Melanona

Background/Aim: Irreversible electroporation (IRE) showed promising results for small-size tumors and very early cancers. However, further development is needed to evolve this procedure into a more efficient ablation technique for long-term control of tumor growth. In this work, we show that it is possible to increase the antitumor efficiency of IRE by simmultaneously injecting c-di-GMP, a STING agonist, intratumorally. Materials and Methods: Intratumoral administration of c-di-GMP simultaneously to IRE was evaluated in murine models of melanona (B16...

This study aimed to obtain tyrosinase inhibitors for treating hyperpigmentation. A series of cinnamyl ester analogues were designed and synthesized with cinnamic acid (CA) and peaonol compounds. The safety, melanin content and inhibitory effects of all target compounds were evaluated. In the enzymatic activity test, the inhibitory rate of compounds 8, 13 and 14 had stronger inhibitory activity with the IC50 values of 20.7 μM, 13.98 μM and 15.16 μM, respectively than the positive drug kojic acid (IC50 with 30...

OBJECTIVES: To create a simple diagnostic method for invasive melanoma with in vivo cutaneous surface microscopy (epiluminescence microscopy, dermoscopy, dermatoscopy) and to analyze the incidence and characteristics of those invasive melanomas that had no diagnostic features by means of hand-held surface microscopes. DESIGN: Pigmented skin lesions were photographed in vivo with the use of immersion oil. All were excised and reviewed for histological diagnosis. A training set of 62 invasive melanomas and 159 atypical nonmelanomas and a test set of 45 invasive melanomas and 119 atypical non-melanomas were used...

Lymphocytes from 12 healthy donors were depleted of monocytes by velocity sedimentation at unit gravity (average monocyte contamination 0.2%) and tested for spontaneous cytotoxicity (SC) against tumor target cells in 23 h microcytotoxicity assays. Sixty percent of all lymphocytes were recovered in this monocyte-depleted lymphocyte fraction (LF). In contrast, with the corresponding unfractionated lymphocytes (UL) the LF cells were not spontaneously cytotoxic on T24 bladder carcinoma, NKI-1, NKI-7, NKI-8, NKI-10 melanoma, and MC-1 mammary carcinoma cell line cells and target cells derived from two short-term melanona cultures (Me 215 and Me 223)...

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Of 1,444 patients with primary cutaneous melanomas, 57 (3.9%) developed more than one. Most had two primary lesions but one had six. Every effort was made to insure that all melanomas were primary tumors. Most patients developed new primary melanonas within five years of the original operation, but an appreciable number developed them many years later. In the largest group, second and subsequent primary tumors developed in different areas of the body at later times. The subsequent tumors were not diagnosed at an earlier biological stage than the original tumors...

No abstract text is available yet for this article.