Maria Bove, Maria Adelaide Palmieri, Martina Santoro, Lisa Pia Agosti, Silvana Gaetani, Adele Romano, Stefania Dimonte, Giuseppe Costantino, Vladyslav Sikora, Paolo Tucci, Stefania Schiavone, Maria Grazia Morgese, Luigia Trabace
Autism Spectrum Disorders (ASD) are principally diagnosed by three core behavioural symptoms, such as stereotyped repertoire, communication impairments and social dysfunctions. This complex pathology has been linked to abnormalities of corticostriatal and limbic circuits. Despite experimental efforts in elucidating the molecular mechanisms behind these abnormalities, a clear etiopathogenic hypothesis is still lacking. To this aim, preclinical studies can be really helpful to longitudinally study behavioural alterations resembling human symptoms and to investigate the underlying neurobiological correlates...
April 17, 2024: Translational Psychiatry