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Lucas Modesto-Costa, Sabrina T Martinez, Angelo C Pinto, Ricardo Vessecchi, Itamar Borges
Pyrrolizidine alkaloids are natural molecules playing important roles in different biochemical processes in nature and in humans. In this work, the electron ionization mass spectrum (EI-MS) of retronecine, an alkaloid molecule found in plants, is investigated computationally. Its mass spectrum can be characterized by three main fragment ions having the following m/z ratios: 111, 94 and 80. In order to rationalize the mass spectrum, minima and transition state geometries were computed using density functional theory (DFT)...
June 23, 2018: Journal of Mass Spectrometry: JMS
Daniel Panchik, Sarah Masco, Patrice Zinnikas, Brooke Hillriegel, Tori Lauder, Erica Suttmann, Vernon Chinchilli, Maureen McBeth, William Hermann
BACKGROUND:  Breast cancer-related lymphedema (BCRL) affects many areas of daily living. Individuals with lymphedema may experience chronic and progressive swelling, recurrent skin infections, and decreased self-image and quality of life. For many years, it was considered best practice for this population to avoid exercise; however, in recent years, research has begun to challenge this belief. This systematic review and meta-analyses examined the recent literature on the effects of exercise for patients with, or at risk for, BCRL to inform best practice...
June 23, 2018: Journal of Reconstructive Microsurgery
Junting Yang, Shunwen Zhang, Jiangdong Wu, Jie Zhang, Jiangtao Dong, Peng Guo, Suyu Tang, Wanjiang Zhang, Fang Wu
BACKGROUND: Sepsis is a life-threatening organ dysfunction caused the dysregulation of host inflammatory response and immunosuppression to infection Early recognition and intervention are hence of paramount importance. In this respect the "sepsis bundle" was proposed in 2004 to be instituted in cases of suspected sepsis. OBJECTIVE AND HYPOTHESIS: We hypothesised that a combination treatment of the sepsis bundle with cyclophosphamide would improve the function of the intestinal mucosa and enhance survival in rats with induced sepsis...
June 12, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Maja Bech Juul, Pernille Hammershoej Jensen, Henriette Engberg, Sonja Wehberg, Andriette Dessau-Arp, Donika Haziri, Helene Bjoerg Kristensen, Joachim Baech, Lene Schurmann, Michael Roost Clausen, Rebecca Valentin, Lene Meldgaard Knudsen, Lars Munksgaard, Tarec Christoffer El-Galaly, Henrik Frederiksen, Thomas Stauffer Larsen
BACKGROUND: Optimal treatment strategy for the oldest patients with diffuse large B-cell lymphoma (DLBCL) remains controversial, as this group often is precluded from clinical trials, and population-based studies are limited. METHODS: All Danish DLBCL-patients ≥75 years diagnosed from 2003 to 2012 were identified, using the Danish National Lymphoma Registry (LYFO). Information regarding baseline characteristics, treatment, comorbidities and outcomes was retrieved from LYFO, the Danish National health registries and medical records...
June 20, 2018: European Journal of Cancer
Michéal Mac Monagail, Enda Cummins, Ricardo Bermejo, Eve Daly, Declan Costello, Liam Morrison
Seaweed has a long-associated history of use as a supplemented livestock feed, providing nutrients and vitamins essential to maintaining animal health. Some species of seaweed, particularly the fucoids, are well-known accumulators of the metalloid arsenic (As). Arsenic toxicity to humans is well established even at low exposure levels and is considered a class 1 human carcinogen. As mankind's appetite for livestock produce continues to grow unabated, there is a concern that consumption of livestock produce reared on a diet supplemented with seaweed animal feed (SAF) may pose a threat to the human population due to potentially high levels of As present in seaweed...
June 20, 2018: Environment International
Valentina Brenzini, Rahul Pathak
There seems to be a limited amount of research about the detection of concealed bloodstains on painted surfaces. The bloodstains on walls and floors are often removed by cleaning, in some cases the surfaces are painted by the perpetrator after committing a violent crime in order to hide the crime that has occurred. The study hereafter extends and deepens on previous researches by investigating the detectability of horse bloodstains on painted ceramic tiles as a function of the number of layers of paint. In this study luminol was used as a reagent to detect the bloodstains...
April 27, 2018: Forensic Science International
Jie Chen, Ling Kong, Xiaokai Sun, Jinhui Feng, Zhiwei Chen, Dawei Fan, Qin Wei
Rapidity and high sensitivity are the critical factors for the diagnoses of heart attacks and cardiac troponin I (cTnI) is used as a gold standard marker for its diagnosis. To realize the accurate detection of cTnI, a novel ultrasensitive photoelectrochemical (PEC) immunosensor for cTnI determination was developed upon dual inhibition effect of Ag@Cu2 O core-shell submicron-particles(SPs) toward CdS sensitized the (001) facets of anatase titanium dioxide nanosheets (TiO2 /CdS). In this study, the TiO2 /CdS composite not only indicated stable and excellent photoelectric signal but also provided abundant functional group to immobilized cTnI antibodies (Ab1 )...
May 24, 2018: Biosensors & Bioelectronics
Gulay Erdogan Kayhan, Mukadder Sanli, Ulku Ozgul, Ramazan Kirteke, Saim Yologlu
STUDY OBJECTIVE: Multimodal analgesic strategies are recommended to decrease opioid requirements and opioid-induced respiratory complications in patients undergoing laparoscopic bariatric surgery. Recent studies have demonstrated that intravenous ibuprofen decreases opioid consumption compared with placebo. The primary aim of this study was to compare the effect of intravenous ibuprofen and intravenous acetaminophen on opioid consumption. We also aimed to compare postoperative pain levels and side effects of the drugs...
June 20, 2018: Journal of Clinical Anesthesia
Mohsen Khalili, Mitra Alavi, Elham Esmaeil-Jamaat, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Brain inflammation is associated with cognitive dysfunction, especially in elderly. Trigonelline is a plant alkaloid and a major component of coffee and fenugreek with anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. In this study, the beneficial effect of trigonelline against lipopolysaccharide (LPS)-induced cognitive decline was assessed in the rat. LPS was injected i.p. at a dose of 500 μg/kg to induce neuroinflammation and trigonelline was administered p.o. at doses of 20, 40, or 80 mg/kg/day 1 h after LPS that continued for one week...
June 20, 2018: International Immunopharmacology
Ningning Zhou, Wei Yu, Suqin Tang, Jianping Wang, Clare Killikelly
Bereavement may trigger different psychological outcomes, such as prolonged grief disorder or post-traumatic growth. The relationship between these two outcomes and potential precipitators remain unknown. The current study aimed to identify classes of Chinese bereaved individuals based on prolonged grief symptoms and post-traumatic growth and to examine predictors for these classes. We used data from 273 Chinese individuals who lost a relative due to disease (92.3%), accident (4.4%) and other reasons (1.8%)...
June 6, 2018: Psychiatry Research
Stacey N Doan, Heimi Son, Lawrence N Kim
In recent years, empirical studies have shown that the inability to tolerate distress is associated with a wide range of negative outcomes including eating addiction, drug abuse, alcohol use, and antisocial behavior in adults. However, few studies have examined family correlates of this ability in children. Also, past literature on child emotional competencies has mainly focused on documenting the linkages between mother and child and has neglected the role of fathers. Children (N = 54, M age = 10.15 years, SD = 1...
June 8, 2018: Psychiatry Research
Carmen T Mulet, Luis E Arroyo-Mora, Lorena A Leon, Elizabeth Gnagy, Anthony P DeCaprio
Methylphenidate (MPH), which is metabolized into ritalinic acid (RA), is an amphetamine derivative largely used in the treatment of attention-deficit hyperactivity disorder, a neurological condition commonly diagnosed in early childhood. Ensuring that patients comply with clinical treatment is crucial and compliance is generally monitored in blood or urine specimens which, especially in the case of children, can be challenging to obtain on a repetitive basis. Here we report validation of a specific, non-invasive, and rapid dilute-and-shoot analytical method for the detection and quantitation of MPH and RA in oral fluid (OF)...
June 20, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Brompoj Prutthiwanasan, Leena Suntornsuk
A simple micellar electrokinetic chromatography (MEKC), using cetyltrimethyl ammonium bromide (CTAB) as micelles, for the determination of ciprofloxacin (CIP), enrofloxacin (ENR), norfloxacin (NOR) and ofloxacin (OFL) residues in surface water was developed. Peak Master was used for predicting amounts of analyte ionic forms to reduce numbers of tedious experiments in optimizing the analyte capacity factors. A baseline separation (Rs  > 2.8) of the analytes was achieved in 7 min using 15 mM sodium dihydrogen phosphate (pH 6...
June 18, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Xiaona Dong, Yiwei Zhang, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Jian Li, Ying Zheng, Baofeng Yang, Guifang Dou
HYD-PEP06 is a novel RGD-modified Endostar mimetic peptide with 30 amino acids that is intended to suppress the formation of neoplasm vessels. This assay was developed and validated to monitor the level of the peptide HYD-PEP06 in rat blood, using liquid chromatography tandem mass spectrometry (LC-MS/MS). HYD-PEP10, another peptide similar to the analyte, was used as an internal standard (IS). A triple quadrupole mass spectrometry in Multiple Reaction Monitoring (MRM) mode and an electrospray interface (ESI) in the positive mode were used for MS analysis...
May 29, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
S Nematollahi, E Ayubi, A Almasi-Hashiani, K Mansori, Y Moradi, Y Veisani, E Jenabi, B Gholamaliei, S Khazaei
OBJECTIVES: Determination of the true burden of hepatitis C virus (HCV) infection among high-risk groups relies heavily on occurrence measures such as prevalence, which are vital for implementation of preventive action plans. Nevertheless, up-to-date data on the prevalence of HCV infection remain scarce in Iran. This study aimed to review the relevant literature systematically and determine the pooled prevalence of HCV infection among high-risk groups in Iran. STUDY DESIGN: Systematic review & meta-analysis...
June 20, 2018: Public Health
Anne Laure Castel, Manuel Toledano, Christophe Tribouilloy, François Delelis, Amandine Mailliet, Nathalie Marotte, Raphaëlle A Guerbaai, Franck Levy, Pierre Graux, Pierre-Vladimir Ennezat, Sylvestre Maréchaux
BACKGROUND: Whether echocardiography platform and analysis software impact left ventricular (LV) volumes, ejection fraction (EF), and stroke volume (SV) by transthoracic tridimensional echocardiography (3DE) has not yet been assessed. Hence, our aim was to compare 3DE LV end-diastolic and end-systolic volumes (EDV and ESV), LVEF, and SV obtained with echocardiography platform from 2 different manufacturers. METHODS: 3DE was performed in 84 patients (65% of screened consecutive patients), with equipment from 2 different manufacturers, with subsequent off-line postprocessing to obtain parameters of LV function and size (Philips QLAB 3DQ and General Electric EchoPAC 4D autoLVQ)...
May 27, 2018: American Heart Journal
Mojtaba Shafiee, Mahsa Ahmadnezhad, Maryam Tayefi, Soheil Arekhi, Hassanali Vatanparast, Habibollah Esmaeili, Mohsen Moohebati, Gordon A Ferns, Naghmeh Mokhber, Seyed Rafie Arefhosseini, Majid Ghayour-Mobarhan
BACKGROUND: Depression and anxiety are significantly associated with systemic inflammation. Moreover, oxidative stress resulting from a disturbance in the prooxidant-antioxidant balance is linked to inflammation-related conditions. Therefore, depression/anxiety symptoms may also be associated with oxidative stress. OBJECTIVE: To examine the association between depression/anxiety symptoms and serum prooxidant-antioxidant balance (PAB) in adults who participated in a large population-based, cross-sectional study...
June 13, 2018: Journal of Affective Disorders
Andy Schieler, Melissa Koenig, David Buttelmann
Infants are selective in their learning from others. However, there is only very limited research on the possible factors that shape this selectivity, especially when it comes to the impact of infants' familiarity with the informant and the context. The current study investigated whether 14-month-olds preferred to receive and use information provided by an unfamiliar informant (experimenter) compared with a familiar informant (parent) and whether this pattern depended on the context (home vs. laboratory). We tested infants either in the laboratory (n = 67) or in their home (n = 70)...
June 20, 2018: Journal of Experimental Child Psychology
Cristiane Aparecida Almeida, André Fernando de Oliveira, Anderson Almeida Pacheco, Renata Pereira Lopes, Antônio Augusto Neves, Maria Eliana Lopes Ribeiro de Queiroz
The Fundão dam collapsed releasing 60 million tons of mining waste into the environment. The mining wastes should be better studied, since some of them are deposited on the alluvial plains soil and at the bottom of the rivers, like sediments, of the region affected. Thus, this work aims to perform the chemical, physical and adsorptive characterization of the samples colleted in region de Paracatu de Baixo. The mining waste has uneven surface, with sizes ranging from 2 to 200 μm, pHPCZ in 6.0. Are composed predominantly by kaolinite, goethite, hematite, gibbsite and quartz...
June 14, 2018: Chemosphere
Lijun Fan, Fenghua Zhao, Jing Liu, Karen A Hudson-Edwards
Realgar (As4 S4 )-rich tailings are iron-deficient arsenical mine wastes. The mechanisms and products of the dissolution of realgar by Acidithiobacillus ferrooxidans (A. ferrooxidans) in the presence (0.2 g and 2 g) and absence of zerovalent iron (ZVI) are investigated for three stages (each of 7 d with fresh A. ferrooxidans medium addition between the stages). SEM-EDX, FTIR, XPS and selective extraction analysis are used to characterize the solid-phase during the experiments. ZVI addition causes the systems to become more acid-generating, although pH increases are observed in the first day due to ZVI dissolution...
June 6, 2018: Chemosphere
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