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Hua-Gang Hou, Nadeem Khan, Gai-Xin Du, Sassan Hodge, Harold M Swartz
The effect of hyperoxygenation with carbogen (95% O2 + 5% CO2) and 100% oxygen inhalation on partial pressure of oxygen (pO2) of radiation-induced fibrosarcoma (RIF-1) tumor was investigated. RIF-1 tumors were innoculated in C3H mice, and aggregates of oximetry probe, lithium phthalocyanine (LiPc), was implanted in each tumor. A baseline tumor pO2 was measured by electron paramagnetic resonance (EPR) oximetry for 20 minutes in anesthetized mice breathing 30% O2 and then the gas was switched to carbogen or 100 % oxygen for 60 minutes...
July 2016: Medical Gas Research
P Saludes, L Proença, G Gruartmoner, L Enseñat, A Pérez-Madrigal, C Espinal, J Mesquida
Central venous-to-arterial carbon dioxide difference (PcvaCO2) has demonstrated its prognostic value in critically ill patients suffering from shock, and current expert recommendations advocate for further resuscitation interventions when PcvaCO2 is elevated. PcvaCO2 combination with arterial-venous oxygen content difference (PcvaCO2/CavO2) seems to enhance its performance when assessing anaerobic metabolism. However, the fact that PCO2 values might be altered by changes in blood O2 content (the Haldane effect), has been presented as a limitation of PCO2-derived variables...
November 10, 2016: Journal of Clinical Monitoring and Computing
Lauren M Bullens, Suzanne Moors, Pieter J van Runnard Heimel, M Beatrijs van der Hout-van der Jagt, S Guid Oei
OBJECTIVE: Solid evidence on the effect of intrauterine resuscitation on neonatal outcome is limited, and superiority of one intervention over the others is not clear. We therefore surveyed the clinical practice variation in fetal monitoring and the management of fetal distress during labor, in Dutch labor wards. In addition, we have compared recommendations from international guidelines. STUDY DESIGN: We conducted a survey among all 86 Dutch hospitals, using a questionnaire on fetal monitoring and management of fetal distress...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Rajeev Kumar Verma, Eugenio Abela, Kaspar Schindler, Heinz Krestel, Elisabeth Springer, Adrian Huber, Christian Weisstanner, Martinus Hauf, Jan Gralla, Roland Wiest
OBJECTIVE: The aim of this study was to investigate variant patterns of cortical venous oxygenation during status epilepticus (SE) using susceptibility-weighted imaging (SWI). METHODS: We analyzed magnetic resonance imaging (MRI) scans of 26 patients with clinically witnessed prolonged seizures and/or EEG-confirmed SE. All MRI exams encompassed SWI, dynamic susceptibility contrast perfusion MRI (MRI-DSC) and diffusion-weighted imaging (DWI). We aimed to identify distinct patterns of SWI signal alterations that revealed regional or global increases of cerebral blood flow (CBF) and DWI restrictions...
2016: PloS One
Mario Schietroma, Beatrice Pessia, Sara Colozzi, Francesco Carlei, Ina Shehaj, Gianfranco Amicucci
UNLABELLED: Propose: The clinical role of hyperoxiato prevent postoperative surgical site infection (SSI) remains uncertain since randomized controlled trials on this topic have reported different results. One of the principal reasons for such mixed results can be that previous trials have entered a heterogeneous population of patients and set of procedures. The aim of our study was to assess the influence of hyperoxygenation on SSI usingan homogeneous study population. METHODS: We studied, in a prospective randomized study, extended on a time interval January 2009 to May 2015, 85 patients who underwent open intraperitoneal anastomosis for acute sigmoid diverticulitis...
May 2016: Chirurgia
Kristofer J Spurling, Ian K Moonsie, Joseph L Perks
BACKGROUND: Patients with respiratory disease are at risk of excessive hypoxemia in the hypobaric commercial aircraft cabin environment, and the consensus is that this is easily corrected with supplementary oxygen. However, despite the risks of hypercapnia with increasing inspired oxygen in some patients being well established, this issue is not currently addressed in medical guidelines for air travel. CASE REPORT: A 76-yr-old woman with chronic type 2 respiratory failure underwent hypoxic challenge testing (HCT) to assess in-flight oxygen requirements...
February 2016: Aerospace Medicine and Human Performance
Prashob Porayette, Sujana Madathil, Liqun Sun, Edgar Jaeggi, Lars Grosse-Wortmann, Shi-Joon Yoo, Edward Hickey, Steven P Miller, Christopher K Macgowan, Mike Seed
OBJECTIVE: We investigated the physiologic impact of acute maternal hyperoxygenation (MH) in human fetuses with and without congenital heart disease (CHD) using fetal cardiac magnetic resonance (CMR) in order to explore the potential therapeutic benefits of chronic MH. METHODS: We examined 17 normal and 20 late gestation human fetuses with CHD on a 1.5 T CMR system. Flows were measured in major fetal vessels using phase contrast MRI. The T2 of umbilical venous blood was measured using T2 mapping...
March 2016: Prenatal Diagnosis
D A Lara, S A Morris, S A Maskatia, M Challman, M Nguyen, D K Feagin, L Schoppe, J Zhang, A Bhatt, S K Sexson-Tejtel, K N Lopez, E J Lawrence, S Andreas, Y Wang, M A Belfort, R Ruano, N A Ayres, C A Altman, K M Aagaard, J Becker
OBJECTIVE: Acute maternal hyperoxygenation (AMH) results in increased fetal left heart blood flow. Our aim was to perform a pilot study to determine the safety, feasibility and direction and magnitude of effect of chronic maternal hyperoxygenation (CMH) on mitral and aortic valve annular dimensions in fetuses with left heart hypoplasia (LHH) after CMH. METHODS: Gravidae with fetal LHH were eligible for inclusion in a prospective evaluation of CMH. LHH was defined as: sum of aortic and mitral valve annuli Z-scores < -4...
September 2016: Ultrasound in Obstetrics & Gynecology
Mario Schietroma, Emanuela Marina Cecilia, Giuseppe De Santis, Francesco Carlei, Beatrice Pessia, Gianfranco Amicucci
BACKGROUND: The clinical role of hyperoxia for preventing surgical site infection (SSI) remains uncertain because randomized controlled trials on this topic have reported disparate results. One of the principal reasons for this outcome may be that prior trials have entered heterogeneous populations of patients and a variety of procedures. The aim of our study was to assess the influence of hyperoxygenation on SSI using a homogeneous study population. METHODS: From January 2004 to April 2013, we studied, in a randomized trial, 239 patients, who underwent open surgery for perforated peptic ulcer (PPU)...
February 2016: Surgical Infections
Roberta Lins Gonçalves, Lucila Midori Tsuzuki, Marcos Giovanni Santos Carvalho
Evidence-based practices search for the best available scientific evidence to support problem solving and decision making. Because of the complexity and amount of information related to health care, the results of methodologically sound scientific papers must be integrated by performing literature reviews. Although endotracheal suctioning is the most frequently performed invasive procedure in intubated newborns in neonatal intensive care units, few Brazilian studies of good methodological quality have examined this practice, and a national consensus or standardization of this technique is lacking...
July 2015: Revista Brasileira de Terapia Intensiva
Lauren M Bullens, Pieter J van Runnard Heimel, M Beatrijs van der Hout-van der Jagt, S Guid Oei
IMPORTANCE: Intrauterine resuscitation techniques during term labor are commonly used in daily clinical practice. Evidence, however, to support the beneficial effect of intrauterine resuscitation techniques on fetal distress during labor is limited and sometimes contradictory. In contrast, some of these interventions may even be harmful. OBJECTIVE: To give insight into the current evidence on intrauterine resuscitation techniques. In addition, we formulate recommendations for current clinical practice and propose directions for further research...
August 2015: Obstetrical & Gynecological Survey
H Sørensen, H B Nielsen, N H Secher
During open abdominal aortic aneurism (AAA) repair cerebral blood flow is challenged. Clamping of the aorta may lead to unintended hyperventilation as metabolism is reduced by perfusion of a smaller part of the body and reperfusion of the aorta releases vasodilatory substances including CO2. We intend to adjust ventilation according end-tidal CO2 tension (EtCO2) and here evaluated to what extent that strategy maintains frontal lobe oxygenation (ScO2) as determined by near infrared spectroscopy. For 44 patients [5 women, aged 70 (48-83) years] ScO2, mean arterial pressure (MAP), EtCO2, and ventilation were obtained retrospectively from the anesthetic charts...
August 2016: Journal of Clinical Monitoring and Computing
Nabeela Nathoo, James A Rogers, V Wee Yong, Jeff F Dunn
Susceptibility-weighted imaging (SWI) detects hypointensities due to iron deposition and deoxyhemoglobin. Previously it was shown that SWI detects hypointensities in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), most of which are due to intravascular deoxyhemoglobin, with a small proportion being due to iron deposition in the central nervous system parenchyma and demyelination. However, animals had to be sacrificed to differentiate these two types of lesions which is impractical for time course studies or for human application...
2015: PloS One
Henrik Sørensen, Hilary P Grocott, Niels H Secher
PURPOSE: Cerebral deoxygenation, as determined by near infrared spectroscopy (NIRS), seems to predict postoperative complications following cardiac surgery. We identify the type of non-vascular abdominal surgery associated with cerebral deoxygenation and/or hyperoxygenation, how such deviations affect patient outcome, and whether maintained cerebral oxygenation improves outcome. METHODS: A systematic literature search was performed on PubMed, EMBASE, Web of Science and Clinicaltrials...
May 15, 2015: Clinical Physiology and Functional Imaging
Inmaculada Lupiañez-Perez, Shakira Kaknani Uttumchandani, Juan Carlos Morilla-Herrera, Francisco Javier Martin-Santos, Magdalena Cuevas Fernandez-Gallego, Francisco Javier Navarro-Moya, Yolanda Lupiañez-Perez, Eugenio Contreras-Fernandez, Jose Miguel Morales-Asencio
UNLABELLED: Pressure ulcers represent a major current health problem and produce an important economic impact on the healthcare system. Most of studies to prevent pressure ulcers have been carried out in hospital contexts, with respect to the use of hyperoxygenated fatty acids and to date, no studies have specifically examined the use of olive oil-based substances. METHODS AND DESIGN: Main objective: To assess the effectiveness of the use of olive oil, comparing it with hyperoxygenated fatty acids, for immobilised home-care patients at risk of suffering pressure ulcers...
2015: PloS One
C Enzensberger, R Axt-Fliedner, J Degenhardt, A Kawecki, A Tenzer, T Kohl, M Krapp
PURPOSE: The aim of the study was to describe the response of fetal lung vasculature to maternal hyperoxygenation (MH) in the case of prenatally diagnosed hypoplastic left heart (HLH) with intact or restrictive (IAS/RAS) and without restriction of the atrial septum. Furthermore, the ability of MH to differentiate between newborns with HLH who do not require immediate atrial septostomy and newborns who will undergo immediate left atrial septoplasty after birth was evaluated. MATERIALS AND METHODS: Cross-sectional prospective study of fetuses ≥ 26 weeks of gestation with prenatally diagnosed HLH...
April 2016: Ultraschall in der Medizin
Anna Leidorf, Marius M Mader, Andreas Hecker, Axel Heimann, Beat Alessandri, Petra Mayr, Oliver Kempski, Gabriele Wöbker
AIM: Monitoring of intracranial pressure (ICP), local cerebral blood flow (CBF) and oxygen is part of modern intensive critical care medicine. Preclinical evaluation of newly developed catheters that should monitor several parameters simultaneously is reported poorly in the literature. The goal of our study was (1) to evaluate a new multi-parametric sensor in brain tissue and (2) to establish a testing protocol using pathophysiological challenges that target measured parameters of the sensor and autoregulatory boundaries and could be used as preclinical standard protocol in future studies...
2014: Turkish Neurosurgery
A Channing, A Szwast, S Natarajan, K Degenhardt, Z Tian, J Rychik
OBJECTIVES: Aneurysm of the atrial septum (AAS) with excessive excursion of septum primum into the left atrium is an uncommon and relatively benign fetal condition associated with impediment to left ventricular (LV) filling and the appearance of a slender, but apex-forming, LV on fetal echocardiography. Impediment to filling can be severe, creating the image of LV hypoplasia with retrograde aortic flow. We hypothesize that maternal hyperoxygenation alters atrial septal position, improves LV filling, and normalizes aortic flow in fetuses with AAS by increasing fetal pulmonary venous return...
June 2015: Ultrasound in Obstetrics & Gynecology
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