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Rakshit K Devappa, Harinder P S Makkar, Klaus Becker
Jatropha is a nonedible oil seed plant belonging to Euphorbiaceae family. Global awareness of sustainable and alternative energy resources has propelled research on Jatropha oil as a feedstock for biodiesel production. During the past two decades, several cultivation projects were undertaken to produce Jatropha oil. In future, the increased cultivation of toxic Jatropha plants and utilization of its agro-industrial by-products may raise the frequency of contact with humans, animals, and other organisms. An attempt was thus made to present known information on toxicity of Jatropha plants...
August 2010: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Manfred Kietzmann, Wolfgang Bäumer
By treatment of single animals or a live stock a treatment regimen has to be chosen, which guarantees a sufficient concentration of the administered drug in the target tissue. On the other hand, particular care has to be taken to avoid that single animals get a too high, intolerable dose of the administered drug. These elementary requirements must be met by the attending veterinarian.The treatment schedule must be in line with the current phamaceutical law. Some of the most outstanding problems associated with application via feed and water are discussed...
June 2009: DTW. Deutsche Tierärztliche Wochenschrift
Cécile Raynal, Thierry Lefebvre
After the presentation of the history of the growing of artificial mineral waters in France, the authors explain the pharmacists' functions in the production of Soda-waters. To illustrate their purpose, they use documents deposited in the Yvelines departemental archives.
January 2007: Revue D'histoire de la Pharmacie
Khitam Muhsen, Abed Athamna, Muhammad Athamna, Anya Spungin-Bialik, Dani Cohen
We conducted a community-based study among 159 healthy Israeli Arab children aged 3 to 5 years old to examine the validity of the HpELISA kit (URINELISA, Otuska Phamaceuticals Co, Ltd, Tokyo, Japan) for detection Helicobacter pylori IgG antibodies in urine. The polyclonal H. pylori stool antigen test (Premier HpSA) served as the gold standard. The sensitivity, specificity, positive and negative predictive values of the URINELISA kit were 34.2%, 96.3%, 90% and 60%, respectively. Using a cutoff value calculated based on the receiver operating characteristic curve (0...
September 2006: Journal of Pediatric Gastroenterology and Nutrition
Renáta Ovádeková, Sona Jantová, Marica Theiszová, Ján Labuda
Quinazolines - 1,3-benzodiazines are biological active compounds, which are used in the phamaceutical industry, in agriculture and in the medicine. As documented in the literature, many derivatives demonstrated anticancer activity and they act as multitarget agents. 3-(5-Nitro-2-thienyl)-9-chloro-5-morpholin-4-yl[1,2,4]triazolo[4,3-c] quinazoline (NTCHMTQ) - a new synthetically prepared quinazoline derivative was the most effective derivative in our primary cytotoxic screening. In this study, we evaluated cytotoxic/antiproliferative activity of NTCHMTQ using human tumor cell line HeLa...
December 2005: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
J-M Descoutures
In the last fifteen years, the preparation of antineoplastic agents has tended to be centralized in the hospital pharmacy for two main reasons: to enable better protection for the staff, to enable better safety for the patient. The consequences of this organization have led to standardization of techniques, implementation of a quality system and also a better use of antineoplastic agents. After protocols have been standardized by the physician and validated by the pharmacist, four main steps are necessary: phamaceutical validation of the prescription, preparation of IV admixtures according to a production file, control of the final product, dispatching of the preparation to the patient...
January 2006: Annales Pharmaceutiques Françaises
Y Ren, W Li, J Shen, R Ren, Y Shun, M Li, L Zhang
The possibility of using near-infrared reflectance spectroscopy for the evaluating quality of analgini powder pharmaceuticals was investigated. We used the multivariate statistical classification technique to identify true, poor and false phamaceuticals of analgini from their first derivative spectra successfully. The results are satisfactory.
June 1997: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
J D Burek, J A Majka, D L Bokelman
Extensive preclinical safety studies with famotidine were performed or sponsored by Yamanouchi Phamaceutical Co, Ltd, Tokyo, Japan, and Merck, Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. These studies were performed in dogs, rats, mice and rabbits, receiving oral and intravenous administration of the compound. Minimal toxicologic effects (after acute, subacute, or chronic administration) have been observed even at extremely high dosage levels (4,000 mg/kg/day) and for extended periods of administration (2,000 mg/kg/day for 105 weeks)...
1985: Digestion
G V Pakholkov, A P Arzamastsev
No abstract text is available yet for this article.
March 1975: Farmatsiia
P P DeLuca
The development of a suitable formulation and a freeze-dry cycle for a pharmaceutical dosage form requires knowledge of some basic properties such as (1) eutectic temperature, if one exists, (2) temperature effect on solubility, (3) degree of supercooling, (4) heat transfer properties of the frozen product and (5) equipment design and equipment capability. Basic work with several inorganic and organic salts shows that eutectic temperature is a function of the melting point and the differential heat of solution of a drug...
October 1976: Developments in Biological Standardization
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