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https://www.readbyqxmd.com/read/28722635/early-life-inflammation-and-neurodevelopmental-outcome-in-bangladeshi-infants-growing-up-in-adversity
#1
Nona M Jiang, Fahmida Tofail, Jennie Z Ma, Rashidul Haque, Beth Kirkpatrick, Charles A Nelson, William A Petri
Exposure to profound adversity can negatively affect the neurodevelopment of children, but biologic mechanisms that underlie this association remain unknown. We sought to determine whether elevated levels of the inflammatory markers C-reactive protein (CRP) and soluble CD14 (sCD14) are associated with neurodevelopmental outcomes in Bangladeshi children. A total of 422 infant-mother pairs from an urban slum in Dhaka, Bangladesh, were enrolled at birth and followed prospectively. Inflammation was measured with sCD14, interleukin (IL)-1β, and IL-6 at 18 weeks, and CRP at 6, 18, 40, and 53 weeks...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28716211/to-serve-and-protect-the-modulatory-role-of-von-willebrand-factor-on-factor-viii-immunogenicity
#2
REVIEW
Robin B Hartholt, Alice S van Velzen, Ivan Peyron, Anja Ten Brinke, Karin Fijnvandraat, Jan Voorberg
Hemophilia A is a bleeding disorder characterized by the absence or dysfunction of blood coagulation factor VIII (FVIII). Patients are treated with regular infusions of FVIII concentrate. In response to treatment, approximately 30% of patients with severe hemophilia A develop inhibitory antibodies targeting FVIII. Both patient and treatment related risk factors for inhibitor development have been described. Multiple studies comparing the immunogenicity of recombinant and plasma-derived FVIII have yielded conflicting results...
July 4, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28716072/effect-of-prenatal-exposure-to-maternal-cortisol-and-psychological-distress-on-infant-development-in-bengaluru-southern-india-a-prospective-cohort-study
#3
Anita Nath, Gudlavalleti Venkata Satyanarayana Murthy, Giridhara R Babu, Gian Carlo Di Renzo
BACKGROUND: The mental health status of a pregnant woman and its consequent impact on foetal well being is not given much importance compared to the risk imposed by obstetric complications and medical conditions. Maternal psychological distress is a major public health problem and needs timely detection and intervention to prevent any adverse pregnancy outcome. There is ample evidence from literature that justifies the association of prenatal maternal mental stress and elevated cortisol with delayed infant motor and cognitive development; evidence from India being rather limited...
July 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28715787/micronutrients-during-pregnancy-and-child-psychomotor-development-opposite-effects-of-zinc-and-selenium
#4
Kinga Polanska, Wojciech Hanke, Anna Krol, Jolanta Gromadzinska, Renata Kuras, Beata Janasik, Wojciech Wasowicz, Fiorino Mirabella, Flavia Chiarotti, Gemma Calamandrei
Studies on the impact of micronutrient levels during different pregnancy periods on child psychomotor functions are limited. The aim of this study was to evaluate the association between maternal plasma concentrations of selected micronutrients, such as: copper (Cu), zinc (Zn), selenium (Se), and child neuropsychological development. The study population consisted of 539 mother-child pairs from Polish Mother and Child Cohort (REPRO_PL). The micronutrient levels were measured in each trimester of pregnancy, at delivery and in the cord blood...
July 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28714930/environmental-tobacco-smoke-exposure-during-pregnancy-and-child-neurodevelopment
#5
Kinga Polanska, Anna Krol, Dorota Merecz-Kot, Danuta Ligocka, Karolina Mikolajewska, Fiorino Mirabella, Flavia Chiarotti, Gemma Calamandrei, Wojciech Hanke
The developing fetus is especially vulnerable to environmental toxicants, including tobacco constituents. The aim of this study was to assess the impact of environmental tobacco smoke (ETS) exposure during pregnancy on child neurodevelopment within the first two years of life. The study population consisted of 461 non-smoking pregnant women (saliva cotinine level <10 ng/mL). Maternal passive smoking was assessed based on the cotinine level in saliva analyzed by the use of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS) and by questionnaire data...
July 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28714772/can-typical-us-home-visits-affect-infant-attachment-preliminary-findings-from-a-randomized-trial-of-healthy-families-durham
#6
Lisa J Berlin, Tiffany L Martoccio, Karen Appleyard Carmody, W Benjamin Goodman, Karen O'Donnell, Janis Williams, Robert A Murphy, Kenneth A Dodge
US government-funded early home visiting services are expanding significantly. The most widely implemented home visiting models target at-risk new mothers and their infants. Such home visiting programs typically aim to support infant-parent relationships; yet, such programs' effects on infant attachment quality per se are as yet untested. Given these programs' aims, and the crucial role of early attachments in human development, it is important to understand attachment processes in home visited families. The current, preliminary study examined 94 high-risk mother-infant dyads participating in a randomized evaluation of the Healthy Families Durham (HFD) home visiting program...
July 17, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28714339/inhaled-and-systemic-steroid-exposure-and-neurodevelopmental-outcome-of-preterm-neonates
#7
Edmond N Kelly, Vibhuti S Shah, Jody Levenbach, Michael Vincer, Orlando DaSilva, Prakesh S Shah
OBJECTIVES: To compare death and/or neurodevelopmental outcomes of preterm infants exposed to inhaled and/or systemic steroids with those without exposure, and examine the impact of timing of exposure. METHODS: Retrospective study of infants born <29 weeks gestation and assessed at 18-21 months corrected age (CA). Neurodevelopmental impairment (NDI) was defined as any Bayley Scales of Infant and Toddler Development-III (BSID-III) score <85, cerebral palsy ≥ grade one, and visual or hearing impairment...
July 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28710046/image-guidance-to-aid-pedicle-screw-fixation-of-a-lumbar-fracture-dislocation-injury-in-a-toddler
#8
John K Houten, Jonathan Nahkla, Shashank Ghandi
BACKGROUND: Pedicle screw fixation of the lumbar spine in children less than two years of age is particularly challenging, as successful cannulation of the small pedicle dimensions require a high level of precision and there are no implants specifically designed for the infantile spine. Image-guided navigation is commonly used in adult spinal surgery and may be particularly helpful for placement of spinal screws where the bony anatomy is small and/or anatomically complex as in the upper cervical area...
July 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28704672/anthropometric-measures-at-birth-and-early-childhood-are-associated-with-neurodevelopmental-outcomes-among-bangladeshi-children-aged-2-3years
#9
Jane J Lee, Kush Kapur, Ema G Rodrigues, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Robert O Wright, David C Bellinger, David C Christiani, Maitreyi Mazumdar
Among a cohort of children located in rural areas of Bangladesh affected by high levels of exposure to environmental metals, we investigated the associations between anthropometric measures, growth trajectory, and neurodevelopment at age 20-40months. Our study population included mothers and their children who participated in a longitudinal birth cohort study that took in place in the Pabna and Sirajdikhan areas of Bangladesh. Anthropometric measures including weight, length, and head circumference were measured at birth, age 12months, and age 20-40months...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28701902/empathy-related-responding-in-chinese-toddlers-factorial-structure-and-cognitive-contributors
#10
Heqing Huang, Yanjie Su, Jian Jin
The critical role of the second year of life in the development of empathy is well accepted by psychologists. However, the developmental trends of the different components of empathy and the potential factors underlying these components during this critical period remain unclear. Eighty-four Chinese toddlers in the second year of life participated in the present study. Empathy-related responses were observed during three simulated procedures performed by each child's primary caregiver, the experimenter and a baby doll...
May 2017: Infant and Child Development
https://www.readbyqxmd.com/read/28700580/infant-viewing-of-social-scenes-is-under-genetic-control-and-is-atypical-in-autism
#11
John N Constantino, Stefanie Kennon-McGill, Claire Weichselbaum, Natasha Marrus, Alyzeh Haider, Anne L Glowinski, Scott Gillespie, Cheryl Klaiman, Ami Klin, Warren Jones
Long before infants reach, crawl or walk, they explore the world by looking: they look to learn and to engage, giving preferential attention to social stimuli, including faces, face-like stimuli and biological motion. This capacity-social visual engagement-shapes typical infant development from birth and is pathognomonically impaired in children affected by autism. Here we show that variation in viewing of social scenes, including levels of preferential attention and the timing, direction and targeting of individual eye movements, is strongly influenced by genetic factors, with effects directly traceable to the active seeking of social information...
July 12, 2017: Nature
https://www.readbyqxmd.com/read/28697405/neurodevelopmental-outcome-of-italian-preterm-children-at-1year-of-corrected-age-by-bayley-iii-scales-an-assessment-using-local-norms
#12
Corinna Gasparini, Barbara Caravale, Monica Rea, Maria Franca Coletti, Valentina Tonchei, Silvia Bucci, Andrea Dotta, Mario De Curtis, Simonetta Gentile, Rosa Ferri
BACKGROUND: Premature birth is often associated with neurodevelopmental difficulties throughout childhood. In the first three years of life, the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III) constitute one of the most used tools for assessing child development. Since Bayley-III original norms are based on United States (US) population, it remains uncertain whether their use in other countries (e.g., European) is appropriate. AIMS: This research aimed to examine neurodevelopment of preterm infants and full-term infants, using Bayley-III US norms in comparison to Italian (IT) norms...
July 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/28687527/the-first-patient-with-sporadic-x-linked-intellectual-disability-with-de-novo-zdhhc9-mutation-identified-by-targeted-next-generation-sequencing
#13
Ji Yoon Han, In Goo Lee, Soyoung Shin, Myungshin Kim, Ja Hyun Jang, Joonhong Park
X-linked intellectual disability (XLID) is a genetically heterogeneous disorder involving more than 100 genes known to date. Here, we describe a Korean male infant with global developmental delay. He had neither facial dysmorphism nor skeletal abnormalities. Bayley scale of infant and toddler development third edition (Bayley-III) measured at age of 2 years revealed marked global developmental delays without Marfanoid habitus, structural brain abnormalities, or epilepsy. The patient's cognitive, motor, and language developmental ages were 8-9 months, 12 months, and 9 months, respectively...
July 4, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28685398/developmental-changes-in-pretend-play-from-22-to-34-months-in-younger-siblings-of-children-with-autism-spectrum-disorder
#14
Susan B Campbell, Amanda S Mahoney, Jessie Northrup, Elizabeth L Moore, Nina B Leezenbaum, Celia A Brownell
Developmental trajectories of children's pretend play and social engagement, as well as parent sensitivity and stimulation, were examined in toddlers with an older sibling with autism spectrum disorder (ASD, high risk; HR) and toddlers with typically-developing older siblings (low risk; LR). Children (N = 168, 97 boys, 71 girls) were observed at 22, 28, and 34 months during free play with a parent and elicited pretend play with an examiner. At 28 and 34 months, children were asked to imagine the consequences of actions pantomimed by the examiner on a pretend transformation task...
July 7, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28683424/prenatal-phenolic-compounds-exposure-and-neurobehavioral-development-at-2-and-7years-of-age
#15
Ching-Chun Lin, Chun-Ju Chien, Meng-Shan Tsai, Chia-Jung Hsieh, Wu-Shiun Hsieh, Pau-Chung Chen
BACKGROUND: Phenolic compounds such as bisphenol A (BPA), nonylphenol (NP), and octylphenol (OP) are known as endocrine-disrupting compounds and are commonly used. Their impacts on the neurodevelopment of children are inconclusive. The current study aims to investigate the association between umbilical cord blood levels of BPA, NP, OP and neurodevelopmental outcomes at 2 and 7years of age. METHODS: The study was based on the Taiwan Birth Panel Study, a prospective birth cohort...
July 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28677512/-a-toddler-with-a-mandibular-fracture
#16
E L van der Linden, R J Bun, E van Os
BACKGROUND: Mandibular fractures are rare in children. Symptoms of these fractures include preauricular pain and swelling, trismus and pain when opening the mouth, and they are often preceded by a fall on the chin. If the diagnosis is missed they may have serious consequences for the growth and development of the jaw. CASE DESCRIPTION: A 3-year-old boy was referred with a swelling in his left cheek, fever and vomiting. Two days earlier he had fallen on his chin...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28672377/case-history-risk-factors-for-specific-language-impairment-a-systematic-review-and-meta-analysis
#17
Johanna M Rudolph
Purpose: Research suggests that the best approach to early identification of children with specific language impairment (SLI) should include assessment of risk factors. However, previous attempts to develop a list for this purpose have been unsuccessful. In this study, systematic review and meta-analytic procedures were used to determine whether any case history factors can be used to identify toddlers at risk of developing SLI. Method: Epidemiological studies that examined the association between risk factors and SLI were identified...
July 3, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28668643/-she-didn-t-have-a-word-of-english-we-didn-t-have-a-word-of-vietnamese-exploring-parent-experiences-of-communication-with-toddlers-who-were-adopted-internationally
#18
Brid McAndrew, Mary-Pat O Malley-Keighran
The purpose of this study was to explore in detail parents' experiences of communicating with toddlers who were adopted internationally. Often, there is a mismatch between parents and children in terms of language, particularly in the early post-adoption period. There is a gap in the literature regarding parent experiences of this phase of their lives. Changing patterns in international adoption have led to an increase in adoptions of toddlers and older children. Due to institutional care, these toddlers and older children often lack exposure to their native language which may lead to language delay...
June 20, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28649582/attachment-and-biobehavioral-catch-up-addressing-the-needs-of-infants-and-toddlers-exposed-to-inadequate-or-problematic-caregiving
#19
Mary Dozier, Kristin Bernard
Parental sensitivity is key to the development of brain architecture, self-regulatory capabilities, and secure, organized attachments for infants and young children. For a variety of reasons, many parents struggle providing sensitive, responsive care. Attachment and Biobehavioral Catch-up (ABC) is a 10-session home visiting program developed to enhance parental sensitivity. ABC has been shown effective in enhancing parental sensitivity, and enhancing children's attachment security and regulatory capabilities...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28644312/early-infections-and-the-risk-of-irritable-bowel-syndrome-a-case-control-study
#20
Edward J Krajicek, Ann E Almazar, Joseph J Larson, Elizabeth J Atkinson, Nicholas J Talley, Yuri A Saito
GOALS: The goal of this study is to evaluate the association between early life infections and subsequent adult onset irritable bowel syndrome (IBS). BACKGROUND: Infections during adulthood are a known risk factor for adult-onset IBS. This investigation examined the role of childhood infections and infection risk factors in the development of IBS symptoms. STUDY: In total, 1010 subjects (509 outpatients with IBS, 501 matched controls) were mailed questionnaires regarding early-life infections during infancy (0 to 12 mo), toddler years (1 to 3 y), and child years (4 to 18 y)...
June 21, 2017: Journal of Clinical Gastroenterology
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