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Retinal vascular calibre

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https://www.readbyqxmd.com/read/27704165/the-teto-rat-as-a-new-translational-model-for-type-2-diabetic-retinopathy-by-inducible-insulin-receptor-knockdown
#1
Nadine Reichhart, Sergio Crespo-Garcia, Nadine Haase, Michaela Golic, Sergej Skosyrski, Anne Rübsam, Christina Herrspiegel, Norbert Kociok, Natalia Alenina, Michael Bader, Ralf Dechend, Olaf Strauss, Antonia M Joussen
AIMS/HYPOTHESIS: Although the renin-angiotensin system plays an important role in the progression of diabetic retinopathy, its influence therein has not been systematically evaluated. Here we test the suitability of a new translational model of diabetic retinopathy, the TetO rat, for addressing the role of angiotensin-II receptor 1 (AT1) blockade in experimental diabetic retinopathy. METHODS: Diabetes was induced by tetracycline-inducible small hairpin RNA (shRNA) knockdown of the insulin receptor in rats, generating TetO rats...
January 2017: Diabetologia
https://www.readbyqxmd.com/read/27508392/the-impact-of-macronutrients-on-retinal-microvasculature-among-singapore-pregnant-women-during-the-mid-late-gestation
#2
Ling-Jun Li, Peng Guan Ong, Marjorelee T Colega, Chad Yixian Han, Ling Wei Chen, Ryan Man Eyn Kidd, Ecosse Lamoureux, Peter Gluckman, Kenneth Kwek, Yap Seng Chong, Seang Mei Saw, Keith M Godfrey, Tien Yin Wong, Mary Chong Foong-Fong
BACKGROUND: Imbalanced macronutrient intakes can induce impairment of endothelial and vascular function, and further lead to metabolic and cardiovascular disease. However, little is known about the influence of such diets on endothelial and vascular dysfunction in pregnant women, even though high-fat diet is a known risk for pregnancy complications such as gestational diabetes and pre-eclampsia. OBJECTIVE: We aimed to assess the association between maternal macronutrient intakes (protein, fat and carbohydrates), dietary quality and retinal microvascular changes in a multi-ethnic Asian mother-offspring cohort...
2016: PloS One
https://www.readbyqxmd.com/read/27494951/assessment-of-retinal-vascular-calibres-as-a-biomarker-of-disease-activity-in-birdshot-chorioretinopathy
#3
Rupesh Agrawal, Nichole Joachim, Ling-Jun Li, Jiaying Lee, Aniruddha Agarwal, Dawn A Sim, Pearse A Keane, Gerald Liew, Carlos E Pavesio
PURPOSE: Birdshot chorioretinopathy (BCR) is a potentially blinding ocular disorder involving the retinal vasculature and choroid without any systemic manifestations. The objective of the study was to describe vascular calibre changes in BCR and analyse the possibility of this optical biomarker for staging and monitoring disease activity in BCR. METHODS: This retrospective case-control study at a tertiary referral eye centre in the UK included 33 eyes from 21 patients with BCR and equal number of eyes from control subjects...
August 6, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27492729/surgically-induced-changes-in-retinal-vessel-diameter-retinal-nerve-fibre-layer-thickness-and-the-optic-disc-after-23-gauge-pars-plana-vitrectomy
#4
Seung Uk Lee, Ki Yup Nam, Sang Joon Lee
The aim of the study is to investigate the retinal vascular calibre, retinal nerve fibre layer's thickness, and optic disc changes in patients after pars plana vitrectomy. We examined 40 eyes in 40 patients who had undergone unilateral pars plana vitrectomy at three time points: prior to surgery, and at 3 and 6 months after the operation. The diameters of central retinal arteries and veins were measured using retinal photographs. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were calculated using the revised Parr-Hubbard formula...
August 4, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27150159/review-of-paediatric-retinal-microvascular-changes-as-a-predictor-of-cardiovascular-disease
#5
Alexander R Newman, Nicholas H Andrew, Robert J Casson
Recent studies have supported the hypothesis that exposure to established cardiovascular risk factors in early life predisposes to the development of adult cardiovascular disease. Retinal imaging is an emerging technique which facilitates non-invasive, accurate and reproducible assessment of the retinal microvasculature. The assessment may be in the form of static vascular calibre measurements and assessment of the vascular geometry or dynamic structural and functional assessments. Paediatric retinal microvascular changes are reported in response to elevated blood pressure, type 1 diabetes, increasing adiposity, diet, physical activity, systemic inflammation, metabolic peptides, family history and prenatal factors...
May 6, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27017067/summarising-the-retinal-vascular-calibres-in-healthy-diabetic-and-diabetic-retinopathy-eyes
#6
Georgios Leontidis, Bashir Al-Diri, Andrew Hunter
Retinal vessel calibre has been found to be an important biomarker of several retinal diseases, including diabetic retinopathy (DR). Quantifying the retinal vessel calibres is an important step for estimating the central retinal artery and vein equivalents. In this study, an alternative method to the already established branching coefficient (BC) is proposed for summarising the vessel calibres in retinal junctions. This new method combines the mean diameter ratio with an alternative to Murray׳s cube law exponent, derived by the fractal dimension,experimentally, and the branch exponent of cerebral vessels, as has been suggested in previous studies with blood flow modelling...
May 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27012863/inter-arm-blood-pressure-difference-and-its-relationship-with-retinal-microvascular-calibres-in-young-individuals-the-african-predict-study
#7
Michél Strauss, Wayne Smith, Aletta E Schutte
BACKGROUND: Bilateral systolic blood pressure (SBP) differences > 10mmHg is a common finding in clinical practice. Such BP differences in older individuals are associated with peripheral vascular disease, linked to microvascular dysfunction. Investigating retinal vessel calibres could provide insight into systemic microvascular function and may predict cardiovascular outcomes. Therefore we investigated the link between inter-arm systolic blood pressure differences (IASBPD) and the retinal microvasculature to determine the usefulness of IASBPD as an early marker of microvascular changes...
August 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27009434/the-vasodilating-effects-of-insulin-and-lactate-are-increased-in-precapillary-arterioles-in-the-porcine-retina-ex%C3%A2-vivo
#8
Peter Skov Jensen, Simon Metz Mariendal Pedersen, Christian Aalkjaer, Toke Bek
PURPOSE: Disturbances in the diameter regulation of the larger retinal vessels are involved in the pathophysiology of a number of vision threatening retinal diseases, but the role of the smaller vessels has received less attention. Therefore, an experimental model was developed for studying diameter changes in retinal vessels at all branching levels secondary to pharmacological interventions ex vivo. METHODS: Porcine hemiretinas were mounted in a tissue chamber that allowed the control of temperature, pH and oxygen saturation...
August 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/26945470/chronic-depression-symptoms-and-salivary-nox-are-associated-with-retinal-vascular-dysregulation-the-sabpa-study
#9
Leoné Malan, Mark Hamer, Roland von Känel, Markus P Schlaich, Manja Reimann, Nancy Frasure-Smith, Gavin W Lambert, Walthard Vilser, Brian H Harvey, Faans Steyn, Nico T Malan
BACKGROUND: Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear. OBJECTIVES AND METHODS: Associations between the retinal vasculature, diastolic ocular perfusion pressure (DOPP) as measure of hypoperfusion, NO metabolites (NOx) and depression symptoms were assessed. Chronic VD risk markers [depression symptoms (Patient Health Questionnaire/PHQ-9 ≥ 10) and 24 h pulse pressure] were determined in a bi-ethnic cohort (n = 313; 48...
May 1, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/26823397/relationship-of-retinal-vascular-calibre-and-diabetic-retinopathy-in-chinese-patients-with-type-2-diabetes-mellitus-the-desheng-diabetic-eye-study
#10
Xiufen Yang, Yu Deng, Hong Gu, Xuetao Ren, Apiradee Lim, Torkel Snellingen, Xipu Liu, Ningli Wang, Jeong Won Pak, Ningpu Liu, Ronald P Danis
AIMS: To describe the relationship of retinal arteriolar and venular calibre with diabetic retinopathy (DR) and related risk factors, including glucose levels and other biomarkers in a Chinese population with type 2 diabetes mellitus (T2DM). METHODS: A cross-sectional study. Patients with T2DM were recruited from a local community in urban Beijing. Seven fields 30° colour fundus photographs were taken and examined for the presence and severity of DR using a standardised grading system...
October 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26806182/retinal-vessel-diameters-in-a-japanese-population-the-locomotive-syndrome-and-health-outcome-in-aizu-cohort-study
#11
Takatoshi Tano, Koichi Ono, Yoshimune Hiratsuka, Koji Otani, Miho Sekiguchi, Shinichi Konno, Shinichi Kikuchi, Yoshihiro Onishi, Misa Takegami, Masakazu Yamada, Shunichi Fukuhara, Akira Murakami
PURPOSE: To describe the relationship between retinal vascular calibre and cardiovascular risk factors in a Japanese population. METHODS: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study is a population-based, cross-sectional survey that included 2346 persons (56.1% of the eligible population) aged 40 to 74 years old. Retinal vascular calibre was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants...
September 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/26766207/a-self-calibrating-approach-for-the-segmentation-of-retinal-vessels-by-template-matching-and-contour-reconstruction
#12
György Kovács, András Hajdu
The automated processing of retinal images is a widely researched area in medical image analysis. Screening systems based on the automated and accurate recognition of retinopathies enable the earlier diagnosis of diseases like diabetic retinopathy, hypertension and their complications. The segmentation of the vascular system is a crucial task in the field: on the one hand, the accurate extraction of the vessel pixels aids the detection of other anatomical parts (like the optic disc Hoover and Goldbaum, 2003) and lesions (like microaneurysms Sopharak et al...
April 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/26551639/microvascular-disease-after-renal-transplantation
#13
Qi Lun Ooi, Foong Kien Newk-Fon Hey Tow, Raj Deva, Ryo Kawasaki, Tien Y Wong, Deb Colville, Francesco Ierino, Anastasia Hutchinson, Judy Savige
BACKGROUND/AIMS: Individuals who reach end-stage kidney disease (CKD5) have a high risk of vascular events that persists even after renal transplantation. This study compared the prevalence and severity of microvascular disease in transplant recipients and patients with CKD5. METHODS: Individuals with a renal transplant or CKD5 were recruited consecutively from renal clinics, and underwent bilateral retinal photography (Canon CR5-45, Canon). Their retinal images were deidentified and reviewed for hypertensive/microvascular signs by an ophthalmologist and a trained grader (Wong and Mitchell classification), and for vessel caliber at a grading centre using a computer-assisted method and Knudtson's modification of the Parr-Hubbard formula...
2015: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/26515220/low-serum-testosterone-and-increased-diastolic-ocular-perfusion-pressure-a-risk-for-retinal-microvasculature
#14
Nico T Malan, Wayne Smith, Roland von Känel, Mark Hamer, Alta E Schutte, Leoné Malan
BACKGROUND: Low levels of testosterone in men and changes in retinal microvascular calibre are both associated with hypertension and cardiovascular disease risk. Sex hormones are also associated with blood flow in microvascular beds which might be a key intermediate mechanism in the development of hypertension. Whether a direct association between endogenous testosterone and retinal microvascular calibre exists is currently unknown. We aimed to determine whether testosterone is independently associated with ocular perfusion via a possible association with retinal vascular calibre or whether it plays only a secondary role via its effect on blood pressure in a bi-ethnic male cohort...
November 2015: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/26232097/retinal-microvascular-calibre-and-risk-of-diabetes-mellitus-a-systematic-review-and-participant-level-meta-analysis
#15
REVIEW
Charumathi Sabanayagam, Weng Kit Lye, Ronald Klein, Barbara E K Klein, Mary Frances Cotch, Jie Jin Wang, Paul Mitchell, Jonathan E Shaw, Elizabeth Selvin, A Richey Sharrett, Tien Y Wong
AIMS/HYPOTHESIS: The calibre of the retinal vessels has been linked to diabetes mellitus but studies have not shown consistent results. We conducted a participant-level meta-analysis to evaluate the association between retinal arteriolar and venular calibre and diabetes. METHODS: We performed a systematic review on MEDLINE and EMBASE for articles published up to December 2014. We identified five population-based prospective cohort studies that provided individual-level data on 18,771 diabetes-free participants...
November 2015: Diabetologia
https://www.readbyqxmd.com/read/25596324/retinal-arteriolar-narrowing-and-incidence-of-knee-replacement-for-osteoarthritis-a-prospective-cohort-study
#16
COMPARATIVE STUDY
S M Hussain, Y Wang, J E Shaw, D J Magliano, T Y Wong, A E Wluka, S Graves, R J Tapp, F M Cicuttini
OBJECTIVES: The role of the microcirculation in the pathogenesis of osteoarthritis (OA) remains unclear. This prospective cohort study examined the association between retinal vascular calibre and incidence of knee replacement for OA. DESIGN: 1838 participants of the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study had retinal vascular calibre measured using a nonmydriatic digital fundus camera in 1999-2000 and were aged ≥ 40 years at joint replacement data collection commencement...
April 2015: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/25587887/-functional-differences-in-the-microcirculatory-units-of-the-eye
#17
REVIEW
R H Funk
This review describes the most important regions of microcirculation within the eye - their architecture as well as their function. A special emphasis is put on the functional heterogeneity of the microvessels and their role regarding the specific functions localised within the different regions of the eye (e.g. oxygen release by the iris capillaries, production of aqueous humor within the ciliary processes). The microvasculature of choroidea and retina will be described in more detail. The precise adjustment of the blood flow to the functional needs of the inner retina is a very important aspect in the retinal vessels...
February 2015: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/25477322/sex-differences-in-retinal-microvasculature-through-puberty-in-type-1-diabetes-are-girls-at-greater-risk-of-diabetic-microvascular-complications
#18
Paul Benitez-Aguirre, Maria E Craig, Helene G Cass, Clare J Sugden, Alicia J Jenkins, Jie Jin Wang, Janine Cusumano, Lauren A B Hodgson, Kim Lee, Tien Yin Wong, Kim C Donaghue
PURPOSE: Adolescent females with type 1 diabetes (T1D) are reported to have greater risk of early microvascular complications than males. We hypothesize sex differences in retinal vascular geometry (RVG) through puberty are associated with earlier-onset microvascular complications. METHODS: Prepubertal patients (n = 64, 35 male) with T1D, complication-free at baseline, were followed through to sexual maturity with detailed Tanner-staging and repeated diabetes complications assessments...
January 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25468505/validation-of-the-automatic-image-analyser-to-assess-retinal-vessel-calibre-altair-a-prospective-study-protocol
#19
MULTICENTER STUDY
Luis Garcia-Ortiz, Manuel A Gómez-Marcos, Jose I Recio-Rodríguez, Jose A Maderuelo-Fernández, Pablo Chamoso-Santos, Sara Rodríguez-González, Juan F de Paz-Santana, Miguel A Merchan-Cifuentes, Juan M Corchado-Rodríguez
INTRODUCTION: The fundus examination is a non-invasive evaluation of the microcirculation of the retina. The aim of the present study is to develop and validate (reliability and validity) the ALTAIR software platform (Automatic image analyser to assess retinal vessel calibre) in order to analyse its utility in different clinical environments. METHODS AND ANALYSIS: A cross-sectional study in the first phase and a prospective observational study in the second with 4 years of follow-up...
December 2, 2014: BMJ Open
https://www.readbyqxmd.com/read/25145456/association-of-retinal-vessel-calibre-and-visual-outcome-in-eyes-with-diabetic-macular-oedema-treated-with-ranibizumab
#20
RANDOMIZED CONTROLLED TRIAL
A Moradi, Y J Sepah, M A Ibrahim, R Sophie, C Moazez, M G Bittencourt, R E Annam, M Hanout, H Liu, D Ferraz, D V Do, Q D Nguyen
PURPOSE: The study aims to identify the association between the baseline retinal vascular calibre and visual outcome of patients with diabetic macular oedema (DMO) treated with intravitreal ranibizumab. METHODS: The 1-M field (as defined in the ETDRS study) of the digital colour fundus photographs of DMO patients who had been treated primarily with ranibizumab in a clinical trial was assessed. Of the 84 patients, 25 had gradable retinal photographs that could be subjected to analyses by the Interactive Vessel Analysis (IVAN) software at baseline...
November 2014: Eye
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