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Brain derived neurotrophic factor

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https://www.readbyqxmd.com/read/29691979/the-bdnf-val68met-polymorphism-modulates-how-developmental-ethanol-exposure-impacts-the-hippocampus
#1
Clark W Bird, Brian C Baculis, Jacob J Mayfield, Glenna J Chavez, Tiahna Ontiveros, Dana J Paine, Aaron J Marks, Alicia L Gonzales, Dorit Ron, C Fernando Valenzuela
Prenatal exposure to alcohol causes a wide range of deficits known as Fetal Alcohol Spectrum Disorders (FASDs). Many factors determine vulnerability to developmental alcohol exposure including timing and pattern of exposure, nutrition, and genetics. Here, we characterized how a prevalent single nucleotide polymorphism in the human brain-derived neurotrophic factor (BDNF) gene (val66met) modulates FASDs severity. This polymorphism disrupts BDNF's intracellular trafficking and activity dependent secretion, and has been linked to increased incidence of neuropsychiatric disorders such as depression and anxiety...
April 24, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29690543/memory-function-in-feeding-habit-transformation-of-mandarin-fish-siniperca-chuatsi
#2
Yaqi Dou, Shan He, Xu-Fang Liang, Wenjing Cai, Jie Wang, Linjie Shi, Jiao Li
Mandarin fish refuse dead prey fish or artificial diets and can be trained to transform their inborn feeding habit. To investigate the effect of memory on feeding habit transformation, we compared the reaction time to dead prey fish and the success rate of feeding habit transformation to dead prey fish with training of mandarin fish in the 1st experimental group (trained once) and the 2nd experimental group (trained twice). The mandarin fish in the 2nd group had higher success rate of feeding habit transformation (100%) than those in the 1st group (67%), and shorter reaction time to dead prey fish (<1 s) than those in the 1st group (>1 s)...
April 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29688525/particulate-matter-triggers-depressive-like-response-associated-with-modulation-of-inflammatory-cytokine-homeostasis-and-brain-derived-neurotrophic-factor-signaling-pathway-in-mice
#3
Xuemei Liu, Xin Qian, Jing Xing, Jinhua Wang, Yixuan Sun, Qin'geng Wang, Huiming Li
Particulate matter (PM) exposure may contribute to depressive-like response in mice. However, few studies have evaluated the adaptive impacts of long-term PM exposure on depressive-like response associated with systemic inflammation and brain-derived neurotrophic factor (BDNF) signaling pathway. We studied the association among depressive-like behaviors, mRNA levels of pro- and anti-inflammatory cytokines, and the expression of BDNF signaling pathway in mice by long-term PM exposure. C57BL/6 male mice were exposed to ambient air alongside control mice breathing air filtered through a high-efficiency air PM (HEPA) filter...
April 23, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29686948/you-can-t-fix-what-isn-t-broken-eight-weeks-of-exercise-do-not-substantially-change-cognitive-function-and-biochemical-markers-in-young-and-healthy-adults
#4
Joanne Gourgouvelis, Paul Yielder, Sandra T Clarke, Hushyar Behbahani, Bernadette Murphy
Objective: The benefits of exercise on brain health is well known in aging and psychiatric populations. However, the relationship between habitual exercise in young and healthy adults remains unclear. This study explored the effects an eight-week exercise prescription on cognitive function, brain-derived neurotrophic factor (BDNF) and cathepsin B (CTHB) in young and healthy adults. Methods: A total of 22 low-active, young and healthy adults were recruited from a local university...
2018: PeerJ
https://www.readbyqxmd.com/read/29686604/ultrasound-triggered-effects-of-the-microbubbles-coupled-to-gdnf-plasmid-loaded-pegylated-liposomes-in-a-rat-model-of-parkinson-s-disease
#5
Peijian Yue, Wang Miao, Lin Gao, Xinyu Zhao, Junfang Teng
Background: The purpose of this study was to investigate ultrasound-triggered effects of PEGylated liposomes-coupled microbubbles mediated gene transfer of glial cell line-derived neurotrophic factor (GDNF) plasmid (PLs-GDNF-MBs) on behavioral deficits and neuron loss in a rat model of Parkinson's disease (PD). Methods: The unloaded PLs-MBs were characterized for particle size, concentration and zeta potential. PD rat model was established by a unilateral 6-hydroxydopamine (6-OHDA) lesion. Rotational, climbing pole, and suspension tests were used to evaluate behavioral deficits...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29685283/blood-biomarkers-are-associated-with-brain-function-and-blood-flow-following-sport-concussion
#6
Alex P Di Battista, Nathan Churchill, Tom A Schweizer, Shawn G Rhind, Doug Richards, Andrew J Baker, Michael G Hutchison
BACKGROUND: Secondary injury pathophysiology after sport-related concussion (SRC) is poorly understood. Blood biomarkers may be a useful tool for characterizing these processes, yet there are limitations in their application as a single modality. Combining blood biomarker analysis with advanced neuroimaging may help validate their continued utility in brain injury research by elucidating important secondary injury mechanisms. Hence, the purpose of this study was to evaluate co-modulation between peripheral blood biomarkers and advanced functional brain imaging after SRC...
June 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29685094/effects-of-alcoholic-beverage-treatment-on-spatial-learning-and-fear-memory-in-mice
#7
Narumi Hashikawa-Hobara, Shuta Mishima, Shotaro Nagase, Keishi Morita, Ami Otsuka, Naoya Hashikawa
Although chronic ethanol treatment is known to impair learning and memory, humans commonly consume a range of alcoholic beverages. However, the specific effects of some alcoholic beverages on behavioral performance are largely unknown. The present study compared the effects of a range of alcoholic beverages (plain ethanol solution, red wine, sake and whiskey; with a matched alcohol concentration of 10%) on learning and memory. 6-week-old C57BL6J mice were orally administered alcohol for 7 weeks. The results revealed that red wine treatment exhibited a trend toward improvement of spatial memory and advanced extinction of fear memory...
April 24, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29683360/hydrogen-rich-water-improves-cognitive-impairment-gender-dependently-in-app-ps1-mice-without-affecting-a%C3%AE-clearance
#8
Chen Hou, Yunhua Peng, Chuan Qin, Fan Fan, Jiankang Liu, Jiangang Long
Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ injection-induced cognitive dysfunction. However, whether and how hydrogen affects AD pathogenesis remains uninvestigated...
April 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29682700/therapeutic-potential-of-a-combination-of-electroacupuncture-and-trkb-expressing-mesenchymal-stem-cells-for-ischemic-stroke
#9
Sung Min Ahn, Yu Ri Kim, Yong-Il Shin, Ki Tae Ha, Seo-Yeon Lee, Hwa Kyoung Shin, Byung Tae Choi
We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly improved motor function compared to that obtained with MSCs+EA or TrkB-MSCs alone. At 30 days after middle cerebral artery occlusion (MCAO), the largest number of grafted MSCs was detected in the TrkB-MSC+EA group...
April 22, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29681219/antidepressant-like-effects-of-embelin-and-its-possible-mechanisms-of-action-in-chronic-unpredictable-stress-induced-mice
#10
Bailing Wang, Xiaoqin Chen, Tiantian Zhou, Xiaoying Wang
Objectives Embelin, a principal active constituent of embelin ribes burm, has good therapeutic effects on various diseases. To explore the effects and underlying mechanisms of embelin on depression, we made a preliminary study to clarify this issue. Methods We first used chronic unpredictable stress (CUS) to construct the model of depression in mice. Then, we determined the effects of embelin on CUS-induced behavioral dysfunction using open field test, sucrose preference test, tail suspension test and forced swimming test...
April 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29680784/silibinin-exerts-antidepressant-effects-by-improving-neurogenesis-through-bdnf-trkb-pathway
#11
Yan-Jiao Li, Yu-Jiao Li, Liu-Di Yang, Kun Zhang, Kai-Yin Zheng, Xin-Miao Wei, Qi Yang, Wen-Min Niu, Ming-Gao Zhao, Yu-Mei Wu
Classic antidepressants benefit depression patients partially by improving neurogenesis and/or brain-derived neurotrophic factor (BDNF)/TrkB pathway which were impaired in depression. In this study, we demonstrated that Silibinin (SLB), a polyphenolic flavanoid from Silybum marianum, ameliorated reserpinized mouse depressant-like behaviors. The antidepressants of SLB administration was associated with increased neural stem cells (NSCs) proliferation and further confirmed in BDNF/TrkB signaling transduction...
April 19, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29680514/brain-blood-cerebrospinal-fluid-and-serum-biomarkers-in-schizophrenia
#12
REVIEW
Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeian
Over the last decade, finding a reliable biomarker for the early detection of schizophrenia (Scz) has been a topic of interest. The main goal of the current review is to provide a comprehensive view of the brain, blood, cerebrospinal fluid (CSF), and serum biomarkers of Scz disease. Imaging studies have demonstrated that the volumes of the corpus callosum, thalamus, hippocampal formation, subiculum, parahippocampal gyrus, superior temporal gyrus, prefrontal and orbitofrontal cortices, and amygdala-hippocampal complex were reduced in patients diagnosed with Scz...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29680240/peptide-derivatives-of-erythropoietin-in-the-treatment-of-neuroinflammation-and-neurodegeneration
#13
Ilkcan Ercan, Kemal Ugur Tufekci, Ezgi Karaca, Sermin Genc, Kursad Genc
During the past 35 years, recombinant DNA technology has allowed the production of a wide range of hematopoietic and neurotrophic growth factors including erythropoietin (EPO). These have emerged as promising protein drugs in various human diseases. Accumulated evidences have recently demonstrated the neuroprotective effect of EPO in preclinical models of acute and chronic degenerative disorders. Nevertheless, tissue protective effect of EPO could not be translated to the clinical trials because of common lethal thromboembolic events, erythropoiesis and hypertension...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29679660/effects-of-aerobic-training-resistance-training-or-both-on-brain-derived-neurotrophic-factor-in-adolescents-with-obesity-the-hearty-randomized-controlled-trial
#14
Gary S Goldfield, Glen P Kenny, Denis Prud'Homme, Martin Holcik, Angela S Alberga, Margaret Fahnestock, Jameason D Cameron, Steve Doucette, Stasia Hadjiyannakis, Heather Tulloch, Mark S Tremblay, Jeremy Walsh, Eva Guerin, Katie E Gunnell, Amedeo D'Angiulli, Ronald J Sigal
Brain derived neurotrophic factor (BDNF) is a protein that plays a critical role in modulating cognition in animals and humans. Aerobic exercise often increases BDNF in adults, but effects of this exercise modality and others among adolescents remain uncertain. This study examined the effects of aerobic training, resistance training, and combined training on resting serum BDNF levels in adolescents with overweight and obesity. After a 4-week pre-randomization treatment, 304 post-pubertal, adolescents with overweight or obesity (70% females) aged 14-18 years were randomized to one of four groups for 22 weeks: aerobic training (N = 75), resistance training (N = 78), combined aerobic and resistance training (N = 75), or non-exercising control (N = 76)...
April 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29679543/retrograde-influences-of-scg-axotomy-on-uninjured-preganglionic-neurons
#15
Sean M Gannon, Kiel Hawk, Brian F Walsh, Aminata Coulibaly, Lori G Isaacson
There is evidence that neuronal injury can affect uninjured neurons in the same neural circuit. The overall goal of this study was to understand the effects of peripheral nerve injury on uninjured neurons located in the central nervous system (CNS). As a model, we examined whether axotomy (transection of postganglionic axons) of the superior cervical ganglion (SCG) affected the uninjured, preganglionic neurons that innervate the SCG. At 7 days post-injury a reduction in choline acetyltransferase (ChAT) and synaptophysin immunoreactivity in the SCG, both markers for preganglionic axons, was observed, and this reduction persisted at 8 and 12 weeks post-injury...
April 18, 2018: Brain Research
https://www.readbyqxmd.com/read/29678562/effects-of-postnatal-handling-on-adult-behavior-and-brain-mrna-expression-of-serotonin-receptor-brain-derived-neurotrophic-factor-and-gaba-a-receptor-subunit
#16
Haiyan Li, Chihiro Ishikawa, Takashi Shiga
Development of brain and behavior is influenced by the interaction of genetic and environmental factors. Postnatal handling, a manipulation that briefly separates mouse offspring from their mother during the postnatal period, has been reported to yield beneficial effects on the behavior of adult offspring. However, brain mechanisms underlying the effects on the behavior have not been well understood. Here we first examined effects of postnatal handling on the behavior of adult male BALB/c mice. Offspring were separated for 15 min every day between postnatal day 1 (P1) and P14 and then various behaviors were tested in the adulthood...
April 17, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29677620/hippocampal-fxr-plays-a-role-in-the-pathogenesis-of-depression-a-preliminary-study-based-on-lentiviral-gene-modulation
#17
Wei-Guan Chen, Jia-Xuan Zheng, Xi Xu, Yu-Ming Hu, Yu-Min Ma
As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious and worldwide neuropsychiatric disease. It was found that chronic unpredictable mild stress (CUMS) fully enhanced the protein and mRNA expressions of FXR in hippocampus, but not medial prefrontal cortex (mPFC)...
April 10, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29676236/monoamine-involvement-in-the-antidepressant-like-effect-of-%C3%AE-caryophyllene
#18
Danillo Ramos Oliveira, Dayane Moreira Silva, Iziara Ferreira Florentino, Adriane de Brito, James Oluwagbamigbe Fajemiroye, Daiany Priscilla Bueno Silva, Fabio da Rocha, Elson Alves Costa, Pablinny Galdino De Carvalho
This study was conducted to evaluate the antidepressant-like activity of sesquiterpene compound β-caryophyllene (BCP) for the possible contribution of the monoamine and hippocampal levels of brain-derived neurotrophic factor (BDNF). Male albino Swiss mice were subjected to the forced swimming test after acute treatment and to the tail suspension test after repeated treatment. Hippocampal levels of BDNF were assayed by enzyme-linked immunosorbent assay. The anti-immobility effect of BCP was reverted by pretreatment with inhibitor of catecholamines α-methyl-p-tyrosine (100 mg/kg, i...
April 20, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29676228/glaucoma-pathogenesis-and-neurotrophins-focus-on-the-molecular-and-genetic-basis-for-therapeutic-prospects
#19
Nitin Chitranshi, Yogita Dheer, Mojdeh Abbasi, Yuyi You, Stuart L Graham, Vivek Gupta
BACKGROUND: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are needed to prevent vision loss which can occur even after conventional medical or surgical treatments to lower intraocular pressure. OBJECTIVE: The aim of this review was to examine the progress in genetics and cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC dysfunction and cell death pathways in glaucoma...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29674117/electroconvulsive-seizures-influence-dendritic-spine-morphology-and-bdnf-expression-in-a-neuroendocrine-model-of-depression
#20
Kristen R Maynard, John W Hobbs, Sumita K Rajpurohit, Keri Martinowich
BACKGROUND: Electroconvulsive therapy (ECT) is a rapid and effective treatment for major depressive disorder. Chronic stress-induced depression causes dendrite atrophy and deficiencies in brain-derived neurotrophic factor (BDNF), which are reversed by anti-depressant drugs. Electroconvulsive seizures (ECS), an animal model of ECT, robustly increase BDNF expression and stimulate dendritic outgrowth. OBJECTIVE: The present study aims to understand cellular and molecular plasticity mechanisms contributing to the efficacy of ECS following chronic stress-induced depression...
April 6, 2018: Brain Stimulation
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