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Therapeutic relationships

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https://www.readbyqxmd.com/read/29035554/star-polymers-reduce-iapp-toxicity-via-accelerated-amyloid-aggregation
#1
Emily H Pilkington, May Lai, Xinwei Ge, William J Stanley, Bo Wang, Miaoyi Wang, Aleksandr Kakinen, Marc-Antoine Sani, Michael R Whittaker, Esteban N Gurzov, Feng Ding, John F Quinn, Thomas P Davis, Pu Chun Ke
Protein aggregation into amyloid fibrils is a ubiquitous phenomenon across the spectrum of neurodegenerative disorders and type 2 diabetes. A common strategy against amyloidogenesis is to minimize the populations of toxic oligomers and protofibrils by inhibiting protein aggregation with small molecules or nanoparticles. However, melanin synthesis in nature is realized by accelerated protein fibrillation to circumvent accumulation of toxic intermediates. Accordingly, we designed and demonstrated the use of star-shaped poly(2-hydroxyethyl acrylate) (PHEA) nanostructures for promoting the aggregation while ameliorating the toxicity of human islet amyloid polypeptide (IAPP), the peptide involved in glycemic control and the pathology of type 2 diabetes...
October 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29035510/crispri-and-crispra-screens-in-mammalian-cells-for-precision-biology-and-medicine
#2
Martin Kampmann
Next-generation DNA sequencing technologies have led to a massive accumulation of genomic and transcriptomic data from patients and healthy individuals. The major challenge ahead is to understand the functional significance of the elements of the human genome and transcriptome, and implications for diagnosis and treatment. Genetic screens in mammalian cells are a powerful approach to systematically elucidate gene function in health and disease states. In particular, recently developed CRISPR/Cas9-based screening approaches have enormous potential to uncover mechanisms and therapeutic strategies for human diseases...
October 16, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29035137/a-review-of-mental-health-treatment-dropout-by-ethnic-minority-youth
#3
Anna M de Haan, Albert E Boon, Joop T V M de Jong, Robert R J M Vermeiren
A large proportion of treatments in youth mental health care are prematurely terminated by the patient. Treatment dropout can have severe consequences. Since ethnic minority youth are treated less often for mental disorders than other youth, it is important to analyse their risk for dropout and to determine if there are ethnicity-specific determinants. This review aimed to provide an overview of the findings from empirical studies on child and adolescent therapy dropout by ethnic minority and to determine if there were ethnicity-specific dropout determinants...
January 1, 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29035092/vitamin-d-supplementation-and-non-alcoholic-fatty-liver-disease-a-critical-and-systematic-review-of-clinical-trials
#4
Nasrin Sharifi, Reza Amani
Previous observational studies have found a relationship between vitamin D deficiency and non-alcoholic fatty liver disease (NAFLD). However, this type of study could not show the causal relationship between these two conditions. Therefore, we systematically and critically reviewed the available clinical trials to elucidate such relationship. We searched databases such as Medline, Scopus and Cochrane to identify the clinical trials that assessed the effects of vitamin D supplementation in adults with NAFLD...
October 16, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29034804/cip2a-expression-predicts-recurrences-of-tamoxifen-treated-breast-cancer
#5
Shawn Baldacchino, Laura M Wastall, Christian Saliba, Thomas A Hughes, Christian Scerri, Angelene Berwick, Valerie Speirs, Andrew M Hanby, Godfrey Grech
CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance. CIP2A drives an oncogenic potential through inhibiting protein phosphatase 2A, stabilizing MYC, and promoting epithelial-to-mesenchymal transition, although further biological mechanisms for CIP2A are yet to be defined. CIP2A protein expression was studied by immunohistochemistry in oestrogen receptor-positive primary breast cancers (n = 250) obtained from the Leeds Tissue Bank...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29034702/taking-a-comprehensive-health-history-learning-through-practice-and-reflection
#6
Shirley Ingram
Taking a comprehensive health history is a core competency of the advanced nursing role. The purpose of the health history is to source important and intimate knowledge about the patient and allow the nurse and patient to establish a therapeutic relationship. Reflective practice, a core value of nursing in Ireland, means learning from experience. This article demonstrates how a recorded comprehensive health history simulation, coupled with reflection, provided insight into an advanced nurse practitioner's history-taking skills, thereby enhancing clinical practice...
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29033951/sphingosine-1-phosphate-receptor-5-modulates-early-stage-processes-during-fibrogenesis-in-a-mouse-model-of-systemic-sclerosis-a-pilot-study
#7
Katrin G Schmidt, Martina Herrero San Juan, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian M Ottenlinger, Dominique Thomas, Frank Zaucke, Josef M Pfeilschifter, Heinfried H Radeke
Systemic sclerosis (SSc) is a rare multi-organ autoimmune disease characterized by progressive skin fibrosis. Inflammation, type 2 immunity, and fibrogenic processes are involved in disease development and may be affected by sphingolipids. However, details about early-stage pathophysiological mechanisms and implicated mediators remain elusive. The sphingolipid sphingosine-1-phosphate (S1P) is elevated in the sera of SSc patients, and its receptor S1P5 is expressed in skin tissue. Nevertheless, almost nothing is known about the dermatological contribution of S1P5 to inflammatory and pro-fibrotic processes leading to the pathological changes seen in SSc...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033850/designing-dietary-recommendations-using-system-level-interactomics-analysis-and-network-based-inference
#8
Tingting Zheng, Yueqiong Ni, Jun Li, Billy K C Chow, Gianni Panagiotou
Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease gene expression signature will lead to a therapeutic effect. However, it has also been shown that globally reversing the disease expression signature is not a prerequisite for drug activity. On the other hand, the basic idea of significant anti-correlation in expression profiles could have great value for establishing diet-disease associations and could provide new insights into the role of dietary interventions in disease...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29033687/interpretation-and-diplomacy-aspects-of-authority-and-care-in-imaging-reports
#9
Werner Albert Golder
Whereas the creative performance of the physician for nuclear medicine is measured against his/her written report, the value of the message will not only be judged by the precision of the medical statement. The same result can be attributed to different words. Numerous habitual and accidental factors exert influence on the decision on what is said and what is not said, how it is assessed, and what is ignored. The less certain a diagnosis is, and the less favorable its possible consequences are, the more subtleties and paraphrases should be expected within the report...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033639/a-survey-focusing-on-lucid-dreaming-metacognition-and-dream-anxiety-in-medical-students
#10
Çağdaş Yokuşoğlu, Mücahit Atasoy, Nurgül Tekeli, Ahmet Ural, Çağla Ulus, Yunus Taylan, Gülser Aydin, Gözde Gültekin, Murat Emül
INTRODUCTION: The aim of this study was to examine the level of lucidity and its relation with metacognitive beliefs and dream anxiety in medical students. METHODS: Nine hundred sixteen medical students were enrolled in the study. The participants were assessed with the Lucidity and Consciousness in Dreams Scale (LuCiD), the Metacognition Questionnaire-30 (MCQ-30), and the Van Dream Anxiety Scale (VDAS). RESULTS: There was no significant difference in mean total lucidity score between females and males, but there were some significant sex differences in subscales of lucidity, and control was significantly higher in male students, while realism, thought, and dissociation were significantly higher in female students...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29032181/the-structure-activity-relationship-of-ginsenosides-on-hypoxia-reoxygenation-induced-apoptosis-of-cardiomyocytes
#11
Ruiqi Feng, Jia Liu, Zhenhua Wang, Jingwen Zhang, Courtney Cates, Thomas Rousselle, Qingguo Meng, Ji Li
Ginsenosides have been studied extensively in recent years due to their therapeutic effects in cardiovascular diseases. While most studies examined the different ginsenosides individually, few studies compare the therapeutic effects among the different types. This study examined how effective protopanaxadiol, protopanaxatriol ginsenosides Rh2, Rg3, Rh1, and Rg2 of the ginsenoside family are in protecting H9c2 cardiomyocytes from damage caused by hypoxia/reoxygenation. In the current study, a model of myocardial ischemia and reperfusion was induced in H9c2 cardiomyocytes by oxygen deprivation via a hypoxia chamber followed by reoxygenation...
October 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29032034/therapeutic-investigations-of-novel-indoxyl-based-indolines-a-drug-target-validation-and-structure-activity-relationship-of-angiotensin-converting-enzyme-inhibitors-with-cardiovascular-regulation-and-thrombolytic-potential
#12
A Manikandan, Pearl Moharil, M Sathishkumar, C Muñoz-Garay, A Sivakumar
A family of 12 members of Naphthalene-2-ol-indolin-2-one-thiocarbamides (5a-l) with pharmacological potentials of cardiovascular modulator were efficiently synthesized and evaluated. These compounds show inhibitory activity on angiotensin-converting enzyme (ACE), which is a principal constituent of the renin-angiotensin system and causative source for hypertension (HTN) (elevated blood pressure) and congestive heart failure (CHF), a parameter that was tested in this report. Prior to this, to get more insight into the binding mode and inhibition of human ACE C-domain (PDB ID: 2XY9) and N-domain (PDB ID: 3NXQ) compounds 5a-l was docked into the active site of them...
October 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031854/angptl-4-induces-diabetic-retinal-inflammation-by-activating-profilin-1
#13
Qianyi Lu, Peirong Lu, Wei Chen, Li Lu, Zhi Zheng
Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. The aim of this work was to assess the temporal relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor, and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway(s) and upstream mediator(s) of ANGPTL-4 were then determined under high glucose (HG) conditions...
October 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29031618/characterization-of-the-inhibitory-activity-of-natural-tanshinones-from-salvia-miltiorrhiza-roots-on-protein-tyrosine-phosphatase-1b
#14
Da Hye Kim, Pradeep Paudel, Ting Yu, Thi Men Ngo, Jeong Ah Kim, Hyun Ah Jung, Takako Yokozawa, Jae Sue Choi
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator that plays an important role in many signaling pathways, especially those associated with insulin resistance. In this study, we investigated the anti-diabetic potential of 12 natural tanshinones isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae), deoxyneocryptotanshinone (1), grandifolia F (2), ferruginol (3), cryptotanshinone (4), tanshinone IIA (5), tanshinol B (6), tanshinone IIB (7), tanshinonal (8), methyl tanshinonate (9), 15,16-dihydrotanshinone I (10), tanshinone I (11), and dehydrodanshenol A (12) and evaluated their inhibitory activity against PTP1B...
October 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29031557/regulation-of-hc11-mouse-breast-epithelial-cell-differentiation-by-the-e-cadherin-rac-axis
#15
Maximilian Niit, Rozanne Arulanandam, Jamaica Cass, Mulu Geletu, Victoria Hoskin, Graham Côté, Patrick Gunning, Bruce Elliott, Leda Raptis
It was previously demonstrated that differentiation of some established breast epithelial cell lines requires confluence and stimulation with hydrocortisone, insulin and prolactin inducers. We and others previously demonstrated that E-cadherin engagement, which is favored under conditions of confluence, increases the levels and activity of the Rac small GTPase. To investigate the functional relationship between the transforming ability of Rac and its role as an integral component of the differentiative E-cadherin signaling pathway, we introduced a mutationally activated form of Rac, Rac(V12), into the mouse breast epithelium-derived cell line, HC11...
October 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29031207/microrna-25-inhibits-high-glucose-induced-apoptosis-in-renal-tubular-epithelial-cells-via-pten-akt-pathway
#16
Huicong Li, Xiaoguang Zhu, Junwei Zhang, Jun Shi
Diabetic nephropathy (DN) has become the major cause of end-stage renal disease (ESRD). It has been demonstrated that apoptosis of renal tubular epithelial cells induced by hyperglycemia contributes to the pathogenesis of DN. Recent researches have corroborated the critical roles of microRNAs (miRNAs) in the apoptosis of various types of cells including renal tubular epithelial cells. However, the eff ; ;ect of miRNAs on the hyperglycemia-induced apoptosis of renal tubular epithelial cells remains unclear...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030945/adenine-induced-chronic-kidney-disease-in-rats
#17
REVIEW
Vishal Diwan, Lindsay Brown, Glenda C Gobe
Many animal models have been developed to study the causes and treatments of chronic kidney disease (CKD) in humans, an insidious disease resulting from kidney injury and characterised by persistent functional decline for more than 3 months, with or without evidence of structural deficit. The eventual outcome of CKD may be end-stage kidney disease (ESKD), where patients need dialysis or transplantation to survive. Cardiovascular disease is accelerated in patients with CKD and contributes to increased mortality, with the relationship between CKD and cardiovascular disease being bi-directional...
October 14, 2017: Nephrology
https://www.readbyqxmd.com/read/29030503/a-qualitative-study-of-a-blended-therapy-using-problem-solving-therapy-with-a-customised-smartphone-app-in-men-who-present-to-hospital-with-intentional-self-harm
#18
Craig Mackie, Nicole Dunn, Sarah MacLean, Valerie Testa, Marnin Heisel, Simon Hatcher
BACKGROUND: Blended therapy describes the use of computerised therapy combined with face-to-face therapy to extend the depth, range and nature of the face-to-face therapy. We wanted to develop a treatment manual for a randomised trial of blended therapy combining face-to-face problem solving and a smartphone app in men who present to hospital with self-harm. OBJECTIVE: To develop a treatment manual and to describe the experience of receiving and delivering a blended therapy...
October 13, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29029679/investigating-habituation-to-premonitory-urges-in-behavior-therapy-for-tic-disorders
#19
David C Houghton, Matthew R Capriotti, Lawrence D Scahill, Sabine Wilhelm, Alan L Peterson, John T Walkup, John Piacentini, Douglas W Woods
Behavior therapy is effective for Persistent Tic Disorders (PTDs), but behavioral processes facilitating tic reduction are not well understood. One process, habituation, is thought to create tic reduction through decreases in premonitory urge severity. The current study tested whether premonitory urges decreased in youth with PTDs (N = 126) and adults with PTDs (N = 122) who participated in parallel randomized clinical trials comparing behavior therapy to psychoeducation and supportive therapy (PST). Trends in premonitory urges, tic severity, and treatment outcome were analyzed according to the predictions of a habituation model, whereby urge severity would be expected to decrease in those who responded to behavior therapy...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29029467/nherf1-together-with-parp1-and-brca1-expression-as-a-new-potential-biomarker-to-stratify-breast-cancer-patients
#20
Anita Mangia, Emanuela Scarpi, Giulia Partipilo, Laura Schirosi, Giuseppina Opinto, Francesco Giotta, Giovanni Simone
It has been recognized that Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) in breast cancer (BC) acts as a tumor suppressor or as an oncogenic protein, depending on its subcellular localization. This study aims to correlate NHERF1 expression to BRCA1 and PARP1 proteins, to investigate their relationship, and their biological and clinical significance. Using immunohistochemistry on tissue microarrays, we evaluated subcellular NHERF1, BRCA1 and PARP1 expression in 308 BCs including a subgroup (n=80) of triple negative BCs (TNBCs)...
September 12, 2017: Oncotarget
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