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https://www.readbyqxmd.com/read/29180204/hyperoxygenated-hydrogen-rich-solution-suppresses-shock-and-resuscitation-induced-liver-injury
#1
Yangjie Dang, Ting Liu, Xiaopeng Mei, Xiangzhong Meng, Xingchun Gou, Bin Deng, Hao Xu, Lixian Xu
BACKGROUND: It is not known whether simultaneous delivery of hydrogen and oxygen can reduce injury caused by hemorrhagic shock and resuscitation (HSR). This study investigated the therapeutic potential of hyperoxygenated hydrogen-rich solution (HHOS), a combined hydrogen/oxygen carrier, in a rat model of HSR-induced liver injury. MATERIALS AND METHODS: Rats (n = 60) were randomly divided into 5 groups (n = 6 per group at each time point). One group underwent sham operation, and the others were subjected to severe hemorrhagic shock and then treated with lactated Ringer's solution (LRS), hydrogen-rich solution, hyperoxygenated solution, or HHOS...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29132470/-effects-of-bone-marrow-mesenchymal-stem-cell-transplantation-on-retinal-neovascularization-in-neonatal-rats-with-oxygen-induced-retinopathy
#2
Qing-Jie Mu, Yue-Hua Zhao, Dan-Dan Cheng, Hai-Yu Wang, Lan-Fen Chen, Yan-Song Zhao, Xiao-Li Wang
OBJECTIVE: To explore the effects of rat bone mesenchymal stem cell (BMSC) transplantation on retinal neovascularization, and to observe the changes of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factors (VEGF) in rats with oxygen-induced retinopathy (OIR). METHODS: Seventy-two seven-day-old Sprague-Dawley rats were randomly divided into three groups: normal control (CON), model (OIR) and BMSC transplantation. In the BMSC transplantation group, BMSCs were transplanted 5 days after oxygen conditioning...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29094032/the-inflammatory-response-of-neutrophils-in-an-in-vitro-model-that-approximates-the-postcardiac-arrest-state
#3
Young-Duck Cho, Sung-Jun Park, Sung-Hyuk Choi, Young-Hoon Yoon, Jung-Youn Kim, Sung-Woo Lee, Chae-Seung Lim
Purpose: Postcardiac arrest syndrome (PCAS) shares many features with sepsis including plasma cytokine elevation with dysregulation of cytokine production, and the presence of endotoxin in plasma. PCAS is closely related to ischemia-reperfusion injury. During ischemia-reperfusion injury, neutrophil, which is the first line of innate immunity, plays a major role. In this study, we investigated the inflammatory response of human neutrophils in an in vitro model which we simulated with hypoxia-normoxia and hypoxia-hyperoxia environments...
October 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29067809/combined-in-vivo-amperometric-oximetry-and-electrophysiology-in-a-single-sensor-a-tool-for-epilepsy-research
#4
Ana Ledo, Cátia F Lourenço, João Laranjinha, Greg A Gerhardt, Rui M Barbosa
Seizures are paroxysmal events in which increased neuronal activity is accompanied by an increase in localized energetic demand. The ability to simultaneously record electrical and chemical events using a single sensor poses a promising approach to identify seizure onset zones in the brain. In the present work, we used ceramic-based platinum microelectrode arrays (MEAs) to perform high-frequency amperometric recording of local pO2 and local field potential (LFP)-related currents during seizures in the hippocampus of chronically implanted freely moving rats...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29054017/hyperventilation-and-electroconvulsive-therapy-a-literature-review
#5
REVIEW
Jorge Gómez-Arnau, Aida de Arriba-Arnau, Javier Correas-Lauffer, Mikel Urretavizcaya
BACKGROUND: Hyperventilation has been proposed as an augmentation strategy in electroconvulsive therapy (ECT) in accordance with its proconvulsant effect. OBJECTIVE: This study reviews the existing literature on the application of hyperventilation in ECT, its efficacy, and tolerance. METHODS: A systematic search was performed in PubMed and EMBASE databases. Search terms ('electroconvulsive therapy' and 'hyperventilation', 'ventilation', 'hyperoxygenation', 'hyperoxia', 'hypocapnia') were used to retrieve works from 1966 to June 2016...
September 23, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28976608/cerebrovascular-response-to-maternal-hyperoxygenation-mh-in-fetuses-with-hypoplastic-left-heart-syndrome-hlhs-depends-upon-gestational-age-ga-and-baseline-cerebrovascular-resistance
#6
Anita Szwast, Mary Putt, J William Gaynor, Daniel Licht, Jack Rychik
OBJECTIVES: Compared to normal fetuses, HLHS fetuses have smaller brain volumes and more brain injury, possibly due to diminished cerebral blood flow and oxygen content. By increasing cerebral oxygen delivery, maternal hyperoxygenation (MH) might improve brain development and reduce brain injury in these fetuses. This study investigates whether gestational age (GA) and baseline cerebrovascular resistance impact response to MH in HLHS fetuses. METHODS: The middle cerebral artery (MCA) pulsatility index (PI), a surrogate measure of cerebrovascular resistance, was assessed in 43 HLHS fetuses...
October 4, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28928616/chronic-antepartum-maternal-hyperoxygenation-in-a-case-of-severe-fetal-ebstein-s-anomaly-with-circular-shunt-physiology
#7
Alisa Arunamata, David M Axelrod, Katherine Bianco, Sowmya Balasubramanian, Amy Quirin, Theresa A Tacy
Perinatal mortality remains high among fetuses diagnosed with Ebstein's anomaly of the tricuspid valve. The subgroup of patients with pulmonary valve regurgitation is at particularly high risk. In the setting of pulmonary valve regurgitation, early constriction of the ductus arteriosus may be a novel perinatal management strategy to reduce systemic steal resulting from circular shunt physiology. We report the use of chronic antepartum maternal oxygen therapy for constriction of the fetal ductus arteriosus and modulation of fetal pulmonary vascular resistance in a late presentation of Ebstein's anomaly with severe tricuspid valve regurgitation, reversal of flow in the ductus arteriosus, and continuous pulmonary valve regurgitation...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28922519/a-cost-minimisation-analysis-of-olive-oil-versus-hyperoxygenated-fatty-acid-treatment-for-the-prevention-of-pressure-ulcers-in-primary-health-care-a-randomised-controlled-trial
#8
Inmaculada Lupiañez-Pérez, Juan Carlos Morilla-Herrera, Shakira Kaknani-Uttumchanchandani, Yolanda Lupiañez-Perez, Magdalena Cuevas-Fernandez-Gallego, Francisco Martin-Santos, Jorge Caro-Bautista, Jose Miguel Morales-Asencio
Pressure ulcers represent a major current health problem and cause an important economic impact on the health care system. Most studies on the prevention of pressure ulcers have been carried out in hospital contexts, with respect to the use of hyperoxygenated fatty acids, and to date no studies have specifically examined the use of olive oil-based treatments. AIM: To evaluate the cost of using extra virgin olive oil, rather than hyperoxygenated fatty acids, in the prevention of pressure ulcers among persons with impaired mobility and receiving home care...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28872934/normobaric-hyperoxygenation-a-potential-neuroprotective-therapy-for-acute-ischemic-stroke
#9
Sven Poli, Jean-Claude Baron, Aneesh B Singhal, Florian Härtig
No abstract text is available yet for this article.
September 13, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28746973/prenatal-maternal-hyperoxygenation-testing-and-implications-for-critical-care-delivery-planning-among-fetuses-with-congenital-heart-disease-early-experience
#10
David N Schidlow, Mary T Donofrio
No abstract text is available yet for this article.
July 26, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28668226/sustained-chronic-maternal-hyperoxygenation-increases-myocardial-deformation-in-fetuses-with-a-small-aortic-isthmus-at-risk-for-coarctation
#11
Shi Zeng, Jiawei Zhou, Qinghai Peng, Wen Deng, Ming Zang, Tao Wang, Qichang Zhou
BACKGROUND: We aimed to assess differences in myocardial deformation in fetuses at risk for coarctation (CoA) and the effects of maternal hyperoxygenation on deformation. METHODS: Fetal echocardiography and velocity vector imaging were performed prospectively and serially in 48 fetuses with a small aortic isthmus and 48 gestation age-matched normal fetuses. Fetuses with a small aortic isthmus were randomly divided into two groups: one group with and the other group without maternal supplemental oxygen administration...
October 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28346330/differentiation-of-impaired-from-preserved-hemodynamics-in-patients-with-fontan-circulation-using-real-time-phase-velocity-cardiovascular-magnetic-resonance
#12
Hermann Körperich, Katja Müller, Peter Barth, Jürgen Gieseke, Nikolaus Haas, Ingram Schulze-Neick, Wolfgang Burchert, Deniz Kececioglu, Kai T Laser
PURPOSE: Progressive impairment of hemodynamics in patients with Fontan circulation is common, multifactorial, and associated with decreased quality of life and increased morbidity. We sought to assess hemodynamic differences between patients with preserved (preserved Fontans) and those with impaired circulation (impaired Fontans) after pulmonary vasodilation using oxygen and under forced breathing conditions. MATERIALS AND METHODS: Real-time phase-contrast cardiovascular magnetic resonance was performed using non-ECG triggered echo-planar imaging (temporal resolution=24 to 28 ms) in the ascending aorta (AAo) and superior vena cava (SVC)/inferior vena cava (IVC) on room air, after 100% oxygen inhalation (4 L/min; 10 min) and on forced breathing in 29 Fontan patients (17...
May 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28277990/preventing-facial-pressure-ulcers-in-patients-under-non-invasive-mechanical-ventilation-a-randomised-control-trial
#13
RANDOMIZED CONTROLLED TRIAL
D Peña Otero, D Vazquez Domínguez, L Hernanz Fernández, A Santano Magariño, V Jimenez González, J V García Klepzing, J V Beneit Montesinos
OBJECTIVE: To comparatively assess the efficacy of four different therapeutic strategies to prevent the development of facial pressure ulcers (FPUs) related to the use of non-invasive mechanical ventilation (NIV) with oro-nasal masks in critically ill hospitalised patients. METHOD: This randomised control trial was performed at the high dependency unit in the University General Hospital Gregorio Marañón in Madrid, Spain. Overall, 152 patients with acute respiratory failure were recruited...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28277907/the-effect-of-maternal-hyperoxygenation-on-fetal-circulatory-system-in-normal-growth-and-iugr-fetuses-what-we-can-learn-from-this-impact
#14
Nizar Khatib, Israel Thaler, Ron Beloosesky, Hanin Dabaja, Nadir Ganem, Philippe Abecassis, Yuval Ginsberg, Zeev Weiner
PURPOSE: The objectives of study were to assess and compare the effects of maternal hyperoxygenation on fetal circulation, in fetuses with intrauterine growth retardation and normal fetal growth. METHODS: Twelve singleton pregnant women with normal fetal growth and 12 singleton pregnant women with intrauterine growth restriction were recruited. Mean gestational age of 35.2 ± 3.5 and 34.7 ± 3.9 weeks, respectively. Doppler blood flow velocity waveforms were obtained from the middle cerebral artery, umbilical, main and proximal right pulmonary arteries...
March 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28263176/enhancing-uniformity-and-overall-quality-of-red-cell-concentrate-with-anaerobic-storage
#15
Tatsuro Yoshida, Abbejane Blair, Angelo D'alessandro, Travis Nemkov, Michael Dioguardi, Christopher C Silliman, Andrew Dunham
BACKGROUND: Recent research focused on understanding stored red blood cell (RBC) quality has demonstrated high variability in measures of RBC function and health across units. Studies have historically linked this high variability to variations in processing, storage method, and age. More recently, a large number of studies have focused on differences in donor demographics, donor iron sufficiency, and genetic predisposition of the donor to poor storage, particularly through mechanisms of accelerated oxidative damage...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28185721/approaches-and-adjuncts-used-by-physiotherapists-when-suctioning-adult-patients-who-are-intubated-and-ventilated-in-intensive-care-units-in-australia-and-new-zealand-a-cross-sectional-survey
#16
Charissa S L Tan, Meg Harrold, Kylie Hill
BACKGROUND: Suctioning is an integral component of care for patients who are intubated and ventilated in an intensive care unit (ICU). There appears to be no published data of physiotherapy suctioning practices in Australia or New Zealand. OBJECTIVE: To describe suctioning practices and the factors which have shaped these practices, of experienced physiotherapists working with adults who are intubated and ventilated in an ICU across Australia and New Zealand. Areas of investigation focused on: (i) suctioning approach (i...
February 6, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28081216/real-time-monitoring-of-placental-oxygenation-during-maternal-hypoxia-and-hyperoxygenation-using-photoacoustic-imaging
#17
Chloé J Arthuis, Anthony Novell, Florian Raes, Jean-Michel Escoffre, Stéphanie Lerondel, Alain Le Pape, Ayache Bouakaz, Franck Perrotin
PURPOSE: This preclinical study aimed to evaluate placental oxygenation in pregnant rats by real-time photoacoustic (PA) imaging on different days of gestation and to specify variations in placental oxygen saturation under conditions of maternal hypoxia and hyperoxygenation. MATERIAL AND METHODS: Placentas of fifteen Sprague-Dawley rats were examined on days 14, 17, and 20 of pregnancy with a PA imaging system coupled to high-resolution ultrasound imaging. Pregnant rats were successively exposed to hyperoxygenated and hypoxic conditions by changing the oxygen concentration in inhaled gas...
2017: PloS One
https://www.readbyqxmd.com/read/28003557/comparing-the-effects-of-two-different-levels-of-hyperoxygenation-on-gas-exchange-during-open-endotracheal-suctioning-a-randomized-crossover-study
#18
RANDOMIZED CONTROLLED TRIAL
Jacqueline Rodrigues de Freitas Vianna, Valéria Amorim Pires Di Lorenzo, Miléa Mara Lourenço da Silva Simões, Maurício Jamami
BACKGROUND: Endotracheal suctioning is required for mechanically ventilated patients to maintain a patent airway. Studies show that open endotracheal suctioning affects respiratory mechanics and gas exchange. The aim of this study was to compare the effectiveness of hyperoxygenation with FIO2 + 0.20 above baseline and hyperoxygenation with FIO2 1.0 in preventing hypoxemia, and to determine the impact of open endotracheal suctioning on the pulmonary ventilation of critical subjects receiving mechanical ventilatory support...
January 2017: Respiratory Care
https://www.readbyqxmd.com/read/27982102/sustained-maternal-hyperoxygenation-improves-aortic-arch-dimensions-in-fetuses-with-coarctation
#19
Shi Zeng, Jiawei Zhou, Qinghai Peng, Wen Deng, Ming Zhang, Yili Zhao, Tao Wang, Qichang Zhou
The aim was to investigate the impact of maternal hyperoxygenation (HO) on cardiac dimensions in fetuses with isolated Coarctation (CoA). Fetal echocardiography was performed serially in 48 fetuses with CoA and gestation age matched normal fetues. The Z-scores for the mitral valve (MV), tricuspid valve (TV), aortic valve (AV), ascending aorta (AAo), isthmus, pulmonary valve (PV), main pulmonary artery (MPA), and descending aorta (DAo) were measured and compared among normal fetuses, CoA fetuses with oxygen and CoA fetuses with air...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27867481/temporal-variation-in-the-response-of-tumors-to-hyperoxia-with-breathing-carbogen-and-oxygen
#20
Hua-Gang Hou, Nadeem Khan, Gai-Xin Du, Sassan Hodge, Harold M Swartz
The effect of hyperoxygenation with carbogen (95% O2 + 5% CO2) and 100% oxygen inhalation on partial pressure of oxygen (pO2) of radiation-induced fibrosarcoma (RIF-1) tumor was investigated. RIF-1 tumors were innoculated in C3H mice, and aggregates of oximetry probe, lithium phthalocyanine (LiPc), was implanted in each tumor. A baseline tumor pO2 was measured by electron paramagnetic resonance (EPR) oximetry for 20 minutes in anesthetized mice breathing 30% O2 and then the gas was switched to carbogen or 100 % oxygen for 60 minutes...
July 2016: Medical Gas Research
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