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https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#1
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29044466/massage-therapy-decreases-cancer-related-fatigue-results-from-a-randomized-early-phase-trial
#2
Becky Kinkead, Pamela J Schettler, Erika R Larson, Dedric Carroll, Margaret Sharenko, James Nettles, Sherry A Edwards, Andrew H Miller, Mylin A Torres, Boadie W Dunlop, Jeffrey J Rakofsky, Mark Hyman Rapaport
BACKGROUND: Cancer-related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, yet treatment options for CRF are limited. In this study, we evaluated the efficacy of weekly Swedish massage therapy (SMT) versus an active control condition (light touch [LT]) and waitlist control (WLC) on persistent CRF in breast cancer survivors. METHODS: This early phase, randomized, single-masked, 6-week investigation of SMT, LT, and WLC enrolled 66 female stage 0-III breast cancer survivors (age range, 32-72 years) who had received surgery plus radiation and/or chemotherapy/chemoprevention with CRF (Brief Fatigue Inventory > 25)...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29037655/differences-in-pressure-pain-threshold-among-men-and-women-after-foam-rolling
#3
Scott W Cheatham, Russell Baker
BACKGROUND: Rehabilitation professionals often prescribe foam rolling as an intervention to augment other manual therapies or as a warm-up or recovery after athletic activity. Currently, there is a gap in the literature regarding how foam rolling effects the pressure pain threshold (PPT) among men and women. PURPOSE: The purpose of this study was to examine the immediate effects of a foam rolling intervention on the ipsilateral agonist, antagonist, and contralateral muscle group PPT among men and women...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037630/hypoalgesic-effects-of-three-different-manual-therapy-techniques-on-cervical-spine-and-psychological-interaction-a-randomized-clinical-trial
#4
Jose Luis Alonso-Perez, Almudena Lopez-Lopez, Roy La Touche, Sergio Lerma-Lara, Emilio Suarez, Javier Rojas, Mark D Bishop, Jorge Hugo Villafañe, Josué Fernández-Carnero
OBJECTIVE: The purpose of this study was to evaluate the extent to which psychological factors interact with a particular manual therapy (MT) technique to induce hypoalgesia in healthy subjects. METHODS: Seventy-five healthy volunteers (36 female, 39 males), were recruited in this double-blind, controlled and parallel study. Subjects were randomly assigned to receive: High velocity low amplitude technique (HVLA), joint mobilization, or Cervical Lateral glide mobilization (CLGM)...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037627/does-ultrasound-therapy-add-to-the-effects-of-exercise-and-mobilization-in-frozen-shoulder-a-pilot-randomized-double-blind-clinical-trial
#5
Safoora Ebadi, Bijan Forogh, Ehsan Fallah, Arash Babaei Ghazani
OBJECTIVE: This study intended to determine the extent to which Ultrasound could add to the effects of exercise and manual therapy in the rehabilitation treatment of primary adhesive capsulitis. DESIGN: A pilot double blind randomized clinical trial was carried out on 50 patients suffering from primary adhesive capsulitis. Intervention included continuous 3 MHz, 1.5 w/cm(2) Ultrasound, applied for the first group and sham Ultrasound for the second group. In addition specific stretching and strengthening exercises as well as glenohumeral joint mobilization were delivered to both groups...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29036756/acupuncture-or-acupressure-for-induction-of-labour
#6
REVIEW
Caroline A Smith, Mike Armour, Hannah G Dahlen
BACKGROUND: This is one of a series of reviews of methods of cervical ripening and labour induction. The use of complementary therapies is increasing. Women may look to complementary therapies during pregnancy and childbirth to be used alongside conventional medical practice. Acupuncture involves the insertion of very fine needles into specific points of the body. Acupressure is using the thumbs or fingers to apply pressure to specific points. The limited observational studies to date suggest acupuncture for induction of labour has no known adverse effects to the fetus, and may be effective...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29036676/anti-crisprdb-a-comprehensive-online-resource-for-anti-crispr-proteins
#7
Chuan Dong, Ge-Fei Hao, Hong-Li Hua, Shuo Liu, Abraham Alemayehu Labena, Guoshi Chai, Jian Huang, Nini Rao, Feng-Biao Guo
CRISPR-Cas is a tool that is widely used for gene editing. However, unexpected off-target effects may occur as a result of long-term nuclease activity. Anti-CRISPR proteins, which are powerful molecules that inhibit the CRISPR-Cas system, may have the potential to promote better utilization of the CRISPR-Cas system in gene editing, especially for gene therapy. Additionally, more in-depth research on these proteins would help researchers to better understand the co-evolution of bacteria and phages. Therefore, it is necessary to collect and integrate data on various types of anti-CRISPRs...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29035718/assessment-of-the-coding-accuracy-of-warfarin-related-bleeding-events
#8
Thomas Delate, Aubrey E Jones, Nathan P Clark, Daniel M Witt
INTRODUCTION: Using International Classification of Diseases, 9th edition (ICD-9) diagnosis codes to identify potential warfarin-related bleeding events from administrative datasets is highly efficient but may be prone to identifying non-events. The objective of this study was to evaluate the ability of bleeding-related ICD-9 codes to identify true bleeding events in patients who were receiving warfarin therapy at the time of hospitalization. METHODS: This was a cross-sectional study conducted in an integrated healthcare delivery system...
October 12, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29034802/unraveling-the-mechanisms-of-manual-therapy-modeling-an-approach
#9
Joel E Bialosky, Jason M Beneciuk, Mark D Bishop, Rogelio A Coronado, Charles W Penza, Corey B Simon, Steven Z George
Synopsis Manual therapy interventions are popular among individual healthcare providers and their patients; however, systematic reviews do not strongly support their effectiveness. Small treatment effect sizes of manual therapy interventions may result from a "one size fits all" approach to treatment. Mechanistic based treatment approaches to manual therapy offer an intriguing alternative for identifying patients likely to respond to manual therapy. However, the current lack of knowledge of the mechanisms through which manual therapy interventions inhibit pain limits such an approach...
October 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29034798/intramuscular-electrical-stimulation-for-muscle-activation-of-tibialis-anterior-after-surgical-repair-a-case-report
#10
Sharon Hollis, Philip McClure
Study Design Case report. Background Loss of voluntary activation of musculature can result in muscle weakness. External neuromuscular stimulation can be utilized to improve voluntary activation but is often poorly tolerated because of pain associated with required stimulus level. Intramuscular electrical stimulation requires much lower voltage and may be better tolerated and therefore more effective at restoring voluntary muscle activation. Case Description A 71-year-old male sustained a rupture of the distal attachment of the tibialis anterior tendon...
October 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29031638/dbgaps-a-comprehensive-database-of-genes-and-genetic-markers-associated-with-psoriasis-and-its-subtypes
#11
Shweta Aggarwal, Arnab Nayek, Dibyabhaba Pradhan, Rashi Verma, Monika Yadav, Kalaiarasan Ponnusamy, Arun Kumar Jain
Psoriasis is a systemic hyperproliferative inflammatory skin disorder, although rarely fatal but significantly reduces quality of life. Understanding the full genetic component of the disease association may provide insight into biological pathways as well as targets and biomarkers for diagnosis, prognosis and therapy. Studies related to psoriasis associated genes and genetic markers are scattered and not easily amendable to data-mining. To alleviate difficulties, we have developed dbGAPs an integrated knowledgebase representing a gateway to psoriasis associated genomic data...
October 11, 2017: Genomics
https://www.readbyqxmd.com/read/29030503/a-qualitative-study-of-a-blended-therapy-using-problem-solving-therapy-with-a-customised-smartphone-app-in-men-who-present-to-hospital-with-intentional-self-harm
#12
Craig Mackie, Nicole Dunn, Sarah MacLean, Valerie Testa, Marnin Heisel, Simon Hatcher
BACKGROUND: Blended therapy describes the use of computerised therapy combined with face-to-face therapy to extend the depth, range and nature of the face-to-face therapy. We wanted to develop a treatment manual for a randomised trial of blended therapy combining face-to-face problem solving and a smartphone app in men who present to hospital with self-harm. OBJECTIVE: To develop a treatment manual and to describe the experience of receiving and delivering a blended therapy...
October 13, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29030218/acupuncture-suppresses-intravenous-methamphetamine-self-administration-through-gaba-receptor-s-mediation
#13
Yi Jeong Choi, Nam Jun Kim, Rong Jie Zhao, Da Hye Kim, Chae Ha Yang, Hee Young Kim, Young S Gwak, Eun Young Jang, Jae Su Kim, Yun Kyu Lee, Hyun Jong Lee, Sang Nam Lee, Sung Chul Lim, Bong Hyo Lee
OBJECTIVES: Methamphetamine is one of the widely abused drugs. In spite of a number of studies, there is still little successful therapy to suppress the methamphetamine abuse. Acupuncture has shown to attenuate the reinforcing effects of psychostimulant. Based on, the present study investigated if acupuncture could suppress intravenous methamphetamine self-administration behavior. In addition, a possible neuronal mechanism was investigated. MATERIALS & METHODS: Male Sprague-Dawley rats weighing 270-300g were trained to intake food pellet...
October 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29029682/a-comparison-of-veterans-who-repeat-versus-who-do-not-repeat-a-course-of-manualized-cognitive-behavioral-therapy-for-posttraumatic-stress-disorder
#14
Jeremiah A Schumm, Nicole D Pukay-Martin, Whitney L Gore
Despite evidence that cognitive-behavioral therapy (CBT) for posttraumatic stress disorder (PTSD) is effective, some individuals do not experience clinically significant reduction or remission of their PTSD symptoms. These individuals may return for additional PTSD-focused psychotherapy. However, there is no research to know whether PTSD treatment repeaters have worse symptoms prior to the initial treatment episode or display differences in other pretreatment characteristics versus nonrepeaters. Research is also needed to explore whether treatment repeaters exhibit PTSD symptom changes during an initial or second course of treatment...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29029058/inter-ethnic-differences-in-valve-morphology-valvular-dysfunction-and-aortopathy-between-asian-and-european-patients-with-bicuspid-aortic-valve
#15
William K F Kong, Madelien V Regeer, Kian K Poh, James W Yip, Philippe J van Rosendael, Tiong C Yeo, Edgar Tay, Vasileios Kamperidis, Enno T van der Velde, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may have important implications for TAVR...
October 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29027815/l-carnosine-as-an-adjunctive-therapy-to-risperidone-in-children-with-autistic-disorder-a-randomized-double-blind-placebo-controlled-trial
#16
Reihaneh Hajizadeh-Zaker, Alireza Ghajar, Bita Mesgarpour, Mohsen Afarideh, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: This study aimed at investigating the efficacy and tolerability of l-carnosine as an add-on to risperidone in the management of children with autism. METHODS: This was a 10-week, randomized, double-blind, placebo-controlled study. Seventy drug-free children aged 4-12 years old with a diagnosis of autism spectrum disorder (ASD), according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (DSM-5) who had an Aberrant Behavior Checklist-Community (ABC-C) scale irritability subscale score of ≥12, entered the study...
October 13, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29023236/end-to-end-workflow-for-finite-element-analysis-of-tumor-treating-fields-in-glioblastomas
#17
Joshua J Timmons, Edwin Lok, Pyay San, Kevin Bui, Eric T Wong
Tumor Treating Fields (TTFields) therapy is an approved modality of treatment for glioblastoma. Patient anatomy-based finite element analysis (FEA) has the potential to reveal not only how these fields affect tumor control but also how to improve efficacy. While the automated tools for segmentation speed up the generation of FEA models, multi-step manual corrections are required, including removal of disconnected voxels, incorporation of unsegmented structures and the addition of 36 electrodes plus gel layers matching the TTFields transducers...
October 12, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29021822/a-review-of-web-based-support-systems-for-students-in-higher-education
#18
REVIEW
Marietta Papadatou-Pastou, Rhianna Goozee, Erika Payne, Alexia Barrable, Patapia Tzotzoli
BACKGROUND: Recent evidence suggests that there is an increasing need for accessible and anonymous services to support higher education (HE) students suffering from psychological and/or academic difficulties. Such difficulties can lead to several negative outcomes, including poor academic performance, sub-optimal mental health, reduced study satisfaction, and dropout from study. Currently, universities in the UK lack financial resources and the on-campus mental health services traditionally offered to students are increasingly economically unsustainable...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29020984/fully-digital-data-processing-during-cardiovascular-implantable-electronic-device-follow-up-in-a-high-volume-tertiary-center
#19
Ingo Staudacher, Asha Roy Nalpathamkalam, Lorenz Uhlmann, Claudius Illg, Sebastian Seehausen, Mohammadreza Akhavanpoor, Anke Buchauer, Nicolas Geis, Patrick Lugenbiel, Patrick A Schweizer, Panagiotis Xynogalos, Maura M Zylla, Eberhard Scholz, Edgar Zitron, Hugo A Katus, Dierk Thomas
BACKGROUND: Increasing numbers of patients with cardiovascular implantable electronic devices (CIEDs) and limited follow-up capacities highlight unmet challenges in clinical electrophysiology. Integrated software (MediConnect(®)) enabling fully digital processing of device interrogation data has been commercially developed to facilitate follow-up visits. We sought to assess feasibility of fully digital data processing (FDDP) during ambulatory device follow-up in a high-volume tertiary hospital to provide guidance for future users of FDDP software...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29018599/qualitative-study-of-healthcare-providers-current-practice-patterns-and-barriers-to-successful-rehydration-for-pediatric-diarrheal-illnesses-in-kenya
#20
Darlene R House, Philip Cheptinga, Daniel E Rusyniak, Rachel C Vreeman
BACKGROUND: For children worldwide, diarrhea is the second leading cause of death. These deaths are preventable by fluid resuscitation. Nasogastric tubes (NGs) have been shown to be equivalent to intravenous fluids for rehydration and recommended by the World Health Organization (WHO) for use in severe dehydration. Despite this, NGs are rarely used for rehydration in Kenya. Our objective was to evaluate clinicians' adherence to rehydration guidelines and to identify barriers to the use of NGs for resuscitating dehydrated children...
2017: PeerJ
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