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https://www.readbyqxmd.com/read/29150937/cgmp-production-and-analysis-of-bg505-sosip-664-an-extensively-glycosylated-trimeric-hiv-1-envelope-glycoprotein-vaccine-candidate
#1
Antu K Dey, Albert Cupo, Gabriel Ozorowski, Vaneet K Sharma, Anna-Janina Behrens, Eden P Go, Thomas J Ketas, Anila Yasmeen, Per J Klasse, Eddy Sayeed, Heather Desaire, Max Crispin, Ian A Wilson, Rogier W Sanders, Thomas Hassell, Andrew Ward, John P Moore
We describe the properties of BG505 SOSIP.664 HIV-1 envelope glycoprotein trimers produced under current Good Manufacturing Practice (cGMP) conditions. These proteins are the first of a new generation of native-like trimers that are the basis for many structure-guided immunogen development programs aimed at devising how to induce broadly neutralizing antibodies (bNAbs) to HIV-1 by vaccination. The successful translation of this prototype demonstrates the feasibility of producing similar immunogens on an appropriate scale and of an acceptable quality for Phase I experimental medicine clinical trials...
November 18, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29150887/is-there-also-room-for-rational-thought
#2
EDITORIAL
F R Rosendaal, P H Reitsma
No abstract text is available yet for this article.
November 18, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29150839/liver-injury-induced-by-clomiphene-citrate-a-case-report-and-literature-reviews
#3
H-M Zhang, X-H Zhao, Y-F He, L-R Sun
WHAT IS KNOWN AND OBJECTIVE: Clomiphene citrate is used to cause ovulation in females and to increase semen production in males. Clomiphene citrate is well tolerated in most patients and rarely induces liver injury. We report a case of liver injury which is associated with administration of clomiphene citrate in a male patient. CASE SUMMARY: A 31-year-old man who was treated by clomiphene citrate for 5 days was transferred to our emergency room with reddish-brown urine and upper abdominal pain...
November 17, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29150090/graph-based-representation-of-behavior-in-detection-and-prediction-of-daily-living-activities
#4
Piotr Augustyniak, Grażyna Ślusarczyk
Various surveillance systems capture signs of human activities of daily living (ADLs) and store multimodal information as time line behavioral records. In this paper, we present a novel approach to the analysis of a behavioral record used in a surveillance system designed for use in elderly smart homes. The description of a subject's activity is first decomposed into elementary poses - easily detectable by dedicated intelligent sensors - and represented by the share coefficients. Then, the activity is represented in the form of an attributed graph, where nodes correspond to elementary poses...
November 10, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29149970/thromboelastography-as-a-predictor-of-outcomes-following-liver-transplantation
#5
C L Trautman, W C Palmer, C B Taner, J M Canabal, T Getz, A Goldman, M G Heckman, N N Diehl, D D Lee, F F Stancampiano
BACKGROUND: Thromboelastography (TEG) has been used perioperatively during liver transplantation (LT) to provide a real-time global hemostasis assessment for targeted blood product replacement. We aimed to analyze the relationship between post-LT TEG results and outcomes. METHODS: We retrospectively analyzed patients undergoing LT from November 2008 to December 2014 at Mayo Clinic Florida. All 441 single-organ 1st-time LT patients aged ≥18 years requiring post-LT intensive care unit management were included...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149877/key-bottlenecks-to-the-provision-of-safe-obstetric-anaesthesia-in-low-income-countries-a-cross-sectional-survey-of-64-hospitals-in-uganda
#6
Isabella Epiu, Agnes Wabule, Andrew Kambugu, Harriet Mayanja-Kizza, Jossy Verel Bahe Tindimwebwa, Gerald Dubowitz
BACKGROUND: Despite recent advances in surgery and anaesthesia which significantly improve safety, many health facilities in low-and middle-income countries (LMICs) remain chronically under-resourced with inability to cope effectively with serious obstetric complications (Knight et al., PLoS One 8:e63846, 2013). As a result many of these countries still have unacceptably high maternal and neonatal mortality rates. Recent data at the national referral hospitals in East Africa reported that none of the national referral hospitals met the World Federation of Societies of Anesthesiologists (WFSA) international standards required to provide safe obstetric anaesthesia (Epiu I: Challenges of Anesthesia in Low-and Middle-Income Countries...
November 17, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29149678/housing-conditions-and-birth-outcomes-the-national-child-development-study
#7
Emily W Harville, Felicia A Rabito
BACKGROUND: Despite their importance to respiratory and other health outcomes, housing conditions have been little-studied with respect to perinatal outcomes. METHODS: 1927 participants in the British National Child Development Study reported on housing conditions and pregnancy outcomes, including presence/severity of mold/dampness; type of heating; and whether remodeling of various sorts had been conducted. Crowding, based on the number of people in the residence and the number of rooms, was also considered...
November 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29149621/the-risk-factors-related-to-bruxism-in-children-a-systematic-review-and-meta-analysis
#8
REVIEW
Huaqi Guo, Tongxia Wang, Xiaohong Niu, Hui Wang, Weihan Yang, Jie Qiu, Lan Yang
OBJECTIVE: This systematic review was performed to determine the risk factors related to bruxism in children. DESIGN: This systematic review was conducted with reporting in agreement to the PRISMA statement and according to guidelines from the Cochrane Handbook for Systematic Reviews of Interventions. We conducted a systematic search of seven online databases, with the last search updated on 1st October 2016. The seven databases were Pubmed, Embase, Cochrane Library database, Web of Science, CNKI, CBM, and WF...
November 11, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29149612/cancer-evolution-no-room-for-negative-selection
#9
Samuel F Bakhoum, Dan A Landau
In this issue of Cell, Martincorena et al. and Campbell et al. interrogated the selection dynamics during tumor evolution using large-scale genomics datasets. They found that somatic mutations in cancer are largely neutral, highlighting a near-complete absence of negative selection. Neutral evolution enables tolerance of hypermutation, which defines a surprisingly large fraction of adult cancer.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29149572/au-i-catalyzed-dimerization-of-two-alkyne-units-interplay-between-butadienyl-and-cyclopropenylmethyl-cation-model-studies-and-trapping-experiments
#10
Mathis Kreuzahler, Sven Fabig, Gebhard Haberhauer, Rolf Gleiter
In recent years, Au(I)-catalyzed reactions proved to be a valuable tool for the synthesis of substituted cycles by cycloaromatization and cycloisomerization starting from alkynes. Despite of the myriads of Au(I)-catalyzed reactions of alkynes, the mono Au(I)-catalyzed pendant to the radical dimerization of non-conjugated alkyne units has not been investigated by quantum chemical calculations. Herein by means of quantum chemical calculations, we describe the mono Au(I)-catalyzed dimerization of two alkyne units as well as the transannular ring closure reaction of a non-conjugated diyne...
November 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29149561/electrochemical-cobalt-catalyzed-c-h-oxygenation-at-room-temperature
#11
Nicolas Sauermann, Tjark Meyer, Cong Tian, Lutz Ackermann
Electrochemical cobalt-catalyzed C-H functionalizations were achieved in terms of C-H oxygenation under mild conditions at 23 °C. The robust electrochemical C-H functionalization was characterized by ample substrate scope, while mechanistic studies provided support for a facile C-H cleavage. The electrochemical cobalt-catalyzed C-H oxygenation proved viable on arenes and alkenes with excellent levels of positional and diastereo-selectivity, avoiding the use of stoichiometric silver(I) oxidants under ambient conditions...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29149469/cuffed-versus-uncuffed-endotracheal-tubes-for-general-anaesthesia-in-children-aged-eight-years-and-under
#12
REVIEW
Flavia A De Orange, Rebeca Gac Andrade, Andrea Lemos, Paulo Sgn Borges, José N Figueiroa, Pete G Kovatsis
BACKGROUND: Since the introduction of endotracheal intubation in paediatrics, uncuffed endotracheal tubes (ETTs) have been the standard of care for children under eight years old, based on the presumption that complications, particularly postoperative stridor, are higher with cuffed ETTs. The major disadvantages of uncuffed ETTs cited for this shift in procedure include the difficulty in achieving tidal volumes due to leakage around an uncuffed ETT. To seal the airway adequately, uncuffed tubes may need to be exchanged for another tube with a larger diameter, which sometimes requires several attempts before the appropriate size is found...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29149317/decision-space-for-health-workforce-management-in-decentralized-settings-a-case-study-in-uganda
#13
Alvaro Alonso-Garbayo, Joanna Raven, Sally Theobald, Freddie Ssengooba, Milly Nattimba, Tim Martineau
The aim of this paper is to improve understanding about how district health managers perceive and use their decision space for human resource management (HRM) and how this compares with national policies and regulatory frameworks governing HRM. The study builds upon work undertaken by PERFORM Research Consortium in Uganda using action-research to strengthen human resources management in the health sector. To assess the decision space that managers have in six areas of HRM (e.g. policy, planning, remuneration and incentives, performance management, education and information) the study compares the roles allocated by Uganda's policy and regulatory frameworks with the actual room for decision-making that district health managers perceive that they have...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29149312/who-are-more-responsive-mixed-methods-comparison-of-public-and-private-sector-physicians-in-rural-bangladesh
#14
Taufique Joarder, Asha George, Malabika Sarker, Saifuddin Ahmed, David H Peters
Responsiveness of physicians (ROPs) reflects the social actions by physicians to meet the legitimate expectations of health care users. Responsiveness is important since it improves understanding and care seeking by users, as well as fostering trust in health systems rather than replicating discrimination and entrenching inequality. Given widespread public and private sector health care provision in Bangladesh, we undertook a mixed-methods study comparing responsiveness of public and private physicians in rural Bangladesh...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29149164/-osservare-project-direct-observation-of-use-of-the-safety-surgery-checklist-in-the-operating-room
#15
Roberto Bentivegna, Annita Caminati, Vanni Agnoletti, Stefano Bonilauri, Stefania Buonaccorso, Giovanna Campaniello, Antonella Dovani, Giuseppina Lanciotti, Vania Maselli, Stefano Mastrangelo, Maria Teresa Montella, Teresa Palladino, Cristiano Pelati, Lorenzo Sciolino, Evita Zoni, Elisa Porcu, Anselmo Campagna, Ottavio Nicastro
INTRODUCTION: Safety Surgery CheckList (SSCL) is a support tool for operating teams, used to carry out safety checks while also encouraging compliance with the implementation of recommended quality and safety standards. In Emilia-Romagna it was deemed appropriate to check actual surgical team compliance with correct checklist application in the operating theatre, through a project called "OssERvare". METHODS: Direct observation was identified as the preferred inspection method...
November 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29149147/hypothalamic-pituitary-adrenocortical-axis-suppression-following-a-single-epidural-injection-of-methylprednisolone-acetate
#16
Aleem Jameel Abdul, Babita Ghai, Dipika Bansal, Naresh Sachdeva, Anil Bhansali, Saravdeep Singh Dhatt
BACKGROUND: Epidural injections (EIs) are the most commonly performed minimally invasive intervention in managing chronic low back pain (CLBP). There is inconsistency in data to accurately predict the degree of hypothalamic-piuitary-adrenal (HPA) axis suppression in patients receiving exogenous steroid therapy, especially in the form of epidural steroid injections (ESIs). OBJECTIVE: We aim to quantify the degree and duration of HPA axis suppression after a single ESI of 80 mg methyl prednisolone acetate in patients with CLBP...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29149116/solving-the-problem-of-smoking-in-the-polish-enterprises-during-2003-2015
#17
Elżbieta Korzeniowska, Krzysztof Puchalski
OBJECTIVES: Tobacco smoking is a major organizational, economical, and public relations-related (PR-related) problem for the company. Moreover, it is an important health determinant of the working population. The paper reports the results of the research which analyzed the current state and the tobacco control activities' transformations undertaken by Polish employers between 2003 and 2015. MATERIAL AND METHODS: Data comes from the research performed in 2006, 2010 and 2015, involving random- selected representative samples of Polish enterprises, employing no fewer than 50 employees...
November 17, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29149083/co-precipitation-synthesis-and-optical-properties-of-mn-4-doped-hexafluoroaluminate-w-led-phosphors
#18
Tim Senden, Robin G Geitenbeek, Andries Meijerink
Mn(4+)-activated hexafluoroaluminates are promising red-emitting phosphors for white light emitting diodes (w-LEDs). Here, we report the synthesis of Na₃AlF₆:Mn(4+), K₃AlF₆:Mn(4+) and K₂NaAlF₆:Mn(4+) phosphors through a simple two-step co-precipitation method. Highly monodisperse large (~20 μm) smoothed-octahedron shaped crystallites are obtained for K₂NaAlF₆:Mn(4+). The large size, regular shape and small size distribution are favorable for application in w-LEDs. All Mn(4+)-doped hexafluoroaluminates show bright red Mn(4+) luminescence under blue light excitation...
November 17, 2017: Materials
https://www.readbyqxmd.com/read/29149061/mechanical-corrosion-and-biological-properties-of-room-temperature-sputtered-aluminum-nitride-films-with-dissimilar-nanostructure
#19
Cristina Besleaga, Viorel Dumitru, Liliana Marinela Trinca, Adrian-Claudiu Popa, Constantin-Catalin Negrila, Łukasz Kołodziejczyk, Catalin-Romeo Luculescu, Gabriela-Cristina Ionescu, Razvan-George Ripeanu, Alina Vladescu, George E Stan
Aluminum Nitride (AlN) has been long time being regarded as highly interesting material for developing sensing applications (including biosensors and implantable sensors). AlN, due to its appealing electronic properties, is envisaged lately to serve as a multi-functional biosensing platform. Although generally exploited for its intrinsic piezoelectricity, its surface morphology and mechanical performance (elastic modulus, hardness, wear, scratch and tensile resistance to delamination, adherence to the substrate), corrosion resistance and cytocompatibility are also essential features for high performance sustainable biosensor devices...
November 17, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29148782/effect-of-side-chain-branching-on-enhancement-of-ionic-conductivity-and-capacity-retention-of-copolymer-electrolyte-membrane
#20
Guopeng Fu, Thein Kyu
Low current drain driven by the low ionic conductivity of solid polymer electrolyte is one of the major obstacles of solid state battery. In an effort to improve the ionic conductivity, polyethylene glycol diacrylate (PEGDA) and monofunctional polyethylene glycol methyl ether acrylate (PEGMEA) were copolymerized via photopolymerization to afford PEGDA network with dangling PEGMEA side chains. By attaching PEGMEA side branches to the PEGDA network backbone, the glass transition temperature (Tg) was found to decrease, which may be controlled by varying relative amounts of PEGMEA and PEGDA...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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