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JOURNAL ARTICLE
Jingru Li, Yiming Shen, Jianjie Wang, Bihua Chen, Yongqin Li
BACKGROUND: The high mortality rates of patients who are resuscitated from cardiac arrest (CA) are attributed to post cardiac arrest syndrome (PCAS). This study evaluated the effect of hyperoxygenation and targeted temperature management (TTM) on PCAS in rats with different causes of CA. METHODS AND RESULTS: One hundred and sixty-eight Sprague-Dawley rats were equally divided into asphyxial and dysrhythmic groups. Animals were further randomized into four subgroups immediately after resuscitation: 1) Normoxia-normothermia (NO-NT): ventilated with 21% oxygen under normothermia; 2) Hyperoxia-normothermia (HO-NT): ventilated with 100% oxygen for 3 h under normothermia; 3) Normoxia-hypothermia (NO-HT): ventilated with 21% oxygen for 3 h under hypothermia; 4) Hyperoxia-hypothermia (HO-HT): ventilated with 100% oxygen for 3 h under hypothermia...
February 14, 2024: Shock
#2
Shovik Bandyopadhyay, Michael Duffy, Kyung Jin Ahn, Minxing Pang, David Smith, Gwendolyn Duncan, Jonathan Sussman, Iris Zhang, Jeffrey Huang, Yulieh Lin, Barbara Xiong, Tamjid Imtiaz, Chia-Hui Chen, Anusha Thadi, Changya Chen, Jason Xu, Melissa Reichart, Vinodh Pillai, Oraine Snaith, Derek Oldridge, Siddharth Bhattacharyya, Ivan Maillard, Martin Carroll, Charles Nelson, Ling Qin, Kai Tan
The bone marrow is the organ responsible for blood production. Diverse non-hematopoietic cells contribute essentially to hematopoiesis. However, these cells and their spatial organization remain largely uncharacterized as they have been technically challenging to study in humans. Here, we used fresh femoral head samples and performed single-cell RNA sequencing (scRNA-Seq) to profile 29,325 enriched non-hematopoietic bone marrow cells and discover nine transcriptionally distinct subtypes. We next employed CO-detection by inDEXing (CODEX) multiplexed imaging of 18 individuals, including both healthy and acute myeloid leukemia (AML) samples, to spatially profile over one million single cells with a novel 53-antibody panel...
March 16, 2024: bioRxiv
#3
REVIEW
Nathaniel Barber, Lindsay Freud
The field of fetal cardiology has evolved significantly in recent years. This review focuses on specific advances in fetal cardiac imaging and intervention that are increasingly used in clinical practice. On the imaging frontier, updated screening guidelines and artificial intelligence hold promise for improving prenatal detection of congenital heart disease. Advances in ultrasound technology and magnetic resonance imaging techniques have enabled greater diagnostic and prognostic accuracy of fetal heart disease from the first to third trimesters, and maternal hyperoxygenation can offer additional physiological insights...
February 2024: CJC Pediatr Congenit Heart Dis
#4
JOURNAL ARTICLE
Giovanni Barco, Zumama Khalid, Alessandra Pulliero, Claudio Angelinetta, Ubaldo Prati, Alberto Izzotti
The possible future emergence of new SARS-CoV-2 virus variants pushes the development of new chemoprophylaxis protocols complementary to the unspecific and specific immune-prophylaxis measures currently used. The SARS-CoV-2 virus is particularly sensitive to oxidation, due to the relevant positive electrical charge of its spike protein used as a ligand for target cells. The present study evaluated the safety and efficacy of a new oxidant preparation, liquid hyperoxygen (IOL), to neutralize the SARS-CoV-2 virus...
March 11, 2024: Pathogens
#5
JOURNAL ARTICLE
Kilian Vellvé, Patricia Garcia-Canadilla, Mariana Nogueira, Lina Youssef, Angela Arranz, Ayako Nakaki, David Boada, Isabel Blanco, Rosa Faner, Francesc Figueras, Àlvar Agustí, Eduard Gratacós, Francesca Crovetto, Bart Bijnens, Fàtima Crispi
The aim of this study was to investigate the pulmonary vasculature in baseline conditions and after maternal hyperoxygenation in growth restricted fetuses (FGR). A prospective cohort study of singleton pregnancies including 97 FGR and 111 normally grown fetuses was carried out. Ultrasound Doppler of the pulmonary vessels was obtained at 24-37 weeks of gestation and data were acquired before and after oxygen administration. After, Machine Learning (ML) and a computational model were used on the Doppler waveforms to classify individuals and estimate pulmonary vascular resistance (PVR)...
March 11, 2024: Scientific Reports
#6
JOURNAL ARTICLE
Theresa M Olasveengen, Christiane Skåre, Marianne Skjerven-Martinsen, Per Hoff-Olsen, Jo Kramer-Johansen, Fredrik Hoff Nordum, Morten Eriksen, Per Anderas Norseng, Lars Wik
AIM: Compare lung injury and hemodynamic effects in synchronized ventilations (between two chest compressions) vs. unsynchronized ventilations during cardiopulmonary resuscitation (CPR) in a porcine model of cardiac arrest. METHODS: Twenty pigs were randomized to either synchronized or unsynchronized group. Ventricular fibrillation was induced electrically and left for 1.5 minutes. Four minutes of basic chest compression:ventilation (30:2) CPR was followed by eight minutes of either synchronized or unsynchronized ventilations (10/min) during continuous compressions before defibrillation was attempted...
March 2024: Resuscitation plus
#7
JOURNAL ARTICLE
Kubra Canarslan-Demir, Kubra Ozgok-Kangal, Ayse Saatci-Yasar, Mehmet Akif Erdol, Bayram Koc
During hyperbaric oxygen (HBO2) therapy in humans, there are changes in cardiovascular physiology due to high pressure and hyperoxygenation. Peripheral vasoconstriction, bradycardia, and a decrease in cardiac output are observed during HBO2 therapy. These physiological effects of HBO2 therapy on the cardiovascular system are tolerated in healthy people. However, patients with underlying cardiac disease may experience severe problems during HBO2 therapy, such as pulmonary edema and death. In addition, cardiac complications may occur in patients with diabetes mellitus (DM)...
2023: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
#8
JOURNAL ARTICLE
Katherine Cironi, Aaron L Albuck, Bryant McLafferty, Alison K Mortemore, Christina McCarthy, Mohammad Hussein, Peter P Issa, Tyler Metz, Marcela Herrera, Eman Toraih, Sharven Taghavi, Emad Kandil, Jacquelyn Turner
Patients with complicated appendicitis have an increased risk for postoperative infections. Potential risk factors for postoperative infections through a meta-analysis and retrospective chart review are discussed. A meta-analysis consisting of 35 studies analyzing complicated appendicitis treated with an appendectomy noting at least 1 postoperative infection was performed. A retrospective review was then conducted in patients diagnosed with complicated appendicitis after appendectomy. Of 5326 patients in total, 15...
February 1, 2024: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
#9
JOURNAL ARTICLE
Tomoaki Aoki, Vanessa Wong, Kei Hayashida, Lance B Becker, Koichiro Shinozaki
Sudden cardiac arrest (CA) is the third leading cause of death. Immediate reoxygenation with high concentrations of supplemental oxygen (O2 ) during cardiopulmonary resuscitation (CPR) is recommended according to the current guidelines for adult CA. However, a point in controversy exists because of the known harm of prolonged exposure to 100% O2 . Therefore, there have been much debate on an optimal use of supplemental O2 , yet little is known about the duration and dosage of O2 administration. To test whether supplying a high concentration of O2 during CPR and post resuscitation is beneficial or harmful, rats subjected to 10-minute asphyxia CA were administered either 100% O2 (n = 8) or 30% O2 (n = 8) for 2 hours after CPR...
2023: Advances in Experimental Medicine and Biology
#10
COMMENT
Gokhan Bolluk, Aylin Oztarhan, Cagdas Vural, Kazim Oztarhan, Ali Gedikbasi
Maternal hyperoxygenation (MH) has been studied as a diagnostic tool to evaluate pulmonary vasculature and as a treatment option to improve the growth of fetal left heart in fetuses with left-sided cardiac defects. Chronic maternal hyperoxygenation (CMH) therapy leads to an improvement in fetal pulmonary blood flow resulting in an enhanced venous return to the left heart with increased gestational age. With this manipulation it is anticipated to augment blood flow directed remodeling of the left heart structures and to improve left heart growth spanning from the mitral valve to the aortic isthmus...
November 2023: Echocardiography
#11
JOURNAL ARTICLE
Sruthy P Sulaiman, Nivedita Jha, Adhisivam Bethou, Hanumanthappa Nandeeha, Ajay Kumar Jha
BACKGROUND: Hyperoxygenation has shown promise in improving suspicious fetal heart patterns in women in labor. However, the effect of hyperoxygenation on neonatal outcomes in women in labor with pathologic fetal heart rate tracing has not been studied. OBJECTIVE: This study aimed to evaluate the effect of fractional inspiration of oxygen of 80% compared with fractional inspiration of oxygen of 40% on neonatal outcomes in women with pathologic fetal heart rate tracing...
September 29, 2023: American Journal of Obstetrics and Gynecology
#12
JOURNAL ARTICLE
G Pérez-Acevedo, A Bosch-Alcaraz, J E Torra-Bou
INTRODUCTION: Purpura fulminans (PF) is a serious complication of sepsis resulting from a set of alterations characterised by the development of ecchymotic haemorrhagic lesions and skin necrosis. AIM: To analyse the efficacy and safety of the topical application of HOFA compound, in the cutaneous microcirculation of PF lesions in paediatric patients affected by sepsis. MATERIAL AND METHODS: A prospective quasi-experimental pre-test/post-test single-group conducted in a Paediatric Intensive Care Unit of a third level hospital was performed...
July 30, 2023: Enfermería intensiva
#13
JOURNAL ARTICLE
Sven Poli, Joshua Mbroh, Jean-Claude Baron, Aneesh B Singhal, Daniel Strbian, Carlos Molina, Robin Lemmens, Guillaume Turc, Robert Mikulik, Patrik Michel, Turgut Tatlisumak, Heinrich J Audebert, Martin Dichgans, Roland Veltkamp, Johannes Hüsing, Holm Graessner, Jens Fiehler, Joan Montaner, Adedolapo Kamaldeen Adeyemi, Katharina Althaus, Juan F Arenillas, Benjamin Bender, Frank Benedikt, Gabriel Broocks, Ina Burghaus, Pere Cardona, Milani Deb-Chatterji, Martina Cviková, Luc Defreyne, Veerle De Herdt, Olivier Detante, Ulrike Ernemann, Fabian Flottmann, Lídia García Guillamón, Monika Glauch, Alexandra Gomez-Exposito, Benjamin Gory, Sylvie Sylvie Grand, Michal Haršány, Till Karsten Hauser, Olivier Heck, Dimitri Hemelsoet, Florian Hennersdorf, Julia Hoppe, Pia Kalmbach, Lars Kellert, Martin Köhrmann, Markus Kowarik, Blanca Lara-Rodríguez, Loic Legris, Tobias Lindig, Steffen Luntz, Jay Lusk, Brian Mac Grory, Andreas Manger, Nicolas Martinez-Majander, Annerose Mengel, Johannes Meyne, Susanne Müller, Sibu Mundiyanapurath, Olivier Naggara, Krassen Nedeltchev, Thanh N Nguyen, Maike A Nilsson, Michael Obadia, Khouloud Poli, Jan C Purrucker, Silja Räty, Sebastien Richard, Hardy Richter, Clotilde Schilte, Eckhard Schlemm, Linda Stöhr, Benjamin Stolte, Marek Sykora, Götz Thomalla, Liisa Tomppo, Noel van Horn, Julia Zeller, Ulf Ziemann, Christine S Zuern, Florian Härtig, Johannes Tuennerhoff
RATIONALE: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. AIMS: PROOF investigates the use of normobaric oxygen therapy (NBO) within six hours of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior circulation occlusion. METHODS AND DESIGN: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial...
July 29, 2023: International Journal of Stroke: Official Journal of the International Stroke Society
#14
REVIEW
Julia Burd, Nandini Raghuraman
PURPOSE OF REVIEW: This review aims to summarize the current evidence regarding maternal oxygen supplementation for Category II fetal heart tracings (FHT) in labor. We aim to evaluate the theoretical rationale for oxygen administration, the clinical efficacy of supplemental oxygen, and the potential risks. RECENT FINDINGS: Maternal oxygen supplementation is an intrauterine resuscitation technique rooted in the theoretic rationale that hyperoxygenating the mother results in increased oxygen transfer to the fetus...
May 18, 2023: Current Obstetrics and Gynecology Reports
#15
REVIEW
Yang Lyu, Ya-Ling Huang, Zhao-Yu Li, Frances Lin
BACKGROUND: Current evidence shows that medical device-related pressure injury (MDRPI) has a high prevalence (10%) and incidence (12%), and much research has been done to prevent MDRPI in recent years. However, to our knowledge, there is limited systematic review available on interventions and strategies to prevent MDRPI. AIM: To synthesise research evidence on interventions and strategies used to prevent MDRPI. METHODS: This systematic review adhered to the PRISMA Guidelines...
June 9, 2023: Journal of Clinical Nursing
#16
JOURNAL ARTICLE
Mauro DiNuzzo, Gerald A Dienel, Kevin L Behar, Ognen A Petroff, Helene Benveniste, Fahmeed Hyder, Federico Giove, Shalom Michaeli, Silvia Mangia, Suzana Herculano-Houzel, Douglas L Rothman
During transient brain activation cerebral blood flow (CBF) increases substantially more than cerebral metabolic rate of oxygen consumption (CMRO2 ) resulting in blood hyperoxygenation, the basis of BOLD fMRI contrast. Explanations for the high CBF vs. CMRO2 slope, termed neurovascular coupling (NVC) constant, focused on maintainenance of tissue oxygenation to support mitochondrial ATP production. However, paradoxically the brain has a 3-fold lower oxygen extraction fraction (OEF) than other organs with high energy requirements, like heart and muscle during exercise...
May 7, 2023: Journal of Neurochemistry
#17
JOURNAL ARTICLE
Sven Kurbel, Vid Ćurković, Borna Kovačić
Hyperbaric oxygen (HBO) therapy still lacks proper interpretations of its many actions. This hypothesis is based on reports of temporarily elevated peripheral vascular resistance (PVR) during HBO sessions. Besides that, during HBO sessions, hyperoxygenated tissues can reduce their perfusion so much that CO2 can accumulate in them. Tissue perfusion depends on vascular innervation and on the balance between systemic constrictors and local dilators. During an HBO session, increased tissue oxygen levels suppress dilatory mechanisms...
June 2023: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
#18
JOURNAL ARTICLE
Yang Bai, Ji-Hua Shi, Qi Liu, Dong-Jing Yang, Zhi-Ping Yan, Jia-Kai Zhang, Hong-Wei Tang, Wen-Zhi Guo, Yang Jin, Shui-Jun Zhang
Normothermic machine perfusion (NMP) could provide a curative treatment to reduce biliary injury in donation after cardiac death (DCD) donor livers; however, the underlying mechanisms remain poorly understood. In a rat model, our study compared air-oxygenated NMP to hyperoxygenated NMP and found that air-oxygenated NMP improved DCD functional recovery. Here, we found that the charged multivesicular body protein 2B (CHMP2B) expression was substantially elevated in the intrahepatic biliary duct endothelium of the cold-preserved rat DCD liver after air-oxygenated NMP or in biliary endothelial cells under hypoxia/physoxia...
March 11, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
#19
JOURNAL ARTICLE
Zehra Kılınç, Elif Aybike Ayyıldız, Ebru Kaya, Ayca Sultan Sahin
Introduction In this study, we planned to investigate the effect of hyperoxygenation on mortality and morbidity in patients with head trauma who were followed and treated in the intensive care unit (ICU). Methods Head trauma cases (n = 119) that were followed in the mixed ICU of a 50-bed tertiary care center in Istanbul between January 2018 and December 2019 were retrospectively analyzed for the negative effects of hyperoxia. Age, gender, height/weight, additional diseases, medications used, ICU indication, Glasgow Coma Scale score recorded during ICU follow-up, Acute Physiology and Chronic Health Evaluation (APACHE) II score, length of hospital/ICU stay, the presence of complications, number of reoperations, length of intubation, and the patient's discharge or death status were evaluated...
January 2023: Curēus
#20
JOURNAL ARTICLE
Pietro Ciliberti, Danilo Cardim, Alberto Giardina, Matjaž Groznik, Lorenzo Ball, Martina Giovannini, Denise Battaglini, Erta Beqiri, Basil Matta, Peter Smielewski, Marek Czosnyka, Paolo Pelosi, Chiara Robba
Introduction: Potential detrimental effects of hyperoxemia on outcomes have been reported in critically ill patients. Little evidence exists on the effects of hyperoxygenation and hyperoxemia on cerebral physiology. The primary aim of this study is to assess the effect of hyperoxygenation and hyperoxemia on cerebral autoregulation in acute brain injured patients. We further evaluated potential links between hyperoxemia, cerebral oxygenation and intracranial pressure (ICP). Methods: This is a single center, observational, prospective study...
2023: Frontiers in Physiology
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