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https://www.readbyqxmd.com/read/28550713/state-of-the-art-on-oocyte-cryopreservation-in-female-cancer-patients-a-critical-review-of-the-literature
#1
REVIEW
Claudia Massarotti, Paola Scaruffi, Matteo Lambertini, Valentino Remorgida, Lucia Del Mastro, Paola Anserini
During the last decades, important advances in therapeutic options have led to increased survival rates in cancer patients; however, cancer treatments are associated with several potential adverse effects including infertility in those diagnosed during their reproductive years. A proper discussion about fertility preservation options before the use of therapies with potential gonadotoxicity (i.e. oncofertility counseling) is standard of care and should be offered to all patients of childbearing age. Temporary ovarian suppression with LH-RH analogs, oocyte and embryo cryopreservation are standard strategies for fertility preservation in female cancer patients...
May 9, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28550349/choice-of-repairing-inguinal-hernia-in-children-open-versus-laparoscopy
#2
Venkatachalam Raveenthiran, Prakash Agarwal
Inguinal hernia is a common disorder of childhood that requires surgical repair at diagnosis. Traditionally, it is operated upon by open inguinal incision. However, with the introduction of laparoscopic repair in 1990, opinion of scientific community is divided concerning the best method of pediatric herniotomy. Educated parents, who long to have the choicest of the best, often gather information from internet and prefer to discuss their concerns with primary care physicians. This descriptive review is intended to provide practicing pediatricians with updated evidence-based information which will enable them to counsel parents regarding the choice of hernia repair...
May 27, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28550146/does-painless-rectal-bleeding-equate-to-a-colonic-polyp
#3
Alison Morag Campbell, Ian Sugarman
BACKGROUND: It is often stated that if a patient presents with 'painless rectal bleeding' then a rectal polyp is the probable diagnosis. The aim of this study is to review our experience of children undergoing endoscopy to assess if the above statement is correct. METHODS: The senior author keeps a prospective database of every child undergoing flexible sigmoidoscopy or colonoscopy. As part of this database, the symptoms and signs that the patient presents with, specifically abdominal pain, diarrhoea, mucous per rectum and rectal bleeding, are recorded...
May 26, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28550004/an-mhealth-app-for-supporting-quitters-to-manage-cigarette-cravings-with-short-bouts-of-physical-activity-a-randomized-pilot-feasibility-and-acceptability-study
#4
Mary Hassandra, Taru Lintunen, Martin S Hagger, Risto Heikkinen, Mauno Vanhala, Tarja Kettunen
BACKGROUND: While gains in reducing smoking rates in Finland have been made, prevalence rates are still substantial. Relapse rates among smokers engaged in quit-smoking programs are high. Physical activity has been proposed as one means to help smokers manage cravings. Software and apps on mobile phone and handheld devices offer an opportunity to communicate messages on how to use physical activity to manage cravings as part of quit-smoking programs. OBJECTIVE: We aimed to test the feasibility, acceptability, usability, and preliminary efficacy of an mHealth mobile phone app, Physical activity over Smoking (PhoS), to assist smokers in quitting smoking in a randomized controlled trial...
May 26, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28549978/gestational-weight-gain
#5
REVIEW
Michelle A Kominiarek, Alan M Peaceman
Prenatal care providers are advised to evaluate maternal weight at each regularly scheduled prenatal visit, monitor progress toward meeting weight gain goals, and provide individualized counseling if significant deviations from a woman's goals occur. Today, nearly 50% of women exceed their weight gain goals with overweight and obese women having the highest prevalence of excessive weight gain. Risks of inadequate weight gain include low birth weight and failure to initiate breastfeeding whereas the risks of excessive weight gain include cesarean deliveries and post-partum weight retention for the mother and large for gestational age infants, macrosomia, and childhood overweight or obesity for the offspring...
May 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28549893/anesthetic-neurotoxicity-in-congenital-hand-surgery-an-overview-of-the-evidence-and-advice-for-counseling-parents
#6
REVIEW
Michael S Gart, Santhanam Suresh, Joshua M Adkinson
Millions of children undergo general anesthesia for surgical procedures each year, the implications of which are not fully understood. Animal models demonstrate neurotoxicity and long-term cognitive impairment following exposure to common general anesthetic agents. However, it is unclear if human brains are affected in a similar fashion and what-if any-the implications on cognitive development may be. Furthermore, it is not known if these effects are additive and if they can be avoided by delaying reconstruction...
May 24, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28549750/shared-decision-making-in-brazil-concrete-efforts-to-empowering-patient-s-voice
#7
Mirhelen Mendes de Abreu, Joao Pedro Simao de Mello, Lilah Ferreira F Ribeiro, Luiza Andrade Mussi, Mariana Luiza L Borges, Maurício Petroli, Nycholas da Costa Tavares, Rafael da Cunha Cancela, Sabrina Fausto de Lima
Patient involvement in healthcare decisions has grown in Brazil at three different levels: 1) the macro level, which includes the patient actively influencing legislation and regulation of medical care as well as political changes in the process of care itself; 2) the meso level, which includes institutions that aim to improve information, empowerment and counseling to patients, and 3) the micro level, which focuses on the actual decision-making process that takes place within patient-physician encounter. In Brazil, the macro and meso levels are stronger than the micro one...
May 23, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28548003/medicolegal-cases-involving-periviable-births-from-a-major-united-states-legal-database
#8
Hemananda Muniraman, Miranda Cascione, Rangasamy Ramanathan, Jimmy Nguyen
OBJECTIVE: The management of expectant mothers and infants born at the threshold of viability is challenging. We describe medicolegal cases from a major United States legal database involving periviable births in an effort to identify areas for improvement. STUDY DESIGN: We conducted a retrospective review of all United States state and federal cases in the Westlaw database from 1980 through 2016 involving peripartum and immediate post-delivery management of infants born between 22 0/7 and 25 6/7 weeks' gestation...
May 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28547664/-it-was-a-lot-tougher-than-i-thought-it-would-be-a-qualitative-study-on-the-changing-nature-of-being-a-hemophilia-carrier
#9
Charlotte von der Lippe, Jan C Frich, Anna Harris, Kari Nyheim Solbrække
Studies on carriers of genetic disorders mainly focus on the process of genetic testing and reproductive choices, and less on how psychosocial aspects of being a carrier change over time. Our study sought to understand more about the psychosocial aspects of hemophilia carrier status, and thereby improve counseling aiming to advance carriers' quality of life and well-being. We analyzed 16 in-depth interviews from women who were carriers of hemophilia and had a son with hemophilia. Three themes emerged: Guilt and sorrow across generations; the choices and future consequences of genetic testing; and preparing to have a child with hemophilia...
May 26, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28547653/identifying-opportunities-for-collaboration-and-growth-of-genetic-counseling-services-in-the-asia-region
#10
Mercy Y Laurino, Darci L Sternen, Jennifer K Thompson, Kathleen A Leppig
The Genetic Counseling Pre-Conference Workshop (GCPCW) was held on September 16, 2015, in Hanoi, Vietnam. We report the GCPCW outcomes obtained from pre- and post-conference questionnaires, case-review breakout session, and an open discussion of needs for genetic counseling services in the Asia region. The GCPCW participants completed questionnaires with closed- and open-ended questions regarding the status and needs of providing genetic counseling services in Asia. Utilizing thematic content analysis, common themes shared during the case-review breakout session are summarized and survey results are tabulated...
May 25, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28547586/both-isolated-and-multi-ligament-posterior-cruciate-ligament-reconstruction-results-in-improved-subjective-outcome-results-from-the-danish-knee-ligament-reconstruction-registry
#11
Martin Lind, Torsten Grønbech Nielsen, Kristian Behrndtz
PURPOSE: There are few descriptions of outcomes after posterior cruciate ligament (PCL) reconstruction in the literature due to the rarity of this type of knee injury. Since 2005, the Danish Knee Ligament Reconstruction Registry (DKRR) has monitored outcomes of PCL reconstructions. This study describes the epidemiology of PCL reconstruction and subsequent outcomes in a Danish population. METHODS: Of 23,253 knee ligament reconstructions performed in 2005-2015, 581 were registered as PCL reconstructions in the DKRR...
May 25, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28546998/uniparental-disomy-determined-by-whole-exome-sequencing-in-a-spectrum-of-rare-motoneuron-diseases-and-ataxias
#12
Dana M Bis, Rebecca Schüle, Jennifer Reichbauer, Matthis Synofzik, Tim W Rattay, Anne Soehn, Peter de Jonghe, Ludger Schöls, Stephan Züchner
BACKGROUND: The genetic causes of many rare inherited motoneuron diseases and ataxias (MND and ATX) remain largely unresolved, especially for sporadic patients, despite tremendous advances in gene discovery. Whole exome data is often available for patients, but it is rarely evaluated for unusual inheritance patterns, such as uniparental disomy (UPD). UPD is the inheritance of two copies of a chromosomal region from one parent, which may generate homozygosity for a deleterious recessive variant from only one carrier-parent...
May 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28546819/the-effectiveness-of-counseling-in-reducing-anxiety-among-nulliparous-pregnant-women
#13
Parisa Parsa, Nafiseh Saeedzadeh, Seyedeh Zahra Masoumi, Ghodratallah Roshanaei
Objective: To determine the effectiveness of counseling in reducing anxiety of nulliparous pregnant women. Materials and methods: In this quasi-experimental study, 110 nulliparous pregnant women were selected out of all pregnant women referring to Fatemieh Hospital in Hamadan, Iran. Then, the subjects were divided into two groups in experimental and control (55 women in each). The data were collected through a questionnaire covering demographic and obstetric characteristics and Spielberger's State-Trait Anxiety Inventory...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28546740/new-developments-in-managing-opioid-addiction-impact-of-a-subdermal-buprenorphine-implant
#14
REVIEW
MariaLisa Itzoe, Michael Guarnieri
Opioid addiction to prescription and illicit drugs is a serious and growing problem. In the US alone, >2.4 million people suffer from opioid use disorder. Government and pharmaceutical agencies have begun to address this crisis with recently released and revised task forces and medication-assisted therapies (MAT). For decades, oral or intravenous (IV) MATs have helped patients in their recovery by administration of opioid agonists (methadone, buprenorphine, oxycodone), antagonists (naltrexone, naloxone), and combinations of the two (buprenorphine/naloxone)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28546662/pregnancy-outcome-in-patients-with-solitary-kidney
#15
Vineet V Mishra, Kavita M Mistry, Sakshi S Nanda, Sumesh Choudhary, Rohina Aggarwal, Khushali Gandhi
BACKGROUND: Solitary kidney may be congenital or as a result of nephrectomy. There is a lot of literature available on quality of life in these patients, but there is limited data on pregnancy outcome. OBJECTIVES: To study pregnancy outcome in patients with solitary kidney either congenital or due to nephrectomy. MATERIALS AND METHODS: Study Design This is a retrospective observational study conducted at tertiary health center in Ahmedabad, from 2011 to 2014...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28546319/effect-on-return-to-work-or-education-of-individual-placement-and-support-modified-for-people-with-mood-and-anxiety-disorders-results-of-a-randomised-clinical-trial
#16
Lone Hellström, Per Bech, Carsten Hjorthøj, Merete Nordentoft, Jane Lindschou, Lene Falgaard Eplov
OBJECTIVES: The effect of Individual Placement and Support (IPS) on return to work or education among people with mood or anxiety disorders is unclear, while IPS increases return to work for people with severe mental illness. We examined the effect of IPS modified for people with mood and anxiety disorders (IPS-MA) on return to work and education compared with services as usual (SAU). METHODS: In a randomised clinical superiority trial, 326 participants with mood and anxiety disorders were centrally randomised to IPS-MA, consisting of individual mentor support and career counselling (n=162) or SAU (n=164)...
May 25, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28545862/a-novel-pathogenic-variant-in-the-fzd6-gene-causes-recessive-nail-dysplasia-in-a-large-iranian-kindred
#17
Javad Mohammadi-Asl, Mohammad Reza Pourreza, Aliasgar Mohammadi, Ameneh Eskandari, Sima Mozafar-Jalali, Mohammad Amin Tabatabaiefar
BACKGROUND: Nail disorder nonsyndromic congenital (NDNC) is a very rare clinically and genetically heterogeneous disease inherited both in recessive or dominant modes. FZD6 is a component of Wnt-FZD signaling pathway in which recessive loss-of-function variants in the corresponding genes could lead to nail anomalies. OBJECTIVE: A large multiplex family with NDNC was referred for genetic counselling. Thorough genetic evaluation was performed. METHODS: PCR-Sanger sequencing was carried out for the coding exons and exon-intron boundaries of the FZD6 gene...
May 13, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28545429/awareness-knowledge-perceptions-and-attitudes-towards-genetic-testing-for-cancer-risk-among-ethnic-minority-groups-a-systematic-review
#18
Katie E J Hann, Madeleine Freeman, Lindsay Fraser, Jo Waller, Saskia C Sanderson, Belinda Rahman, Lucy Side, Sue Gessler, Anne Lanceley
BACKGROUND: Genetic testing for risk of hereditary cancer can help patients to make important decisions about prevention or early detection. US and UK studies show that people from ethnic minority groups are less likely to receive genetic testing. It is important to understand various groups' awareness of genetic testing and its acceptability to avoid further disparities in health care. This review aims to identify and detail awareness, knowledge, perceptions, and attitudes towards genetic counselling/testing for cancer risk prediction in ethnic minority groups...
May 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28545201/treatment-experiences-of-women-with-reproductive-cancers-in-odisha-india-a-qualitative-exploration-of-enablers-and-barriers
#19
Sanghamitra Pati, Abhimanyu Singh Chauhan, Sandeep Mahapatra, Sabita Nayak, Sukdev Nayak, David Weller
Introduction: Cancer continues to be a major menace to our Indian society notwithstanding significant progress in diagnosis and treatment. In India cancer mortality rates in women are high compared to other countries, despite efforts to improve survival through the development of effective detection techniques and increased numbers of viable treatment options. Indian women’s advanced stage of disease at diagnosis is largely attributable to delay in seeking treatment. The present qualitative inquiry was conducted with the aim of capturing the treatment experiences of patients with gynecology cancer at a tertiary care hospital and understanding the barriers, enablers, stress and apprehension they experience during the treatment phases...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544995/intrauterine-exposure-to-tobacco-and-executive-functioning-in-high-school
#20
Ruth Rose-Jacobs, Mark A Richardson, Kathryn Buchanan-Howland, Clara A Chen, Howard Cabral, Timothy C Heeren, Jane Liebschutz, Leah Forman, Deborah A Frank
BACKGROUND: Executive functioning (EF), an umbrella construct encompassing gradual maturation of cognitive organization/management processes, is important to success in multiple settings including high school. Intrauterine tobacco exposure (IUTE) correlates with negative cognitive/behavioral outcomes, but little is known about its association with adolescent EF and information from real-life contexts is sparse. We evaluated the impact of IUTE on teacher-reported observations of EF in urban high school students controlling for covariates including other intrauterine and adolescent substance exposures...
May 10, 2017: Drug and Alcohol Dependence
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