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Brain derived neurotrophic factor

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https://www.readbyqxmd.com/read/28098876/bdnf-regulates-the-expression-and-secretion-of-vegf-from-osteoblasts-via-the-trkb-erk1-2-signaling-pathway-during-fracture-healing
#1
Zitao Zhang, Yan Zhang, Zhengnan Zhou, Hongfei Shi, Xusheng Qiu, Jin Xiong, Yixin Chen
Brain‑derived neurotrophic factor (BDNF), a member of the neurotropic family, is expressed in osteoblast‑like cells of a fracture callus, however, its role in fracture healing remains to be fully elucidated. Osteoblasts isolated from Sprague Dawley rats were stimulated by BDNF in a dose‑ and time‑dependent manner. Immunoblotting and immunofluorescence was used to detect the expression and distribution of targeted proteins. The concentration of vascular endothelial growth factor (VEGF) released in medium was determined using an ELISA...
January 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28098423/brain-derived-neurotrophic-factor-attenuates-doxorubicin-induced-cardiac-dysfunction-through-activating-akt-signalling-in-rats
#2
Pengzhou Hang, Jing Zhao, Li Sun, Minghui Li, Yu Han, Zhimin Du, Yue Li
The clinical application of doxorubicin (Dox) is limited by its adverse effect of cardiotoxicity. Previous studies have suggested the cardioprotective effect of brain-derived neurotrophic factor (BDNF). We hypothesize that BDNF could protect against Dox-induced cardiotoxicity. Sprague Dawley rats were injected with Dox (2.5 mg/kg, 3 times/week, i.p.), in the presence or absence of recombinant BDNF (0.4 μg/kg, i.v.) for 2 weeks. H9c2 cells were treated with Dox (1 μM) and/or BDNF (400 ng/ml) for 24 hrs. Functional roles of BDNF against Dox-induced cardiac injury were examined both in vivo and in vitro...
November 7, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28097465/hydroxysafflor-yellow-a-improves-motor-dysfunction-in-the-rotenone-induced-mice-model-of-parkinson-s-disease
#3
Tian Wang, Lijie Wang, Cuiting Li, Bing Han, Zhenhua Wang, Ji Li, Yan Lv, Shuyun Wang, Fenghua Fu
Dopamine D3 receptor (DRD3) is diminished in patients of Parkinson's disease (PD). Brain-derived neurotrophic factor (BDNF) is responsible for regulating expression of the DRD3 in the brain. Our previous study showed that hydroxysafflor yellow A (HSYA) could increase BDNF content in the striatum of PD mice. This experiment aimed to evaluate whether HSYA can improve the motor dysfunction induced by rotenone through regulating the BDNF/TrkB/DRD3 signaling pathway in mice. Male C57/BL6 mice were intraperitoneally treated with HSYA...
January 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28096878/reversion-of-bdnf-akt-and-creb-in-hippocampus-of-chronic-unpredictable-stress-induced-rats-effects-of-phytochemical-bacopa-monnieri
#4
Somoday Hazra, Sourav Kumar, Goutam Kumar Saha, Amal Chandra Mondal
OBJECTIVE: The aims of the present study were to explore the behavioural effects and to understand the possible mode of action of Bacopa monnieri extract (BME) on chronic unpredictable stress (CUS) induced depressive model and the biochemical alterations such as brain derived neurotrophic factor (BDNF), Akt, cyclic-AMP response element binding (CREB) protein level in the hippocampus of rats. METHODS: We examined the effects of chronic administration of BME on CUS exposed rats for 28 days...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28096497/bdnf-regains-function-in-hippocampal-long-term-potentiation-deficits-caused-by-diencephalic-damage
#5
Lindsey C Vedder, Lisa M Savage
Thiamine deficiency (TD), commonly associated with chronic alcoholism, leads to diencephalic damage, hippocampal dysfunction, and spatial learning and memory deficits. We show a decrease in the magnitude of long-term potentiation (LTP) and paired-pulse facilitation (PPF) at CA3-CA1 synapses, independent of sex, following diencephalic damage induced by TD in rats. Thus, despite a lack of extensive hippocampal cell loss, diencephalic brain damage down-regulates plastic processes within the hippocampus, likely contributing to impaired hippocampal-dependent behaviors...
February 2017: Learning & Memory
https://www.readbyqxmd.com/read/28096470/dampened-amphetamine-stimulated-behavior-and-altered-dopamine-transporter-function-in-the-absence-of-brain-gdnf
#6
Jaakko Kopra, Anne Panhelainen, Sara Af Bjerkén, Lauriina Porokuokka, Kärt Varendi, Soophie Olfat, Heidi Montonen, T Petteri Piepponen, Mart Saarma, Jaan-Olle Andressoo
: Midbrain dopamine neuron dysfunction contributes to various psychiatric and neurological diseases including drug addiction and Parkinson's disease. Because of its well-established dopaminotrophic effects, the therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) has been extensively studied in various disorders with disturbed dopamine homeostasis. The outcomes from pre-clinical and clinical studies vary, however, highlighting a need for a better understanding of the physiological role of GDNF on striatal dopaminergic function...
January 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28095731/n-palmitoylethanolamine-oxazoline-pea-oxa-as-a-new-therapeutic-strategy-to-control-neuroinflammation-neuroprotective-effects-in-experimental-models-of-spinal-cord-and-brain-injury
#7
Daniela Impellizzeri, Marika Cordaro, Giuseppe Bruschetta, Rosalba Siracusa, Rosalia Crupi, Emanuela Esposito, Salvatore Cuzzocrea
Modulation of N-acylethanolamine-hydrolyzing acid amidase (NAAA) represents a potential alternative strategy in the treatment of neuroinflammation. Recent studies showed that pharmacological modulation of NAAA could be achieved with the oxazoline of palmitoylethanolamide (PEA) (PEA-OXA). The aim of this study was to evaluate the neuroprotective effects of PEA-OXA in the secondary neuro-inflammatory events induced by spinal and brain trauma in mice. Animals were subjected to spinal cord and brain injury models and PEA-OXA (10 mg/kg) administered both intraperitoneally and orally 1 h and 6 h after trauma...
January 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28095363/curcumin-confers-neuroprotection-against-alcohol-induced-hippocampal-neurodegeneration-via-creb-bdnf-pathway-in-rats
#8
Majid Motaghinejad, Manijeh Motevalian, Sulail Fatima, Hajar Hashemi, Mina Gholami
BACKGROUND: Alcohol abuse causes severe damage to the brain neurons. Studies have reported the neuroprotective effects of curcumin against alcohol-induced neurodegeneration. However, the precise mechanism of action remains unclear. METHODS: Seventy rats were equally divided into 7 groups (10 rats per group). Group 1 received normal saline (0.7ml/rat) and group 2 received alcohol (2g/kg/day) for 21days. Groups 3, 4, 5 and 6 concurrently received alcohol (2g/kg/day) and curcumin (10, 20, 40 and 60mg/kg, respectively) for 21days...
January 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28093570/vitamin-d-administration-cognitive-function-bbb-permeability-and-neuro-inflammatory-factors-in-high-fat-diet-induced-obese-rats
#9
G Hajiluian, G Nameni, P Shahabi, M Mesgari-Abbasi, S Sadigh-Eteghad, M A Farhangi
OBJECTIVES: The purpose of this research is to investigate the effects of vitamin D administration on cognitive function, nuclear factor Kappa-B (NF-kB), brain derived neurotrophic factor (BDNF) concentration in the hippocampus and blood-brain barrier (BBB) permeability in high-fat diet (HFD) induced obese rats. METHODS: Male Wistar rats were fed either a control diet or HFD for 16 weeks (n=20); then each group was randomized into two subgroups supplemented orally with 500 IU/kg vitamin D for 5 weeks...
January 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28092760/serum-brain-derived-neurotrophic-factor-and-stability-of-depressive-symptoms-in-coronary-heart-disease-patients-a-prospective-study
#10
Stella L Kuhlmann, Mira Tschorn, Volker Arolt, Katja Beer, Julia Brandt, Laura Grosse, Wilhelm Haverkamp, Jacqueline Müller-Nordhorn, Nina Rieckmann, Johannes Waltenberger, Katharina Warnke, Rainer Hellweg, Andreas Ströhle
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. METHODS: At baseline, N=225 CHD patients were enrolled while hospitalized...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28092195/serum-bdnf-levels-in-patients-with-gambling-disorder-are-associated-with-the-severity-of-gambling-disorder-and-iowa-gambling-task-indices
#11
Sam-Wook Choi, Young-Chul Shin, Jung Yeon Mok, Dai-Jin Kim, Jung-Seok Choi, Samuel Suk-Hyun Hwang
Background and aims Gambling disorder (GD) shares many similarities with substance use disorders (SUDs) in clinical, neurobiological, and neurocognitive features, including decision-making. We evaluated the relationships among, GD, decision-making, and brain-derived neurotrophic factor (BDNF), as measured by serum BDNF levels. Methods Twenty-one male patients with GD and 21 healthy sex- and age-matched control subjects were evaluated for associations between serum BDNF levels and the Problem Gambling Severity Index (PGSI), as well as between serum BDNF levels and Iowa Gambling Task (IGT) indices...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28092086/anxiety-related-behaviours-associated-with-microrna-206-3p-and-bdnf-expression-in-pregnant-female-mice-following-psychological-social-stress
#12
Zhuang Miao, Fengbiao Mao, Jialong Liang, Moshe Szyf, Yan Wang, Zhong Sheng Sun
Stress during pregnancy can induce various psychological disorders in women. However, the association linking psychological stress during pregnancy with abnormal behaviours in females remains largely unknown. We employed a novel psychological stress model by introducing pregnant mice to witness the defeat process of their mated partner (WDPMP) and examined the effects of WDPMP on depression-/anxiety-like behaviours and on the expression of brain-derived neurotrophic factor (BDNF) and miR-206-3p in the hippocampus, medial prefrontal cortex (mPFC) and amygdala...
January 14, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28089578/dual-influences-of-early-life-maternal-deprivation-on-histone-deacetylase-activity-and-recognition-memory-in-rats
#13
Manoel Osório Albuquerque Filho, Betânia Souza de Freitas, Rebeca Carvalho Lacerda Garcia, Pedro Castilhos de Freitas Crivelaro, Nadja Schröder, Maria Noêmia Martins de Lima
Exposure to stress early in life may negatively impact nervous system functioning, including increasing the proneness to learning and memory impairments later in life. Maternal deprivation, a model of early-life stress, hinders memory in adult rats and lessens brain-derived neurotrophic factor (BDNF) levels in the hippocampus in a very heterogeneous way among individuals. The main goal of the present study was to investigate the possible epigenetic modulation underlying recognition memory impairment and reduced BDNF levels in the hippocampus of adult maternally deprived rats...
January 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28089079/repeated-subarachnoid-administrations-of-autologous-mesenchymal-stromal-cells-supported-in-autologous-plasma-improve-quality-of-life-in-patients-suffering-incomplete-spinal-cord-injury
#14
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Celia Bonilla, Concepción Aguayo, Cecilia Fernández, Noemí Tapiador, Marta Sevilla, Carlos Morejón, Jesús Montilla, Francisco Martínez, Esperanza Marín, Salvador Bustamante, David Vázquez, Joaquín Carballido, Alicia Rodríguez, Paula Martínez, Coral García, Mercedes Ovejero, Marta V Fernández
BACKGROUND AIMS: Cell therapy with mesenchymal stromal cells (MSCs) offers new hope for patients suffering from spinal cord injury (SCI). METHODS: Ten patients with established incomplete SCI received four subarachnoid administrations of 30 × 10(6) autologous bone marrow MSCs, supported in autologous plasma, at months 1, 4, 7 and 10 of the study, and were followed until the month 12. Urodynamic, neurophysiological and neuroimaging studies were performed at months 6 and 12, and compared with basal studies...
January 6, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28089025/brain-derived-neurotrophic-factor-and-the-orbitofrontal-regulation-of-behavior
#15
Trevor W Robbins
No abstract text is available yet for this article.
February 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28081461/bdnf-gene-delivery-mediated-by-neuron-targeted-nanoparticles-is-neuroprotective-in-peripheral-nerve-injury
#16
Cátia D F Lopes, Nádia P Gonçalves, Carla P Gomes, Maria J Saraiva, Ana P Pêgo
Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimally invasive intramuscular administration. Nanoparticles were grafted with the non-toxic carboxylic fragment of the tetanus neurotoxin (HC) to allow neuron targeting and were explored to deliver a plasmid DNA encoding for the brain-derived neurotrophic factor (BDNF) in a peripheral nerve injury model...
December 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/28080173/evaluation-of-long-term-cryostorage-of-brain-tissue-sections-for-quantitative-histochemistry
#17
Larissa I Estrada, Amy A Robinson, Ana C Amaral, Eustathia L Giannaris, Nadine C Heyworth, Farzad Mortazavi, Laura B Ngwenya, Debra E Roberts, Howard J Cabral, Ronald J Killiany, Douglas L Rosene
Storage of tissue sections for long periods allows multiple samples, acquired over months or years, to be processed together, in the same reagents, for quantitative histochemical studies. Protocols for freezer storage of free-floating frozen sections using sucrose with different additives have been reported and assert that storage has no effect on histochemistry, but no quantitative support has been provided. The present study analyzed the efficacy of long-term storage of brain tissue sections at -80C in buffered 15% glycerol...
January 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28077306/the-interaction-of-dietary-isoflavones-and-estradiol-replacement-on-behavior-and-brain-derived-neurotrophic-factor-in-the-ovariectomized-rat
#18
Ashley L Russell, Jamie Moran Grimes, Darwin O Larco, Danette F Cruthirds, Joanna Westerfield, Lawren Wooten, Margaret Keil, Michael J Weiser, Michael R Landauer, Robert J Handa, T John Wu
Phytoestrogens are plant derived, non-steroidal compounds naturally found in rodent chows that potentially have endocrine-disrupting effects. Isoflavones, the most common phytoestrogens, have a similar structure and molecular weight to 17β-estradiol (E2) and have the ability to bind and activate both isoforms of the estrogen receptor (ER). Most isoflavones have a higher affinity for ERβ, which is involved in sexually dimorphic behavioral regulation. The goal of this study was to examine the interaction of isoflavones and E2 presence in the OVX rat on anxiety- and depressive- like behavior and the related BDNF pathophysiology...
January 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28072837/locally-produced-bdnf-promotes-sclerotic-change-in-alveolar-bone-after-nerve-injury
#19
Hiroko Ida-Yonemochi, Yurie Yamada, Hiroyuki Yoshikawa, Kenji Seo
Brain-derived neurotrophic factor (BDNF), which is released due to nerve injury, is known to promote the natural healing of injured nerves. It is often observed that damage of mandibular canal induces local sclerotic changes in alveolar bone. We reported that peripheral nerve injury promotes the local production of BDNF; therefore, it was possible to hypothesize that peripheral nerve injury affects sclerotic changes in the alveolar bone. This study aimed to evaluate the effect of BDNF on osteogenesis using in vitro osteoblast-lineage cell culture and an in vivo rat osteotomy model...
2017: PloS One
https://www.readbyqxmd.com/read/28070911/effects-of-exercise-training-on-brain-derived-neurotrophic-factor-in-skeletal-muscle-and-heart-of-rats-post-myocardial-infarction
#20
Heow Won Lee, Monir Ahmad, Hong-Wei Wang, Frans H H Leenen
Exercise training post myocardial infarction (MI) attenuates progressive left ventricle (LV) remodeling and dysfunction, but the peripheral stimuli induced by exercise which trigger these beneficial effects are still unclear. We investigated as possible mediators fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF) in the skeletal muscle and heart. Male Wistar rats underwent either sham surgery or ligation of left descending coronary artery, and surviving MI rats were allocated to either sedentary (Sed-MI) or exercise group (ExT-MI)...
January 9, 2017: Experimental Physiology
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