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Blood pressure, pulse pressure, end organ damage

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https://www.readbyqxmd.com/read/27900498/central-hemodynamics-and-arterial-stiffness-in-idiopathic-and-multiple-system-atrophy
#1
Klaas Franzen, Sabine Fliegen, Jelena Koester, Rafael Campos Martin, Günther Deuschl, Michael Reppel, Kai Mortensen, Susanne A Schneider
Blood pressure is commonly abnormal in parkinsonian disorders, but central hemodynamics and arterial stiffness, well-established predictors of total cardiovascular risk, have rarely been studied in these disorders. 32 patients [27 with idiopathic Parkinson's disease (iPD); 5 with multiple system atrophy (MSA)] and 15 controls matched for cardiac risk factors underwent 24 h-ambulatory blood pressure recordings using an I.E.M. device (Mobil-O-Graph™), measuring peripheral pressure and calculating central pressures and arterial stiffness...
November 29, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27815929/challenges-in-the-management-of-hypertension-in-older-populations
#2
Lisa Pont, Tariq Alhawassi
The prevalence of hypertension increases with age making it a significant health concern for older persons. Aging involves a range of physiological changes such as increases in arterial stiffness, widening pulse pressure, changes in renin and aldosterone levels, decreases in renal salt excretion, declining in renal function, changes in the autonomic nervous system sensitivity and function and changes to endothelial function all of which may not only affect blood pressure but may also affect individual response to pharmacotherapy used to manage hypertension and prevent end organ damage and other complications associated with poor blood pressure control...
November 5, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27754006/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#3
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753950/os-07-06-the-association-between-home-versus-ambulatory-nighttime-blood-pressure-and-end-organ-damage-in-the-general-population
#4
Annika Lindroos, Jouni Johansson, Pauli Puukka, Ilkka Kantola, Veikko Salomaa, Eeva Juhanoja, Sam Sivén, Pekka Jousilahti, Antti Jula, Teemu Niiranen
OBJECTIVE: The aim of this study was to test the agreement between nighttime home and nighttime ambulatory blood pressure (BP) and to compare their associations with hypertensive end-organ damage for the first time in the general population. DESIGN AND METHOD: A population sample of 248 participants underwent measurements for nighttime home BP (3 measurements on 2 nights with a timer-equipped home device), nighttime ambulatory BP, pulse wave velocity (PWV), carotid intima-media thickness (IMT) and echocardiographic left ventricular mass index (LVMI)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753855/hw-01-3-cardiac-and-vascular-mri-in-hypertension-evaluation
#5
Sang-Chol Lee
Chronic hypertension can result in deleterious effects on various vascular organs including the heart and vessels. Cardiovascular magnetic resonance (CMR) has the unique advantage of the ability to assess ventricular volumes and function, valvular abnormalities, vascular pathology, myocardial perfusion and tissue characterization with high accuracy and reproducibility and also avoid the risk of radiation. As this is the case, CMR seems to be an ideal method for comprehensive assessment of patients with systemic hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27651468/albuminuria-and-masked-uncontrolled-hypertension-in-chronic-kidney-disease
#6
Rajiv Agarwal
BACKGROUND: Masked uncontrolled hypertension (MUCH) is associated with greater target organ damage such as left ventricular hypertrophy, increased arterial stiffness and albuminuria. Whether MUCH independently associates with greater cardiovascular end-organ damage or kidney damage is unclear. The objective of this study was to assess the strength of the relationship of MUCH (awake ambulatory blood pressure ≥135/85 mmHg and clinic blood pressure <140/90 mmHg) with target organ damage...
September 20, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27643345/os-07-06-the-association-between-home-versus-ambulatory-nighttime-blood-pressure-and-end-organ-damage-in-the-general-population
#7
Annika Lindroos, Jouni Johansson, Pauli Puukka, Ilkka Kantola, Veikko Salomaa, Eeva Juhanoja, Sam Sivén, Pekka Jousilahti, Antti Jula, Teemu Niiranen
OBJECTIVE: The aim of this study was to test the agreement between nighttime home and nighttime ambulatory blood pressure (BP) and to compare their associations with hypertensive end-organ damage for the first time in the general population. DESIGN AND METHOD: A population sample of 248 participants underwent measurements for nighttime home BP (3 measurements on 2 nights with a timer-equipped home device), nighttime ambulatory BP, pulse wave velocity (PWV), carotid intima-media thickness (IMT) and echocardiographic left ventricular mass index (LVMI)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643092/hw-01-3-cardiac-and-vascular-mri-in-hypertension-evaluation
#8
Sang-Chol Lee
Chronic hypertension can result in deleterious effects on various vascular organs including the heart and vessels. Cardiovascular magnetic resonance (CMR) has the unique advantage of the ability to assess ventricular volumes and function, valvular abnormalities, vascular pathology, myocardial perfusion and tissue characterization with high accuracy and reproducibility and also avoid the risk of radiation. As this is the case, CMR seems to be an ideal method for comprehensive assessment of patients with systemic hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642917/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#9
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27579902/ambulatory-versus-clinic-blood-pressure-in-predicting-overall-subclinical-target-organ-damage-progression-in-essential-hypertensive-patients-a-3-year-follow-up-study
#10
Yan Yang, Jian-Zhong Xu, Yan Wang, Ping-Jin Gao
BACKGROUND: Ambulatory blood pressure (BP) was shown to predict specific subclinical target organ damage (TOD) progression better than clinic BP, whereas the usefulness of ambulatory and clinic BP measurements to predict overall TOD progression is not well established. METHODS AND RESULTS: Clinic and 24-h ambulatory BP values were obtained in 280 patients on baseline. A total of 199 participants (mean age 62.5±9.5, 59.3% men) were followed up for an average of 39 months and overall subclinical TOD were recorded at the end of follow-up period...
August 30, 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27508780/-op-6b-07-nighttime-blood-pressure-measured-with-a-timer-equipped-home-device-an-alternative-to-ambulatory-monitoring
#11
A Lindroos, A Jula, P Puukka, I Kantola, V Salomaa, E Juhanoja, S Sivén, P Jousilahti, J Johansson, T Niiranen
OBJECTIVE: Our objective was to test the agreement between nighttime home and nighttime ambulatory blood pressure (BP) and to compare their associations with left ventricular hypertrophy, arterial stiffness and carotid atherosclerosis. DESIGN AND METHOD: A population sample of 248 participants underwent measurements for 24-hour ambulatory BP and nighttime home BP (3 measurements at 2, 3 and 4 hours during 2 nights). We measured ambulatory BP with a Microlife WatchBP O3 device and home BP with a timer-equipped Microlife WatchBP Home N device...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508736/-op-5b-02-pulse-pressure-amplification-and-aortic-reflected-wave-magnitude-but-not-aortic-pressures-or-augmentation-indices-add-to-brachial-pulse-pressure-associations-with-end-organ-changes
#12
G Norton, M J Sibiya, H L Booysen, G Tade, I Ballim, P Sareli, A J Woodiwiss
OBJECTIVE: Although several indices of aortic pressure are associated with cardiovascular damage independent of brachial blood pressure (BP), those indices which enhance associations beyond brachial BP are uncertain. We aimed to identify those aortic pressure indices that best enhance brachial BP relations with end-organ measures. DESIGN AND METHOD: Aortic function was determined using radial applanation tonometry and SphygmoCor software in 1197 community participants...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508596/-op-lb03-07-effects-of-lercanidipine-enalapril-compared-with-amlodipine-enalapril-and-hydrochlorothiazide-enalapril-on-target-organ-damage-and-sympathetic-activity-in-hypertension
#13
C Tsioufis, A Kasiakogias, K Dimitriadis, T Kalos, I Liatakis, D Konstantinidis, E Andrikou, L Nikolopoulou, E Vlachos, K Kyriazopoulos, D Tousoulis
OBJECTIVE: The aim of the study is to compare in essential hypertensives the effects of lercanidipine/enalapril versus amlodipine/enalapril and enalapril/hydrochlorothiazide on various target organ damage end-points as well as on sympathetic nervous system activation during a follow-up period of 3 months. DESIGN AND METHOD: We studied 56 untreated patients with essential hypertension stage II [age: 56 ± 10 years, 30 males, office blood pressure (BP): 148/92 ± 14/11 mmHg] who were randomized to lercanidipine 10 mg/enalapril 20 mg (once daily) or amlodipine 5 mg/enalapril 20 mg (once daily) or enalapril 20 mg/hydrochlorothiazide 12...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27348519/the-association-between-home-vs-ambulatory-night-time-blood-pressure-and-end-organ-damage-in-the-general-population
#14
Annika S Lindroos, Jouni K Johansson, Pauli J Puukka, Ilkka Kantola, Veikko Salomaa, Eeva P Juhanoja, Sam S E Sivén, Pekka Jousilahti, Antti M Jula, Teemu J Niiranen
OBJECTIVE: The aim of this study was to test the agreement between night-time home and night-time ambulatory blood pressure (BP) and to compare their associations with hypertensive end-organ damage for the first time in the general population. METHODS: A population sample of 248 participants underwent measurements for night-time home BP (three measurements on two nights with a timer-equipped home device), night-time ambulatory BP, pulse wave velocity (PWV), carotid intima-media thickness (IMT) and echocardiographic left ventricular mass index (LVMI)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27195237/determinants-and-prognostic-significance-of-the-renal-resistive-index
#15
REVIEW
Nicholas Cauwenberghs, Tatiana Kuznetsova
BACKGROUND: The noninvasive assessment of renal hemodynamics is currently possible by assessing the renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as (peak systolic velocity - end-diastolic velocity)/peak systolic velocity. In this review, we outline the important determinants of the RRI to clarify the true identity of the RRI and highlight its potential diagnostic and prognostic value in renal and cardiovascular pathology. SUMMARY: Although the RRI was initially considered to reflect intrarenal vascular pathological processes, this index is actually a product of a complex interaction between renal and systemic vascular wall properties and hemodynamic factors...
April 2016: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/26911232/usefulness-of-the-second-derivative-of-the-finger-photoplethysmogram-for-assessment-of-end-organ-damage-the-j-shipp-study
#16
Yasuharu Tabara, Michiya Igase, Yoko Okada, Tokihisa Nagai, Tetsuro Miki, Yasumasa Ohyagi, Fumihiko Matsuda, Katsuhiko Kohara
Early detection of pathological changes in the vasculature is required to identify individuals at risk of cardiovascular diseases. Noninvasive measurement of the second derivative of photoplethysmogram (SDPTG) might aid in evaluating vascular aging. Here we clarified the diagnostic significance of four SDPTG indices for end-organ damage. A total of 1613 community residents (65±10 years) were enrolled. Changes in blood flow volume at the forefinger were measured by photoplethysmography. SDPTG was computationally calculated from the plethysmogram, and the height of five peaks (a-e) on the SDPTG was measured...
July 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/26337967/the-internist-and-the-renal-resistive-index-truths-and-doubts
#17
Maria Boddi, Fabrizia Natucci, Elisa Ciani
The renal resistive index (RRI) is measured by Doppler sonography in an intrarenal artery, and is the difference between the peak systolic and end-diastolic blood velocities divided by the peak systolic velocity. The RRI is used for the study of vascular and renal parenchymal renal abnormalities, but growing evidence indicates that it is also a dynamic marker of systemic vascular properties. Renal vascular resistance is only one of several renal (vascular compliance, interstitial and venous pressure), and extrarenal (heart rate, aortic stiffness, pulse pressure) determinants that combine to determine the RRI values, and not the most important one...
December 2015: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/26237557/reflected-rather-than-forward-wave-pressures-account-for-brachial-pressure-independent-relations-between-aortic-pressure-and-end-organ-changes-in-an-african-community
#18
Moekanyi J Sibiya, Angela J Woodiwiss, Hendrik L Booysen, Andrew Raymond, Aletta M E Millen, Muzi J Maseko, Olebogeng H I Majane, Pinhas Sareli, Elena Libhaber, Gavin R Norton
AIMS: To determine whether brachial blood pressure (BP)-independent relations between aortic pressure and cardiovascular damage are better explained by reflected (backward) (Pb) or forward (Pf) wave pressure effects. METHODS: In 1174 participants from a community of African ancestry, we assessed central aortic pulse pressure (PPc), Pb, and Pf (radial applanation tonometry, SphygmoCor) as well as left ventricular mass index (LVMI) (n = 786), aortic pulse wave velocity (PWV) (n = 1019), carotid intima-media thickness (IMT) (n = 578), transmitral early-to-late left ventricular diastolic velocity (E/A) (n = 779) and estimated glomerular filtration rate (eGFR) (n = 1174)...
October 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/26202829/nutraceuticals-for-serum-lipid-and-blood-pressure-control-in-hypertensive-and-hypercholesterolemic-subjects-at-low-cardiovascular-risk
#19
Alberto Mazza, Salvatore Lenti, Laura Schiavon, Marco Zuin, Maria D'Avino, Emilio Ramazzina, Edoardo Casiglia
INTRODUCTION: Primary cardiovascular (CV) prevention may be achieved by lifestyle/nutrition changes, although a relevant role is now emerging for specific, functional foods and nutraceutical compounds (NCs). The aim of this study was to investigate the efficacy and safety of NCs in lowering blood pressure (BP) and improving lipid profile, when added to diet and lifestyle management versus diet alone in a group of patients with hypertension (HT) and hypercholesterolemia (HCh) with low CV risk...
July 2015: Advances in Therapy
https://www.readbyqxmd.com/read/25992488/effects-of-a-selective-aldosterone-blocker-and-thiazide-type-diuretic-on-blood-pressure-and-organ-damage-in-hypertensive-patients
#20
RANDOMIZED CONTROLLED TRIAL
Yuko Ohta, Azusa Ishizuka, Shinichiro Hayashi, Yoshio Iwashima, Masatsugu Kishida, Fumiki Yoshihara, Satoko Nakamura, Yuhei Kawano
The aim of the present study was to compare the effects of the aldosterone blocker eplerenone and thiazide-like diuretic indapamide on blood pressure (BP) and target organs with reference to salt intake in hypertensive outpatients. Twenty hypertensive patients (nine women and 11 men, mean age 71 ± 13 years) with inadequate BP control despite taking calcium channel blockers (CCBs) and angiotensin II receptor blockers (ARBs) were administered eplerenone (50 mg/day) or indapamide (1 mg/day) for 3 months each in a randomized crossover manner...
2015: Clinical and Experimental Hypertension: CHE
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