keyword
MENU ▼
Read by QxMD icon Read
search

Practical noradrenalin

keyword
https://www.readbyqxmd.com/read/27867511/is-tapentadol-different-from-classical-opioids-a-review-of-the-evidence
#1
Richard M Langford, Roger Knaggs, Paul Farquhar-Smith, Anthony H Dickenson
Tapentadol is a single molecule able to deliver analgesia by two distinct mechanisms, a feature which differentiates it from many other analgesics. Pre-clinical data demonstrate two mechanisms of action: mu-opioid receptor agonist activity and noradrenaline re-uptake inhibition. From these, one may predict that tapentadol would be applicable across a broad spectrum of pain from nociceptive to neuropathic. The evidence in animal models suggests that norepinephrine re-uptake inhibition (NRI) is a key mechanism and may even predominate over opioid actions in chronic (and especially neuropathic) pain states, reinforcing that tapentadol is different to classical opioids and may, therefore, be an a priori choice for the treatment of neuropathic and mixed pain...
November 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27687422/in-vitro-antimicrobial-activity-of-commonly-used-vasoactive-drugs
#2
Ozgun Cuvas Apan, Teoman Zafer Apan, Alparslan Apan
STUDY OBJECTIVE: Microbial contamination during preparation of the infusion drugs is an important issue in intensive care units. Objective of this study was to investigate in vitro antimicrobial properties of commonly used vasoactive drugs. DESIGN: Prospective study. SETTING: Clinical microbiology laboratory of a university hospital. MEASUREMENTS: Growth of the microorganisms Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans in saline dilutions of adrenaline at 1, 10, and 100 μg/mL; noradrenaline at 1, 10, and 100 μg/mL; and dopamine at 0...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27611642/tapentadol-prolonged-release-for-chronic-pain-a-review-of-clinical-trials-and-5-years-of-routine-clinical-practice-data
#3
Ralf Baron, Leopold Eberhart, Kai-Uwe Kern, Stefan Regner, Roman Rolke, Christian Simanski, Thomas Tölle
Tapentadol prolonged release (PR) for the treatment of moderate to severe chronic pain combines 2 modes of action. These are μ-opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule that allows higher analgesic potency through modulation of different pharmacological targets within the pain transmitting systems. At the same time, this can also serve as a clue for modulation of different pain-generating mechanisms according to nociceptive, neuropathic, or mixed pain conditions. Tapentadol PR has now been on the market for 5 years, with over 2...
September 9, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27443661/prevalence-and-type-of-antidepressant-therapy-used-by-german-general-practitioners-to-treat-female-patients-with-osteoporosis%C3%A2
#4
Julia Drosselmeyer, Michael A Rapp, Karel Kostev
OBJECTIVE: To estimate the prevalence and type of antidepressant medication prescribed by German primary care physicians for patients with depression and osteoporosis. METHODS: This study was a retrospective database analysis conducted in Germany utilizing the Disease Analyzer® Database (IMS Health, Germany). The study population included 3,488 female osteoporosis patients aged between 40 and 90 years recruited from 1,179 general practitioner practices and who were initially diagnosed with depression during the index period (January 2004 to December 2013)...
October 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27291070/shock-treatment-in-a-cohort-of-scandinavian-intensive-care-units-in-2014
#5
COMMENT
M Kollind, F Wickbom, E Wilkman, M S C Snäckestrand, A Holmén, A Oldner, A Perner, A Åneman, M S Chew
BACKGROUND: Shock is common in intensive care units, and treatment includes fluids, vasopressor and/or inotropic drugs, guided by hemodynamic monitoring. The aim of this study was to identify current practice for treatment of shock in Scandinavian intensive care units. METHODS: Seven-day inception cohort study in 43 intensive care units in Scandinavia. Patients ≥ 15 years old receiving more than 4 h of cardiovascular acting drug infusion were included. The use of fluids, vasopressor and inotropic drugs, type of monitoring, and target values were recorded...
August 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27250671/review-of-therapeutic-agents-employed-by-an-australian-aeromedical-prehospital-and-retrieval-service
#6
Marcus D Hayward, Luke Regan, John Glasheen, Brian Burns
OBJECTIVE: There is little current evidence regarding which therapeutic agents are actually used within existing aeromedical services. The Greater Sydney Area Helicopter Emergency Medical Service operates a large, physician-staffed, multimodal, prehospital and interhospital retrieval service. The aim of the present study was to identify the range and frequency of drug, fluid and blood product use within our service. METHODS: This was a retrospective cross-sectional study...
June 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/27125775/treatment-of-depression-in-patients-with-cardiovascular-diseases-by-german-psychiatrists
#7
Marcel Konrad, Louis Jacob, Michael A Rapp, Karel Kostev
OBJECTIVE: To estimate the prevalence and the type of antidepressant medication prescribed by German psychiatrists to patients with depression and cardiovascular diseases (CVD). METHODS: This study was a retrospective database analysis in Germany using the Disease Analyzer Database (IMS Health, Germany). The study population included 2,288 CVD patients between 40 and 90 years of age from 175 psychiatric practices. The observation period was between 2004 and 2013...
August 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26996722/correlation-between-the-increased-release-of-catecholamines-evoked-by-local-anesthetics-and-their-analgesic-and-adverse-effects-role-of-k-channel-inhibition
#8
Carmen Sircuta, Alexandra Lazar, Leonard Azamfirei, Mária Baranyi, E Sylvester Vizi, Zoltán Borbély
Because local anesthetics are known to inhibit both sodium and potassium channels, and anesthetic properties have been attributed to the former effect, we compared their effects with those of tetrodotoxin (TTX), a selective Na(+) channel inhibitor with anesthetic activity, and 4-aminopyridine (4-AP), a selective potassium channel blocker with convulsive activity, on transmitter release during rest and in response to field (axonal) stimulation using the microvolume perfusion method and isolated prefrontal cortex and spinal cord slice preparations loaded with the radioactive transmitters [(3)H]dopamine ([(3)H]DA) and [(3)H]noradrenaline ([(3)H]NA)...
June 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/26991592/evaluation-of-patients-sleep-by-nurses-in-an-icu
#9
Marita Ritmala-Castren, Irina Virtanen, Tero Vahlberg, Sanna Leivo, Kirsi-Maija Kaukonen, Helena Leino-Kilpi
AIMS AND OBJECTIVES: To determine how intensive care unit evaluations of patients' sleep by nurses correspond to polysomnography and if changes in patients' physiologic parameters could be helpful in sleep evaluation. BACKGROUND: The evaluations of patients' sleep by nurses have not corresponded very well with objective sleep recordings, so there is a need for further knowledge in this field. DESIGN: Correlational study of patients' sleep, nurses' sleep evaluations and the sleep-related heart rate and blood pressure changes...
June 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/26794933/adrenergic-stimulation-of-single-rat-astrocytes-results-in-distinct-temporal-changes-in-intracellular-ca-2-and-camp-dependent-pka-responses
#10
Anemari Horvat, Robert Zorec, Nina Vardjan
During the arousal and startle response, locus coeruleus neurons, innervating practically all brain regions, release catecholamine noradrenaline, which reaches neural brain cells, including astrocytes. These glial cells respond to noradrenergic stimulation by simultaneous activation of the α- and β-adrenergic receptors (ARs) in the plasma membrane with increasing cytosolic levels of Ca(2+) and cAMP, respectively. AR-activation controls a myriad of processes in astrocytes including glucose metabolism, gliosignal vesicle homeostasis, gene transcription, cell morphology and antigen-presenting functions, all of which have distinct temporal characteristics...
April 2016: Cell Calcium
https://www.readbyqxmd.com/read/26247561/-boosting-in-paralympic-athletes-with-spinal-cord-injury-doping-without-drugs
#11
F Mazzeo, S Santamaria, Alessandro Iavarone
The intentional activation of autonomic dysreflexia (AD, also called "boosting"), a practice sometimes used by athletes affected by spinal cord injury (SCI), is banned by the International Paralympic Committee (IPC). Although various studies have addressed doping and AD as separate issues, studies evaluating AD as a doping method are lacking. The aim of this brief review is to contribute to better understanding of the relationship between doping and AD. We conducted a literature search of the PubMed database (from 1994 onwards)...
August 6, 2015: Functional Neurology
https://www.readbyqxmd.com/read/26225899/sleep-bruxism-in-respiratory-medicine-practice
#12
REVIEW
Pierre Mayer, Raphael Heinzer, Gilles Lavigne
Sleep bruxism (SB) consists of involuntary episodic and repetitive jaw muscle activity characterized by occasional tooth grinding or jaw clenching during sleep. Prevalence decreases from 20% to 14% in childhood to 8% to 3% in adulthood. Although the causes and mechanisms of idiopathic primary SB are unknown, putative candidates include psychologic risk factors (eg, anxiety, stress due to life events, hypervigilance) and sleep physiologic reactivity (eg, sleep arousals with autonomic activity, breathing events)...
January 2016: Chest
https://www.readbyqxmd.com/read/26146091/how-physical-infusion-system-parameters-cause-clinically-relevant-dose-deviations-after-setpoint-changes
#13
Annemoon M Timmerman, Roland A Snijder, Peter Lucas, Martine C Lagerweij, Joris H Radermacher, Maurits K Konings
Multi-infusion therapy, in which multiple pumps are connected to one access point, is frequently used in patient treatments. This practice is known to cause dosing errors following setpoint changes in the drug concentrations that actually enter the patients. Within the Metrology for Drug Delivery Project, we analyzed and quantified the two main physical phenomena leading to these errors: the "push-out" effect and the system mechanical compliance. We compared the dosing errors of a three-pump system with two infusion sets, both with and without anti-reflux valves, using in vitro spectrophotometric experiments...
August 2015: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/26103124/aerobic-exercise-training-increases-nitrergic-innervation-function-and-decreases-sympathetic-innervation-function-in-mesenteric-artery-from-rats-fed-a-high-fat-diet
#14
Esther Sastre, Laura Caracuel, Gloria Balfagón, Javier Blanco-Rivero
INTRODUCTION: We investigated whether high-fat diet (HFD)-induced obesity was associated with modifications in mesenteric innervation function, the mechanisms involved, and the possible effects of aerobic exercise training on these changes. MATERIALS AND METHODS: Male Wistar rats were divided into three groups: rats fed a standard diet (control group); rats fed a HFD (35% fat) for 8 weeks; and HFD rats submitted to aerobic exercise training (8 weeks, 5 times per week for 50  min)...
September 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/26082973/serotonin-syndrome-analysis-of-cases-registered-in-the-french-pharmacovigilance-database
#15
Delphine Abadie, Vanessa Rousseau, Sophie Logerot, Judith Cottin, Jean-Louis Montastruc, François Montastruc
BACKGROUND: More information would be required for a better understanding of the actual circumstances of serotonin syndrome (SS) occurrence in routine clinical practice. AIM: The objective of the study was to analyze characteristics of SS French pharmacovigilance reports, especially involved drugs and nature of drug-drug interactions (DDIs). METHOD: We performed a retrospective analysis of SS registered in the French pharmacovigilance database between January 1, 1985 and May 27, 2013...
August 2015: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26074800/a-neurophysiological-and-neuropsychological-consideration-of-mindful-movement-clinical-and-research-implications
#16
REVIEW
Tamara Anne Russell, Silvia Maria Arcuri
In this article, we present ideas related to three key aspects of mindfulness training: the regulation of attention via noradrenaline, the importance of working memory and its various components (particularly the central executive and episodic buffer), and the relationship of both of these to mind-wandering. These same aspects of mindfulness training are also involved in the preparation and execution of movement and implicated in the pathophysiology of psychosis. We argue that by moving in a mindful way, there may be an additive effect of training as the two elements of the practice (mindfulness and movement) independently, and perhaps synergistically, engage common underlying systems (the default mode network)...
2015: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/25810948/monoamine-reuptake-inhibitors-in-parkinson-s-disease
#17
REVIEW
Philippe Huot, Susan H Fox, Jonathan M Brotchie
The motor manifestations of Parkinson's disease (PD) are secondary to a dopamine deficiency in the striatum. However, the degenerative process in PD is not limited to the dopaminergic system and also affects serotonergic and noradrenergic neurons. Because they can increase monoamine levels throughout the brain, monoamine reuptake inhibitors (MAUIs) represent potential therapeutic agents in PD. However, they are seldom used in clinical practice other than as antidepressants and wake-promoting agents. This review article summarises all of the available literature on use of 50 MAUIs in PD...
2015: Parkinson's Disease
https://www.readbyqxmd.com/read/25723082/-urinary-incontinence-induced-by-the-antidepressants-case-report
#18
J Krhut, M Gärtner
AIM: Case study of the patient with urinary incontinence induced by the antidepressant mirtazapin and the review of the related literature. DESIGN: Case Report. SETTING: Department of Urology, University Hospital Ostrava-Poruba. CASE REPORT: A case of 55-years old patiens, who was reffered to the surgical treatment of the urinary incontinence. We found a major discrepancies during the evaluation that led us to suspect that this is not a common uncomplicated case of stress urinary incontinence...
January 2015: Ceská Gynekologie
https://www.readbyqxmd.com/read/25583895/efficacy-and-acceptability-of-pharmacological-treatments-for-depressive-disorders-in-primary-care-systematic-review-and-network-meta-analysis
#19
REVIEW
Klaus Linde, Levente Kriston, Gerta Rücker, Susanne Jamil, Isabelle Schumann, Karin Meissner, Kirsten Sigterman, Antonius Schneider
PURPOSE: The purpose of this study was to investigate whether antidepressants are more effective than placebo in the primary care setting, and whether there are differences between substance classes regarding efficacy and acceptability. METHODS: We conducted literature searches in MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and PsycINFO up to December 2013. Randomized trials in depressed adults treated by primary care physicians were included in the review...
January 2015: Annals of Family Medicine
https://www.readbyqxmd.com/read/25568776/autonomic-dysfunction-in-essential-hypertension-a-systematic-review
#20
REVIEW
Elliott R Carthy
INTRODUCTION: Greater sympathetic drive has been established in the early stages of essential hypertension, suggesting that neurohormonal dysregulation may be key to its aetiology and progression. The aims of this review are to discuss evidence of the role of autonomic dysfunction in essential hypertension and proposed mechanisms, and also some applications of this knowledge to current management strategies of essential hypertension. METHODS: A computer search was performed using the PUBMED database for peer reviewed original articles comparing autonomic function tested via heart rate variability (HRV), muscle sympathetic nerve activity (MSNA) or plasma noradrenaline levels in normotensive (mean blood pressure (BP) of ≤140/90 mmHg or ≤135/85 mmHg if measured via home BP measurements) and hypertensive groups (mean resting BP of ≥140/90 mmHg (or ≥135/85 mmHg if measured via home BP measurements)...
March 2014: Annals of Medicine and Surgery
keyword
keyword
21702
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"