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https://www.readbyqxmd.com/read/29345946/cooperative-metal-ligand-catalyzed-intramolecular-hydroamination-and-hydroalkoxylation-of-allenes-using-a-stable-iron-catalyst
#1
Osama El-Sepelgy, Aleksandra Brzozowska, Jan Sklyaruk, Yoon Kyung Jang, Viktoriia Zubar, Magnus Rueping
A new iron-catalyzed chemoselective intramolecular hydroamination and hydroalkoxylation of the readily available α-allenic amines and alcohols to valuable unsaturated 5-membered heterocycles, 2,3-dihydropyrrole and 2,3-dihydrofuran, is reported. Effective selectivity control is achieved by a metal-ligand cooperative activation of the substrates. The mild reaction conditions and the use of low amounts of an air and moisture stable iron catalyst allow for the hydrofunctionalization of a wide range of allenes bearing different functional groups in good yields in the absence of base or any sensitive additives...
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29345861/ruthenium-catalyzed-aerobic-oxidation-of-amines
#2
Debabrata Maiti, Goutam Kumar Lahiri, Ritwika Ray, Arijit Singha Hazari
Amine oxidation is one of the fundamental reactions in organic synthesis since it leads to a variety of value-added products like oximes, nitriles, imines and amides among many others. These products comprise the key N-containing building blocks in modern chemical industry, and such transformations when achieved in presence of molecular oxygen without using stoichiometric oxidants, are much preferred since they circumvent the production of unwanted wastes. In parallel, versatility of ruthenium catalysts in various oxidative transformations is well-documented...
January 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29345854/-ch3nh3-4ga4sbs9s0-28o0-72h-a-three-dimensionally-open-framework-heterometallic-chalcogenidoantimonate-exhibiting-ni2-ion-exchange-property
#3
Bo Zhang, Wei-An Li, Yi-Yu Liao, Chen Zhang, Mei-Ling Feng, Xiao-Ying Huang
An open-framework chalcogenidoantimonate, namely, [CH3NH3]4Ga4SbS9S0.28O0.72H (1), has been solvothermally synthesized and structurally characterized. Interestingly, 1 showed Ni2+ ion-exchange properties and wide pH resistance, with a maximum exchange capacity of 76.9 mg/g. To the best of our knowledge, this is the first example of amine-directed three-dimensional (3D) heterometallic chalcogenidometalates for the highly selective Ni2+ ion capture with the high distribution coefficient (Kd = 1.65 × 105 mL/g)...
January 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29345708/triphenylstannyl-arylimino-methyl-benzoates-with-selective-potency-that-induce-g1-and-g2-m-cell-cycle-arrest-and-trigger-apoptosis-via-ros-in-human-cervical-cancer-cells
#4
Tushar S Basu Baul, Imliwati Longkumer, Andrew Duthie, Priya Singh, Biplob Koch, M Fátima C Guedes da Silva
Metal complexes with organelle specificity and potent but selective cytotoxicity are highly desirable. A novel series of triphenylstannyl 4-((arylimino)methyl)benzoates (2-8) were obtained by the reactions of triphenylstannyl 4-formylbenzoate [Ph3Sn(L1)] 1 with primary aromatic amines. Two representative compounds (10, 11) were also synthesized by reacting aqua-triphenylstannyl 2-formylbenzoate [Ph3Sn(L9)(H2O)] (9) with aniline and p-fluoroaniline, respectively. These compounds were characterized by elemental analysis, IR and 1H, 13C and 119Sn NMR spectroscopy, as well as single-crystal X-ray diffraction for compounds 5, 7-11 and three pro-ligands...
January 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29345139/catalytically-enantioselective-synthesis-of-acyclic-%C3%AE-tertiary-amines-through-desymmetrization-of-2-substituted-2-nitro-1-3-diols
#5
Shan-Shui Meng, Wu-Bang Tang, Wen-Hua Zheng
Highly enantioselective synthesis of acyclic α-tertiary amines through asymmetric desymmetrization is reported. This approach is based on chiral phosphoric acid mediated, enantioselective, oxidative desymmetrization of 2-substituted 2-nitro-1,3-diolbenzylidine acetals in the presence of DMDO as an oxidant. The method allows for the formation of a wide variety of chiral 2-nitro-1,3-diols in high enantioselectivity, which could be transformed into optically pure, unnatural α-alkyl series. The synthetic utility of this method has been further demonstrated by the expedient construction of the core structure of natural products manzacidins enantioselectively...
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29345128/synthesis-of-%C3%AE-formylated-n-heterocycles-and-their-1-1-diacetates-from-inactivated-cyclic-amines-involving-an-oxidative-ring-contraction
#6
Fang Wang, Yan He, Miaomiao Tian, Xinying Zhang, Xuesen Fan
A novel synthesis of pyrrolidine-2-carbaldehydes or tetrahydropyridine-2-carbaldehydes from the cascade reactions of N-arylpiperidines or N-arylazepanes is presented. Mechanistically, the formation of the title compounds involves an unprecedented oxidative ring contraction of inactivated cyclic amines via Cu(OAc)2/KI/O2-promoted oxidative cleavage and reformation of the C-N bond. Interestingly, when PhI(OAc)2 was used in place of KI, 1,1-diacetates of the corresponding aldehydes were directly obtained with good efficiency...
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29345067/supramolecular-gels-derived-from-the-salts-of-variously-substituted-phenylacetic-acid-and-dicyclohexyl-amine-design-synthesis-structures-and-dye-adsorption
#7
Parthasarathi Dastidar, Rajdip Roy, Tapas Kumar Adalder
A well-studied supramolecular synthon namely secondary ammonium monocarboxylate (SAM) was exploited to generate a new series of organic salts derived from variously substituted phenylacetic acid (PA) and dicyclohexyl amine (DCA) as potential low molecular weight gelators (LMWGs). As much as 25% of the SAM salts under study were gelators. The gels were characterized by rheology and the morphology of the gel networks was studied by high resolution electron microscopy. Single crystal and powder X-ray diffraction data were employed to study structure-property (gelation) correlation...
January 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29345033/total-synthesis-and-conformational-study-of-the-anti-tubercular-cyclic-peptide-callyaerin-a-bearing-a-rare-rigidifying-z-2-3-diaminoacrylamide-moiety
#8
Margaret Anne Brimble, Shengping Zhang, Luis De Leon Rodriguez, Ivanhoe Leung, Greg Cook, Paul Harris
The first synthesis of the anti-TB cyclic peptide callyaerin A containing a rare (Z)-2,3-diaminoacrylamide bridging motif is reported. Fmoc-formylglycine-diethylacetal was used as a masked equivalent of formylglycine in the synthesis of the linear precursor of callyaerin A. Intramolecular cyclization between the formylglycine residue and the N-terminal amine in the linear peptide precursor afforded the macrocyclic natural product callyaerin A. Synthetic callyaerin A possessed potent anti-TB activity (MIC100 = 32 µM) while its all-amide congener was inactive...
January 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29344536/a-cry-for-help-and-protest-self-immolation-in-young-kurdish-iraqi-women-a-qualitative-study
#9
Pakestan Mohammad Amin, Jila Mirlashari, Alireza Nikbakht Nasrabadi
Background: Suicide is a major psychiatric emergency that has always been a topic of great interest to researchers. Self-immolation is a heinous suicide method that is common in Eastern societies. The present study was conducted to explore probable issues which might lead to self-immolation in young Kurdish Iraqi women. Methods: The present qualitative study was conducted in Soran, Erbil Governorate in Iraq, and the surrounding villages of Soran District (March 2015 to May 2016)...
January 2018: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29344526/the-effects-of-team-based-learning-on-learning-outcomes-in-a-course-of-rheumatology
#10
Seyedeh Tahereh Faezi, Kamran Moradi, Ali Ghafar Rahimi Amin, Massoomeh Akhlaghi, Fatemeh Keshmiri
Introduction: We evaluated the effects of implementing Team-Based Learning (TBL) on student engagement, accountability, satisfaction, and preference for lecture or team-based learning. Moreover, we assessed the effect of TBL on knowledge retention and application over time through short answer questions based on clinical scenarios addressing history taking and diagnosis skills in medical students. Methods: The study was conducted in a quasi-experimental design. The study population were all of the third-year medical students (n = 84) participating in a course of rheumatology in Shariati Hospital, which is a teaching hospital affiliated to Tehran University of Medical Sciences...
January 2018: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/29344525/psychometric-properties-of-the-communication-skills-attitude-scale-csas-measure-in-a-sample-of-iranian-medical-students
#11
Afsaneh Yakhforoshha, Mandana Shirazi, Naser Yousefzadeh, Amin Ghanbarnejad, Mohammadali Cheraghi, Rita Mojtahedzadeh, Behrooz Mahmoodi-Bakhtiari, Seyed Amir Hossein Emami
Introduction: Communication skill (CS) has been regarded as one of the fundamental competencies for medical and other health care professionals. Student's attitude toward learning CS is a key factor in designing educational interventions. The original CSAS, as positive and negative subscales, was developed in the UK; however, there is no scale to measure these attitudes in Iran. The aim of this study was to assess the psychometric characteristic of the Communication Skills Attitude Scale (CSAS), in an Iranian context and to understand if it is a valid tool to assess attitude toward learning communication skills among health care professionals...
January 2018: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/29343163/magnetic-resonance-imaging-changes-following-natalizumab-discontinuation-in-multiple-sclerosis-patients-with-progressive-multifocal-leukoencephalopathy
#12
Jérôme Hodel, Blanche Bapst, Olivier Outteryck, Sébastien Verclytte, Vincent Deramecourt, Mohamed Amine Benadjaoud, Jean-Pierre Pruvo, Patrick Vermersch, Xavier Leclerc
BACKGROUND: Detecting early progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) is clinically relevant. OBJECTIVE: Evaluating magnetic resonance imaging (MRI) changes following natalizumab (NTZ) discontinuation and preceding PML-IRIS. METHODS: MRIs (including diffusion-weighted imaging (DWI), T2-weighted fluid-attenuated inversion recovery (T2-FLAIR), post-contrast T1-weighted sequences) were performed every week following PML diagnosis in 11 consecutive NTZ-PML patients...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29342409/development-and-characterization-of-an-allergoid-of-cat-dander-for-immunotherapy
#13
J P Sola, Y Pedreño, A Cerezo, M Peñalver-Mellado
BACKGROUND: Allergy to cats is a frequent cause of sensitization to indoor allergens and currently there are few alternatives to specific immunotherapy with cat native extracts. The objective is to develop and characterize a new allergoid to increase the tools available for use in clinical practice. METHODS: The allergoid cat dander extract (ACD) was developed from a native cat dander extract (NCD) by modification with glutaraldehyde, and the optimal process control was determined by SDS-PAGE, DOT BLOT and determination of free amine groups...
January 13, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29341893/targeting-bdnf-modulation-by-plant-glycosides-as-a-novel-therapeutic-strategy-in-the-treatment-of-depression
#14
REVIEW
Haroon Khan, Surriya Amin, Seema Patel
Current therapies in clinical practice face strong criticism regarding their efficacy, and side effects, which forced the neuro-researchers to discover novel agents with different mechanistic insights. Glycosides are naturally-occurring plant secondary metabolites with significant medicinal potential and clinical scope as antidepressant. The aim of this review is to focus on the antidepressant effects of glycosides in preclinical studies, with an emphasis on the possible mechanisms. The literature search revealed that only a few phytoglycosides have been evaluated for their relevance in depression alleviation...
January 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29341614/synthesis-of-quinazolines-via-an-iron-catalyzed-oxidative-amination-of-n-h-ketimines
#15
Cheng-Yi Chen, Fengxian He, Guangrong Tang, Huiqing Yuan, Ning Li, Jinmin Wang, Roger Faessler
An efficient synthesis of quinazolines based on an iron-catalyzed C(sp3)-H oxidation and intramolecular C-N bond formation using tert-BuOOH as the terminal oxidant is described. The reaction of readily available 2-alkylamino benzonitriles with various organometallic reagents led to 2-alkylamino N-H ketimine species. The FeCl2-catalyzed C(sp3)-H oxidation of the alkyl group employing tert-BuOOH followed by intramolecular C-N bond formation and aromatization afforded a wide variety of 2,4-disubstituted quinazolines in good to excellent yields...
January 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29341599/a-ni-catalyzed-carbon-carbon-bond-forming-reductive-amination
#16
Christoph Heinz, J Patrick Lutz, Eric M Simmons, Michael M Miller, William R Ewing, Abigail G Doyle
This report describes a three-component, Ni-catalyzed reductive coupling that enables the convergent synthesis of tertiary benzhydryl amines, which are challenging to access by traditional reductive amination methodologies. The reaction makes use of iminium ions generated in situ from the condensation of secondary N-trimethylsilyl amines with benzaldehydes, and these species undergo reaction with several distinct classes of organic electrophiles. The synthetic value of this process is demonstrated by a single-step synthesis of antimigraine drug flunarizine (Sibelium®) and high yielding derivatization of paroxetine (Paxil®) and metoprolol (Lopressor®)...
January 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29341435/bifunctional-fluorescent-probe-for-sequential-sensing-thiols-and-primary-aliphatic-amines-in-distinct-fluorescence-channels
#17
Lingliang Long, Meiyu Huang, Ning Wang, Xiangqi Yuan, Siyu Cao, Aihua Gong, Kun Wang
Thiols and primary aliphatic amines (PAA) are ubiquitous and extremely important species in biological system. They have performed significant interplaying roles in complex biological events. A single fluorescent probe differentiating both thiol and PAA can contribute to understanding the intrinsic inter-relationship of thiols and PAA in biological processes. Herein, we rationally constructed the first fluorescent probe that can respond to thiols and PAA in different fluorescence channels. The probe exhibited high selectivity and sensitivity to thiols and PAA...
January 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29341383/co2-triggered-switchable-hydrophilicity-of-heterogeneous-conjugated-polymer-photocatalyst-for-enhanced-catalytic-activity-in-water
#18
Jeehye Byun, Wei Huang, Di Wang, Run Li, Kai A I Zhang
Water-compatibility of heterogeneous photocatalysts has been pursued for energy and environmental applications. However, there exists a trade-off between hydrophilicity and recyclability of the photocatalyst. Herein, we report a conjugated polymer photocatalyst with tertiary amine terminals that reversibly binds CO2 in water, generating a switchable hydrophilicity. The CO2-assisted hydrophilicity boosted up the photocatalytic efficiency in aqueous medium with minimum dosage. When CO2 was desorbed, the photocatalyst could be simply regenerated from reaction media, facilitating the repeated use of photocatalyst...
January 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29340980/facile-synthesis-of-chitosan-capped-mesoporous-silica-nanoparticles-a-ph-responsive-smart-delivery-platform-for-raloxifene-hydrochloride
#19
Priya V Shah, Sadhana J Rajput
An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive drug delivery system. A silanol skeleton of MSN has been productively modified to amine intermediate which served as a firm platform to adapt chitosan grafted assembly and systematically evaluated...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29340956/semi-targeted-analysis-of-complex-matrices-by-esi-ft-icr-ms-or-how-an-experimental-bias-may-be-used-as-an-analytical-tool
#20
Jasmine Hertzog, Vincent Carré, Anthony Dufour, Frédéric Aubriet
Ammonia is well suited to favor deprotonation process in electrospray ionization mass spectrometry (ESI-MS) to increase the formation of [M - H]-. Nevertheless, NH3 may react with carbonyl compounds (aldehyde, ketone) and bias the composition description of the investigated sample. This is of significant importance in the study of complex mixture such as oil or bio-oil. To assess the ability of primary amines to form imines with carbonyl compounds during the ESI-MS process, two aldehydes (vanillin and cinnamaldehyde) and two ketones (butyrophenone and trihydroxyacetophenone) have been infused in an ESI source with ammonia and two different amines (aniline and 3-chloronaniline)...
January 16, 2018: Journal of the American Society for Mass Spectrometry
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