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https://www.readbyqxmd.com/read/28817770/photoinduced-copper-catalyzed-alkylation-of-amines-a-mechanistic-study-of-the-cross-coupling-of-carbazole-with-alkyl-bromides
#1
Jun Myun Ahn, Tanvi S Ratani, Kareem Hannoun, Gregory C Fu, Jonas C Peters
We have recently reported that a variety of couplings of nitrogen, sulfur, oxygen, and carbon nucleophiles with organic halides can be achieved under mild conditions (-40 to 30 °C) through the use of light and a copper catalyst. Insight into the various mechanisms by which these reactions proceed may enhance our understanding of chemical reactivity and facilitate the development of new methods. In this report, we apply an array of tools (EPR, NMR, transient absorption, and UV-vis spectroscopy; ESI-MS; X-ray crystallography; DFT calculations; reactivity, stereochemical, and product studies) to investigate the photoinduced, copper-catalyzed coupling of carbazole with alkyl bromides...
August 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28817292/theoretical-analysis-of-the-retro-diels-alder-reactivity-of-oxanorbornadiene-thiol-and-amine-adducts
#2
Jason S Fell, Steven A Lopez, Cody J Higginson, M G Finn, K N Houk
Additions of amines or thiols to 7-oxanorbornadienes promote retro-[4 + 2] reactions to yield furans. Substitution at the bridgehead position also greatly influences the stability of the oxanorbornene adducts. Activation and reaction energies were computed with the M06-2X density functional, the origins of amine and thiol promoted fragmentation, and how substituent effects control fragmentation rates and reaction energetics are reported.
August 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/28817291/assembly-of-2-arylbenzothiazoles-through-three-component-oxidative-annulation-under-transition-metal-free-conditions
#3
Xingzong Che, Jingjing Jiang, Fuhong Xiao, Huawen Huang, Guo-Jun Deng
Highly efficient methods for the synthesis of 2-arylbenzothiazoles and 2-arylnaphtho[2,1-d]thiazoles have been developed. Readily available aromatic amines, benzaldehydes, and elemental sulfur were directly assembled through oxidative annulation and C-H functionalization under transition-metal-free conditions, where DMSO or oxygen served as the oxidant. NH4I or KI as the catalyst was found to be effective to promote the transformations to give the annulation products in good to excellent yields with wide functional group tolerance...
August 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/28817269/the-chemistry-of-co2-capture-in-an-amine-functionalized-metal-organic-framework-under-dry-and-humid-conditions
#4
Robinson W Flaig, Thomas M Osborn Popp, Alejandro M Fracaroli, Eugene A Kapustin, Markus J Kalmutzki, Rashid M Altamimi, Farhad Fathieh, Jeffrey A Reimer, Omar M Yaghi
The use of two primary alkylamine functionalities covalently tethered to the linkers of IRMOF-74-III results in a material which can uptake CO2 at low pressures through a chemisorption mechanism. In contrast to other primary amine-functionalized solid adsorbents which uptake CO2 primarily as ammonium carbamates, we observe using solid state NMR that the major chemisorption product for this material is carbamic acid. The equilibrium of reaction products also shifts to ammonium carbamate when water vapor is present; a new finding that has impact on control of the chemistry of CO2 capture in MOF materials and one that highlights the importance of geometric constraints and the mediating role of water within the pores of MOFs...
August 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28817110/extractive-spectrophotometric-determination-of-nortriptyline-hydrochloride-using-sudan-ii-iv-and-black-b
#5
A S Amin, H M Saleh
A simple spectrophotometric methods has been developed for the determination of nortriptyline hydrochloride in pure and in pharmaceuticalformulations based on the formation of ion-pair complexes with sudun II (SII), sudan (IV) (SIV) and sudan black B (SBB). The selectivity of the method was improved through extraction with chloroform. The optimum conditions for complete extracted colour development were assessed. The absorbance measurements were made at 534, 596 and 649 nm for SII, SIV and SBB complexes, respectively...
August 17, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28816499/inclusion-of-gaming-disorder-in-the-diagnostic-classifications-and-promotion-of-public-health-response
#6
Behrang Shadloo, Rabert Farnam, Masoumeh Amin-Esmaeili, Marziyeh Hamzehzadeh, Hosein Rafiemanesh, Maral Mardaneh Jobehdar, Kamyar Ghani, Nader Charkhgard, Afarin Rahimi-Movaghar
There are ongoing controversies regarding the upcoming ICD-11 concept of gaming disorder. Recently, Aarseth et al. have put this diagnostic entity into scrutiny. Although we, a group of Iranian researchers and clinicians, acknowledge some of Aarseth et al.'s concerns, believe that the inclusion of gaming disorder in the upcoming ICD-11 would facilitate necessary steps to raise public awareness, enhance development of proper diagnostic approaches and treatment interventions, and improve health and non-health policies...
August 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28816448/metal-free-oxidative-c-c-coupling-of-arylamines-using-a-quinone-based-organic-oxidant
#7
Sudhakar Maddala, Sudesh Mallick, Parthasarathy Venkatakrishnan
A variety of arylamines are shown to undergo oxidative C-C bond formation using quinone-based chloranil/H(+) reagent as the recyclable organic (metal-free) oxidant system to afford benzidines/naphthidines. Arylamines (3°/2°) designed with various substituents were employed to understand the steric as well as electronic preferences of oxidative dimerization, and a mechanism involving amine radical cation has been proposed. The tetraphenylbenzidine derivative obtained via oxidative C-C coupling has been further converted to blue-emissive hole-transporting material via a simple chemical transformation...
August 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28816447/sequential-functionalizations-of-carbohydrates-enabled-by-boronic-esters-as-switchable-protective-activating-groups
#8
Ross S Mancini, Jessica B Lee, Mark S Taylor
Processes for site-selective, sequential functionalizations of carbohydrate derivatives are described. In these processes, a tricoordinate boronic ester initially serves as a protective group for a sugar-derived 1,2- or 1,3-diol motif, permitting functionalization of free OH groups. In a second step, addition of a Lewis base generates a tetracoordinate adduct, which serves as an activating group, enabling functionalization of one of the boron-bound oxygen atoms by a second electrophile. By combining an initial acylation, alkylation, or glycosylation step with an amine-mediated glycosylation of the boronic ester, a variety of selectively protected di- and trisaccharide derivatives can be accessed in an operationally simple fashion without purification of intermediates...
August 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28816445/tracking-the-progress-and-mechanism-study-of-a-solvothermal-in-situ-domino-n-alkylation-reaction-of-triethylamine-and-ammonia-assisted-by-ferrous-sulfate
#9
Jin-Ping Zhong, Bin Liu, Tao Yang, Yue-Jin Liu, Zhong-Hong Zhu, Bing-Feng Shi, Mohamedally Kurmoo, Ming-Hua Zeng
Atom economic in situ domino N-alkylation reactions of triethylamine/ammonia with 2-(hydroxymethyl)quinolin-8-ol (HL-OH) assisted by FeSO4·7H2O were realized under mild solvothermal conditions at 120 °C in acetonitrile. The resulting tripodal 2,2',2″-[nitrilotris(methylene)]tris(quinolin-8-ol) (H3L3-N) forms a linear trimer [Fe3(L3-N)2] (1). Electrospray ionization mass spectrometry of the reaction solution provides evidence for the intermediates of three steps, while crystallography and X-ray photoelectron spectroscopy characterize the trimer...
August 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28816328/palladium-catalyzed-allylic-amination-a-powerful-tool-for-the-enantioselective-synthesis-of-acyclic-nucleoside-phosphonates
#10
Mariam Azzouz, Sébastien Soriano, Margarita Escudero-Casao, M Isabel Matheu, Sergio Castillón, Yolanda Díaz
Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate.
August 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28816315/a-highly-selective-and-sensitive-fluorescent-nanosensor-for-dopamine-based-on-formate-bridged-tb-iii-complex-and-silver-nanoparticles
#11
Huihui Li, Jin Shen, Rongwei Cui, Chongmei Sun, Yanyan Zhao, Xia Wu, Na Li, Bo Tang
Highly selective determination of dopamine (DA) over other catecholamines is an urgent need for the precise diagnosis and therapy of DA related diseases. Herein, a new formate-bridged Tb(iii)-complex and silver nanoparticles (AgNPs) enhanced fluorescent nanosensor was constructed. HCOO(-) acted as a co-ligand of Tb(iii) and also as a linker between the Tb(iii) complex and AgNPs and more readily combined with the primary amine of DA than with epinephrine (EP). The formate-bridged action strengthened AgNPs-based surface enhanced fluorescence of the Tb(3+)-DA complex and improved the selectivity towards DA...
August 17, 2017: Analyst
https://www.readbyqxmd.com/read/28816075/psychological-impact-of-female-genital-mutilation-among-adolescent-egyptian-girls-a-cross-sectional-study
#12
Magdy R Ahmed, Mohamed M Shaaban, Heba K Meky, Mohamed E Amin Arafa, Tamer Y Mohamed, Waleed F Gharib, Abeer B Ahmed
OBJECTIVES: Worldwide, at least 200 million women and girls have undergone female genital mutilation (FGM). The medical and sexual consequences have been documented, but the psychological impact has not been studied to the same extent. The aim of this study was to explore the relationship between FGM and psychiatric problems among adolescent girls. METHODS: A total of 204 girls, aged 14-19 years, were included in a cross-sectional study conducted at Suez Canal University Hospitals...
August 17, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28816044/action-of-gold-nanospikes-based-nanoradiosensitizers-cellular-internalization-radiotherapy-and-autophagy
#13
Ningning Ma, Peidang Liu, Nongyue He, Ning Gu, Fu-Gen Wu, Zhan Chen
A major challenge to achieve effective X-ray radiation therapy is to use a relatively low and safe radiation dose. Various radiosensitizers, which can significantly enhance the radiotherapeutic performance, have been developed. Gold-based nanomaterials, as a new type of nanoparticle-based radiosensitizers, have been extensively used in researches involving cancer radiotherapy. However, the cancer therapeutic effect using the gold nanoparticle-based radiotherapy is usually not significant because of the low cellular uptake efficiency and the autophagy-inducing ability of these gold nanomaterials...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28815903/rhenium-loaded-tio2-a-highly-versatile-and-chemoselective-catalyst-for-the-hydrogenation-of-carboxylic-acid-derivatives-and-the-n-methylation-of-amines-using-h2-and-co2
#14
Takashi Toyao, Hakim S M A Siddiki, Yoshitsugu Morita, Takashi Kamachi, Abeda S Touchy, Wataru Onodera, Kenichi Kon, Shinya Furukawa, Hiroko Ariga, Kiyotaka Asakura, Kazunari Yoshizawa, Ken-Ichi Shimizu
Herein, we report a heterogeneous TiO2-supported Re catalyst (Re/TiO2) that promotes various selective hydrogenation reactions, e.g. hydrogenation of esters to alcohols, hydrogenation of amides to amines, and N-methylation of amines using H2 and CO2. Initially, Re/TiO2 was evaluated in the context of the selective hydrogenation of 3-phenylpropionic acid methyl ester to afford 3-phenylpropanol (pH2 = 5 MPa, T = 180 ºC), where revealed a superior performance relative to other catalysts explored in this study...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815856/molecular-dynamics-insights-into-polyamine-dna-binding-modes-implications-for-cross-link-selectivity
#15
Emmanuelle Bignon, Chen-Hui Chan, Christophe Morell, Antonio Monari, Jean-Luc Ravanat, Elise Dumont
Biogenic polyamines, which play a role in DNA condensation and stabilization, are ubiquitous and are found at millimolar concentration in the nucleus of eukaryotic cells. The interaction modes of three polyamines-putrescine (Put), spermine (Spm), and spermidine (Spd)-with a self-complementary 16 base pair (bp) duplex, are investigated by all-atom explicit-solvent molecular dynamics. The length of the amine aliphatic chain leads to a change of the interaction mode from minor groove binding to major groove binding...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815236/ring-closing-metathesis-of-unprotected-peptides
#16
Ellen C Gleeson, W Roy Jackson, Andrea J Robinson
An efficient and expedient route to the synthesis of dicarba peptides from protecting group-free sequences is reported using Ru-alkylidene catalysed olefin metathesis. A range of cyclic peptides was prepared from linear peptides containing two Z-crotyl glycine residues. Free amine groups were masked as salts with Brønsted acids preventing in situ catalyst decomposition. Excellent RCM conversion was obtained in both DMF and methanol.
August 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28814950/morinda-citrifolia-l-leaf-extract-prevent-weight-gain-in-sprague-dawley-rats-fed-a-high-fat-diet
#17
Najla Gooda Sahib Jambocus, Amin Ismail, Alfi Khatib, Fawzi Mahomoodally, Nazamid Saari, Muhammad Waseem Mumtaz, Azizah Abdul Hamid
Background: Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile. Design: Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28813911/design-and-kinematic-analysis-of-a-novel-upper-limb-exoskeleton-for-rehabilitation-of-stroke-patients
#18
Amin Zeiaee, Rana Soltani-Zarrin, Reza Langari, Reza Tafreshi
This paper details the design process and features of a novel upper limb rehabilitation exoskeleton named CLEVER (Compact, Low-weight, Ergonomic, Virtual/Augmented Reality Enhanced Rehabilitation) ARM. The research effort is focused on designing a lightweight and ergonomic upper-limb rehabilitation exoskeleton capable of producing diverse and perceptually rich training scenarios. To this end, the knowledge available in the literature of rehabilitation robotics is used along with formal conceptual design techniques...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813910/reference-path-generation-for-upper-arm-exoskeletons-considering-scapulohumeral-rhythms
#19
Rana Soltani-Zarrin, Amin Zeiaee, Reza Langari, Nina Robson
This paper proposes a reference path generation method for upper-limb rehabilitation exoskeletons considering the scapulohumeral rhythms of the shoulder. The developed method is based on Central Nervous System's (CNS) governing rules for coordination of arm motions, and to the best of our knowledge is the first computational model to consider the motion of the inner shoulder in path generation. Existing reference generation methods which utilize computational models such as minimum jerk, minimum torque, etc, are based on the assumption that the shoulder joint does not move, and the origin of the reference frame is defined at the center of the glenohumeral (GH) joint...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813479/metabolomic-profiling-of-amines-in-sepsis-predicts-changes-in-nos-canonical-pathways
#20
Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell
RATIONALE: Nitric oxide synthase (NOS) is a biomarker/target in sepsis. NOS activity is driven by amino acids, which cycle to regulate the substrate L-arginine in parallel with cycles which regulate the endogenous inhibitors ADMA and L-NMMA. The relationship between amines and the consequence of plasma changes on iNOS activity in early sepsis is not known. OBJECTIVE: Our objective was to apply a metabolomics approach to determine the influence of sepsis on a full array of amines and what consequence these changes may have on predicted iNOS activity...
2017: PloS One
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