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https://www.readbyqxmd.com/read/28340388/evaluation-of-cr-vi-reduction-mechanism-and-removal-by-cellulosimicrobium-funkei-strain-ar8-a-novel-haloalkaliphilic-bacterium
#1
Chinnannan Karthik, Selvaraj Barathi, Arivalagan Pugazhendhi, Vijayan Sri Ramkumar, Ngoc Bao Dung Thi, Padikasan Indra Arulselvi
The present study, a novel haloalkaliphilic Cr(VI) tolerant bacterial strain, Cellulosimicrobium funkei AR8, was isolated and characterized for its high Cr(VI) reduction. In batch experiments, Cr(VI) reduction was evaluated under different parametric conditions which include different pH (5-9), temperature (25-45°C), NaCl (0-3%) and Cr(VI) concentrations (100-250μg/ml). Variations in the cell surface functional groups and morphology of the bacterial cells after Cr(VI) reduction were characterized by FT-IR and SEM-EDX...
March 18, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340368/synthesis-molecular-docking-antimycobacterial-and-antimicrobial-evaluation-of-new-pyrrolo-3-2-c-pyridine-mannich-bases
#2
Gilish Jose, Tholappanavara H Suresha Kumara, Haliwana B V Sowmya, Dharmarajan Sriram, Tayur N Guru Row, Amar A Hosamani, Sunil S More, Bhavya Janardhan, B G Harish, Sandeep Telkar, Yalegara Siddappa Ravikumar
In this report, we describe the synthesis and biological evaluation of a new series of pyrrolo[3,2-c]pyridine Mannich bases (7a-v). The Mannich bases were obtained in good yields by one-pot three component condensation of pyrrolo[3,2-c]pyridine scaffold (6a-c) with secondary amines and excess of formaldehyde solution in AcOH. The chemical structures of the compounds were characterized by (1)H NMR, (13)C NMR, LC/MS and elemental analysis. Single crystal X-ray diffraction has been recorded for compound 7k ([C23H29ClN4](+2), H2O)...
March 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28339927/characterizing-the-early-inflammatory-contribution-of-the-donor-kidney-following-reperfusion
#3
John P Stone, Muna Mohamud, Kavit Amin, William R Critchley, Rebecca J Edge, Marc J Clancy, Alexandra L Ball, James E Fildes
Background.: Donor kidneys contain a large reservoir of passenger leucocytes that contribute to acute rejection via direct alloantigen presentation and pro-inflammatory cytokine secretion. However, the early contribution of these cells following revascularization has not previously been described. We performed a secondary, high-volume preservation flush following cold storage to characterize the inflammatory contribution of the donor kidney upon reperfusion. Methods.: Porcine kidneys were retrieved using a protocol analogous to current UK clinical practice...
February 27, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339212/nickel-catalyzed-reduction-of-secondary-and-tertiary-amides
#4
Bryan J Simmons, Marie Hoffmann, Jaeyeon Hwang, Moritz K Jackl, Neil K Garg
The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.
March 24, 2017: Organic Letters
https://www.readbyqxmd.com/read/28335499/synthesis-of-substituted-%C3%AE-trifluoromethyl-piperidinic-derivatives
#5
REVIEW
Sarah Rioton, Domingo Gomez Pardo, Janine Cossy
A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.
March 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335421/pamam-dendrimers-cross-the-blood-brain-barrier-when-administered-through-the-carotid-artery-in-c57bl-6j-mice
#6
Bhairavi Srinageshwar, Sarah Peruzzaro, Melissa Andrews, Kayla Johnson, Allison Hietpas, Brittany Clark, Crystal McGuire, Eric Petersen, Jordyn Kippe, Andrew Stewart, Olivia Lossia, Abeer Al-Gharaibeh, Aaron Antcliff, Rebecca Culver, Douglas Swanson, Gary Dunbar, Ajit Sharma, Julien Rossignol
Drug delivery into the central nervous system (CNS) is challenging due to the blood-brain barrier (BBB) and drug delivery into the brain overcoming the BBB can be achieved using nanoparticles such as dendrimers. The conventional cationic dendrimers used are highly toxic. Therefore, the present study investigates the role of novel mixed surface dendrimers, which have potentially less toxicity and can cross the BBB when administered through the carotid artery in mice. In vitro experiments investigated the uptake of amine dendrimers (G1-NH₂ and G4-NH₂) and novel dendrimers (G1-90/10 and G4-90/10) by primary cortical cultures...
March 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335214/graphene-fets-with-low-resistance-hybrid-contacts-for-improved-high-frequency-performance
#7
Chowdhury Al-Amin, Mustafa Karabiyik, Phani Kiran Vabbina, Raju Sinha, Nezih Pala
This work proposes a novel geometry field effect transistor with graphene as a channel-graphene field-effect transistor (GFET), having a hybrid contact that consists of an ohmic source/drain and its extended part towards the gate, which is capacitively coupled to the channel. The ohmic contacts are used for direct current (DC) biasing, whereas their capacitive extension reduces access region length and provides the radio frequency (RF) signal a low impedance path. Minimization of the access region length, along with the paralleling of ohmic contact's resistance and resistive part of capacitively coupled contact's impedance, lower the overall source/drain resistance, which results in an increase in current gain cut-off frequency, fT...
May 10, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335208/the-influence-of-fluorination-on-nano-scale-phase-separation-and-photovoltaic-performance-of-small-molecular-pc71bm-blends
#8
Zhen Lu, Wen Liu, Jingjing Li, Tao Fang, Wanning Li, Jicheng Zhang, Feng Feng, Wenhua Li
To investigate the fluorination influence on the photovoltaic performance of small molecular based organic solar cells (OSCs), six small molecules based on 2,1,3-benzothiadiazole (BT), and diketopyrrolopyrrole (DPP) as core and fluorinated phenyl (DFP) and triphenyl amine (TPA) as different terminal units (DFP-BT-DFP, DFP-BT-TPA, TPA-BT-TPA, DFP-DPP-DFP, DFP-DPP-TPA, and TPA-DPP-TPA) were synthesized. With one or two fluorinated phenyl as the end group(s), HOMO level of BT and DPP based small molecular donors were gradually decreased, inducing high open circuit voltage for fluorinated phenyl based OSCs...
April 21, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335197/cationic-nanoparticles-assembled-from-natural-based-steroid-lipid-for-improved-intracellular-transport-of-sirna-and-pdna
#9
Ruilong Sheng, Xiaoqing Zhuang, Zhao Wang, Amin Cao, Kaili Lin, Julian X X Zhu
Developing new functional biomaterials from biocompatible natural-based resources for gene/drug delivery has attracted increasing attention in recent years. In this work, we prepared a series of cationic nanoparticles (Diosarg-DOPE NPs) by assembly of a natural steroid diosgenin-based cationic lipid (Diosarg) with commercially-available helper lipid 1,2-dioleoyl-sn-glycero-3-phosphorethanolamine (DOPE). These cationic Diosarg-DOPE NPs were able to efficiently bind siRNA and plasmid DNA (pDNA) via electrostatic interactions to form stable, nano-sized cationic lipid nanoparticles instead of lamellar vesicles in aqueous solution...
April 13, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334507/comparative-study-of-cytotoxicity-and-genotoxicity-of-commercial-jeffamines%C3%A2-and-polyethylenimine-in-cho-k1-cells
#10
Leniher Castan, Cristiano José da Silva, Eduardo Ferreira Molina, Raquel Alves Dos Santos
Jeffamines(®) are a family of polymers containing primary amine groups attached to the extremities of polyether backbone which can be used as biomaterials. They have been used in combination with polyethylenimine (PEI) to improve biocompatibility in drug and gene delivery systems. Despite these facts, very few studies have been done on cytotoxicity and genotoxicity of pure Jeffamines(®) or compared with PEI. The present study aimed to evaluate and compare the cytotoxic and genotoxic effects of Jeffamines(®) and PEI in CHO-K1 cells...
March 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28334500/efficient-and-stable-vacuum-free-processed-perovskite-solar-cells-enabled-by-a-robust-solution-processed-hole-transport-layer
#11
Chih-Yu Chang, Bo-Chou Tsai, Yu-Cheng Hsiao
In this work, efficient and stable vacuum-free processed perovskite solar cells (PeSCs) is demonstrated by employ solution-processed molybdenum tris-[1-(trifluoroethanoyl)-2-(trifluoromethyl)ethane-1,2-dithiolene] (Mo(tfd-COCF3)3)-doped poly(3,4-ethylenedioxythiophene) (PEDOT) film as hole transport layer (HTL). Our results indicate that the incorporation of Mo(tfd-COCF3)3 dopant can induce p-doping via the charge transfer from the highest occupied molecular orbital level of PEDOT host to the electron affinity of Mo(tfd-COCF3)3, leading to an increase in conductivity by more than three orders of magnitude...
March 23, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28334484/amine-transaminase-engineering-for-spatially-bulky-substrate-acceptance
#12
Uwe Bornscheuer, Martin S Weiß, Ioannis V Pavlidis, Paul Spur, Steven P Hanlon, Beat Wirz, Hans Iding
Amine transaminase (ATA) catalysing stereoselective amination of prochiral ketones is an attractive alternative to transition metal catalysis. As wild-type ATAs accept only non-sterically hindered ketones, efforts to widen the substrate scope to more challenging targets are of general interest. We recently designed ATAs to accept aromatic and thus planar bulky amines, via a sequenced based motif that supports the identification of novel enzymes. However, these variants were not active against 2,2-dimethyl-1-phenyl-propan-1-one, which carries a spatially bulky tert-butyl substituent adjacent to the carbonyl function...
March 23, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28334393/adjuvant-human-papillomavirus-vaccination-for-secondary-prevention-a-systematic-review
#13
Gregory R Dion, Stephanie Teng, Leslie R Boyd, Antonia Northam, Charlotte Mason-Apps, Dorice Vieira, Milan R Amin, Ryan C Branski
Importance: Human papillomavirus (HPV) vaccination is recommended for children and younger adults but not older adults or those with prior HPV exposure, leaving a large portion of the population at risk for HPV-mediated disease. Emerging data suggest a possible role for vaccination as an adjuvant treatment for individuals with HPV-related clinical disease. Objective: To systematically review the literature regarding HPV vaccination for secondary disease prevention after treatment of active clinical disease across disease sites to serve as a platform for the management of HPV-related disease of the head and neck...
March 23, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28334045/plasma-soluble-l-selectin-in-medicated-patients-with-schizophrenia-and-healthy-controls
#14
Satyajit Mohite, Fang Yang, Pooja A Amin, Giovana Zunta-Soares, Gabriela D Colpo, Laura Stertz, Ajaykumar N Sharma, Gabriel R Fries, Consuelo Walss-Bass, Jair C Soares, Olaoluwa O Okusaga
Immune dysfunction has been implicated in the pathophysiology of schizophrenia. Leukocyte migration to the site of inflammation is a fundamental step of immune response which involves P-, E-, and L-selectins. Elevated selectin levels have been reported in un-medicated first-episode patients with schizophrenia but not in medicated patients with multi-episode schizophrenia. We measured fasting plasma soluble P-, E-, and L-selectin in 39 medicated patients with multi-episode schizophrenia and 19 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28333984/synthesis-and-bioevaluation-of-n-4-diaryl-1-3-thiazole-2-amines-as-tubulin-inhibitors-with-potent-antiproliferative-activity
#15
Maolin Sun, Qile Xu, Jingwen Xu, Yue Wu, Yueting Wang, Daiying Zuo, Qi Guan, Kai Bao, Jian Wang, Yingliang Wu, Weige Zhang
A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors and evaluated for their antiproliferative activity in three human cancer cell lines. Most of the target compounds displayed moderate antiproliferative activity, and N-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1,3-thiazol-2-amine (10s) was determined to be the most potent compound. Tubulin polymerization and immunostaining experiments revealed that 10s potently inhibited tubulin polymerization and disrupted tubulin microtubule dynamics in a manner similar to CA-4...
2017: PloS One
https://www.readbyqxmd.com/read/28333470/intramolecular-aminoalkoxylation-of-unfunctionalized-olefins-via-intramolecular-iodoamination-and-aziridinium-ion-ring-opening-sequence
#16
Hui Sun, Bin Cui, Lili Duan, Yue-Ming Li
The preparation of prolinol ether type compounds was realized via MnI2-catalyzed intramolecular iodoamination of unfunctionalized olefins and subsequent ring opening of an aziridinium ion intermediate with alcohols/phenols. In the presence of a catalytic amount of MnI2 and 2 equiv of NaI, intramolecular aminoalkoxylation of different N-benzyl-5-methylhex-4-en-1-amine substrates proceeded readily in alcoholic solvents, leading to 2-(alkoxyalkyl)pyrrolidine products in up to 90% isolated yields.
March 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28333467/stereospecific-nucleophilic-substitution-of-enantioenriched-tertiary-benzylic-amines-via-in-situ-activation-with-benzyne
#17
Yang Gui, Shi-Kai Tian
A one-pot protocol has been developed for sequential benzyne activation and nucleophilic substitution of enantioenriched tertiary benzylic amines. In the presence of 2-(trimethylsilyl)phenyl triflate and CsF, a range of enantioenriched tertiary benzylic amines were substituted by various nucleophiles, delivering structurally diverse benzylic compounds in moderate to excellent yields with excellent retention of enantiopurity. Importantly, this operationally simple protocol permitted formation of various chiral C-S, C-Se, C-C, and C-N bonds with excellent enantiopurity under metal-free conditions...
March 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28332843/asymmetric-total-synthesis-of-aspidophylline-a
#18
Taimin Wang, Xiaoguang Duan, Hua Zhao, Shengxian Zhai, Cheng Tao, Huifei Wang, Yun Li, Bin Cheng, Hongbin Zhai
An asymmetric total synthesis of (-)-aspidophylline A has been accomplished. The key transformations include an asymmetric hydride transfer hydrogenation of an α,β-acetylenic ketone and a cationic gold(I)-catalyzed 6-exo-dig cyclization involving an alkynylindole/aminal formation cascade, which enables stereoselective establishment of the requisite quaternary carbon center.
March 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28332831/layer-by-layer-assembly-of-amine-reactive-multilayers-using-an-azlactone-functionalized-polymer-and-small-molecule-diamine-linkers
#19
Yashira M Zayas-Gonzalez, Benjamin J Ortiz, David M Lynn
We report the reactive layer-by-layer assembly of amine-reactive polymer multilayers using an azlactone-functionalized polymer and small-molecule diamine linkers. This approach yields crosslinked polymer/linker-type films that can be further functionalized, after fabrication, by treatment with functional primary amines, and provides opportunities to incorporate other useful functionality that can be difficult to introduce using other polyamine building blocks. Films fabricated using poly(2-vinyl-4,4-dimethylazlactone) (PVDMA) and three model non-degradable aliphatic diamine linkers yielded reactive thin films that were stable upon incubation in physiologically relevant media...
March 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28332830/performance-and-mechanism-of-uranium-adsorption-from-seawater-to-polydopamine-inspired-sorbents
#20
Fengcheng Wu, Ning Pu, Gang Ye, Taoxiang Sun, Zhe Wang, Yang Song, Wenqing Wang, Xiaomei Huo, Yuexiang Lu, Jing Chen
Developing facile and robust technologies for effective enrichment of uranium from the seawater is of great significance for resource sustainability and environmental safety. By exploiting the mussel-inspired polydopamine (PDA) chemistry, diverse types of PDA-functionalized sorbents including magnetic nanoparticle (MNP), ordered mesoporous carbon (OMC) and glass fiber carpet (GFC) were synthesized. The PDA functional layers with abundant catechol and amine/imine groups provided an excellent platform for the binding to uranium...
March 23, 2017: Environmental Science & Technology
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