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https://www.readbyqxmd.com/read/29241300/prevalence-of-fluoroquinolone-resistant-rectal-flora-in-patients-undergoing-transrectal-ultrasound-guided-prostate-needle-biopsy-a-prospective-multicenter-study
#1
Ho Seok Chung, Eu Chang Hwang, Ho Song Yu, Seung Il Jung, Sun Ju Lee, Dong Hoon Lim, Won Jin Cho, Hyun Sop Choe, Seung-Ju Lee, Sung Woon Park
OBJECTIVES: To estimate the prevalence of fluoroquinolone-resistant rectal flora in patients undergoing transrectal ultrasound-guided prostate needle biopsy and to identify the high-risk groups. METHODS: From January 2015 to March 2016, rectal swabs of 557 men who underwent transrectal ultrasound-guided prostate needle biopsy were obtained from five institutions. Clinical variables, including demographics, rectal swab culture results and infectious complications, were evaluated...
December 14, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29241298/etiology-of-salinity-and-water-origin-the-main-dilemma-of-badab-sourt-a-unique-travertine-spring
#2
Rahim Bagheri, Hadi Jafari, Fatemeh Bagheri
Badab Sourt travertine-depositing springs in the north of Iran, naturally create a unique surreal landscape containing a range of stepped travertine terraces, similarly found only in a few other places on earth. This site comprises of three travertine saline springs with different values of salinity and discharge (SP1 , SP2 , and SP3 ) and one non-travertine fresh karstic spring (SP4 ) within a distance of about 300 m. The etiology behind this salinity and the water origin are the main research's dilemma that were investigated using geological, hydrochemical, and stable isotopic techniques...
December 14, 2017: Ground Water
https://www.readbyqxmd.com/read/29241296/evolving-aptamers-with-unnatural-base-pairs
#3
Michiko Kimoto, Ken-Ichiro Matsunaga, Ichiro Hirao
A novel technology, genetic alphabet expansion, has rapidly advanced through the successful creation of unnatural base pairs that function as a third base pair in replication. Recently, genetic alphabet expansion has been applied to some practical areas. Among them, the application to DNA aptamer generation is a good example of the broad utility of this technology. A hydrophobic unnatural base pair, Ds-Px, which exhibits high fidelity in replication as a third base pair, has been applied to an evolutionary engineering method called SELEX (Systematic Evolution of Ligands by EXponential enrichment) to generate DNA aptamers that bind to targets...
December 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/29241295/in-vitro-selection-and-characterization-of-dna-aptamers-to-a-small-molecule-target
#4
Annamaria Ruscito, Erin M McConnell, Anna Koudrina, Ranganathan Velu, Christopher Mattice, Vernon Hunt, Maureen McKeague, Maria C DeRosa
Aptamers, synthetic oligonucleotide-based molecular recognition probes, have found use in a wide array of biosensing technologies based on their tight and highly selective binding to a variety of molecular targets. However, the inherent challenges associated with the selection and characterization of aptamers for small molecule targets have resulted in their underrepresentation, despite the need for small molecule detection in fields such as medicine, the environment, and agriculture. This protocol describes the steps in the selection, sequencing, affinity characterization, and truncation of DNA aptamers that are specific for small molecule targets...
December 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/29241294/early-stage-formulation-considerations
#5
Robert W Lee, Mark Mitchnick
When a drug candidate-i.e., a new chemical entity (NCE) or new molecular entity (NME)-is discovered, there is a requirement to identify a vehicle for in vitro and/or in vivo evaluation to assess the activity and/or toxicity of the compound (here we refer to the biologically active compound as the active pharmaceutical ingredient: API). Ideally, this vehicle will not impart any biological activity or any toxicity that would mask or confound the effects of the API. At this early stage in development, and given the high attrition rates of drug candidates in discovery, it does not make sense to fully characterize the API-speed and cost are generally the driving factors...
December 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/29241287/-where-and-how-does-yoga-work-a-scientific-overview
#6
Holger Cramer
As a traditional health care system, yoga combines physical activity, breathing techniques and meditation. It is increasingly used as a preventive or therapeutic means. Yoga has been researched in hundreds of randomized controlled trials. Positive effects are especially found for chronic pain conditions, hypertension, depression and in supportive cancer care. While there are case reports of serious adverse events associated with yoga, the risk seems to be extremely low and comparable to other forms of physical activity...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29241286/-humor-in-medicine-the-art-of-leaping-over-the-shadows
#7
Barbara Wild
Humor and laughter are integral parts of human life and communication - and so of course they occur in medical contacts.Humor is defined as a personality based cognitive emotional style of processing situations, characterized by the ability to find positive aspects even in negative situations, and the ability to communicate this point of view to others and to cheer them up. Humor can support healing processes and coping with illness. Humor and jokes reduce anxiety and stress (for patients and doctors). Humorous people have a more realistic, flexible and less fearful behaviour...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29241283/-there-is-no-season-for-gifts
#8
Klaus Lieb, Cora Koch
Gifts and payments from pharmaceutical manufacturers to medical doctors constitute a conflict of interest, which may lead to an undue influence on prescribing behavior. In Germany, 35 research-based pharmaceutical companies, organized in the "Verband der forschenden Arzneimittelhersteller (VfA)" paid € 562 million to medical doctors and hospitals in 2016. Of these, € 356 million were paid for clinical trials and non-interventional studies, € 105 million for sponsored presentations and CME and € 101 million went to hospitals and other organizations for sponsoring, consulting and events...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29241277/dual-energy-computed-tomography-in-musculoskeletal-imaging-with-focus-on-fragility-fractures-of-the-pelvis
#9
Carsten Hackenbroch, Hans-Joachim Riesner, Patricia Lang, Fabian Stuby, Meinrad Beer, Benedikt Friemert, Hans-Georg Palm
Dual energy computed tomography (DECT) is a constantly evolving technology, which opens up new diagnostic possibilities. It is particularly valuable for musculoskeletal (MSK) imaging. Due to the lack of recognition and availability of dual energy scanners, routine use is only established in a few centres. The intention of this review is to show the possibilities and fields of applications of the DECT in MSK imaging, as well as to describe technical principles and typical indications. We mainly focus on the use of DECT in the context of fragility fractures of the pelvis...
December 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29241276/multiband-mucosectomy-for-the-treatment-of-challenging-non-pedunculated-colorectal-polyps
#10
Joaquín Rodríguez-Sánchez, Eva De la Santa Belda, Pilar Olivencia Palomar, Margarita Úbeda Muñoz, José Olmedo Camacho
Background and study aims Endoscopic mucosal resection is the gold standard treatment for non-pedunculated colorectal polyps; however, some specific situations (location behind folds, scarred or flat morphology) can make this technique challenging. We aimed to assess the efficacy and safety of multiband mucosectomy (MBM) for resection of non-pedunculated colorectal polyps. Patients and methods This was a retrospective study of patients in whom MBM was performed to resect large non-pedunculated colorectal polyps...
December 14, 2017: Endoscopy
https://www.readbyqxmd.com/read/29241263/systematic-review-of-oral-therapy-for-the-treatment-of-symptoms-of-bladder-pain-syndrome-the-brazilian-guidelines
#11
Thaís Guimarães Dos Santos, Isabela Albuquerque Severo de Miranda, Christiana Campani Nygaard, Lucas Schreiner, Rodrigo de Aquino Castro, Jorge Milhen Haddad
Interstitial cystitis (IC), including bladder pain syndrome (BPS), is a chronic and debilitating disease that mainly affects women. It is characterized by pelvic pain associated with urinary urgency, frequency, nocturia and negative urine culture, with normal cytology. In 2009, the Society for Urodynamics and Female Urology (SUFU) defined the term IC/BPS as "an unpleasant sensation (pain, pressure, and discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms for more than 6 weeks duration, in the absence of infection or other identifiable causes...
December 14, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29241259/-competence-based-catalogue-of-learning-objectives-for-rehabilitation-physical-medicine-naturopathic-treatment-revised-version-joint-recommendations-of-the-german-society-of-rehabilitation-science-and-the-german-society-of-physical-medicine-and-rehabilitation
#12
Wilfried Mau, Max Emanuel Liebl, Ruth Deck, Uwe Lange, Ulrich Christian Smolenski, Susanne Walter, Christoph Gutenbrunner
Since the first publication of learning objectives for the interdisciplinary subject "Rehabilitation, Physical Medicine, Naturopathic Treatment" in undergraduate medical education in 2004 a revision is reasonable due to heterogenous teaching programmes in the faculties and the introduction of the National Competence Based Catalogue of Learning Objectives in Medicine as well as the "Masterplan Medical Education 2020". Therefore the German Society of Rehabilitation Science and the German Society of Physical Medicine and Rehabilitation started a structured consensus process using the DELPHI-method to reduce the learning objectives and arrange them more clearly...
December 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/29241258/-changes-of-motor-balance-in-the-course-of-an-inpatient-psychosomatic-rehabilitation
#13
ElisabethJohanna Grub, Georg Wydra, Michael Käfer, Volker Köllner
Aim of the study For many rehabilitants both the motor balance and the feeling of being emotionally stable and in balance are essential preconditions for participation in employment and society. The goal of this study was to capture changes in motor balance in the course of an inpatient psychosomatic rehabilitation and to set them in relation to changes in mental variables. Methods 118 patients of a psychosomatic clinic (49.3±8.6 years; 75.4 % women) were examined at the beginning and the end of rehabilitation...
December 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/29241254/patient-self-management-of-asthma-using-mobile-health-applications-a-systematic-review-of-the-functionalities-and-effects
#14
Mehrdad Farzandipour, Ehsan Nabovati, Reihane Sharif, Marzieh Heidarzadeh Arani, Shima Anvari
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29241249/health-it-usability-focus-section-data-use-and-navigation-patterns-among-medical-icu-clinicians-during-electronic-chart-review
#15
Matthew E Nolan, Rizwan Siwani, Haytham Helmi, Brian W Pickering, Pablo Moreno-Franco, Vitaly Herasevich
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29241244/physician-beliefs-about-the-meaningful-use-of-the-electronic-health-record-a-follow-up-study
#16
Srinivas Emani, David Y Ting, Michael Healey, Stuart R Lipsitz, Andrew S Karson, David W Bates
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29241233/hyperbaric-oxygen-in-the-treatment-of-acute-retinal-artery-occlusion
#17
Mark J Elder, John A Rawstron, Michael Davis
INTRODUCTION: Acute retinal artery occlusion (ARAO) is a major cause of sudden, painless visual loss, often leaving no useful vision in the affected eye. Its incidence is cited at 0.85 per 100,000 persons per year but may be higher because of under-reporting. The natural history is difficult to study, but a spontaneous resolution rate of < 1-8% for acute, non-arteritic ARAO has been cited. Occurrence in an only eye is devastating for the patient. There is currently no consensus regarding management of ARAO and little evidence to support any treatment modality...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29241231/influence-of-repetitive-diving-in-freshwater-on-pressure-equalization-and-eustachian-tube-function-in-recreational-scuba-divers
#18
Stefanie Jansen, Manuela Boor, Moritz F Meyer, Eberhard D Pracht, Ruth Volland, Heinz D Klünter, Karl-Bernd Hüttenbrink, Dirk Beutner, Maria Grosheva
INTRODUCTION: We investigated the effect of repetitive pressure exposure during freshwater dives on Eustachian tube function and the middle ear, assessed by the Eustachian tube function test (ETFT). METHODS: This prospective observational cohort study included 23 divers over three consecutive days of diving in freshwater lakes in Nordhausen, Germany. Participants underwent otoscopy and ETFT before the first dive, between each dive and after the last dive. ETFT included regular tympanometry (R-tymp), tympanometry after Valsalva (V-tymp) and after swallowing (S-tymp)...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29241230/influence-of-repetitive-diving-in-saltwater-on-pressure-equalization-and-eustachian-tube-function-in-recreational-scuba-divers
#19
Moritz F Meyer, Manuela Boor, Stefanie Jansen, Eberhard D Pracht, Moritz Felsch, Heinz D Klünter, Karl-Bernd Hüttenbrink, Dirk Beutner, Maria Grosheva
INTRODUCTION: We investigated in a prospective, observational trial the feasibility of using the Eustachian tube function test (ETFT) to measure the effect of repetitive pressure exposure during open seawater dives on Eustachian tube function. METHODS: The study included 28 adult divers during six consecutive days of diving in the Red Sea. Participants underwent otoscopy and ETFT before the first dive, between each dive and after the last dive. ETFT included regular tympanometry (R-tymp), tympanometry after Valsalva (V-tymp) and after swallowing (S-tymp)...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29241223/tumour-sidedness-and-intrinsic-subtypes-in-patients-with-stage-ii-iii-colon-cancer-analysis-of-nsabp-c-07-nrg-oncology
#20
S Rim Kim, Nan Song, Greg Yothers, Patrick G Gavin, Carmen J Allegra, Soonmyung Paik, Katherine L Pogue-Geile
BACKGROUND: We tested the association of colon tumour sidedness with prognosis and with molecular subtypes recently shown to be predictive of oxaliplatin benefit in stage III colon cancer. METHODS: NSABP/NRG C-07 trial (N=1603) was used to determine association of tumour sidedness with molecular subtypes and recurrence-free survival (RFS) and overall survival (OS). RESULTS: Sidedness was associated with molecular subtypes except stem-like/CMS4 subtype...
December 14, 2017: British Journal of Cancer
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