Xiao Li, Jeffrey Eastham, Jennifer M Giltnane, Wei Zou, Andries Zijlstra, Evgeniy Tabatsky, Romain Banchereau, Ching-Wei Chang, Barzin Y Nabet, Namrata S Patil, Luciana Molinero, Steve Chui, Maureen Harryman, Shari Lau, Linda Rangell, Yannick Waumans, Mark Kockx, Darya Orlova, Hartmut Koeppen
Cancer immunotherapy has transformed the clinical approach to patients with malignancies, as profound benefits can be seen in a subset of patients. To identify this subset, biomarker analyses increasingly focus on phenotypic and functional evaluation of the tumor microenvironment to determine if density, spatial distribution, and cellular composition of immune cell infiltrates can provide prognostic and/or predictive information. Attempts have been made to develop standardized methods to evaluate immune infiltrates in the routine assessment of certain tumor types; however, broad adoption of this approach in clinical decision-making is still missing...
March 25, 2024: Journal of Pathology