Rodolfo Solís-Vivanco, Josefina Ricardo-Garcell, Mario Rodríguez-Camacho, Roberto A Prado-Alcalá, Ulises Rodríguez, Mayela Rodríguez-Violante, Yaneth Rodríguez-Agudelo
Dopaminergic nigro-striatal depletion interferes with the detection of novel stimuli. This suggests that Parkinson's disease (PD) may generate from the initial stages a failure in involuntary attention (IA), which can be studied through the distraction potential, composed by the mismatch negativity (MMN), the P3a and the reorientation negativity (RON). This study analyzed IA using event-related potentials (ERPs) in patients with early PD with and without dopaminergic replacement therapy. Twenty-five medicated, and 17 non-medicated patients with early PD were studied, as well as 20 healthy control subjects...
May 16, 2011: Neuroscience Letters