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https://www.readbyqxmd.com/read/29906229/engineering-cardiac-microphysiological-systems-to-model-pathological-extracellular-matrix-remodeling
#1
Nethika Ruvini Ariyasinghe, Davi Marco Lyra-Leite, Megan L McCain
Many cardiovascular diseases are associated with pathological remodeling of the extracellular matrix (ECM) in the myocardium. ECM remodeling is a complex, multi-factorial process that often contributes to declines in myocardial function and progression towards heart failure. However, the direct effects of the many forms of ECM remodeling on myocardial cell and tissue function remain elusive, in part because conventional model systems used to investigate these relationships lack robust experimental control over the ECM...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29906128/microrna-203-increase-cell-radiosensitivity-via-directly-targeting-bmi-1-in-hepatocellular-carcinoma
#2
Yingjie Shao, Dachuan Zhang, Xiaodong Li, Jing Yang, Lujun Chen, Zhonghua Ning, Yun Xu, Guohua Deng, Min Tao, Yibei Zhu, Jingting Jiang
BACKGROUND: It has been reported that B-cell-specific moloney leukemia virus insertion site 1 (Bmi-1) has important roles in various cancers, but its regulation through microRNAs (miRNAs) and its functions in hepatocellular carcinoma (HCC) remains unclear. METHODS: We investigated Bmi-1 expression and its prognostic significance in HCC by using tissue samples and The Cancer Genome Atlas (TCGA) datasets. The relationship between miRNAs and Bmi-1 was verified by bioinformatics prediction and immunofluorescence...
June 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29904014/is-it-time-to-change-the-definition-of-acute-exacerbation-of-chronic-obstructive-pulmornary-disease-what-do-we-need-to-add
#3
REVIEW
Maria Montes de Oca, Maria Eugenia Laucho-Contreras
Acute exacerbations in chronic obstructive pulmonary disease (AECOPD) are associated with increased mortality, rate of hospitalization, use of healthcare resources, and have a negative impact on disease progression, quality of life and lung function of patients with chronic obstructive pulmonary disease (COPD). There is an imperative need to homogenize the definition of AECOPD because the incidence of exacerbations has a significant influence or implication on treatment decision making, particularly in pharmacotherapy and could impact the outcome or change the statistical significance of a therapeutic intervention in clinical trials...
June 14, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29902778/toxic-metal-loid-based-pollutants-and-their-possible-role-in-autism-spectrum-disorder
#4
REVIEW
Geir Bjørklund, Anatoly V Skalny, Md Mostafizur Rahman, Maryam Dadar, Heba A Yassa, Jan Aaseth, Salvatore Chirumbolo, Margarita G Skalnaya, Alexey A Tinkov
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, verbal and non-verbal communication, and stereotypic behaviors. Many studies support a significant relationship between many different environmental factors in ASD etiology. These factors include increased daily exposure to various toxic metal-based environmental pollutants, which represent a cause for concern in public health. This article reviews the most relevant toxic metals, commonly found, environmental pollutants, i...
June 11, 2018: Environmental Research
https://www.readbyqxmd.com/read/29902722/benzo-d-thiazole-2-carbanilides-as-new-anti-tb-chemotypes-design-synthesis-biological-evaluation-and-structure-activity-relationship
#5
Tejas M Dhameliya, Rishu Tiwari, Arkaprabha Banerjee, Sahaj Pancholia, Dharmarajan Sriram, Dulal Panda, Asit K Chakraborti
Tuberculosis is the second leading cause of deaths worldwide. The inadequacy of existing drugs to treat TB due to developed resistance and TB-HIV synergism urges for new anti-TB drugs. Seventy-two benzo[d]thiazole-2-carbanilides have been synthesized through CDI-mediated direct coupling of benzo[d]thiazole-2-carboxylic acids with aromatic amines using a three step methodology which includes a green protocol for synthesis of ethyl benzo[d]thiazole-2-carboxylates, precursor of the desired carboxylic acids. The compounds were evaluated in vitro for anti-tubercular activity against M...
June 8, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29902076/quantitative-magnetic-resonance-imaging-and-radiogenomic-biomarkers-for-gliomas-characterisation-a-systematic-review
#6
Pohchoo Seow, Jeannie Hsiu Ding Wong, Azlina Ahmad Annuar, Abhishek Mahajan, Nor Aniza Abdullah, Norlisah Ramli
  The diversity of tumour characteristics among glioma patients, even within same tumour grade, is a big challenge for disease outcome prediction. A possible approach for improved radiological imaging could come from combining information obtained at molecular level. This review assembles recent evidence highlighting the value of using radiogenomic biomarkers to infer underlying biology of gliomas and correlation with imaging features.  Methods:  Literature search was done for articles published between 2002 and 2017 on Medline electronic databases...
June 14, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29901557/association-between-infliximab-drug-and-antibody-levels-and-therapy-outcome-in-pediatric-inflammatory-bowel-diseases
#7
Bella Ungar, Yoav Glidai, Miri Yavzori, Orit Picard, Ella Fudim, Avishay Lahad, Yael Haberman, Dror S Shouval, Ilana Weintraub, Rami Eliakim, Shomron Ben-Horin, Batia Weiss
OBJECTIVES: While infliximab pharmacokinetics are associated with therapy outcome in adult IBD population, limited data is available in pediatric patients. We aimed to define the relationship between Infliximab trough and antibodies' levels (IFX-TL, ATI) and clinical, biomarker remission. METHODS: IFX-TL and ATI were routinely obtained between 2011-2017. Associations with clinical and inflammatory (C-reactive protein, CRP) end-points were studied throughout the first year of infliximab therapy...
June 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29901544/limits-of-intravascular-contrast-extravasation-on-computed-tomography-scan-to-define-the-need-for-pelvic-angioembolization-in-pelvic-blunt-trauma-a-specific-assessment-on-the-risk-of-false-positives
#8
Séverin Ramin, Margaux Hermida, Ingrid Millet, Thibault Murez, Valérie Monnin, Mazen Hamoui, Xavier Capdevila, Jonathan Charbit
BACKROUND: The objective was to assess the predictive performance of different intravascular contrast extravasation (ICE) characteristics for need for pelvic transarterial embolization (TAE) to determine the risk factors of false-positives. METHODS: A retrospective study was performed in our trauma center between 2010 and 2015. All severe trauma patients with pelvic fracture were included. Pelvic ICE characteristics on computed tomography (CT) scan were studied: arterial (aSICE), portal surface (pSICE), and extension (exSICE) anatomic relationships...
June 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29901304/-the-role-of-tadalafil-in-the-management-of-sexual-dysfunctions
#9
E A Efremov, E V Kasatonova, Ya I Mel'nik, A A Nikushina
Erectile dysfunction (ED) has a significant negative impact on the quality of life of the patients and their partners. The sequence and regimens of ED therapy have become quite evident since the advent of phosphodiesterase type 5 inhibitors (PDE-5). However, there have been continued basic research of the efficacy and safety of these agents and studies aimed at new therapeutic goals. In recent years, the attention of researchers has shifted into a wider range of issues related to the personalized PDE-5 therapy, including sexual satisfaction, psychosocial variables (e...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29900745/a-case-report-asymptomatic-esophageal-eosinophilia-after-herpes-simplex-esophagitis-controversies-in-the-therapeutic-approach
#10
Ainara Iriarte Rodríguez, Itziar Frago Marquínez, Gina Patricia de Lima Piña
The coexistence of eosinophilic esophagitis and herpes simplex virus in patients has been published in numerous case reports in the last few years. Both entities can be diagnosed simultaneously or one prior to the other, raising a possible causal relationship. Esophageal eosinophilia is a histological finding, and its underlying cause should be investigated. Eosinophilic esophagitis is one of the most common causes of esophageal eosinophilia. Eosinophilic esophagitis is a clinicopathologic disease, which is characterized by dysphagia and food impaction...
June 14, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29900680/guided-self-help-to-manage-binge-eating-in-a-dietetic-led-community-weight-management-service
#11
G D Traviss-Turner, U Philpot, J Wilton, K Green, S Heywood-Everett, A J Hill
An estimated 30% of patients accessing community weight management services experience symptoms of binge eating disorder (BED). Guided self-help (GSH) is the recommended first line of treatment for BED. This study is a preliminary investigation into the effectiveness of GSH delivered by dietitians for patients with binge eating within a weight management service and a consideration of the association between wellbeing, therapeutic relationship and outcomes. The study was conducted as a single group, pre- and post-intervention study with 24 patients reporting symptoms of binge eating who completed the self-help manual with guidance from a trained community dietitian...
June 14, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29900044/cd133-directed-car-t-cells-for-advanced-metastasis-malignancies-a-phase-i-trial
#12
Yao Wang, Meixia Chen, Zhiqiang Wu, Chuan Tong, Hanren Dai, Yelei Guo, Yang Liu, Jianhua Huang, Haiyan Lv, Can Luo, Kai-Chao Feng, Qing-Ming Yang, Xiao-Lei Li, Weidong Han
Expressed by cancer stem cells of various epithelial cell origins, CD133 is an attractive therapeutic target for cancers. Autologous chimeric antigen receptor-modified T-cell directed CD133 (CART-133) was first tested in this trial. The anti-tumor specificity and the postulated toxicities of CART-133 were first assessed. Then, we conducted a phase I clinical study in which patients with advanced and CD133-positive tumors received CART-133 cell-infusion. We enrolled 23 patients (14 with hepatocellular carcinoma [HCC], 7 with pancreatic carcinomas, and 2 with colorectal carcinomas)...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29899374/role-and-prognostic-value-of-individual-ambulatory-blood-pressure-components-in-chronic-kidney-disease
#13
Fabio Angeli, Giorgio Gentile, Monica Trapasso, Paolo Verdecchia, Gianpaolo Reboldi
Hypertension is a key risk factor for chronic kidney disease (CKD), but can also be a detrimental consequence of established CKD. Unsurprisingly, the majority of subjects with abnormal creatinine in the general population are also hypertensive, with a huge toll on national health care systems worldwide due to a staggering increase in the risk of cardiovascular complications and end-stage renal disease requiring renal replacement therapy. In this setting, a comprehensive and careful assessment of the whole 24-h blood pressure (BP) profile could be of paramount importance in ensuring a timely diagnosis of hypertension and an optimal therapeutic control...
June 13, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29898451/pathophysiology-of-depression-molecular-regulation-of-melatonin-homeostasis-current-status
#14
REVIEW
Monika Dmitrzak-Weglarz, Edyta Reszka
Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body's circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood...
June 13, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29898191/satisfaction-and-burden-of-mental-health-personnel-data-from-healthcare-services-for-substance-users-and-their-families
#15
Juliana B Hilgert, Augusto B Bidinotto, Mayra P Pachado, Letícia S Fara, Lisia von Diemen, Raquel B De Boni, Mary C Bozzetti, Flávio Pechansky
OBJECTIVE: To evaluate satisfaction and burden of mental health personnel providing mental health services for substance users and their families. METHOD: Five hundred twenty-seven mental health workers who provide treatment for substance users in five Brazilian states were interviewed. Data on sociodemographic characteristics and measures of satisfaction (SATIS-BR) and burden of mental health personnel (IMPACTO-BR) were collected. RESULTS: Type of mental health service and educational attainment were associated with degree of satisfaction and burden...
June 11, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29897466/increased-activity-of-linezolid-in-combination-with-rifampicin-in-a-murine-pneumonia-model-due-to-mrsa
#16
Yu-Feng Zhou, Yan Q Xiong, Meng-Ting Tao, Liang Li, Ming-Xiao Bu, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu
Objectives: The chloramphenicol/florfenicol resistance gene cfr, which mediates cross-resistance to linezolid and other classes of antimicrobial agents, represents a global therapeutic challenge due to its dissemination among MDR nosocomial pathogens, including MRSA. This study aimed to compare the efficacy of the linezolid/rifampicin combination in a murine pneumonia model caused by cfr-positive and cfr-negative clinical MRSA strains. Methods: Synergistic activity between linezolid and rifampicin was evaluated by chequerboard and time-kill assays...
April 20, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29896281/involvement-of-non-coding-rnas-in-chemotherapy-resistance-of-ovarian-cancer
#17
REVIEW
Yang Shao, Hui Li, Ran Du, Jiao Meng, Gong Yang
Ovarian cancer (OC) is the most lethal gynecological malignancy, with a low 5-year survival rate. Most patients with ovarian cancer are diagnosed in late-stages. A rising number of non-coding RNAs (ncRNAs) have been found to act as key regulators of gene expression by applying novel high-thought methods, such as next generation sequencing (NGS). Non-coding RNAs not only play important roles in carcinogenesis, but also affect the clinical treatment strategies. One of the biggest challenge in OC treatment was chemoresistance, which causes poor prognosis and high recurrence rate after applying traditional remedies...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896229/long-non-coding-rna-gas5-inhibits-ovarian-cancer-cell-proliferation-via-the-control-of-microrna-21-and-spry2-expression
#18
Nana Ma, Shaoru Li, Quanhua Zhang, Hongmei Wang, Haixia Qin, Shijin Wang
In recent decades, numerous long non-coding (lnc)RNAs, including growth arrest-specific transcript 5 (GAS5), have been demonstrated to exert promoting or suppressive effects in human cancers. Decreased expression of the lncRNA GAS5 was reported to promote cell proliferation, migration and invasion and indicate poor prognosis in ovarian cancer. However, the exact underlying molecular mechanism through which GAS5 is involved in ovarian cancer growth remains unknown. The present study aimed to investigate the regulatory mechanism of GAS5 in ovarian cancer cell proliferation...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896129/gut-brain-axis-and-mood-disorder
#19
REVIEW
Lu Liu, Gang Zhu
Humans have over 100 trillion bacteria, highly abundant in the intestinal tract. Evidence suggests that intestinal microbiota is associated with the neuro-endocrine-immune pathways and can be associated with various mood disorders. This review summarizes findings from studies looking into neurobiochemical, neuroendocrine, and neuroimmune system mechanisms of the gut-brain axis to determine the relationship between intestinal microbiota and mood disorders. The effect of prebiotics, probiotics and antibiotics on mood disorders are also discussed, with the aim to propose some new therapeutic strategies for mood disorders...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29895278/observational-study-on-the-prognostic-value-of-testosterone-and-adiposity-in-postmenopausal-estrogen-receptor-positive-breast-cancer-patients
#20
Elisabetta Venturelli, Annalisa Orenti, Aline S C Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini, Elia Biganzoli
BACKGROUND: Despite the clear endocrine-metabolic relationship between androgenic activity and adiposity, the role of androgens in breast cancer prognosis according to patient's adiposity is scarcely explored. Here, we aimed at investigating the prognostic value of circulating testosterone in association with patient's body mass index (BMI). METHODS: Circulating testosterone and BMI were evaluated at breast cancer diagnosis in 460 estrogen receptor (ER)-positive postmenopausal patients...
June 13, 2018: BMC Cancer
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