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Marwa Rashad Salem, Tarek Tawfik Amin, Abdulhamid Abdulrahman Alhulaybi, Abdulaziz Sami Althafar, Rehab Ahmed Abdelhai
Background: No previous studies had addressed the perceived risk of cervical cancer (CC) and its influence on screening practices and perceived barriers in Saudi Arabia. Methods: This cross-sectional study was conducted on 506 randomly selected Saudi female secondary school teachers in Al Hassa, Saudi Arabia to assess their level of knowledge about risk factors and signs of CC in relation to perceived risk and to characterize CC screening compliance using a self-administered questionnaire. Results: Of the included female Saudi teachers, 65...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Ragu Sasikumar, Palraj Ranganathan, Shen-Ming Chen, Syang-Peng Rwei, Muthukrishnan
A highly sensitive o-phenylenediamine (OPD) sensor based on a Fe3O4 doped with functionalized multi-walled carbon nanotubes (Fe3O4@f-MWCNTs) composite fabricated glassy carbon electrode (GCE) was developed. The modified Fe3O4@f-MWCNTs/GCE showed an enhanced current (Ipa) response toward OPD relative to that of a Fe3O4/GCE, f-MWCNTs/GCE, and a bare GCE. Under optimum conditions, the Fe3O4@f-MWCNTs/GCE showed a wide linear range remove at OPD concentrations of 0.6-80µM. The limit of detection and sensitivity of the f-MWCNTs/GCE, Fe3O4/GCE sensor were found to be 50µM, and 2...
May 17, 2017: Journal of Colloid and Interface Science
E Van der Sluijs, G A Van der Weijden, N L Hennequin-Hoenderdos, D E Slot
AIM: To compare the effects of a regimen consisting of a tooth/tongue gel, tongue cleaner and mouthwash with the effects of using standard fluoride dentifrice on the organoleptic oral malodour score (ORG) and volatile sulphur compounds (VSCs). MATERIALS AND METHODS: A total, 66 non-dental students participated in a 3-week parallel, single-blind, randomized, controlled clinical trial. The test group used a tongue cleaner, a tooth/tongue gel and mouthwash containing amine fluoride/stannous fluoride and zinc lactate as oral malodour counteractive...
May 24, 2017: International Journal of Dental Hygiene
Anna Péterfi, József Csorba, Tamás Figeczki, József Kiss, Katalin Medgyesi-Frank, János Posta, V Anna Gyarmathy
The appearance and spread of new psychoactive substances (NPS) is a phenomenon detected throughout Europe since 2008. Synthetic cathinones, a group of NPS, have been self-reported as the drug injected by the vast majority of people who inject drugs (PWID) in Hungary. This study aims at updating our knowledge on what exactly the compounds injected by PWID. This multi-site study analysed residues from used injecting drug paraphernalia collected from PWID via low threshold services and from public places in Budapest, Debrecen, Miskolc, Szeged, Békéscsaba and Pécs between March 2015 and February 2016...
May 23, 2017: Drug Testing and Analysis
Aurelien de la Torre, Veronica Tona, Nuno Maulide
The synthesis of alpha-amino carbonyl compounds is an important challenge in synthesis en route to biologically essential structures. While classical approaches involve the use of enol or enolate chemistries in combination with an electrophilic source of nitrogen, those strategies usually necessitate further transformations in order to reach the desired targets. In recent years, a new approach arose involving the direct use of nucleophilic sources of nitrogen along with an oxidant. This advantageously leads in one-pot to the biologically relevant alpha-amino compounds, without further transformation required...
May 20, 2017: Angewandte Chemie
John J Griffith, Katherine A Amin, Nikhil Waingankar, Susan M Lerner, Veronica Delaney, Scott A Ames, Ketan Badani, Michael A Palese, Reza Mehrazin
The objective of this review is to explore the available literature on solid renal masses (SRM) in transplant allograft kidneys to better understand the epidemiology and management of these tumors. A literature review using PubMed was performed according to the PRISMA methodology. Fifty-six relevant studies were identified from 1988-2015. A total of 174 SRMs in 163 patients, were identified with a mean tumor size of 2.75 cm (0.5-9.0cm). Tumor histology was available in 164 (94.3%) tumors: clear cell renal cell carcinoma (RCC) (45...
May 19, 2017: American Journal of Transplantation
Mathew Vetticatt, Juliet Macharia, Victor Wambua, Yun Hong, Lawrence Harris, Jennifer S Hirschi, Gary B Evans
The rational design and implementation of enantiodivergent enamine catalysis is reported. A simple secondary amine catalyst, 2-methyl-L-proline, and its tetrabutylammonium salt function as an enantiodivergent catalyst pair delivering opposite enantiomers of α-functionalized aldehyde products in excellent enantioselectivities. This novel concept of 'designed enantiodivergence' is applied to the enantioselective α-amination, aldol and α-aminoxylation/α-hydroxyamination reactions of aldehydes.
May 23, 2017: Angewandte Chemie
Joshua Britton, Timothy F Jamison
A rapid and modular continuous flow synthesis of highly functionalized fluorinated pyrazoles and pyrazolines has been developed. Flowing fluorinated amines through sequential reactor coils mediates diazoalkane formation and [3+2] cycloaddition to generate more than 30 azoles in a telescoped fashion. Pyrazole cores are then sequentially modified through additional reactor modules performing N-alkylation and arylation, deprotection, and amidation to install broad molecular diversity in short order. Continuous flow synthesis enables the safe handling of diazoalkanes at elevated temperatures, and the use of aryl alkyne dipolarphiles under catalyst free conditions...
May 25, 2017: Angewandte Chemie
Wei Wang, He Huang, Chenguang Yu, Xiangmin Li, Yongqiang Zhang, Yueteng Zhang, Xiaobei Chen, Patrick S Mariano, Hexin Xie
We report a conceptually novel organocatalytic strategy for formylation of boronic acids, in which a new reactivity is engineered into the α-amino acid forming Petasis reaction occurring between aryl boron acids, amines and glyoxylic acid. The feasibility and preparative power of the protocol was demonstrated by its use to prepare aldehydes from broadly accessible aryl and alkenyl boronic acids, glyoxylic acid, and the cheap N-alkylaniline derivatives, tetrahydroquinoline and indoline, as catalysts. Furthermore, the operational simplicity of the process, which is performed by simply mixing these reagents under ambient conditions, and its ability to generate structurally diverse and valued aryl, heteroaryl and α,β-unsaturated aldehydes containing a wide array of functional groups, demonstrates the practical utility of the newly unveiled synthetic strategy...
May 23, 2017: Angewandte Chemie
Julius Juhyun Chung, Wonmin Choi, Tao Jin, Jung Hee Lee, Seong-Gi Kim
Chemical exchange (CE)-sensitive MRI benefits greatly from stronger magnetic fields; however, field effects on CE-sensitive imaging have not yet been studied well in vivo. We have compared CE-sensitive Z-spectra and maps obtained at the fields of 9.4 T and 15.2 T in phantoms and rats with off-resonance chemical-exchange-sensitive spin lock (CESL), which is similar to conventional chemical exchange saturation transfer. At higher fields, the background peak at water resonance has less spread and the exchange rate relative to chemical shift decreases, thus CESL intensity is dependent on B0 ...
May 22, 2017: NMR in Biomedicine
Elena G Shcherbakova, Valentina Brega, Vincent M Lynch, Tony D James, Pavel Anzenbacher
A simple and efficient method for determination of the yield, enantiomeric/diasteriomeric excess (ee/de), and absolute configuration of crude chiral diols without the need of work-up and product isolation in a high throughput setting is described. This approach utilizes a self-assembled iminoboronate ester formed as a product by dynamic covalent self-assembly of a chiral diol with an enantiopure fluorescent amine such as tryptophan methyl ester or tryptophanol and 2-formylphenylboronic acid. The resulting diastereomeric boronates display different photophysical properties and allow for fluorescence-based ee determination of molecules containing a 1,2- or 1,3-diol moiety...
May 23, 2017: Chemistry: a European Journal
Nao Hiwatashi, Peter A Benedict, Gregory R Dion, Renjie Bing, Iv Kraja, Milan R Amin, Ryan C Branski
OBJECTIVE: Recent reports highlight the efficacy of small interfering RNA (siRNA) targeting SMAD3 to regulate transforming growth factor β (TGF-β)-mediated fibroplasia in vocal fold fibroblasts. The current study sought to investigate SMAD3 expression during wound healing in vivo and quantify the downstream transcriptional events associated with SMAD3 knockdown in vitro. STUDY DESIGN: In vivo and in vitro. METHODS: Unilateral vocal fold injury was created in a rabbit model...
May 20, 2017: Laryngoscope
Macarena Faunes, J Martin Wild
In our traditional view of the avian somatosensory system, input from the beak and head reaches the telencephalon via a disynaptic pathway, involving projections from the principal sensory nucleus (PrV) directly to nucleus basorostralis (previously called nucleus basalis), whereas input from the rest of the body follows a trisynatic pathway similar to that in mammals, involving projections from the dorsal column nuclei to the thalamus, and thence to somatosensory cortex. However, the role of the nuclei of the descending trigeminal tract (nTTD) in this scenario is unclear, partly because their ascending projections have been examined in only one species, the mallard duck (Arends & Dubbeldam, 1984, Neuroscience 13(3):797-817)...
May 23, 2017: Journal of Comparative Neurology
Niyaz Mohammad Mahmoodi, Mina Oveisi, Mokhtar Alina Asli, Mohammad Ali Rezvani, Amin Valipour
In this paper, cobalt ferrite magnetic nanoparticle was modified by N-(2-aminoethyl)-3-(trimethoxysilyl) propyl amine. Polyoxometalate was immobilized on the modified bi-amino surface functionalized nanoparticle to prepare the environmentally friendly catalyst nanoparticle (EFCN). The synthesized EFCN was characterized using Fourier transform infrared, scanning electron microscopy and X-ray powder diffraction. The EFCN was used for photocatalytic dye degradation. Acid Red 18 and Direct Red 81 were used as model dyes...
May 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Dahong Chen, Lele Peng, Yifei Yuan, Yue Zhu, Zhiwei Fang, Chunshuang Yan, Gang Chen, Reza Shahbazian-Yassar, Jun Lu, Khalil Amine, Guihua Yu
A general template-directed strategy is developed for the controlled synthesis of two-dimensional (2D) Co3O4 nanosheets with unique holey architecture and tunable hole sizes that enable greatly improved alkali-ion storage properties (demonstrated for both Li and Na ion storage). The as-synthesized holey Co3O4 nanosheets with 10 nm holes exhibit excellent reversible capacities of 1324 mAh/g at 0.4 A/g and 566 mAh/g at 0.1 A/g, for Li and Na ion storage, respectively. The improved alkali-ion storage properties are attributed to the unique interconnected holey framework that enables efficient charge/mass transport as well as accommodates volume expansion...
May 25, 2017: Nano Letters
Maren Rasmussen, Christian Näther, Jan van Leusen, Paul Kögerler, Lyuben Zhechkov, Thoma Heine, Wolfgang Bensch
The formation of [{Co(II)(teta)2}{Co(II)2(tren)(teta)2}V(IV)15Sb(III)6O42(H2O)]·ca.9H2O [teta = triethylenetetraamine; tren = tris(2-aminoethyl)amine] illustrates a strategy toward reducing the molecular charge of polyoxovanadates, a key challenge in their use as components in single-molecule electronics. Here, a V-O-Co bond to a binuclear Co(2+)-centered complex and a Sb-N bond to the terminal N atom of a teta ligand of a mononuclear Co(2+) complex allow for full charge compensation of the archetypal molecular magnet [V15Sb6O42(H2O)](6-)...
May 25, 2017: Inorganic Chemistry
Weiming Hu, Qingheng Zheng, Song Sun, Jiang Cheng
A Rh(iii)-catalyzed bilateral cyclization was developed for the efficient construction of acridines proceeding with C-H functionalization whereby in situ formation and removal of an imino transient directing group in the presence of catalytic amount of BnNH2 are achieved. In this transformation, a sequential Rh(iii)-catalyzed C-H amination, cyclization, and aromatization process was involved.
May 25, 2017: Chemical Communications: Chem Comm
S A Khan, B Amin, Li-Yong Gan, Iftikhar Ahmad
The structural, electronic, and photocatalytic properties of two-dimensional Ti2CO2, Zr2CO2, and Hf2CO2 MXenes were investigated by first-principles (PBE and hybrid) calculations. Transition from an indirect to a direct band gap was achieved for the biaxial tensile strain of 3% for Ti2CO2, 8% for Zr2CO2, and 13% for Hf2CO2 while the nature of the band gap remained indirect in the case of the compressive strain. The size of the band gap passed through a maximum under tensile strain and decreased monotonically under compressive strain...
May 25, 2017: Physical Chemistry Chemical Physics: PCCP
Xin Zhang, Hong Ke, Zhiming Wang, Weiwei Guo, Amin Zhang, Chusen Huang, Nengqin Jia
An ultrasensitive electrochemiluminescence (ECL) immunosensor for carbohydrate antigen 19-9 (CA19-9) detection using multi-walled carbon nanotube-platinum-luminol nanocomposites (MWCNT-Pt-luminol) as nanointerface and signal tags was designed. First, the MWCNT-Pt-luminol nanocomposite was decorated on the surface of a glassy carbon electrode (GCE) through the film-forming properties of chitosan (Chi). Then, the CA19-9 antibody (anti-CA19-9) was attached to the modified electrode surface via crosslinking with glutaraldehyde (GA)...
May 25, 2017: Analyst
Chen Wang, Li Tian, Wei Zhu, Shiqiang Wang, Peng Wang, Yun Liang, Wanlin Zhang, Hongwei Zhao, Guangtao Li
By incorporating a cationic dye within metal-organic framework (MOF) through ion-exchange process, a responsive dye@bio-MOF-1 composite has been synthesized, serving as a dual-emitting platform for enhanced detection of different kinds of nitro-explosives, especially the nitroalkanes, nitramines and nitrate esters. The dye@bio-MOF-1 composite was constructed with free amines on their well-defined cavities, which is essential for the capture of explosives into their confined nanospace. It was observed that the encapsulation of explosives into the constructed dye@bio-MOF-1 composite could dramatically alter the luminescent properties of the dyes as well as the MOF skeletons owing to the size exclusivity and confinement-induced effect...
May 25, 2017: ACS Applied Materials & Interfaces
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