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Csaba Fábri, Attila G Császár
The first application of quantum graphs to the vibrational quantum dynamics of molecules is reported. The quantum-graph model is applied to the quasistructural molecular ion CH5+, whose nuclear dynamics challenges the traditional understanding of chemical structures and molecular spectra. The vertices of the quantum graph represent versions of the equilibrium structure with distinct atom numbering, while the edges refer to collective nuclear motions transforming the versions of the equilibrium structure into one another...
June 15, 2018: Physical Chemistry Chemical Physics: PCCP
Jaqueline Suemi Hassumi, Gabriel Mulinari-Santos, André Luis da Silva Fabris, Ricardo Garcia Mureb Jacob, Alaíde Gonçalves, Ana Cláudia Rossi, Alexandre Rodrigues Freire, Leonardo Pérez Faverani, Roberta Okamoto
INTRODUCTION: Alveolar bone healing after upper incisor extraction in rats is a classical model of preclinical studies. The underlying morphometric, cellular and molecular mechanism, however, remains imprecise in a unique study. OBJECTIVES: The aim of this study was therefore to characterize the alveolar bone healing after upper incisor extraction in rats by micro computed tomographic (Micro-CT), immunohistochemical and real-time polymerase chain reaction (RT-PCR) analysis...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
Luara Teixeira Colombo, Raquel Barroso Parra da Silva, Gabriel Mulinari-Santos, Leonardo Freitas da Silva, André Luis da Silva Fabris, Francisley Ávila Souza
The facial fractures in pediatric patients are rare, and they can need an immediate treatment to recover the function and aesthetic to the young patients. However, the open reduction internal fixation is controversial in pediatrics; it can be effectiveness to treat complex mandible fractures. Therefore, we present a case of a pediatric patient with a complex mandible fracture caused by an auto accident. The immediate treatment was successful with the use of open reduction internal fixation.
June 11, 2018: Journal of Craniofacial Surgery
Seok-Ho Shin, Min-Ho Park, Jin-Ju Byeon, Byeong Ill Lee, Yuri Park, Ah-Ra Ko, Mi-Ran Seong, Soyeon Lee, Mi Ra Kim, Jinwook Seo, Myung Eun Jung, Dong-Kyu Jin, Young G Shin
Fabry disease is a rare lysosomal storage disorder resulting from the lack of α-Gal A gene activity. Globotriaosylceramide (GB3, ceramide trihexoside) is a novel endogenous biomarker which predicts the incidence of Fabry disease. At the early stage efficacy/biomarker study, a rapid method to determine this biomarker in plasma and in all relevant tissues related to this disease simultaneously is required. However, the limited sample volume, as well as the various levels of GB3 in different matrices makes the GB3 quantitation very challenging...
June 7, 2018: Pharmaceutics
S Baig, R Vijapurapu, F Alharbi, S Nordin, R Kozor, J Moon, B Bembi, T Geberhiwot, R P Steeds
Fabry Disease (FD) has been a diagnostic challenge since it was first recognised in 1898, with patients traditionally suffering from considerable delay before a diagnosis is made. Cardiac involvement is the current leading cause of death in FD. A combination of improved enzyme assays, availability of genetic profiling, together with more organised clinical services for rare diseases, has led to a rapid growth in the prevalence of FD. The earlier and more frequent diagnosis of asymptomatic individuals before development of the phenotype has focussed attention on early detection of organ involvement and closer monitoring of disease progression...
June 6, 2018: QJM: Monthly Journal of the Association of Physicians
Alex J Thompson, Maura Power, Guang-Zhong Yang
Fiber-optic sensors have numerous existing and emerging applications spanning areas from industrial process monitoring to medical diagnosis. Two of the most common fiber sensors are based on the fabrication of Bragg gratings or Fabry-Perot etalons. While these techniques offer a large array of sensing targets, their utility can be limited by the difficulties involved in fabricating forward viewing probes (Bragg gratings) and in obtaining sufficient signal-to-noise ratios (Fabry-Perot systems). In this article we present a micro-scale fiber-optic force sensor produced using direct laser writing (DLW)...
May 28, 2018: Optics Express
Domenico D'Agostino, Daan Lenstra, Huub Ambrosius, Meint Smit
We present a simple to process tunable laser, fabricated in a low-cost generic fabrication process and based on two coupled Fabry-Perot cavities. The complex coupling coefficients of the coupling element are analytically derived from a 3×3 MMI using coupled mode theory and chosen to maximize the SMSR during lasing operation. Additionally, one of the cavities contains a reflective interferometer, which acts as coarse wavelength selector. This interferometer is derived from a Michelson Interferometer, by replacing the two independent mirrors with our optimized coupling element, leading to a doubled Free Spectral Range...
May 28, 2018: Optics Express
David J Bang, Yudeuk Kim, Yoohan Kim, Myung-Jik Kim, Kyong Hon Kim
We introduce a new method for simultaneously measuring group and phase refractive indices, the dispersion profile, and the physical thickness of transparent plates by using low coherent Fabry-Perot (FP) interferometry without using any mechanical scanning and sample rotation. A broadband infrared light source was used for a fiber-type FP interferometer, and the Fourier transform analysis on the measured interference spectra was performed to determine the refractive indices and thickness of BK7, quartz, and fused silica samples over its wavelength range...
June 1, 2018: Applied Optics
Muhammad A Othman, Yasser M Sabry, Mohamed Sadek, Ismail M Nassar, Diaa A Khalil
In this work, we report the analysis, fabrication, and characterization of an optical cavity built using a Bragg-coated fiber (BCF) mirror and a metal-coated microelectromechanical systems (MEMS) slotted micromirror, where the latter allows transmission output from the cavity. Theoretical modeling, using Fourier optics analysis for the cavity response based on tracing the propagation of light back and forth between the mirrors, is presented. Detailed simulation analysis is carried out for the spectral response of the cavity under different design conditions...
June 1, 2018: Applied Optics
Ming-Jia Hsu, Fu-Pang Chang, Yung-Hsiu Lu, Sheng-Che Hung, Yu-Chen Wang, An-Hang Yang, Han-Jui Lee, Shih-Hsien Sung, Yen-Feng Wang, Wen-Chung Yu, Ting-Rong Hsu, Po-Hsun Huang, Sheng-Kai Chang, Ivan Dzhagalov, Chia-Lin Hsu, Dau-Ming Niu
PURPOSE: Evaluation standards and treatment initiation timing have been debated for a long time, particularly for late-onset Fabry disease (FD), because of its slow progression. However, early initiation of enzyme replacement therapy (ERT) for FD could be effective in stabilizing the disease progression and potentially preventing irreversible organ damage. We aimed to examine globotriaosylceramide (Gb3) deposits in patients' endomyocardial biopsies to understand the early pathogenesis of FD cardiomyopathy...
June 6, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Mian Yao, Xia Ouyang, Jushuai Wu, A Ping Zhang, Hwa-Yaw Tam, P K A Wai
Miniature optical fiber-tip sensors based on directly µ-printed polymer suspended-microbeams are presented. With an in-house optical 3D μ-printing technology, SU-8 suspended-microbeams are fabricated in situ to form Fabry⁻Pérot (FP) micro-interferometers on the end face of standard single-mode optical fiber. Optical reflection spectra of the fabricated FP micro-interferometers are measured and fast Fourier transform is applied to analyze the cavity of micro-interferometers. The applications of the optical fiber-tip sensors for refractive index (RI) sensing and pressure sensing, which showed 917...
June 5, 2018: Sensors
Shushan Liu, Xiaoxia Li, Sergio Rossi, Lily Wang, Wei Li, Eryuan Liang, Steven W Leavitt
PREMISE OF THE STUDY: Most dendroecological studies focus on dominant trees, but little is known about the growing season of trees belonging to different size classes and their sensitivity to biotic factors. The objective of this study was to compare the dynamics of xylem formation between dominant and suppressed trees of Abies fabri of similar age growing in the Gongga Mountains, southeastern Tibetan Plateau, and to identify the association between xylem growth and climate. METHODS: The timing and duration of xylogenesis in histological sections were investigated weekly during the 2013-2015 growing seasons...
June 6, 2018: American Journal of Botany
Gabriel Dequigiovanni, Santiago Linorio Ferreyra Ramos, Alessandro Alves-Pereira, Eliane Gomes Fabri, Doriane Picanço-Rodrigues, Charles Roland Clement, Paul Gepts, Elizabeth Ann Veasey
Annatto (Bixa orellana L.) is a tropical American crop, commercially valuable due to its application in the food and cosmetics industries as a natural dye. The wild ancestor of cultivated annatto is B. orellana var. urucurana. Although never cultivated, this variety occurs in open forests and anthropogenic landscapes, and is always associated with riparian environments. In this study, we evaluated the genetic diversity and structure of B. orellana var. urucurana populations in Brazilian Amazonia using 16 microsatellite loci...
2018: PloS One
Akiomi Yoshihisa, Takatoyo Kiko, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Yasuchika Takeishi
The differential diagnosis of cardiomyopathy is important. It has been recently reported that urinary titin N (U-TN) is increased in patients with muscular dystrophy (MD), and is associated with muscular damage. We aimed to clarify whether U-TN is useful as a diagnostic tool for distinguishing MD from various cardiomyopathies [e.g. dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM)]. We measured and compared the U-TN/creatinine ratio (U-TN/Cr; pmol/mg/dl) in 278 control subjects and 331 patients with various cardiomyopathies (DCM, n = 199; sarcoidosis, n = 18; HCM, n = 86; amyloidosis, n = 15; Fabry disease, n = 6; MD, n = 7)...
June 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Qinggeng Zhuang, Andrew J Franjesevic, Thomas S Corrigan, William H Coldren, Rachel Dicken, Sydney Sillart, Ashley DeYong, Nathan Yoshino, Justin Smith, Stephanie Fabry, Keegan Fitzpatrick, Travis G Blanton, Jojo Joseph, Ryan J Yoder, Craig A McElroy, Ozlem Dogan Ekici, Christopher S Callam, Christopher M Hadad
After inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction, referred to as aging, of the phosphylated serine can occur. When aged, known reactivators of OP-inhibited AChE are no longer effective. Realkylation of aged AChE may provide a route to reverse aging. We designed and synthesized a library of quinone methide precursors (QMPs) as proposed realkylators of aged AChE. Our lead compound (C8) from an in vitro screening, successfully resurrected 32.7% and 20...
June 5, 2018: Journal of Medicinal Chemistry
Eurico Camargo Neto, Jaqueline Schulte, Jamile Pereira, Heydy Bravo, Claudio Sampaio-Filho, Roberto Giugliani
We describe the initial results of a neonatal screening program for four lysosomal storage diseases (MPS I, Pompe, Gaucher and Fabry) using the digital microfluidics methodology. The method successfully identified patients previously diagnosed with these diseases and was used to test dried blood spot samples obtained from 10,527 newborns aged 2 to 14 days. The digital microfluidic technology shows potential for a simple, rapid and high-throughput screening for these four diseases in a standard neonatal screening laboratory...
June 4, 2018: Genetics and Molecular Biology
Lothar Hauth, Jeroen Kerstens, Laetitia Yperzeele, François Eyskens, Paul M Parizel, Barbara Willekens
Introduction: A 16-year-old male presented with episodic headaches and a brain magnetic resonance imaging (MRI) that showed multifocal punctate to patchy white matter lesions. The diagnosis of Fabry disease (FD) was suggested upon the finding of significantly reduced plasma alpha-galactosidase A activity (0.62 µmol/L or 13% of normal; normal range ≥ 1.65 μmol/L) and genetic investigation confirmed the presence of a hemizygous missense variant in the galactosidase alpha (GLA) gene (p...
2018: Frontiers in Neurology
Monique E Francois, Nicole M Gilbertson, Natalie Z M Eichner, Emily M Heiston, Chiara Fabris, Marc Breton, J Hunter Mehaffey, Taryn Hassinger, Peter T Hallowell, Steven K Malin
Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on ß-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 ± 6 kg/m²) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and ß-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IRfasting ) insulin resistance (IR)...
June 3, 2018: Nutrients
Konstantin E Mochalov, Ivan S Vaskan, Dmitriy S Dovzhenko, Yury P Rakovich, Igor Nabiev
Light-matter interaction between a molecular ensemble and a confined electromagnetic field is a promising area of research, as it allows light-control of the properties of coupled matter. The common way to achieve coupling is to place an ensemble of molecules or quantum emitters into a cavity. In this approach, light-matter coupling is evidenced by modification of the spectral response of the emitter, which depends on the strength of interaction between emitter and cavity modes. However, there is not yet a user-friendly approach that allows the study of a large number of different and replaceable samples in a wide optical range using the same resonator...
May 2018: Review of Scientific Instruments
Stefano Albani, Enrico Fabris, Sara Doimo, Giulia Barbati, Andrea Perkan, Marco Merlo, Giuseppe Gatti, Andrea Di Lenarda, Arnoud Van't Hof, Patrizia Maras, Gianfranco Sinagra
Aims: The occurrence of drug intolerance (DI) after an acute coronary syndrome (ACS) or percutaneous coronary revascularization (PCI) is an important reason for quitting treatment. Nevertheless, the association between DI and major cardiac and cerebrovascular events (MACCE) is poorly reported in literature, therefore we analysed potential relationship between DI and MACCE (a composite of ACS, PCI, heart failure, stroke) during follow-up. Methods and Results: From 1/1/2014 to 31/12/2015, 891 consecutive patients after ACS or coronary revascularization were referred to Cardiac Rehabilitation (CR) Program and included in a dedicated registry where DI was analysed and treatment appropriately tailored...
May 29, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
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