposure therapy in the treatment of posttraumatic stress disorder (PTSD) and co-occurring substance use disorders. Little is known, however, about the mechanisms of change in treatment for patients with PTSD and co-occurring substance use disorders. The aim of the present study was to examine whether within- and between-session habituation of distress and substance craving during imaginal exposure relates to treatment outcomes among U...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28217424/joint-mobilization-in-the-management-of-persistent-insertional-achilles-tendinopathy-a-case-report
#10
Dhinu J Jayaseelan, Andrew A Post, John J Mischke, Josiah D Sault
BACKGROUND & PURPOSE: Insertional Achilles tendinopathy (IAT) can be a challenging condition to manage conservatively. Eccentric exercise is commonly used in the management of chronic tendinopathy; however, it may not be as helpful for insertional tendon problems as compared to mid-portion dysfunction. While current evidence describing the physical therapy management of IAT is developing, gaps still exist in descriptions of best practice. The purpose of this case report is to describe the management of a patient with persistent IAT utilizing impairment-based joint mobilization, self-mobilization, and exercise...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28215058/effect-of-cervical-versus-thoracic-spinal-manipulation-on-peripheral-neural-features-and-grip-strength-in-subjects-with-chronic-mechanical-neck-pain-a-randomized-controlled-trial
#11
Francisco Bautista-Aguirre, Ángel Oliva-Pascual-Vaca, Alberto M Heredia-Rizo, Juan J Boscá-Gandía, François Ricard, Cleofás Rodriguez-Blanco
BACKGROUND: Cervical and thoracic spinal manipulative therapy has shown positive impact for relief of pain and improve function in non-specific mechanical neck pain. Several attempts have been made to compare their effectiveness although previous studies lacked a control group, assessed acute neck pain or combined thrust and nonthrust techniques. AIM: To compare the immediate effects of cervical and thoracic spinal thrust manipulations on mechanosensitivity of upper limb nerve trunks and grip strength in patients with chronic non-specific mechanical neck pain...
February 17, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28212641/local-constraints-to-access-appropriate-malaria-treatment-in-the-context-of-parasite-resistance-in-cambodia-a-qualitative-study
#12
Jesse Verschuere, Tom Decroo, Dara Lim, Jean-Marie Kindermans, Chea Nguon, Rekol Huy, Yasmine Alkourdi, Koen Peeters Grietens, Charlotte Gryseels
BACKGROUND: Despite emerging drug resistance in Cambodia, artemisinin-based combination therapy (ACT) is still the most efficacious therapy. ACT is available free of charge in the Cambodian public sector and at a subsidized rate in the private sector. However, un- and mistreated cases in combination with population movements may lead to the further spread of resistant parasites, stressing the importance of understanding how the perceived aetiology of malaria and associated health-seeking behaviour may delay access to appropriate treatment...
February 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28210229/longitudinal-associations-between-posttraumatic-stress-disorder-severity-and-personality-disorder-features-among-female-rape-survivors
#13
Michelle J Bovin, Erika J Wolf, Patricia A Resick
This study evaluated how change in posttraumatic stress disorder (PTSD) symptoms was associated with residualized change in comorbid personality disorder (PD) features and vice versa over the course of 5-10 years. The sample was comprised of 79 female rape survivors who met criteria for PTSD and who were a part of a larger study examining the effects of trauma-focused therapy. PTSD was assessed with the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) version of the Clinician-Administered PTSD Scale [CAPS-IV (1)] and PD features were assessed with the DSM-IV dimensional PD scales on the Schedule for Non-adaptive and Adaptive Personality [SNAP (2)]...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28210066/effects-of-interactive-metronome-training-on-postural-stability-and-upper-extremity-function-in-parkinson-s-disease-a-case-study
#14
Arim Kim, Hye-Sun Lee, Chiang-Soon Song
[Purpose] The purpose of this study was to examine the effects of interactive metronome training on the postural stability and upper extremity function of an individual with Parkinson's disease. [Subject and Methods] The participant of this case study was a 75-year-old female with Parkinson's disease diagnosed 7 years prior. This study was a single-subject research with an A-B-A design. She received IM training during the treatment phase (B phase) for 40 minutes per session. She was assessed pretest and posttest using the Berg balance scale and Wolf motor function test, and at baseline and the treatment phase using the measured box-and-block test and a Tetrax system...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28210055/effects-of-simplified-lymph-drainage-on-the-body-in-females-with-menopausal-disorder
#15
Kazuhisa Inoue, Hiroshi Maruoka
[Purpose] Hormone replacement therapy has been reported to be effective for alleviating menopausal symptoms, its side effects have been a concern. Therefore, it is necessary to investigate methods that could alleviate menopausal symptoms but with fewer side effects. Few previous reports have investigated the effects of simplified, viable manual lymph drainage, particularly the effects of one-time therapy on physiologically active substances and other variables. Effects of one-time simplified lymph drainage performed at salon A were investigated in females with any type of menopausal symptoms, such as edema or a sense of fatigue...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28209638/the-effect-of-implementing-an-automated-oxygen-control-on-oxygen-saturation-in-preterm-infants
#16
H A Van Zanten, K L A M Kuypers, B J Stenson, T E Bachman, S C Pauws, A B Te Pas
OBJECTIVE: To evaluate the effect of implementing automated oxygen control as routine care in maintaining oxygen saturation (SpO2) within target range in preterm infants. METHODS: Infants <30 weeks gestation in Leiden University Medical Centre before and after the implementation of automated oxygen control were compared. The percentage of time spent with SpO2 within and outside the target range (90-95%) was calculated. SpO2 values were collected every minute and included for analysis when infants received extra oxygen...
February 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28208231/fast-left-ventricle-tracking-using-localized-anatomical-affine-optical-flow
#17
Sandro Queirós, João L Vilaça, Pedro Morais, Jaime C Fonseca, Jan D'hooge, Daniel Barbosa
In daily clinical cardiology practice, left ventricle (LV) global and regional function assessment is crucial for disease diagnosis, therapy selection and patient follow-up. Currently, this is still a time-consuming task, spending valuable human resources. In this work, a novel fast methodology for automatic LV tracking is proposed based on localized anatomically constrained affine optical flow. This novel method can be combined to previously proposed segmentation frameworks or manually delineated surfaces at an initial frame to obtain fully delineated datasets and, thus, assess both global and regional myocardial function...
February 16, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28196991/efficacy-of-mindfulness-integrated-cognitive-behavior-therapy-in-patients-with-predominant-obsessions
#18
Ajay Kumar, Mahendra P Sharma, Janardhanan C Narayanaswamy, Thennarasu Kandavel, Y C Janardhan Reddy
BACKGROUND: Cognitive behavior therapy (CBT) involving exposure and response prevention is the gold standard psychotherapeutic intervention for obsessive-compulsive disorder (OCD). However, applying traditional CBT techniques to treat patients with predominant obsessions (POs) without covert compulsions is fraught with problems because of inaccessibility of mental compulsions. In this context, we examined the efficacy of mindfulness-integrated CBT (MICBT) in patients with POs without prominent overt compulsions...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28195561/automatic-and-hierarchical-segmentation-of-the-human-skeleton-in-ct-images
#19
Yabo Fu, Shi Liu, Hui Harold Li, Deshan Yang
Accurate segmentation of each bone in human skeleton is useful in many medical disciplines. Results of bone segmentation could facilitate bone disease diagnosis and post-treatment assessment, and support planning and image guidance for many treatment modalities including surgery and radiation therapy. As a medium level medical image processing task, accurate bone segmentation can facilitate automatic internal organ segmentation by providing stable structural reference for inter- or intra-patient registration and internal organ localization...
February 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28194375/rehabilitation-of-hamstring-muscle-injuries-a-literature-review
#20
REVIEW
Gabriel Amorim Ramos, Gustavo Gonçalves Arliani, Diego Costa Astur, Alberto de Castro Pochini, Benno Ejnisman, Moisés Cohen
Hamstring injuries are among the most frequent in sports. The high relapse rate is a challenge for sports medicine and has a great impact on athletes and sport teams. The treatment goal is to provide the athlete the same functional level as before the injury. Thus, functional rehabilitation is very important to the success of the treatment. Currently, several physical therapy modalities are used, according to the stage of the lesion, such as cryotherapy, laser therapy, therapeutic ultrasound, therapeutic exercise, and manual therapy...
January 2017: Revista Brasileira de Ortopedia
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