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Ran Ditcovski, Tal Ellenbogen
We use numerical simulations to study the effects of nanowire geometry on the emission spectra of nanowire-based lasers. The studied nanowire lasers are made from gallium-nitride and the simulations are performed using finite difference time domain method. We show that changes in the diameter of the nanowire lasers also change the effective refractive index of their optical guided modes, which allows control over their Fabry-Perot spectrum. In addition, we show that evanescent coupling of two vertically standing nanowire lasers, having different cross section sizes, leads to a Vernier effect, which results in single mode emission from the small footprint coupled lasers system...
November 27, 2017: Optics Express
Kunjian Cao, Yi Liu, Shiliang Qu
A compact and robust fiber temperature sensor based on a hermetically-sealed liquid-filling Fabry-Perot (FP) cavity was fabricated by low-cost but efficient processes, including fusion splicing, liquid injection, and fused tapering. Owing to the high thermal optical coefficient (TOC) of the ethanol, the optical path difference (OPD) in the FP cavity varied strongly with temperature, which consequently induced a drastic wavelength shift of the reflection spectrum. Meanwhile, the low freezing point of the ethanol caused the fiber sensor to have the ability of detecting the sub-zero temperatures...
November 27, 2017: Optics Express
Jian Zhou, Yonggang Wu, Zihuan Xia, Xuefei Qin, Zongyi Zhang
Single nanowire solar cells show great promise for next-generation photovoltaics and for powering nanoscale devices. Here, we present a detailed study of light absorption in a single standing semiconductor-dielectric core-shell nanowire (CSNW). We find that the CSNW structure can not only concentrate the incident light into the structure, but also confine most of the concentrated light to the semiconductor core region, which boosts remarkably the light absorption cross-section of the semiconductor core. The CSNW can support multiple higher-order HE modes, as well as Fabry-Pérot (F-P) resonance, compared to the bare nanowire (BNW)...
November 27, 2017: Optics Express
Jinlong Zhang, Han Wu, Hongfei Jiao, Sven Schröder, Marcus Trost, Zhanshan Wang, Xinbin Cheng
Light scattering in quarter-wave high-reflection (QWHR) coatings with fully correlated interfaces was reduced by adding Fabry-Perot (FP) cavity structures on top of the multilayer. The properly designed FP cavity can induce destructive interference for fully correlated interfaces and reduce the scattering loss. Compared to QWHR coatings, adding one FP cavity could decrease the scattering at the near specular angles, and two FP cavities have the potential to reduce light scattering in a broad angular range. A low-scattering HR (LSHR) coating using two FP cavities has been realized to suppress light scattering...
December 1, 2017: Optics Letters
Sergiy Suntsov, Christian E Rüter, Tom Schipkowski, Detlef Kip
We report on a fiber-integrated refractive index sensor based on a Fabry-Perot micro-resonator fabricated using simple diamond blade dicing of a single-mode step-index fiber. The performance of the device has been tested for the refractive index measurements of sucrose solutions as well as in air. The device shows a sensitivity of 1160 nm/RIU (refractive index unit) at a wavelength of 1.55 μm and a temperature cross-sensitivity of less than 10-7  RIU/°C. Based on evaluation of the broadband reflection spectra, refractive index steps of 10-5 of the solutions were accurately measured...
November 20, 2017: Applied Optics
Yung-Hsiu Lu, Po-Hsun Huang, Li-Yun Wang, Ting-Rong Hsu, Hsing-Yuan Li, Pi-Chang Lee, Yu-Ping Hsieh, Sheng-Che Hung, Yu-Chen Wang, Sheng-Kai Chang, Ya-Ting Lee, Ping-Hsun Ho, Hui-Chen Ho, Dau-Ming Niu
Many female carriers of Fabry disease are likely to develop severe morbidity and mortality. However, by our own estimation, around 80% of female newborns are missed by our current enzyme-based screening approach. Our team's aim was to develop an improved cost-effective screening method that is able to detect Fabry disease among female newborns. In Taiwan, based on a database of 916,000 newborns, ~98% of Fabry patients carry mutations out of a pool of only 21 pathogenic mutations. An Agena iPLEX platform was designed to detect these 21 pathogenic mutations using only a single-assay panel...
November 15, 2017: Journal of Human Genetics
Qixin He, Minhan Lou, Chuantao Zheng, Weilin Ye, Yiding Wang, Frank K Tittel
A Pound-Drever-Hall (PDH)-based mode-locked cavity-enhanced sensor system was developed using a distributed feedback diode laser centered at 1.53 µm as the laser source. Laser temperature scanning, bias control of the piezoelectric ceramic transducer (PZT) and proportional-integral-derivative (PID) feedback control of diode laser current were used to repetitively lock the laser modes to the cavity modes. A gas absorption spectrum was obtained by using a series of absorption data from the discrete mode-locked points...
December 2, 2017: Sensors
Yu-Cheng Chen, Xiaotian Tan, Qihan Sun, Qiushu Chen, Wenjie Wang, Xudong Fan
Detection of nuclear biomarkers such as nucleic acids and nuclear proteins is critical for early-stage cancer diagnosis and prognosis. Conventional methods relying on morphological assessment of cell nuclei in histopathology slides may be subjective, whereas colorimetric immunohistochemical and fluorescence-based imaging are limited by strong light absorption, broad-emission bands and low contrast. Here, we describe the development and use of a scanning laser-emission-based microscope that maps lasing emissions from nuclear biomarkers in human tissues...
2017: Nature Biomedical Engineering
Toshiyuki Yano, Ryo Takahashi, Tomohisa Yamashita, Nobutaka Nagano, Aki Ishikawa, Akihiro Sakurai, Hiroki Maruyama, Tetsuji Miura
No abstract text is available yet for this article.
December 2017: Circulation. Heart Failure
Mario H Cardiel, Enrique R Soriano, Eloisa Silva Dutra de Oliveira Bonfá, Graciela S Alarcón, Ariel Izcovich, Mary Carmen Amigo Castañeda, Leonor A Barile-Fabris, Margarita Duarte, Graciela Espada, Mercedes A García, Roger A Levy, Loreto Massardo, Emilia I Sato, Gloria Vásquez, Eduardo M Acevedo-Vásquez, Luis J Catoggio, Rosa Chacón-Díaz, Claudio M Galarza Maldonado, Antonio J Iglesias Gamarra, José F Molina Restrepo, Oscar Neira, Clovis A Silva, Andrea Vargas Peña, Bernardo A Pons-Estel
No abstract text is available yet for this article.
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Yang Du, Yizheng Chen, Chen Zhu, Yiyang Zhuang, Jie Huang
We report, for the first time, a low cost, compact, and novel mechanically designed extrinsic Fabry-Perot interferometer (EFPI)-based optical fiber sensor with a strain amplification mechanism for strain measurement. The fundamental design principle includes a buckled beam with a coated gold layer, mounted on two grips. A Fabry-Perot cavity is produced between the buckled beam and the endface of a single mode fiber (SMF). A ceramic ferrule is applied for supporting and orienting the SMF. The principal sensor elements are packaged and protected by two designed metal shells...
November 2017: Review of Scientific Instruments
F Markotic, D Jurisic, M Curkovic, M Puljiz, M Novinscak, K Bonassin, D Vrdoljak, Z Vojvodic, S Permozer Hajdarovic, T Pekez-Pavlisko, M Tomicic, I Diminic-Lisica, S Fabris Ivsic, D Nejasmic, I Miosic, I Novak, L Puljak
OBJECTIVE: To analyse the frequency of nonrecreational prescription analgesic sharing, associated factors and differences between lenders and borrowers. METHODS: A cross-sectional study was conducted in 10 outpatient family medicine practices in Croatia amongst 1000 patients to whom their physicians have prescribed analgesics at least once in their lives. A questionnaire was used to collect data about patients' pain intensity, prescription analgesic sharing habits, factors associated with this behaviour, perception of risks associated with the conduct and demographic data...
December 1, 2017: European Journal of Pain: EJP
Sara Doimo, Patrizia Maras, Giulia Barbati, Enrico Fabris, Alessio Della Mattia, Kareem Salame, Giuseppe Gatti, Gianfranco Sinagra
BACKGROUND: Cardiac rehabilitation (CR) is a model of care proven to reduce mortality and morbidity in patients with coronary artery disease. The aim of this study is to describe the ambulatory CR model of the Cardiovascular Department of Trieste (Italy), analyzing the outcome of the population. METHODS: We analyzed clinical and instrumental characteristics of all consecutive patients after ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), coronary artery bypass graft with or without valve surgery (CABG/CABGV), or planned percutaneous coronary intervention (PCI), referred for CR from January 1, 2009, to December 31, 2015...
December 2017: Giornale Italiano di Cardiologia
Fulvio Camerini, Enrico Fabris, Gianfranco Sinagra
The attention of the medical community to the appropriateness of diagnostic and therapeutic procedures has increased in recent years, recognizing the need for a careful use of resources and for avoiding unnecessary and sometimes harmful medical tests, procedures and therapies. Not only healthcare providers, but also public, patients and politicians, should know the consequences of inappropriate decisions and behaviors. Indeed, inappropriateness has clinical (risks), economic (waste of resources), but also ethical implications (i...
December 2017: Giornale Italiano di Cardiologia
Veronica De Miguel-Soto, Daniel Leandro, Aitor Lopez-Aldaba, Juan Jesus Beato-López, José Ignacio Pérez-Landazábal, Jean-Louis Auguste, Raphael Jamier, Philippe Roy, Manuel Lopez-Amo
In this work, the performance of five different fiber optic sensors at cryogenic temperatures has been analyzed. A photonic crystal fiber Fabry-Pérot interferometer, two Sagnac interferometers, a commercial fiber Bragg grating (FBG), and a π-phase shifted fiber Bragg grating interrogated in a random distributed feedback fiber laser have been studied. Their sensitivities and resolutions as sensors for cryogenic temperatures have been compared regarding their advantages and disadvantages. Additionally, the results have been compared with the given by a commercial optical backscatter reflectometer that allowed for distributed temperature measurements of a single mode fiber...
November 30, 2017: Sensors
Alaa Abou Daher, Tatiana El Jalkh, Assaad A Eid, Alessia Fornoni, Brian Marples, Youssef H Zeidan
Sphingolipids, long thought to be passive components of biological membranes with merely a structural role, have proved throughout the past decade to be major players in the pathogenesis of many human diseases. The study and characterization of several genetic disorders like Fabry's and Tay Sachs, where sphingolipid metabolism is disrupted, leading to a systemic array of clinical symptoms, have indeed helped elucidate and appreciate the importance of sphingolipids and their metabolites as active signaling molecules...
November 25, 2017: International Journal of Molecular Sciences
Johannes Krämer, Malte Lenders, Sima Canaan-Kühl, Peter Nordbeck, Nurcan Üçeyler, Daniela Blaschke, Thomas Duning, Stefanie Reiermann, Jörg Stypmann, Stefan-Martin Brand, Timo Gottschling, Stefan Störk, Christoph Wanner, Claudia Sommer, Eva Brand, Frank Weidemann
Background: Fabry patients on reduced dose of agalsidase-beta or after switch to agalsidase-alfa show a decline in estimated glomerular filtration rate (eGFR) and an increase of the Mainz Severity Score Index. Methods: In this prospective observational study, we assessed end-organ damage and clinical symptoms in 112 patients who had received agalsidase-beta (1.0 mg/kg) for >1 year, who were (i) non-randomly assigned to continue this treatment regime (regular-dose group, n = 37); (ii) received a reduced dose of agalsidase-beta and subsequent switch to agalsidase-alfa (0...
November 23, 2017: Nephrology, Dialysis, Transplantation
Qinyu Qian, Changqing Xu, Chinhua Wang
We report on an all-dielectric, polarization-independent angular filter with one-dimension (1D) photonic crystal (PC) composed of semiconductor compatible Si/SiO2 pairs. The near-symmetric directional band gap of p- and s-polarized components and Fabry-Pérot (F-P) resonances are utilized to realize efficient polarization-independent angular filtering for normal incidence. The proposed angular filter is designed and experimentally demonstrated in a large area (5 cm × 5 cm) with multilayer sputtering depositions...
November 29, 2017: Scientific Reports
Ivan Vannini, Petra M Wise, Kishore B Challagundla, Meropi Plousiou, Mirco Raffini, Erika Bandini, Francesca Fanini, Giorgia Paliaga, Melissa Crawford, Manuela Ferracin, Cristina Ivan, Linda Fabris, Ramana V Davuluri, Zhiyi Guo, Maria Angelica Cortez, Xinna Zhang, Lu Chen, Shuxing Zhang, Cecilia Fernandez-Cymering, Leng Han, Silvia Carloni, Samanta Salvi, Hui Ling, Mariam Murtadha, Paolo Neviani, Barbara J Gitlitz, Ite A Laird-Offringa, Patrick Nana-Sinkam, Massimo Negrini, Han Liang, Dino Amadori, Amelia Cimmino, Muller Fabbri, George A Calin
The transcribed ultraconserved regions (T-UCRs) encode long non-coding RNAs implicated in human carcinogenesis. Their mechanisms of action and the factors regulating their expression in cancers are poorly understood. Here we show that high expression of uc.339 correlates with lower survival in 210 non-small cell lung cancer (NSCLC) patients. We provide evidence from cell lines and primary samples that TP53 directly regulates uc.339. We find that transcribed uc.339 is upregulated in archival NSCLC samples, functioning as a decoy RNA for miR-339-3p, -663b-3p, and -95-5p...
November 27, 2017: Nature Communications
Charlotte von der Lippe, Plata S Diesen, Kristin B Feragen
BACKGROUND: Individuals with rare diseases may face challenges that are different from those experienced in more common medical conditions. A wide range of different rare conditions has resulted in a myriad of studies investigating the specificities of the diagnosis in focus. The shared psychological experiences of individuals with a rare condition, however, have not been reviewed systematically. METHODS: We performed a systematic review, including qualitative studies on adults, published between 2000 and 2016...
November 2017: Molecular Genetics & Genomic Medicine
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