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REVIEW
Walusa A Gonçalves-Ferri, Agnes A S Albuquerque, Patricia Martinez Evora, Paulo R B Evora
The present review was carried out to describe publications on the use of methylene blue (MB) in pediatrics and neonatology, discussing dose, infusion rate, action characteristics, and possible benefits for a pediatric patient group. The research was performed on the data sources PubMed, BioMed Central, and Embase (updated on Aug 31, 2020) by two independent investigators. The selected articles included human studies that evaluated MB use in pediatric or neonatal patients with vasoplegia due to any cause, regardless of the applied methodology...
2022: Current Pediatric Reviews
#22
REVIEW
Abdullah Khalid Omer, Rebin Rafaat Mohammed, Peshraw S Mohammed Ameen, Zaniar Ali Abas, Kamil Ekici
Essential foods as part of a daily meal may include numerous kinds of biogenic amines (BAs) at various concentrations. BAs have a variety of toxicological effects on human health and have been linked to multiple outbreaks of foodborne disease. BAs also are known to cause cancer based on their ability to react with nitrite salts, resulting in the production of carcinogenic organic compounds (nitrosamines). Ingestion of large quantities of BAs in food causes toxicological effects and health disorders, including psychoactive, vasoactive, and hypertensive effects and respiratory, gastrointestinal, cardiovascular, and neurological disorders...
September 1, 2021: Journal of Food Protection
#23
JOURNAL ARTICLE
Lanfranco Pellesi, Mohammad Al-Mahdi Al-Karagholi, Roberto De Icco, Hande Coskun, Fatima Azzahra Elbahi, Cristina Lopez-Lopez, Josefin Snellman, Jens Hannibal, Faisal Mohammad Amin, Messoud Ashina
Importance: Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) are structurally and functionally related, yet different in their migraine-inducing properties. It remains unclear whether the lack of migraine induction can be attributed to the only transient vasodilatory response after a 20-minute infusion of VIP. Objective: To determine whether a 2-hour infusion of VIP would provoke migraine attacks. Design, Setting, and Participants: A randomized, double-blind, placebo-controlled, crossover study was conducted between May and September 2020 at the Danish Headache Center in Copenhagen, Denmark...
August 2, 2021: JAMA Network Open
#24
JOURNAL ARTICLE
Igor Dias, Marta Laranjo, Maria Eduarda Potes, Ana Cristina Agulheiro-Santos, Sara Ricardo-Rodrigues, Ana Rita Fialho, Joana Véstia, Maria J Fraqueza, Margarida Oliveira, Miguel Elias
Dry-cured sausages are traditional in Mediterranean countries, and Paio do Alentejo (PA) is one of the most popular in South Portugal. The aim of the present work was to evaluate the effect of combined starters on the safety and quality of PA preserving its sensory quality. Physicochemical parameters, namely pH and water activity (aW ), microbiological parameters, biogenic amines, color, texture, and sensory attributes were assessed. Three starter cultures were used, namely Staphylococcus equorum S2M7 and Lactobacillus sakei CV3C2, both separate and combined with the 2RB4 yeast strain at a concentration of 106 cfu/g...
July 2, 2021: International Journal of Environmental Research and Public Health
#25
Mohammed Mahdi, Muhammet Ozer, Muhammad Tahseen
The critical state of circulatory collapse and hypoperfusion that results in end-organ damage has been called shock. Carcinoid crisis is a rare cause of shock, which is difficult to identify in the presence of infection. It occurs due to the release of vasoactive amines into the systemic circulation following an inciting event. In the presence of a neuroendocrine tumor, carcinoid crisis should be suspected in case of resistant shock. Herein, we report a rare case of carcinoid crisis, in which a quick response to the somatostatin analog therapy, octreotide, was helpful to confirm the diagnosis...
June 2021: Curēus
#26
RANDOMIZED CONTROLLED TRIAL
Jean Reignier, Amélie Le Gouge, Jean-Baptiste Lascarrou, Djillali Annane, Laurent Argaud, Yannick Hourmant, Pierre Asfar, Julio Badie, Mai-Anh Nay, Nicolae-Vlad Botoc, Laurent Brisard, Hoang-Nam Bui, Delphine Chatellier, Louis Chauvelot, Alain Combes, Christophe Cracco, Michael Darmon, Vincent Das, Matthieu Debarre, Agathe Delbove, Jérôme Devaquet, Sebastian Voicu, Nadia Aissaoui-Balanant, Louis-Marie Dumont, Johanna Oziel, Olivier Gontier, Samuel Groyer, Bertrand Guidet, Samir Jaber, Fabien Lambiotte, Christophe Leroy, Philippe Letocart, Benjamin Madeux, Julien Maizel, Olivier Martinet, Frédéric Martino, Emmanuelle Mercier, Jean-Paul Mira, Saad Nseir, Walter Picard, Gael Piton, Gaetan Plantefeve, Jean-Pierre Quenot, Anne Renault, Laurent Guérin, Jack Richecoeur, Jean Philippe Rigaud, Francis Schneider, Daniel Silva, Michel Sirodot, Bertrand Souweine, Florian Reizine, Fabienne Tamion, Nicolas Terzi, Didier Thévenin, Guillaume Thiéry, Nathalie Thieulot-Rolin, Jean-François Timsit, François Tinturier, Patrice Tirot, Thierry Vanderlinden, Isabelle Vinatier, Christophe Vinsonneau, Diane Maugars, Bruno Giraudeau
INTRODUCTION: International guidelines include early nutritional support (≤48 hour after admission), 20-25 kcal/kg/day, and 1.2-2 g/kg/day protein at the acute phase of critical illness. Recent data challenge the appropriateness of providing standard amounts of calories and protein during acute critical illness. Restricting calorie and protein intakes seemed beneficial, suggesting a role for metabolic pathways such as autophagy, a potential key mechanism in safeguarding cellular integrity, notably in the muscle, during critical illness...
May 11, 2021: BMJ Open
#27
JOURNAL ARTICLE
Ana María González-Castillo, Juan Sancho-Insenser, Maite De Miguel-Palacio, Josep-Ricard Morera-Casaponsa, Estela Membrilla-Fernández, María-José Pons-Fragero, Miguel Pera-Román, Luis Grande-Posa
BACKGROUND: Acute calculous cholecystitis (ACC) is the second most frequent surgical condition in emergency departments. The recommended treatment is the early laparoscopic cholecystectomy; however, the Tokyo Guidelines (TG) advocate for different initial treatments in some subgroups of patients without a strong evidence that all patients will benefit from them. There is no clear consensus in the literature about who is the unfit patient for surgical treatment. The primary aim of the study is to identify the risk factors for mortality in ACC and compare them with Tokyo Guidelines (TG) classification...
May 11, 2021: World Journal of Emergency Surgery: WJES
#28
JOURNAL ARTICLE
Abdullah Omer, Rebin Rafaat Mohammed, Peshraw S Mohammed Ameen, Zaniar Ali Abas, Kamil Ekici
Essential foods of a daily meal have been reported to comprise of numerous kinds of biogenic amines (BAs) at different levels. BAs have a variety of toxicological impacts on human health, and they have been connected to multiple outbreaks of foodborne disease. They also are known to cause cancer based on their ability to react with nitrite salts resulting in the production of a carcinogenic organic compound (i.e. nitrosamines). BAs toxicity is often linked to the ingestion of large quantities of BAs in food that causes toxicological threats and health disorders and has psychoactive, vasoactive, and hypertensive effects and can cause respiratory, gastrointestinal, cardiovascular and neurological disorders...
May 6, 2021: Journal of Food Protection
#29
RANDOMIZED CONTROLLED TRIAL
A Bichon, J Carvelli, J Bourenne, M Gainnier, J-R Harlé, N Schleinitz
INTRODUCTION: Idiopathic systemic capillary leak syndrome (ISCLS) also known as Clarkson syndrome is a rare and sudden life-threatening entity. Three consecutive phases are described. A first non-specific prodromal phase often manifests as "flu-like" symptoms and precedes capillary leak phase with major hypovolemic and distributive shock leading to serious and frequent multiorgan dysfunction syndrome (MODS). Severe hypovolemia contrasts with edema, and hemoconcentration with hypoalbuminemia...
September 2021: La Revue de Médecine Interne
#30
JOURNAL ARTICLE
Mohammed E Draz, Hany W Darwish, Ibrahim A Darwish, Ahmed S Saad
Tyramine (TYR) is a vasoactive biogenic amine found in food products due to improper storage and poor hygiene. High TYR intake results in a wide range of life-threatening physiological reactions. The work optimizes a solid-state potentiometric sensor in the absence of a reported potentiometric method for rapid and direct TYR assay. The optimization study included thirteen membrane cocktails of different compositions. The optimized sensor proved a near-Nernstian slope of 57.30 mV/decade, a quantification limit of 10...
December 26, 2020: Food Chemistry
#31
JOURNAL ARTICLE
Elisangela da Costa Lima, Barbara Dias Camarinha, Nathalia Cristina Ferreira Bezerra, Anderson Gonçalves Panisset, Raquel Belmino de Souza, Marcus Tolentino Silva, Luciane Cruz Lopes
Children are exposed to drug-drug interactions (DDI) risks due to their organism's complexity and the need for several medicines prescriptions in pediatric intensive care units (PICU). This study aimed to assess the prevalence of potential DDIs in a Brazilian PICU. We carried out a cross-sectional study at a pediatric teaching hospital from Rio de Janeiro (Brazil) over one year. Potential DDIs (pDDIs) between prescribed medicines for hospitalized children in PICU ( n = 143) were analyzed according to severity using Micromedex® ...
2020: Frontiers in Pharmacology
#32
JOURNAL ARTICLE
Dudy Arman Hanafy, I Komang Adhi Parama Harta, I Made Indra Prasetya, Pribadi Wiranda Busroh, Tri Wisesa Soetisna, Sugisman, Dicky Aligheri Wartono, Amin Tjubandi, Bagus Herlambang
BACKGROUND: Based on our previous pilot study, systemic inflammatory response syndrome is more common in off-pump compared to on-pump coronary artery bypass. Therefore, we conducted a clinical trial of dexamethasone in patients undergoing off-pump coronary artery bypass. METHODS: Sixty consecutive patients undergoing off-pump coronary artery bypass were enrolled from August 2018 to January 2019 and randomized to a dexamethasone or placebo group of 30 each. Clinical outcomes were analyzed...
December 1, 2020: Asian Cardiovascular & Thoracic Annals
#33
JOURNAL ARTICLE
Andrew P AhYoung, Sterling C Eckard, Alvin Gogineni, Hongkang Xi, S Jack Lin, Stefan Gerhardy, Christian Cox, Qui T Phung, Jason A Hackney, Anand Kumar Katakam, Mike Reichelt, Patrick Caplazi, Paolo Manzanillo, Juan Zhang, Merone Roose-Girma, Lucinda W Tam, Robert J Newman, Aditya Murthy, Robby M Weimer, Jennie R Lill, Wyne P Lee, Michele Grimbaldeston, Daniel Kirchhofer, Menno van Lookeren Campagne
Vascular leakage, or edema, is a serious complication of acute allergic reactions. Vascular leakage is triggered by the release of histamine and serotonin from granules within tissue-resident mast cells. Here, we show that expression of Neutrophil Serine Protease 4 (NSP4) during the early stages of mast cell development regulates mast cell-mediated vascular leakage. In myeloid precursors, the granulocyte-macrophage progenitors (GMPs), loss of NSP4 results in the decrease of cellular levels of histamine, serotonin and heparin/heparan sulfate...
November 19, 2020: Communications Biology
#34
EDITORIAL
P Conti, Al Caraffa, G Tetè, C E Gallenga, R Ross, S K Kritas, I Frydas, A Younes, P Di Emidio, G Ronconi
SARS-CoV-2 virus is an infectious agent commonly found in certain mammalian animal species and today also in humans. SARS-CoV-2, can cause a pandemic infection with severe acute lung injury respiratory distress syndrome in patients with COVID-19, that can lead to patient death across all ages. The pathology associated with pandemic infection is linked to an over-response of immune cells, including virus-activated macrophages and mast cells (MCs). The local inflammatory response in the lung that occurs after exposure to SARS-CoV-2 is due to a complex network of activated inflammatory innate immune cells and structural lung cells such as bronchial epithelial cells, endothelial cells and fibroblasts...
September 2020: Journal of Biological Regulators and Homeostatic Agents
#35
JOURNAL ARTICLE
Cibelle Ferreira Louzada, Alexandre Rodrigues Ferreira
OBJECTIVE: To assess the prevalence of acute kidney injury in pediatric intensive care unit (PICU) according to diagnostic criteria - pediatric risk, injury, failure, loss, end-stage renal disease (pRIFLE), Acute Kidney Injury Network (AKIN) and Acute Kidney Injury Work Group, or Kidney Disease: Improving Global Outcomes (KDIGO) -, and determining factors associated with acute kidney injury as well as its outcome. METHODOLOGY: This was a cross-sectional monocentric observational study, including patients aged between 29 days and 17 years who were admitted to the PICU between January 1, 2012 and December 31, 2016...
September 10, 2020: Jornal de Pediatria
#36
JOURNAL ARTICLE
Igor Rakoczy, Marzena Ocetek, Marzena Wiatr, Patrycja Zięba, Michał Panek, Piotr Kuna
The aim:The article describes and summarizes the immunological pathomechanisms controlling the development of non-necrotizing granulomas in the course of non-specific inflammatory bowel diseases (IBD) in lungs and intestines; it also reviews the possible clinical correlations between the processes in the gastrointestinal and respiratory tracts based on the example of Crohn's disease (CD) and non-specific inflammatory bowel disease (IBC). While the dominant cell subpopulation in ulcerative colitis (UC) is Th2, which produces interleukins IL-4, IL-5, IL-6, IL-10 and IL-13 and Th17 cells; CD characterized by the Th1 cell subpopulation and macrophages predominate, producing IL-23...
2020: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
#37
JOURNAL ARTICLE
Lanfranco Pellesi, Mohammad Al-Mahdi Al-Karagholi, Basit Ali Chaudhry, Cristina Lopez Lopez, Josefin Snellman, Jens Hannibal, Faisal Mohammad Amin, Messoud Ashina
BACKGROUND: In recent years, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptides (PACAPs) have gained special interest in headache science. VIP and PACAPs (two isoforms, PACAP27 and PACAP38) are related in structure and function, as are their receptors, but they show differences in vasodilating- and headache-inducing properties. Intravenous infusion of PACAP27 or PACAP38, but not VIP, induces a long-lasting dilation of cranial arteries and delayed headache...
October 2020: Cephalalgia: An International Journal of Headache
#38
REVIEW
Abhay Ps Rathore, Ashley L St John
Mast cells (MCs) are long-lived immune cells. They are armed with preformed mediators within granules that can be instantaneously released in response to an invading pathogen, including certain viruses. At the skin and mucosae, they initiate innate immune responses and promote the development of adaptive immune responses, through cellular recruitment or antigen presentation. However, systemic MC activation may promote immune pathologies through their vasoactive proteases and biogenic amines. Recently, MC products were identified to contribute to pathologies associated with viral hemorrhagic fever, such vascular leakage and thrombocytopenia...
October 2020: Current Opinion in Immunology
#39
JOURNAL ARTICLE
Fernanda Virginia Barreto Mota, Marlene Saraiva de Araújo Neta, Eryvelton de Souza Franco, Isla Vanessa Gomes Alves Bastos, Larissa Cardoso Correia da Araújo, Sandra Cabral da Silva, Tatiane Bezerra de Oliveira, Eduarda Karynne Souza, Valderes Moraes de Almeida, Rafael Matos Ximenes, Maria Bernadete de Sousa Maia, Francisco Jaime Bezerra Mendonça Junior, Pascal Marchand, Antônio Rodolfo de Faria, Teresinha Gonçalves da Silva
The aim of this study was to investigate the anti-inflammatory effects of two new isoxazoline-acylhydrazone derivatives: N '-(4-methoxybenzylidene)-6-(4-nitro-benzoyl)-3 a ,5,6,6 a -tetrahydro-4 H -pyrrolo[3,2- d ]isoxazole-3-carbohydrazide (R-123) and N '-(4-chlorobenzylidene)-6-(4-chlorobenzoyl)-3 a ,5,6,6 a -tetrahydro-4 H -pyrrolo[3,2- d ]isoxazole-3-carbohydrazide (R-99). An air pouch induced by carrageenan was used for screening the best dose of R-99 and R-123. Using this mouse model, leukocyte migration and cytokine levels (TNF-α and IL-1β) were determined...
November 1, 2019: MedChemComm
#40
REVIEW
Ronan Lordan, Alexandros Tsoupras, Ioannis Zabetakis, Constantinos A Demopoulos
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced histamine release from rabbit platelets producing antibodies in passive cutaneous anaphylaxis. Henson described a 'soluble factor' released from leukocytes that induced vasoactive amine release in platelets. Later observations by Siraganuan and Osler observed the existence of a diluted substance that had the capacity to cause platelet activation. In 1972, the term platelet-activating factor (PAF) was coined by Benveniste, Henson, and Cochrane...
December 3, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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