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GI lymphoma clinicopathologic review

Beenu Thakral, Jane Zhou, L Jeffrey Medeiros
The head and neck region is a common site for extranodal lymphomas, second only to the gastrointestinal tract; and 12% to 15% of all head and neck tumors are lymphomas. Non-Hodgkin lymphomas are most common, and Hodgkin lymphoma occurs rarely at extranodal sites in the head and neck. Most non-Hodgkin lymphomas of the head and neck region are of B-cell lineage, and the Waldeyer ring is the most common site. Head and neck lymphomas have distinctive epidemiological and clinicopathologic features, including an association with immunosuppression, infectious organisms, or autoimmune disorders; site-specific differences (eg, thyroid gland versus ocular adnexa) for common lymphomas, such as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue; and genetic differences that provide insights into etiology...
August 2015: Human Pathology
Sanam Loghavi, Khaled Alayed, Tariq N Aladily, Zhuang Zuo, Siok-Bian Ng, Guilin Tang, Shimin Hu, C Cameron Yin, Roberto N Miranda, L Jeffrey Medeiros, Joseph D Khoury
BACKGROUND: Plasmablastic lymphoma (PBL) is a rare aggressive neoplasm with lymphoid and plasmacytic differentiation that is commonly associated with immunodeficiency and an unfavorable prognosis. Clinicopathologic features have been largely derived from cases reports and small series with limited outcome analyses. PATIENTS AND METHODS: The demographic, clinicopathologic features, and clinical outcomes of a cohort of 61 patients with PBL were reviewed and analyzed...
2015: Journal of Hematology & Oncology
Samar M Said, Karen L Grogg, Thomas C Smyrk
Gastrointestinal involvement by amyloidosis is common, but large clinicopathological studies specifically addressing gastric amyloidosis are lacking. Seventy-nine patients with biopsy-proven, gastric amyloidosis were identified by a retrospective review of our pathology archives, from 2007 to 2013. Amyloid typing was performed by laser microdissection/mass spectrometry (in 44 patients), immunohistochemistry, immunofluorescence, and/or genetic testing. The median age at diagnosis was 62years, with 61% being males...
April 2015: Human Pathology
Minrui Li, Shenghong Zhang, Fang Gu, Weiwei Xiao, Jiayan Yao, Kang Chao, Minhu Chen, Juan Li, Bihui Zhong
Primary gastrointestinal lymphoma (PGIL) is a kind of relatively rare cancer and easily misdiagnosed due to its unspecific signs in digestive tract. Data including 216 patients histologically diagnosed as PGIL between January 1991 and October 2012 from The First Affiliated Hospital of Sun Yat-sen University were reviewed. This study was to investigate the clinicopathological features and prognosis, and make the comparison between the different sites of PGIL. Abdominal pain (75.9%) was the most frequent symptom and intermediate-grade lymphoma (53...
2014: International Journal of Clinical and Experimental Pathology
Guohui Jiao, Zhongqing Zheng, Kui Jiang, Jie Zhang, Bangmao Wang
The gastrointestinal tract is the most common location for primary extranodal non-Hodgkin lymphoma (NHL) with cases less commonly found in the intestine. The majority of primary intestinal B-cell lymphomas are exophytic, whereas enteropathy-associated T-cell lymphomas present predominantly as thickened plaques, ulcers or strictures. Crohn's disease (CD) is a chronic inflammatory disease of the intestines with fissures and ulcers, which is difficult for clinicians to diagnose based on endoscopic observations alone...
July 2014: Oncology Letters
Po-Jui Chi, Sung-Nan Pei, Tung-Liang Huang, Shun-Chen Huang, Hwee Yeong Ng, Chien-Te Lee
Mucosa associated lymphoid tissue lymphoma (MALT lymphoma) is mostly seen in the gastrointestinal tract; origin from the kidney is extremely rare. Waldenström macroglobulinemia (WM) is a clinicopathologic syndrome denoted by the presence of monoclonal gammopathy in the serum, typically caused by lymphoproliferative disorder. Literature review did not find any report of renal MALT lymphoma accompanied by WM. Herein, for the first time, we report a 72 year-old female patient with a history of chronic kidney disease, presenting with solitary renal mass; MALT lymphoma was confirmed by pathological examination...
April 2014: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Masaya Iwamuro, Hiroyuki Okada, Katsuyoshi Takata, Soichiro Nose, Katsuya Miyatani, Tadashi Yoshino, Kazuhide Yamamoto
The purpose of this study was to reveal the diagnostic accuracy of initial pathologic assessment of biopsied samples in patients with gastrointestinal follicular lymphoma lesions. A total of 48 patients with follicular lymphoma (Lugano system stage I: n = 30; II1: n = 4; II2: n = 4; IV: n = 10) with gastrointestinal involvement who underwent endoscopic biopsy were enrolled and retrospectively reviewed. Nine (18.8%) of the 48 patients were not appropriately diagnosed as having follicular lymphoma at the initial biopsy...
April 2014: Annals of Diagnostic Pathology
Shuai Huang, Zhao-xu Zheng, Quan Xu, Xing-hua Yuan
OBJECTIVE: To summarize and analyze the diagnosis, clinical features and therapy of primary colorectal non-Hodgkin's lymphoma (NHL). METHODS: The clinicopathological data of 52 patients with primary colorectal NHL diagnosed and treated in our department from January 2000 to January 2010 were reviewed and analyzed retrospectively in this study. RESULTS: This group of patients was composed of 45 cases of B cell and 7 T cell lymphomas, including 33 males and 19 females, with a male to female ratio of 1...
April 2013: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Jun Zhou, Bo Yu, Yan He, Bo Wu, Xin-hua Zhang, Xiao-jun Zhou, Qun-li Shi
OBJECTIVE: To study the clinicopathologic features, diagnosis and differential diagnosis of intestinal natural killer (NK)/T-cell lymphoma. METHODS: The clinical features, histopathology, immunohistochemical findings and follow-up data of 14 cases of intestinal NK/T-cell lymphoma were retrospectively reviewed. RESULTS: The male-to-female ratio was 9:5. The medium age of patients was 45 years. The sites of involvement included small intestine (6 cases), colon (6 cases) or both (2 cases)...
April 2013: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
R Vaidya, T M Habermann, J H Donohue, K M Ristow, M J Maurer, W R Macon, J P Colgan, D J Inwards, S M Ansell, L F Porrata, I N Micallef, P B Johnston, S N Markovic, C A Thompson, G S Nowakowski, T E Witzig
BACKGROUND: Perforation is a serious life-threatening complication of lymphomas involving the gastrointestinal (GI) tract. Although some perforations occur as the initial presentation of GI lymphoma, others occur after initiation of chemotherapy. To define the location and timing of perforation, a single-center study was carried out of all patients with GI lymphoma. PATIENTS AND METHODS: Between 1975 and 2012, 1062 patients were identified with biopsy-proven GI involvement with lymphoma...
September 2013: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Amir Aledavood, Mohammad Reza Ghavam Nasiri, Bahram Memar, Soodabeh Shahidsales, Hamid Reza Raziee, Kamran Ghafarzadegan, Samira Mohtashami
BACKGROUND: Extranodal lymphoma may arise anywhere outside lymph nodes mostly in the gastrointestinal (GI) tract as non-Hodgkin's disease. We reviewed the clinicopathological features and treatment results of patients with primary GI lymphoma. MATERIALS AND METHODS: A total number of 30 cases with primary GI lymphoma were included in this study. Patients referred to the Radiation Oncology Department of Omid Hospital (Mashhad, Iran) during a 5-year period (2006-11)...
May 2012: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Andrew J Rand, Diana M Cardona, Alan D Proia, Anand S Lagoo
An elderly patient with watery diarrhea for 3 months received extensive laboratory, radiographic and upper and lower gastrointestinal (GI) endoscopic work up including colonic biopsies, but a diagnosis was not established before death. At autopsy enteropathy associated T-cell lymphoma-type II (EATL-II) with multifocal mucosal involvement of the jejunum was identified. The colon was completely uninvolved grossly and microscopically. The stomach showed only subtle lesions grossly but microscopic examination revealed involvement by lymphoma in the stomach as well as other organs in abdomen and chest...
March 2013: Journal of Gastrointestinal Oncology
Miguel Alonso-Ruano, Eugeni López-Bonet, Maria Victoria Huerta-Anaya, Ester Vila-Camps, Luis Bernadó, Francesc Tuca-Rodríguez, Pedro Suarez-Pumariega, Javier A Menendez
Neuroendocrine tumors (NETs) are frequently associated with second primary malignancies (SPMs). Earlier studies have demonstrated that NETs are highly associated with synchronous or metachronous gastrointestinal and genitourinary SPMs. We report, for the first time, a case of pure NE breast carcinoma (NEBC) exhibiting all of the World Health Organization (WHO)-categorized morphological and phenotypic NE features (i.e., round solid nests of spindle cells, plasmacytoid cells, large clear or mucinous signet-ring cells with a peripheral palisading tendency and immunohistochemical positivity for the NE markers synaptophysin and chromogranin in more than 50% of the tumor cell population) along with synchronous abdominal non-Hodgkin's lymphoma...
February 2013: Oncology Letters
Yuan-Yuan Li, Shu Yang, Li-Na Zhang, Lei Fan, Li Wang, Run Zhang, Ji Xu, Wei Xu, Jian-Yong Li
This study was aimed to investigate the clinicopathological features, immunophenotye and differential diagnosis of primary gastric peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS), so as to promote its early recognition for the clinical and pathological physicians. Four patients with primary gastric PTCL-NOS between September 2008 to October 2011 in our hospital were reviewed retrospectively. Clinical records, histo-morphological features and immunohistochemical markers were analyzed. All 4 patients were admitted to hospital because of gastrointestinal symptoms, such as abdominal discomfort, pain or diarrhea, therefore gastroscope biopsy or operation were performed and this disease was found...
December 2012: Zhongguo Shi Yan Xue Ye Xue za Zhi
Jerome S Burke
CONTEXT: The gastrointestinal tract is the most common site of extranodal lymphomas. Although all histologic categories of malignant lymphoma develop in the gastrointestinal tract, large B-cell lymphomas predominate, followed by extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) type; the latter is especially prevalent in stomach. The acceptance of extranodal marginal zone lymphoma of MALT type as a clinicopathologic entity has reduced the number of cases that formerly were interpreted as florid lymphoid hyperplasia ("pseudolymphoma")...
October 2011: Archives of Pathology & Laboratory Medicine
Chang Hyun Kim, Bong Hyeon Kye, Jae Im Lee, Soo Hong Kim, Hyung Jin Kim, Won Kyung Kang, Seong Taek Oh
PURPOSE: Tumors of the small bowel are rare, accounting for about 3-6% of all gastrointestinal neoplasms, though they cover more than 90% of the intestinal surface. However, diagnosis and treatment are difficult and present an ongoing challenge for both gastrointestinal surgeons and gastroenterologists. The aim of this study was to investigate the clinical features of small bowel tumors. METHODS: Between November 1994 and November 2007, 81 patients underwent treatments for primary tumors in the jejuno-ileal region at the Department of Surgery, Kangnam St...
October 2010: Journal of the Korean Society of Coloproctology
Haresh Mani, Fina Climent, Lluís Colomo, Stefania Pittaluga, Mark Raffeld, Elaine S Jaffe
Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare. We present the clinicopathological features of 19 cases from our files; 14 patients had primary lymphoma (13 involving gall bladder and 1 involving common hepatic duct), while 5 had systemic lymphoma on further work-up. Most patients presented with symptoms mimicking cholecystitis. The most common primary lymphoma types were diffuse large B-cell lymphoma, extranodal marginal zone lymphoma, B-lymphoblastic lymphoma, and follicular lymphoma...
September 2010: American Journal of Surgical Pathology
Jiajia Huang, WenQi Jiang, Ruihua Xu, HuiQiang Huang, Yue Lv, ZhongJun Xia, XiaoFei Sun, ZhongZhen Guan, Tongyu Lin, ZhiMing Li
BACKGROUND: Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in Chinese patients with PGL. METHODS: The clinicopathological features of 83 Chinese patients with PGL were retrospectively reviewed. Staging was performed according to the Lugano staging system for gastrointestinal non-Hodgkin's lymphoma...
2010: BMC Cancer
Huaiyin Shi, Yan Li, Lixin Wei, Lu Sun
AIMS: Primary colorectal inflammatory myofibroblastic tumours are rare. Here we report seven such cases to demonstrate their clinicopathological features and prognosis. METHODS: Clinical and pathological data of seven cases of colorectal inflammatory myofibroblastic tumour were reviewed. Immunohistochemical staining was also performed. RESULTS: The presenting symptoms included abdominal or pelvic mass (7 patients), abdominal pain (7 patients), and lower gastrointestinal haemorrhage (2 patients)...
April 2010: Pathology
Yoshie Shimoyama, Naoko Asano, Masaru Kojima, Satoko Morishima, Kazuhito Yamamoto, Takashi Oyama, Tomohiro Kinoshita, Shigeo Nakamura
EBV is prevalent among healthy individuals, and is implicated in numerous reactive and neoplastic processes in the immune system. The authors originally identified a series of senile or age-related EBV-associated B-cell lymphoproliferative disorders (LPD) bearing a resemblance to immunodeficiency-associated ones, which may be associated with immune senescence in the elderly and which are now incorporated into the 2008 World Health Organization lymphoma classification as EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly...
December 2009: Pathology International
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