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https://www.readbyqxmd.com/read/28109063/chemical-variability-antioxidant-and-antifungal-activities-of-essential-oils-and-hydrosol-extract-of-calendula-arvensis-l-from-western-algeria
#1
Rania Belabbes, Mohammed El Amine Dib, Nassim Djabou, Faiza Ilias, Boufeldja Tabti, Jean Costa, Alain Muselli
The chemical composition of the essential oils and hydrosol extract from aerial parts of Calendula arvensis L. was investigated using GC-FID and GC/MS. Intra-species variations of the chemical compositions of essential oils from 18 Algerian sample locations were investigated using statistical analysis. Chemical analysis allowed the identification of fifty-three compounds amounting to 92.3-98.5% with yields varied of 0.09-0.36% and the main compounds were zingiberenol 1 (8.7-29.8%), eremoligenol (4.2-12.5%), β-curcumene (2...
January 21, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28109015/a-single-centre-experience-of-roux-en-y-enteric-drainage-for-pancreas-transplantation
#2
Irum Amin, Andrew J Butler, Gail Defries, Neil K Russell, Simon J F Harper, Asif Jah, Kourosh Saeb-Parsy, Gavin J Pettigrew, Christopher J E Watson
Exocrine drainage following pancreas transplantation can be achieved by drainage into the bladder or bowel, the latter typically by direct duodeno-jejunostomy; the use of Roux-en-Y enteric drainage is uncommon. We report a retrospective analysis of a single centre experience of Roux-en-Y enteric drainage following pancreas transplantation. Over a 14-year period (2001- 2015), 204 consecutive adult pancreas transplants were performed (96.6% simultaneous pancreas and kidney transplants), of which 26.0% were from donors after circulatory death (DCD)...
January 21, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28108974/design-and-evaluation-of-topical-diclofenac-sodium-gel-using-hot-melt-extrusion-technology-as-a-continuous-manufacturing-process-with-kolliphor%C3%A2-p407
#3
Jaywant Pawar, Rajkiran Narkhede, Purnima Amin, Vaishali Tawde
The aim of the present context was to develop and evaluate a Kolliphor® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process. In this study, we have explored first time ever HME as an industrially feasible and continuous manufacturing technology for the manufacturing of gel formulation using Kolliphor® P407 and Kollisolv® PEG400 as a gel base. Diclofenac sodium was used as a model drug. The HME parameters such as feeding rate, screw speed, and barrel temperature were crucial for the semisolid product development, and were optimized after preliminary trials...
January 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28108959/innovative-root-end-filling-materials-based-on-calcium-silicates-and-calcium-phosphates
#4
Ali Abedi-Amin, Arlinda Luzi, Massimo Giovarruscio, Gaetano Paolone, Atanaz Darvizeh, Victoria Vivó Agulló, Salvatore Sauro
This in vitro study evaluated the apical sealing ability, bioactivity and biocompatibility of an experimental calcium silicate-based and two light-curing calcium silicate/calcium-phosphate cements as potential root end filling materials. A calcium silicate Portland-based (Control PC), an experimental calcium silicate (Exp. PC) and two light-curing cements (LC-CaP; LC-Si/CaP) were assessed for their alkalinising activity (pH) and biocompatibility. Single-rooted human canines were endodontically treated, filled with gutta-percha and finally submitted to apicoectomy...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28108768/severe-hypercapnia-and-outcome-of-mechanically-ventilated-patients-with-moderate-or-severe-acute-respiratory-distress-syndrome
#5
Nicolas Nin, Alfonso Muriel, Oscar Peñuelas, Laurent Brochard, José Angel Lorente, Niall D Ferguson, Konstantinos Raymondos, Fernando Ríos, Damian A Violi, Arnaud W Thille, Marco González, Asisclo J Villagomez, Javier Hurtado, Andrew R Davies, Bin Du, Salvatore M Maggiore, Luis Soto, Gabriel D'Empaire, Dimitrios Matamis, Fekri Abroug, Rui P Moreno, Marco Antonio Soares, Yaseen Arabi, Freddy Sandi, Manuel Jibaja, Pravin Amin, Younsuck Koh, Michael A Kuiper, Hans-Henrik Bülow, Amine Ali Zeggwagh, Antonio Anzueto, Jacob I Sznajder, Andres Esteban
PURPOSE: To analyze the relationship between hypercapnia developing within the first 48 h after the start of mechanical ventilation and outcome in patients with acute respiratory distress syndrome (ARDS). PATIENTS AND METHODS: We performed a secondary analysis of three prospective non-interventional cohort studies focusing on ARDS patients from 927 intensive care units (ICUs) in 40 countries. These patients received mechanical ventilation for more than 12 h during 1-month periods in 1998, 2004, and 2010...
January 20, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28108646/postnatal-resveratrol-supplementation-improves-cardiovascular-function-in-male-and-female-intrauterine-growth-restricted-offspring
#6
Amin Shah, Anita Quon, Jude S Morton, Sandra T Davidge
Intrauterine growth restriction (IUGR) may predispose offspring to an increased susceptibility of developing cardiovascular disease (CVD) in adult life. The window of opportunity to treat later life CVD programmed in fetal life is critical. The aim of this study was to identify the effect of resveratrol treatment of IUGR offspring at a time of known CV dysfunction. Sprague-Dawley male and female rat offspring who experienced normoxia (21% O2; control) or hypoxia (11% O2; IUGR) in utero were fed a high-fat (HF) diet (3-21 weeks of age) or a HF diet (3-21 weeks of age) supplemented with resveratrol from 13 to 21 weeks of age...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28108251/discovery-of-7-3-piperazin-1-yl-phenyl-pyrrolo-2-1-f-1-2-4-triazin-4-amine-derivatives-as-highly-potent-and-selective-pi3k%C3%AE-inhibitors
#7
Lan-Ying Qin, Zheming Ruan, Robert J Cherney, T G Murali Dhar, James Neels, Carolyn A Weigelt, John S Sack, Anurag S Srivastava, Lyndon A M Cornelius, Joseph A Tino, Kevin Stefanski, Xiaomei Gu, Jenny Xie, Vojkan Susulic, Xiaoxia Yang, Melissa Yarde-Chinn, Stacey Skala, Ruth Bosnius, Christine Goldstein, Paul Davies, Stefan Ruepp, Luisa Salter-Cid, Rajeev S Bhide, Michael A Poss
As demonstrated in preclinical animal models, the disruption of PI3Kδ expression or its activity leads to a decrease in inflammatory and immune responses. Therefore, inhibition of PI3Kδ may provide an alternative treatment for autoimmune diseases, such as RA, SLE, and respiratory ailments. Herein, we disclose the identification of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent, selective and orally bioavailable PI3Kδ inhibitors. The lead compound demonstrated efficacy in an in vivo mouse KLH model...
January 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28108248/a-new-efficient-method-of-generating-photoaffinity-beads-for-drug-target-identification
#8
Yoichi Nishiya, Tomoko Hamada, Masayuki Abe, Michio Takashima, Kyoko Tsutsumi, Katsuya Okawa
Affinity purification is one of the most prevalent methods for the target identification of small molecules. Preparation of an appropriate chemical for immobilization, however, is a tedious and time-consuming process. A decade ago, a photoreaction method for generating affinity beads was reported, where compounds are mixed with agarose beads carrying a photoreactive group (aryldiazirine) and then irradiated with ultraviolet light under dry conditions to form covalent attachment. Although the method has proven useful for identifying drug targets, the beads suffer from inefficient ligand incorporation and tend to shrink and aggregate, which can cause nonspecific binding and low reproducibility...
January 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28107922/-rough-guide-evanescent-wave-optrode-for-colorimetric-metalloporphyrine-sensors
#9
Abraham Kirwa Tuwei, Nicholas H Williams, Mohammad Yusuf Mulla, Corrado Di Natale, Roberto Paolesse, Martin Grell
When films of zinc 5-(4-carboxyphenyl),10,15,20-triphenyl porphyrin (ZnTPP) are exposed to waterborne amine in pH- neutral or alkaline media, both Q- band and Soret band respond with a change of absorbance due to the donation of amine 'lone pair' electrons to the metalloprophyrin π orbital. However, this is difficult to reveal with a conventional spectrometer even under high amine concentration. We therefore introduce optical fibres coated with ZnTPP into a bespoke 'light balance' evanescent wave absorbance meter [doi:10...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107609/carbon-nanodot-solar-cells-from-renewable-precursors
#10
Maria-Magdalena Titirici, Adam Marinovic, Steve Dunn, Lim Swee Kiat, Joe Briscoe
It has recently been shown that waste biomass can be converted into a wide range of functional materials, including those with desirable optical and electronic properties, offering the opportunity to find new uses for these renewable resources. Photovoltaics is one area where finding the combination of abundant, low-cost and non-toxic materials with the necessary functionality can be challenging. In this paper we compare the performance of carbon nanodots derived from a wide range of biomaterials obtained from different biomass sources as sensitizers for TiO2-based nanostructured solar cells; polysaccharides (chitosan and chitin), monosaccharide (D-glucose), amino acids (L-arginine and L-cysteine) and raw lobster shells are all used to produce carbon nanodots via hydrothermal carbonisation...
January 20, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28107019/oxidation-reduction-condensation-of-diazaphosphites-for-carbon-heteroatom-bond-formation-based-on-mitsunobu-mechanism
#11
Hai Huang, Jun Yong Kang
An efficient oxidation-reduction condensation reaction of diazaphosphites with various nonacidic pronucleophiles in the presence of DIAD as a weak oxidant has been developed for carbon-heteroatom bond formation. This mild process affords structurally diverse tertiary amines, secondary amines, esters, ethers, and thioethers in moderate to excellent yields. The selective synthesis of secondary amines from primary amines has been achieved. Importantly, a practical application to the synthesis of antiparkinsonian agent piribedil has been demonstrated...
January 20, 2017: Organic Letters
https://www.readbyqxmd.com/read/28106992/discovery-of-n-pyridin-4-yl-1-5-naphthyridin-2-amines-as-potential-tau-pathology-pet-tracers-for-alzheimer-s-disease
#12
Frederik J R Rombouts, José-Ignacio Andrés, Manuela Ariza, José Manuel Alonso, Nigel Austin, Astrid Bottelbergs, Lu Chen, Vladimir Chupakhin, Erna Cleiren, Katleen Fierens, Alberto Fontana, Xavier Langlois, Joseph E Leenaerts, Jonas Mariën, Carolina Martinez Lamenca, Rhys Salter, Mark E Schmidt, Paula Te Riele, Cindy Wintmolders, Andrés A Trabanco, Wei Zhang, Gregor J Macdonald, Diederik Moechars
A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggregated tau with modest selectivity versus aggregated β-amyloid (Aβ). Initial medicinal chemistry efforts identified key elements for potency and selectivity, as well as suitable positions for radiofluorination, leading to a first generation of fluoroalkyl-substituted quinoline tau binding ligands with sub-optimal physicochemical properties...
January 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28106855/pharmacomodulation-of-the-antimalarial-plasmodione-synthesis-of-biaryl-and-n-arylalkylamine-analogues-antimalarial-activities-and-physicochemical-properties
#13
Karène Urgin, Mouhamad Jida, Katharina Ehrhardt, Tobias Müller, Michael Lanzer, Louis Maes, Mourad Elhabiri, Elisabeth Davioud-Charvet
With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as starting material, a 2-step sequence using a Kochi-Anderson reaction and subsequent Pd-catalyzed Suzuki-Miyaura coupling was developed to prepare three representative biphenyl derivatives in good yields for antimalarial evaluation...
January 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106742/mechanochemical-lignin-mediated-strecker-reaction
#14
Saumya Dabral, Mathias Turberg, Andrea Wanninger, Carsten Bolm, José G Hernández
A mechanochemical Strecker reaction involving a wide range of aldehydes (aromatic, heteroaromatic and aliphatic), amines, and KCN afforded a library of α-aminonitriles upon mechanical activation. This multicomponent process was efficiently activated by lignocellulosic biomass as additives. Particularly, commercially available Kraft lignin was found to be the best activator for the addition of cyanide to the in situ formed imines. A comparative study of the (31)P-NMR (Nuclear Magnetic Resonance) along with IR (Infrared) data analysis for the Kraft lignin and methylated Kraft lignin samples ascertained the importance of the free hydroxyl groups in the activation of the mechanochemical reaction...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106315/peptide-n-amination-supports-%C3%AE-sheet-conformations
#15
Matthew P Sarnowski, Chang Won Kang, Yassin M Elbatrawi, Lukasz Wojtas, Juan R Del Valle
The conformational heterogeneity of backbone N-substituted peptides limits their ability to adopt stable secondary structures. Herein, we describe a practical synthesis of backbone aminated peptides that readily adopt β-sheet folds. Data derived from model N-amino peptides suggest that extended conformations are stabilized through cooperative steric, electrostatic, and hydrogen-bonding interactions.
January 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28106299/improved-and-general-manganese-catalyzed-n-methylation-of-aromatic-amines-using-methanol
#16
Jacob Neumann, Saravanakumar Elangovan, Anke Spannenberg, Kathrin Junge, Matthias Beller
A novel lutidine based manganese PNP pincer complex has been synthesized for the selective N methylation of aromatic amines with methanol. Using borrowing hydrogen methodology a selection of different functionalized aniline derivatives is methylated selectively in good yields.
January 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28106163/synergistically-enhanced-selective-intracellular-uptake-of-anticancer-drug-carrier-comprising-folic-acid-conjugated-hydrogels-containing-magnetite-nanoparticles
#17
Haneul Kim, Ara Jo, Seulgi Baek, Daeun Lim, Soon-Yong Park, Soo Kyung Cho, Jin Woong Chung, Jinhwan Yoon
Targeted drug delivery has long been extensively researched since drug delivery and release at the diseased site with minimum dosage realizes the effective therapy without adverse side effects. In this work, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemo-therapy, we have designed targeted multifunctional anticancer drug carrier hydrogels. Temperature-responsive poly(N-isopropylacrylamide) (PNIPAm) hydrogel core containing superparamagnetic magnetite nanoparticles (MNP) were prepared using precipitation polymerization, and further polymerized with amine-functionalized copolymer shell to facilitate the conjugation of targeting ligand...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105660/selective-reductions-of-n-n-bis-chloro-aryl-phosphino-amines-yielding-three-five-six-and-eight-membered-cyclic-azaphosphanes
#18
Uwe Rosenthal, Martha Hoehne, Markus Joksch, Katharina Konieczny, Bernd Harald Mueller, Anke Spannenberg, Normen Peulecke
To date a plethora of λ3-P nitrogen containing-compounds is known. A large part of them is used as ligands in coordination chemistry and homogeneous catalysis. PN-containing compounds tend to build up cyclic moieties which have received less attention in regard to their application as ligands in transition metal chemistry. Hence different dehalogenation reactions of N,N-Bis{chloro(aryl)-phosphino}-amines have being developed to synthesize different P-N-P containing cyclic compounds. Their coordination behaviour to group (VI) transition metal carbonyls was explored...
January 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28105558/immunology-of-bee-venom
#19
REVIEW
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Ricardo D Zwiener
Bee venom is a blend of biochemicals ranging from small peptides and enzymes to biogenic amines. It is capable of triggering severe immunologic reactions owing to its allergenic fraction. Venom components are presented to the T cells by antigen-presenting cells within the skin. These Th2 type T cells then release IL-4 and IL-13 which subsequently direct B cells to class switch to production of IgE. Generating venom-specific IgE and crosslinking FcεR1(s) on the surface of mast cells complete the sensitizing stage in allergic individuals who are most likely to experience severe and even fatal allergic reactions after being stung...
January 20, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28105510/diversity-and-distribution-of-thermophilic-bacteria-in-hot-springs-of-pakistan
#20
Arshia Amin, Iftikhar Ahmed, Nimaichand Salam, Byung-Yong Kim, Dharmesh Singh, Xiao-Yang Zhi, Min Xiao, Wen-Jun Li
Chilas and Hunza areas, located in the Main Mantle Thrust and Main Karakoram Thrust of the Himalayas, host a range of geochemically diverse hot springs. This Himalayan geothermal region encompassed hot springs ranging in temperature from 60 to 95 °C, in pH from 6.2 to 9.4, and in mineralogy from bicarbonates (Tato Field), sulfates (Tatta Pani) to mixed type (Murtazaabad). Microbial community structures in these geothermal springs remained largely unexplored to date. In this study, we report a comprehensive, culture-independent survey of microbial communities in nine samples from these geothermal fields by employing a bar-coded pyrosequencing technique...
January 19, 2017: Microbial Ecology
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