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https://www.readbyqxmd.com/read/27933675/c3-symmetric-boron-lewis-acid-with-a-cage-shape-for-chiral-molecular-recognition-and-asymmetric-catalysis
#1
Akihito Konishi, Koichi Nakaoka, Hikaru Maruyama, Hideto Nakajima, Tomohiro Eguchi, Akio Baba, Makoto Yasuda
Chiral Lewis acids have played an important role in the precise construction of various types of chiral molecules. Here, we designed and synthesized a cage-shaped borate 2 as a chiral Lewis acid, which possesses a unique C3-symmetric structure composed of three homochiral binaphthyl moieties. The highly symmetrical structure of 2 with homochirality was clearly elucidated by X-ray crystallographic analysis. The peculiar chiral environment of 2·THF exhibited the chiral recognition of some simple amines and a sulfoxide...
December 8, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27933632/association-of-alirocumab-therapy-with-inflammatory-lesions-of-the-vocal-folds-a-case-report
#2
Peter A Benedict, Rania M Abdou, Gregory R Dion, Peak Woo, Ryan C Branski, Milan R Amin
Therapeutic monocolonal antibodies (MAbs) are a new, rapidly growing class of medications that frequently have poorly characterized side-effect profiles. We present a patient who developed inflammatory lesions of the vocal folds in temporal relation to the initiation of alirocumab. Lesions of the vocal folds represent a previously unreported adverse effect of alirocumab therapy, making it the second MAb documented with such a side effect. The potential laryngeal effects of alirocumab specifically, and of MAbs more broadly, warrant investigation...
December 9, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27932949/muscle-type-nicotinic-receptor-modulation-by-2-6-dimethylaniline-a-molecule-resembling-the-hydrophobic-moiety-of-lidocaine
#3
Armando Alberola-Die, Gregorio Fernández-Ballester, José M González-Ros, Isabel Ivorra, Andrés Morales
To identify the molecular determinants responsible for lidocaine blockade of muscle-type nAChRs, we have studied the effects on this receptor of 2,6-dimethylaniline (DMA), which resembles lidocaine's hydrophobic moiety. Torpedo marmorata nAChRs were microtransplanted to Xenopus oocytes and currents elicited by ACh (IACh), either alone or co-applied with DMA, were recorded. DMA reversibly blocked IACh and, similarly to lidocaine, exerted a closed-channel blockade, as evidenced by the enhancement of IACh blockade when DMA was pre-applied before its co-application with ACh, and hastened IACh decay...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27932945/monoaminergic-and-histaminergic-strategies-and-treatments-in-brain-diseases
#4
REVIEW
Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J Smolders, Anna Stasiak, Wieslawa A Fogel, Philippe De Deurwaerdère
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27930980/vitamin-d3-intake-as-regulator-of-insulin-degrading-enzyme-and-insulin-receptor-phosphorylation-in-diabetic-rats
#5
Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Ali
Insulin-degrading enzyme (IDE, insulysin) is a rate-limiting enzyme in the insulin degradation process. It is an intracellular 110-kDa thiol zinc-metalloendopeptidase located in the cytosol, peroxisomes, endosomes and cell surface. IDE catalyzes degradation of several small proteins including insulin, amylin and β-amyloid protein. In addition, insulin clearance was expressed as a target in the treatment of type 2 diabetes given the role of hyperinsulinemia in the pathogenesis of insulin resistance. In this study, fourtyadult male Wistar albino rats were used, thirty rats received 20% fructose in drinking water (HFW) for six weeks to induce diabetes...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930973/phytosomal-curcumin-a-review-of-pharmacokinetic-experimental-and-clinical-studies
#6
REVIEW
Hamed Mirzaei, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, Amirhossein Sahebkar
Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930832/borinic-acid-catalysed-hydrosilanes-reduction-of-tertiary-amides-a-mild-and-chemoselective-synthesis-of-amines
#7
Aurélien Chardon, Tharwat Mohy El Dine, Rémi Legay, Michael De Paolis, Jacques Rouden, Jérôme Blanchet
A reduction of various aryl, alkyl and α,β-unsaturated amides with phenylsilane catalysed by a borinic acid is reported. The reaction carried out under unprecedented very mild conditions and led to useful amines. Furthermore, the reaction tolerates a variety of functional groups. Initial investigation of the reaction mechanism was shown to involve an intermediate diarylhydroborane.
December 8, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27930671/reaction-pathways-in-catechol-primary-amine-mixtures-a-window-on-crosslinking-chemistry
#8
Juan Yang, Vittorio Saggiomo, Aldrik H Velders, Martien A Cohen Stuart, Marleen Kamperman
Catechol chemistry is used as a crosslinking tool abundantly in both natural organisms (e.g. mussels, sandcastle worms) and synthetic systems to achieve the desired mechanical properties. Despite this abundance and success, the crosslinking chemistry is still poorly understood. In this study, to simplify the system, yet to capture the essential chemistry, model compounds 4-methyl catechol and propylamine are used. The reaction of 4-methyl catechol (2 mM) with propylamine (6 mM) is carried out in the presence of NaIO4 (2 mM) in 10 mM Na2CO3 aqueous solution...
2016: PloS One
https://www.readbyqxmd.com/read/27930295/birth-of-a-w-sex-chromosome-by-horizontal-transfer-of-wolbachia-bacterial-symbiont-genome
#9
Sébastien Leclercq, Julien Thézé, Mohamed Amine Chebbi, Isabelle Giraud, Bouziane Moumen, Lise Ernenwein, Pierre Grève, Clément Gilbert, Richard Cordaux
Sex determination is a fundamental developmental pathway governing male and female differentiation, with profound implications for morphology, reproductive strategies, and behavior. In animals, sex differences between males and females are generally determined by genetic factors carried by sex chromosomes. Sex chromosomes are remarkably variable in origin and can differ even between closely related species, indicating that transitions occur frequently and independently in different groups of organisms. The evolutionary causes underlying sex chromosome turnover are poorly understood, however...
December 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27929735/development-of-adsorptive-hybrid-filters-to-enable-two-step-purification-of-biologics
#10
Nripen Singh, Abhiram Arunkumar, Michael Peck, Alexei M Voloshin, Angela M Moreno, Zhijun Tan, Jonathan Hester, Michael C Borys, Zheng Jian Li
Recent progress in mammalian cell culture process has resulted in significantly increased product titers, but also a substantial increase in process- and product-related impurities. Due to the diverse physicochemical properties of these impurities, there is constant need for new technologies that offer higher productivity and improved economics without sacrificing the process robustness required to meet final drug substance specifications. Here, we examined the use of new synthetic adsorptive hybrid filters (AHF) modified with the high binding capacity of quaternary amine (Emphaze™ AEX) and salt-tolerant biomimetic (Emphaze™ ST-AEX) ligands for clearance of process-related impurities like host cell protein (HCP), residual DNA, and virus...
December 8, 2016: MAbs
https://www.readbyqxmd.com/read/27929166/intramolecular-cation-%C3%AF-interactions-in-protonated-phenylalanine-derivatives
#11
Weiqiang Fu, Patrick J J Carr, Michael J Lecours, Michael Burt, Rick A Marta, Vincent Steinmetz, Eric Fillion, Terrance B McMahon, W Scott Hopkins
The structures and properties of a series of phenylalanine (Phe) derivatives have been investigated in a joint computational and experimental infrared multiple photon dissociation (IRMPD) study. IRMPD spectra in the 1000-2000 cm(-1) region show that protonation is localized on the amine group in all cases. Intramolecular cation-π interactions between the ammonium group and the phenyl ring heavily influence molecular geometries and properties such as gas phase basicity and proton affinity. By varying substituents on the phenyl ring, one can sensitively tune the cation-π interaction and, therefore, the molecular structure and properties...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27929123/rnai-mediated-mortality-of-the-whitefly-through-transgenic-expression-of-double-stranded-rna-homologous-to-acetylcholinesterase-and-ecdysone-receptor-in-tobacco-plants
#12
Hassan Jamil Malik, Amir Raza, Imran Amin, Jodi A Scheffler, Brian E Scheffler, Judith K Brown, Shahid Mansoor
The whitefly Bemisia tabaci (Genn.) is a pest and vector of plant viruses to crop and ornamental plants worldwide. Using RNA interference (RNAi) to down regulate whitefly genes by expressing their homologous double stranded RNAs in plants has great potential for management of whiteflies to reduce plant virus disease spread. Using a Tobacco rattle virus-derived plasmid for in planta transient expression of double stranded RNA (dsRNA) homologous to the acetylcholinesterase (AChE) and ecdysone receptor (EcR) genes of B...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928815/comparing-monotherapy-with-tadalafil-or-tamsulosin-and-their-combination-therapy-in-men-with-benign-prostatic-hyperplasia-a-randomized-clinical-trial
#13
Hossein Karami, Amin Hassanzadeh-Hadad, Morteza Fallah-Karkan
PURPOSE: To compare monotherapy with tadalafil or tamsulosin and their combination therapy in men with benignprostatic hyperplasia and erectile dysfunction by comparing IPSS score, prostate volume and Qmax and someother outcomes. MATERIALS AND METHODS: This randomized, single-blind, paralleled group clinical trial was done in 2013 on patientswho had referred to our hospital in Tehran. All patients with lower urinary tract symptoms, benign prostatichyperplasia and any grade of erectile dysfunction were recruited...
December 8, 2016: Urology Journal
https://www.readbyqxmd.com/read/27928562/an-unexpected-copper-catalyzed-carbonylative-acetylation-of-amines
#14
Yahui Li, Changsheng Wang, Fengxiang Zhu, Zechao Wang, Jean François Soulé, Pierre H Dixneuf, Xiao-Feng Wu
A novel copper-catalyzed carbonylative acetylation of amines has been developed. With peroxide as the oxidant as well as the methyl source with a copper catalyst under CO pressure, good yields of N-acetyl amides could be obtained. Notably, this is the first example of carbonylative acetylation.
December 8, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27928523/quality-of-life-in-elderly-iranian-population-using-the-qol-brief-questionnaire-a-systematic-review
#15
REVIEW
Zahra Cheraghi, Amin Doosti-Irani, Sima Nedjat, Parvin Cheraghi, Saharnaz Nedjat
BACKGROUND: Due to the increase in the elderly population in different societies, their primary needs, physical and mental health, and quality of life, is important. This study aimed to estimate the overall mean score of the QOL based on the Qol-Brief questionnaire in the elderly population of Iran. METHODS: The international and national databases, including; Medline, Scopus, Science Direct, MagIran, and SID were searched up to Feb 2015. All studies, addressed the quality of life among the healthy Iranian elderly population using WHO-QOL-BRIEF questionnaire, were included...
August 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27928493/putting-an-ultrahigh-concentration-of-amine-groups-into-a-metal-organic-framework-for-co2-capture-at-low-pressures
#16
Pei-Qin Liao, Xun-Wei Chen, Si-Yang Liu, Xu-Yu Li, Yan-Tong Xu, Minni Tang, Zebao Rui, Hongbing Ji, Jie-Peng Zhang, Xiao-Ming Chen
Tremendous efforts have been devoted to increasing the CO2 capture performance of porous materials, especially for low CO2 concentration environments. Here, we report that hydrazine can be used as a diamine short enough to functionalize the small-pore metal-organic framework [Mg2(dobdc)] (H4dobdc = 2,5-dihydroxyl-1,4-benzenedicarboxylic acid). By virtue of the ultrahigh concentration of free amine groups (6.01 mmol g(-1) or 7.08 mmol cm(-3)) capable of reversible carbamic acid formation, the new material [Mg2(dobdc)(N2H4)1...
October 19, 2016: Chemical Science
https://www.readbyqxmd.com/read/27928265/link-between-the-platelet-to-lymphocyte-ratio-and-coronary-artery-disease-severity
#17
Hilman Zulkifli Amin, Lukman Zulkifli Amin, Firman Zulkifli Amin
No abstract text is available yet for this article.
April 13, 2016: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/27928078/polymerase-chain-reaction-based-assays-for-the-diagnosis-of-active-and-relapsed-cases-of-human-brucellosis
#18
Mohammad Reza Hasanjani Roushan, Seyed Mahmoud Amin Marashi, Zahra Moulana
This study aimed to compare polymerase chain reaction (PCR) with serum agglutination test (SAT) in the diagnosis of patients before and 6 months after treatment. Peripheral blood specimens from 50 patients with brucellosis (case group) and 30 subjects without brucellosis (control group) were selected and entered into the study. The diagnosis of brucellosis was established using SAT ≥ 1:160 and 2-mercaptoethanol (2-ME) ≥ 1:80 with clinical signs and symptoms compatible with brucellosis. For each case, both before treatment and 6 months after completion of therapy, SAT, 2-ME, and PCR were performed...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27927201/epidemiology-and-risk-factors-for-pneumonia-severity-and-mortality-in-bangladeshi-children-5-years-of-age-before-10-valent-pneumococcal-conjugate-vaccine-introduction
#19
Shampa Saha, Md Hasan, Lindsay Kim, Jennifer L Farrar, Belal Hossain, Maksuda Islam, Asm Nawshad Uddin Ahmed, M Ruhul Amin, Mohammed Hanif, Manzoor Hussain, Shams El-Arifeen, Cynthia G Whitney, Samir K Saha
BACKGROUND: Pneumonia is the leading infectious cause of morbidity and mortality in young children in Bangladesh. We present the epidemiology of pneumonia in Bangladeshi children <5 years before 10-valent pneumococcal conjugate vaccine introduction and investigate factors associated with disease severity and mortality. METHODS: Children aged 2-59 months admitted to three Bangladeshi hospitals with pneumonia (i.e., cough or difficulty breathing and age-specific tachypnea without danger signs) or severe pneumonia (i...
December 7, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27927194/melastoma-malabathricum-linn-attenuates-complete-freund-s-adjuvant-induced-chronic-inflammation-in-wistar-rats-via-inflammation-response
#20
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Dinesh Kumar Patel, Nikunj Sethi, Atul Kumar, Nikhil Kumar Sachan, Gaurav Kaithwas, F A Al-Abbasi, Firoz Anwar, Amita Verma
BACKGROUND: Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as "putki," has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats. METHODS: High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract...
December 7, 2016: BMC Complementary and Alternative Medicine
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