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https://www.readbyqxmd.com/read/28734194/high-yield-one-pot-production-of-18-f-fch-via-a-modified-tracerlab-fxfn-module
#1
Ya-Yao Huang, Chia-Ling Tsai, Hsiang-Ping Wen, Kai-Yuan Tzen, Ruoh-Fen Yen, Chyng-Yann Shiue
INTRODUCTION: [(18)F]Fluoromethylcholine ([(18)F]FCH) is a potent tumors imaging agent. In order to fulfill the demand of pre-clinical and clinical studies, we have developed an automated high yield one-pot synthesis of this potent tumors imaging agent. METHODS: [(18)F]FCH was synthesized using a modified TRACERlab FxFN module. Briefly, dibromomethane (10% in CH3CN) was fluorinated with K[(18)F]/K 2.2.2 in a glassy carbon reaction vessel at 120°C for about 5min to generate [(18)F]fluorobromomethane ([(18)F]FBM)...
July 15, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28693028/desgarros-del-epitelio-pigmentario-de-la-retina-factores-de-riesgo-mecanismo-y-control-terap%C3%A3-utico
#2
Christoph R Clemens, Nicole Eter
Los desgarros del epitelio pigmentario de la retina (EPR) se asocian en la mayoría de los casos con los desprendimientos vascularizados del EPR debido a una degeneración macular asociada a la edad (DMAE), y normalmente implican una pérdida adversa de la agudeza visual. Estudios recientes indican que ha habido un aumento en la incidencia de desgarros del EPR desde la introducción de fármacos anti-factor de crecimiento del endotelio vascular (anti-VEGF) así como una asociación temporal entre el desgarro y la inyección intravítrea...
July 11, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28634348/distinct-arsenic-metabolites-following-seaweed-consumption-in-humans
#3
Vivien F Taylor, Zhigang Li, Vicki Sayarath, Thomas J Palys, Kevin R Morse, Rachel A Scholz-Bright, Margaret R Karagas
Seaweeds contain arsenic primarily in the form of arsenosugars, which can be metabolized to a wide range of arsenic compounds. To characterize human exposure to arsenic from seaweed consumption, we determined concentrations of arsenic species in locally available seaweeds, and assessed urinary arsenic compounds in an experimental feeding study. A total of 11 volunteers consumed 10 g per day of three types of seaweeds (nori, kombu, and wakame) for three days each, while abstaining from rice and seafood following a three-day washout period...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421807/los-antioxidantes-en-el-proceso-de-patolog%C3%A3-as-oculares
#4
Ana Fernández-Araque, Andrea Giaquinta Aranda, Consuelo Laudo Pardo, Abel Rojo Aragüés
Introducción: la influencia de los antioxidantes en los procesos oculares ha tomado en los últimos años una relevancia importante por sus efectos en la salud visual. El estrés oxidativo es un factor implicado en el desarrollo de las principales patologías tales como cataratas, glaucoma y degeneración macular asociada a la edad (DMAE).Objetivo: establecer la evidencia científica que existe sobre los distintos tipos de antioxidantes y sus efectos en procesos patológicos oculares mediante una revisión sistemática...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27767254/the-chemiluminescence-immunoassay-for-aflatoxin-b1-based-on-functionalized-magnetic-nanoparticles-with-two-strategies-of-antigen-probe-immobilization
#5
Manwen Yao, Linyu Wang, Chengzhi Fang
A rapid and sensitive chemiluminescence immunoassay (CLIA) based on magnetic nanoparticles (MNPs) was developed to detect aflatoxin B1 (AFB1), which is a potent carcinogen in nature. We prepared monodisperse MNPs (300 nm in diameter) according to the solvothermal synthesis reaction and the MNPs were coated with silica by the Stöber method. Triethox was used as a one-step carboxylation reagent, and 3-aminopropyltriethoxysilane (APTES) an amination reagent, to modify the MNPs. We prepared two types of solid phase antigens using the above synthesized functionalized MNPs coupled with the later prepared AFB1-oxime active ester and the purchased BSA-AFB1 respectively...
June 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/27729930/acute-toxicity-and-cytotoxicity-evaluation-of-dendrobium-moniliforme-aqueous-extract-in-vivo-and-in-vitro
#6
Mu-Jin Lee, Ho-Kyung Jung, Min-Suk Kim, Ji-Hun Jang, Mi-Ok Sim, Tea-Mook Kim, Ho Park, Byung-Kwan Ahn, Hyun-Woo Cho, Jung-Hee Cho, Won-Seok Jung, Jong-Choon Kim
Dendrobium moniliforme (L.) Sw., an herb of the Orchidaceae family, has long been used in traditional medicine to strengthen bones, nourish the stomach, and promote the production of bodily fluid. Recently, polysaccharides isolated from Dendrobium have been used in functional foods and nutraceutical products. A traditional method to process Dendrobium is to soak fresh stems in an ethanol solution, which is the most important factor to ensure high yields of aqueous-extractable polysaccharides. The present study was carried out to investigate the potential acute toxicity of D...
September 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/27549401/fabrication-of-pristine-mn2o3-and-ag-mn2o3-composite-thin-films-by-aacvd-for-photoelectrochemical-water-splitting
#7
Rabia Naeem, Muhammad Ali Ehsan, Rosiyah Yahya, Manzar Sohail, Hamid Khaledi, Muhammad Mazhar
Pristine Mn2O3 and Ag-Mn2O3 composite thin films have been developed on fluorine doped tin oxide (FTO) coated glass substrates at 450 °C by aerosol assisted chemical vapor deposition (AACVD) using a methanol solution of a 1 : 2 mixture of acetatoargentate(i), Ag(CH3COO), and a newly synthesized manganese complex, [Mn(dmae)2(TFA)4] (1) (dmae = N,N-dimethylaminoethanolate, TFA = trifluoroacetate). The phase purity and stoichiometric composition of the films were investigated by X-ray diffraction (XRD) and Raman spectroscopy techniques...
October 14, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27484616/a-multinuclear-metal-complex-based-dnase-mimetic-artificial-enzyme-matrix-cleavage-for-combating-bacterial-biofilms
#8
Zhaowei Chen, Haiwei Ji, Chaoqun Liu, Wei Bing, Zhenzhen Wang, Xiaogang Qu
Extracellular DNA (eDNA) is an essential structural component during biofilm formation, including initial bacterial adhesion, subsequent development, and final maturation. Herein, the construction of a DNase-mimetic artificial enzyme (DMAE) for anti-biofilm applications is described. By confining passivated gold nanoparticles with multiple cerium(IV) complexes on the surface of colloidal magnetic Fe3 O4  /SiO2 core/shell particles, a robust and recoverable artificial enzyme with DNase-like activity was obtained, which exhibited high cleavage ability towards both model substrates and eDNA...
August 26, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27433836/identification-of-telomerase-activating-blends-from-naturally-occurring-compounds
#9
Ghania Ait-Ghezala, Samira Hassan, Miles Tweed, Daniel Paris, Gogce Crynen, Zuchra Zakirova, Stefan Crynen, Fiona Crawford
Context • Telomeres are repeated deoxyribonucleic acid (DNA) sequences (TTAGGG) that are located on the 5' ends of chromosomes, and they control the life span of eukaryotic cells. Compelling evidence has shown that the length of a person's life is dictated by the limited number of times that a human cell can divide. The enzyme telomerase has been shown to bind to and extend the length of telomeres. Thus, strategies for activating telomerase may help maintain telomere length and, thus, may lead to improved health during aging...
June 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27143955/methacryloxylethyl-cetyl-ammonium-chloride-induces-dna-damage-and-apoptosis-in-human-dental-pulp-cells-via-generation-of-oxidative-stress
#10
Yang Jiao, Sai Ma, Yirong Wang, Jing Li, Lequn Shan, Jinlong Sun, Jihua Chen
The polymerizable antibacterial monomer methacryloxylethyl cetyl ammonium chloride (DMAE-CB) has provided an effective strategy to combat dental caries. However, the application of such material raises the question about the biological safety and the question remains open. The mechanism of this toxic action, however, is not yet clearly understood. The present study aims at providing novel insight into the possible causal link between cellular oxidative stress and DNA damage, as well as apoptosis in human dental pulp cells exposed to DMAE-CB...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/26304388/dynamic-microwave-assisted-extraction-combined-with-continuous-flow-microextraction-for-determination-of-pesticides-in-vegetables
#11
Lijie Wu, Mingzhu Hu, Zhanchao Li, Ying Song, Cui Yu, Hanqi Zhang, Aimin Yu, Qiang Ma, Ziming Wang
A simple, rapid, solventless and cost-effective dynamic microwave-assisted extraction (DMAE) combined with continuous-flow microextraction (CFME) system was firstly assembled and validated for extraction of eight organophosphorus pesticides in vegetables. The method combines the advantages of DMAE and CFME, and extends the application of the single drop microextraction to complex solid samples. The extraction, separation, and enrichment were performed in a single step, which could greatly simplify the operation and reduce the whole pretreatment time...
February 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26274909/n-acetyl-cysteine-nac-directed-detoxification-of-methacryloxylethyl-cetyl-ammonium-chloride-dmae-cb
#12
Yang Jiao, Sai Ma, Jing Li, Lequn Shan, Yingjie Wang, Min Tian, Yanwei Yang, Jinlong Sun, Jinghao Ban, Jihua Chen
Methacryloxylethyl cetyl ammonium chloride (DMAE-CB) is a polymerizable antibacterial monomer and has been proved as an effective strategy to achieve bioactive bonding with reliable bacterial inhibitory effects. However, the toxicity of DMAE-CB may hamper its wide application in clinical situations. Thus, this study was designed to investigate the toxicity of DMAE-CB and explore the possible protective effects of N-acetyl cysteine (NAC). High performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) analysis showed that chemical binding of NAC and DMAE-CB occurred in a time dependent manner...
2015: PloS One
https://www.readbyqxmd.com/read/26031849/direct-competitive-chemiluminescence-immunoassays-based-on-gold-coated-magnetic-particles-for-detection-of-chloramphenicol
#13
Xiaohui Liang, Xiangyi Fang, Manwen Yao, Yucong Yang, Junfeng Li, Hongjun Liu, Linyu Wang
Direct competitive chemiluminescence immunoassays (CLIA) based on gold-coated magnetic nanospheres (Au-MNPs) were developed for rapid analysis of chloramphenicol (CAP). The Au-MNPs were modified with carboxyl groups and amino groups by 11-mercaptoundecanoic acid (MUA) and cysteamine respectively, and then were respectively conjugated with CAP base and CAP succinate via an activating reaction using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). NSP-DMAE-NHS, a new and effective luminescence reagent, was employed to label anti-CAP antibody (mAb) as a tracer in direct CLIA for CAP detection using a 'homemade' luminescent measurement system that was set up with a photomultiplier tube (PMT) and a photon counting unit linked to a computer...
February 2016: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/25923376/cationic-polyrotaxanes-as-a-feasible-framework-for-the-intracellular-delivery-and-sustainable-activity-of-anionic-enzymes-a-comparison-study-with-methacrylate-based-polycations
#14
Atsushi Tamura, Go Ikeda, Kei Nishida, Nobuhiko Yui
We have developed cationic polyrotaxanes composed of N,N-dimethylaminoethyl (DMAE) group-modified α-cyclodextrins (α-CDs) threaded along a poly(ethylene glycol) (PEG) chain capped with a terminal bulky stopper (DMAE-PRX) for the intracellular delivery of proteins through the polyelectrolyte complexation. Herein, to ascertain the effect of supramolecular backbone structure of cationic polyrotaxanes, the physicochemical properties and biological activity of polyelectrolyte complex with anionic β-galactosidase (β-gal) were investigated in comparison to a cationic linear polymer, poly[2-(N,N-dimethylaminoethyl) methacrylate] (PDMAEMA)...
August 2015: Macromolecular Bioscience
https://www.readbyqxmd.com/read/25618681/integrated-microwave-processing-system-for-the-extraction-of-organophosphorus-pesticides-in-fresh-vegetables
#15
Lijie Wu, Ying Song, Mingzhu Hu, Xu Xu, Hanqi Zhang, Aimin Yu, Qiang Ma, Ziming Wang
A simple and efficient integrated microwave processing system (IMPS) was firstly assembled and validated for the extraction of organophosphorus pesticides in fresh vegetables. Two processes under microwave irradiation, dynamic microwave-assisted extraction (DMAE) and microwave-accelerated solvent elution (MASE), were integrated for simplifying the pretreatment of the sample. Extraction, separation, enrichment and elution were finished in a simple step. The organophosphorus pesticides were extracted from the fresh vegetables into hexane with DMAE, and then the extract was directly introduced into the enrichment column packed with active carbon fiber (ACF)...
March 2015: Talanta
https://www.readbyqxmd.com/read/25443092/contribution-of-arsenic-species-in-unicellular-algae-to-the-cycling-of-arsenic-in-marine-ecosystems
#16
REVIEW
Elliott G Duncan, William A Maher, Simon D Foster
This review investigates the arsenic species produced by and found in marine unicellular algae to determine if unicellular algae contribute to the formation of arsenobetaine (AB) in higher marine organisms. A wide variety of arsenic species have been found in marine unicellular algae including inorganic species (mainly arsenate--As(V)), methylated species (mainly dimethylarsenate (DMA)), arsenoribosides (glycerol, phosphate, and sulfate) and metabolites (dimethylarsenoethanol (DMAE)). Subtle differences in arsenic species distributions exist between chlorophyte and heterokontophyte species with As(V) commonly found in water-soluble cell fractions of chlorophyte species, while DMA is more common in heterokontophyte species...
January 6, 2015: Environmental Science & Technology
https://www.readbyqxmd.com/read/25133239/effects-of-dimethylaminoethanol-and-compound-amino-acid-on-d-galactose-induced-skin-aging-model-of-rat
#17
Su Liu, Zhenyu Chen, Xia Cai, Ying Sun, Cailing Zhao, Fangjun Liu, Dalie Liu
A lasting dream of human beings is to reverse or postpone aging. In this study, dimethylaminoethanol (DMAE) and compound amino acid (AA) in Mesotherapy were investigated for their potential antiaging effects on D-galactose induced aging skin. At 18 days after D-gal induction, each rat was treated with intradermal microinjection of saline, AA, 0.1% DMAE, 0.2% DMAE, 0.1% DMAE + AA, or 0.2% DMAE + AA, respectively. At 42 days after treatment, the skin wound was harvested and assayed. Measurement of epidermal and dermal thickness in 0...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/24756425/semiconducting-composite-oxide-y2cuo4-5cuo-thin-films-for-investigation-of-photoelectrochemical-properties
#18
Sohail Ahmed, Muhammad Adil Mansoor, Muhammad Mazhar, Tilo Söhnel, Hamid Khaledi, Wan Jefrey Basirun, Zainudin Arifin, Shahzad Abubakar, Bakhtiar Muhammad
An octa-nuclear heterobimetallic complex [Y2Cu6Cl0.7(dmae)6(OAc)7.3(OH)4(H2O)2]·3H2O·0.3CH3C6H5 (dmae = dimethylaminoethanoate; OAc = acetato) was synthesized, characterized by melting point analysis, elemental analysis, FT-IR, and single crystal X-ray diffraction analysis and implemented at 600 °C under an oxygen atmosphere for the deposition of Y2CuO4-5CuO composite thin films by aerosol assisted chemical vapor deposition (AACVD). The chemical composition and surface morphology of the deposited thin film have been determined by X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis that suggest the formation of impurity-free crystallite mixtures of the Y2CuO4-5CuO composite, with well-defined evenly distributed particles in the size range of 19-24 nm...
June 14, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/24590497/comprehensive-evaluation-of-the-physicochemical-properties-of-ln-iii-complexes-of-aminoethyl-do3a-as-ph-responsive-t-1-mri-contrast-agents
#19
Zsolt Baranyai, Gabriele A Rolla, Roberto Negri, Attila Forgács, Giovanni B Giovenzana, Lorenzo Tei
N-Substituted aminoethyl groups were attached to 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A) with the aim to design pH-responsive Ln(III) complexes based on the pH-dependent on/off ligation of the amine nitrogen to the metal ion. The following ligands were synthesized: AE-DO3A (aminoethyl-DO3A), MAE-DO3A (N-methylaminoethyl-DO3A), DMAE-DO3A (N,N-dimethylaminoethyl-DO3A) and MEM-AE-DO3A (N-methoxyethyl-N-methylaminoethyl-DO3A). The physicochemical properties of the Ln(III) complexes were investigated for the evaluation of their potential applicability as magnetic resonance imaging (MRI) contrast agents...
March 3, 2014: Chemistry: a European Journal
https://www.readbyqxmd.com/read/24112803/a-ph-and-thermosensitive-choline-phosphate-based-delivery-platform-targeted-to-the-acidic-tumor-microenvironment
#20
Xifei Yu, Xiaoqiang Yang, Sonja Horte, Jayachandran N Kizhakkedathu, Donald E Brooks
Solid tumors generally exhibit an acidic microenvironment which has been recognized as a potential route to distinguishing tumor from normal tissue for purposes of drug delivery or imaging. To this end we describe a pH and temperature sensitive polymeric adhesive that can be derivatized to carry drugs or other agents and can be tuned synthetically to bind to tumor cells at pH 6.8 but not at pH 7.4 at 37 °C. The adhesive is based on the universal reaction between membrane phosphatidyl choline (PC) molecules and polymers derivatized with multiple copies of the inverse motif, choline phosphate (CP)...
January 2014: Biomaterials
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