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Adverse skin side effects

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https://www.readbyqxmd.com/read/29665030/dermatologic-toxicity-from-novel-therapy-using-antimicrobial-peptide-ll-37-in-melanoma-a-detailed-examination-of-the-clinicopathologic-features
#1
Tsetan Dolkar, Celestine M Trinidad, Kelly C Nelson, Rodabe N Amaria, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Jonathan L Curry, Phyu P Aung
LL-37 is a naturally occurring 37-amino acid that is part of innate immunity in human skin. Preclinical studies have demonstrated that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a Phase 1 clinical trial for melanoma patients with cutaneous metastases. We report dermatologic toxicity in a 63-year-old woman with stage IIIC melanoma of the right calf and inguinal lymph nodes...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29622382/prospective-study-of-breast-radiation-dermatitis
#2
Leah Drost, Nim Li, Danny Vesprini, Arneet Sangha, Justin Lee, Eric Leung, Eileen Rakovitch, Caitlin Yee, Edward Chow, Mark Ruschin
BACKGROUND: Despite clear benefits of radiotherapy (RT) for breast cancer, there are numerous side effects. Radiation dermatitis has a significant impact on quality of life and can result in treatment interruptions or cessation. The purpose of this study was to prospectively follow breast radiation dermatitis and determine trends including peak toxicity. PATIENTS AND METHODS: Upon initiation of RT treatment, to assess skin reaction, each patient was seen weekly by the healthcare team, or contacted via telephone to assess patient-reported symptoms...
March 15, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29607625/turmeric-tonic-as-a-treatment-in-scalp-psoriasis-a-randomized-placebo-control-clinical-trial
#3
Parichehr Bahraini, Mehdi Rajabi, Parvin Mansouri, Golnaz Sarafian, Reza Chalangari, Zahra Azizian
BACKGROUND: Psoriasis is an autoimmune and recurrent chronic inflammatory skin disorder with a strong genetic basis. The characteristic features are hyperproliferation of keratinocytes, leading to redness, thickening, and scaling of the epidermis followed by itching and the appearance of lesions, which in most cases can affect the patients both medically and psychologically. The scalp is one of the most common sites for psoriasis. This condition is predominantly managed with steroids, which are associated with various side effects...
April 1, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29606995/double-blind-placebo-controlled-trial-to-evaluate-the-effectiveness-of-polypodium-leucotomos-extract-in-the-treatment-of-melasma-in-asian-skin-a-pilot-study
#4
Chee-Leok Goh, Sai Yee Chuah, Steven Tien, Guan Thng, María Alejandra Vitale, Arancha Delgado-Rubin
Introduction: Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern Polypodium leucotomos (PLE), Fernblock® (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Methods: Forty healthy adult patients with clinical diagnoses of melasma who were receiving treatment with topical 4% hydroquinone cream and sunscreen with a sun protection factor (SPF) of 50+ were recruited for inclusion in this study from the National Skin Centre in Singapore...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29560479/topical-interferon-alpha-2b-in-the-treatment-of-refractory-pseudophakic-cystoid-macular-edema
#5
Arash Maleki, Hossein Aghaei, Stacey Lee
Purpose: To report the efficacy and safety of interferon alpha 2b in the treatment of pseudophakic cystoid macular edema resistant to conventional therapy. Observations: A 64-year-old patient presented with pseudophakic cystoid macular edema in her left eye, which developed two months after an uncomplicated cataract surgery and was resistant to multiple topical NSAIDs and multiple intravitreal bevacizumab injections over the course of nine months. She also developed side effects to oral acetazolamide and intravitreal triamcinolone injection; a skin rash and a rise in intraocular pressure (34 mmHg), respectively...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29553959/a-comparison-of-neuromuscular-electrical-stimulation-and-traditional-therapy-versus-traditional-therapy-in-patients-with-longstanding-dysphagia
#6
Jo Frost, Fiona Robinson, Judi Hibberd
PURPOSE OF REVIEW: Dysphagia in adults arises from a range of causes including acquired neurological disorders and some cancers. Previous research has suggested that treatment using neuromuscular electrical stimulation (NMES) when used in conjunction with conventional therapy is effective. This review describes the recent literature and a small prospective case series carried out in the United Kingdom. This study contributed to support National Institute of Clinical Excellence (NICE) guidance for clinicians who wish to include NMES in a rehabilitation programme for dysphagic patients, specifically with reference to safety and the impact on swallowing function of this intervention...
March 16, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29551427/don-t-play-with-your-nodule-case-report-of-tachycardia-and-other-adverse-reactions-from-manipulation-of-an-exenatide-injection-site-nodule
#7
Caitlin Sandman, Benjamin Krainin, Jamie Roper
BACKGROUND: Type II diabetes mellitus (DM) is an increasingly prevalent cause of morbidity and mortality among U.S. adults, with increasing prevalence in emergency department (ED) visits. Multiple medications, such as exenatide, a glucagon-like peptide-1 agonist, have been developed in the past decade to combat this growing problem. This medication is well documented to cause gastrointestinal upset and skin nodules at the injection site. However, currently no documented cases exist regarding manipulation of injection nodules causing increased absorption or reports demonstrating an increase in adverse drug reactions...
March 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29534693/severe-eye-complications-from-toxic-epidermal-necrolysis-following-initiation-of-nevirapine-based-haart-regimen-in-a-child-with-hiv-infection-a-case-from-cameroon
#8
Xavier Tchetnya, Calypse Asangbe Ngwasiri, Tiayah Munge, Leopold Ndemnge Aminde
BACKGROUND: Toxic epidermal necrolysis (TEN) is a rare life threatening dermatological disorder characterized by extensive epidermal detachment and erosion of mucous membranes. It is typically a side effect of some medications. Nevirapine, a nonnucleoside reverse transcriptase inhibitor (NNRTI) is one of the frequently used components of highly active antiretroviral therapy (HAART). Skin rash is its common adverse reaction, usually mild and rarely progressing to TEN. Ophthalmic involvement is common as well but rarely progresses to blindness especially in the pediatric population...
March 13, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29518457/assessing-the-safety-of-superficial-chemical-peels-in-darker-skin-a-retrospective-study
#9
Shalini Vemula, Mayra B C Maymone, Eric A Secemsky, Raphael Widjajahakim, Nicole M Patzelt, Dana Saade, Neelam A Vashi
BACKGROUND: Chemical peels have shown efficacy in the treatment of acne, photoaging, and pigmentary dyschromias; however, studies evaluating side effects, particularly in patients with skin of color, are limited. OBJECTIVE: We sought to determine the frequency of side effects and complications associated with superficial chemical peels in patients with skin types III-VI. METHODS: A 5-year single center retrospective analysis was performed...
March 5, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29516985/effectiveness-and-the-strategy-to-treat-the-side-effects-of-sorafenib-administration-after-transarterial-chemoembolization-in-advanced-hepatocellular-carcinoma-patients
#10
Kai Zhang, Xiangyang Sun, Fubo Xie, Wencheng Jian, Caixia Li
Objective: The aim is to study the effectiveness and side effects of sorafenib administration after transarterial chemoembolization (TACE) in advanced hepatocellular carcinoma (HCC) patients. To evaluate the safety of the combination of sorafenib and TACE to treat HCC. Materials and Methods: A total of 36 unresectable HCC patients were enrolled. After TACE, administration of sorafenib was carried out. Follow-up was taken for every 4 weeks. Liver and renal function and alpha-fetoprotein were tested...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29516968/clinical-analysis-of-electroacupuncture-and-multiple-acupoint-stimulation-in-relieving-cancer-pain-in-patients-with-advanced-hepatocellular-carcinoma
#11
Lili Xu, Yongxian Wan, Juan Huang, Fangyuan Xu
Objective: The objective of this study is to investigate the clinical efficacy and safety of electroacupuncture and multiple acupoint stimulation in relieving cancer pain in patients with advanced hepatocellular carcinoma. Methods: Sixty-five cases of advanced hepatocellular carcinoma with cancer pain were selected in our hospital and were divided into electroacupuncture multiple acupoint stimulation group (electroacupuncture group) (n = 32) and fentanyl transdermal patch analgesia group (control group) (n = 33) according to analgesic methods and intentions...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29514582/a-case-of-an-acute-cutaneous-drug-reaction-with-hydroxychloroquine
#12
Amritakaur Randhawa, Grant Wylie
Hydroxychloroquine is considered a relatively benign drug and is regularly used by rheumatologists and dermatologists. We highlight the severe adverse drug reaction potential of this commonly prescribed medication. We report the case of a 63-year-old male, who presented with widespread skin eruption following initiation of hydroxychloroquine two weeks earlier for an inflammatory arthritis. He had typical clinical, biochemical and histological features of the now recognised formal 'diagnosis' of severe cutaneous adverse drug reaction...
January 1, 2018: Scottish Medical Journal
https://www.readbyqxmd.com/read/29507555/the-incidence-and-management-of-cutaneous-adverse-events-of-the-epidermal-growth-factor-receptor-inhibitors
#13
REVIEW
Witold Owczarek, Monika Słowińska, Aleksandra Lesiak, Magdalena Ciążyńska, Aldona Maciąg, Elwira Paluchowska, Luiza Marek-Józefowicz, Rafał Czajkowski
Overexpression of the epidermal growth factor receptor (EGFR) is found in many cancers, including those of the head and neck area, non-small-cell lung cancer, and colorectal, cervical, prostate, breast, ovary, stomach, and pancreatic cancer. The EGFR inhibitors are used at present in the treatment of such cancers. Skin lesions that develop during and after cancer treatment may be due to specific cytostatics, molecular-targeted drugs, radiation therapy, complementary therapy, or the cancer itself, and hence knowledge is essential to distinguish between them...
October 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29505831/continuous-manganese-delivery-via-osmotic-pumps-for-manganese-enhanced-mouse-mri-does-not-impair-spatial-learning-but-leads-to-skin-ulceration
#14
Dulcie A Vousden, Elizabeth Cox, Rylan Allemang-Grand, Christine Laliberté, Lily R Qiu, Zsuzsa Lindenmaier, Brian J Nieman, Jason P Lerch
Manganese-enhanced magnetic resonance imaging (MEMRI) is a widely used technique in rodent neuroimaging studies. Traditionally, Mn2+ is delivered to animals via a systemic injection; however, this can lead to toxic effects at high doses. Recent studies have shown that subcutaneously implanted mini-osmotic pumps can be used to continuously deliver manganese chloride (MnCl2 ), and that they produce satisfactory contrast while circumventing many of the toxic side effects. However, neither the time-course of signal enhancement nor the effect of continuous Mn2+ delivery on behaviour, particularly learning and memory, have been well-characterized...
March 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29504972/ablative-fractional-carbon-dioxide-laser-combined-with-intense-pulsed-light-for-the-treatment-of-photoaging-skin-in-chinese-population-a-split-face-study
#15
Xue-Ling Mei, Li Wang
Intense pulsed light (IPL) is effective for the treatment of lentigines, telangiectasia, and generalized erythema, but is less effective in the removal of skin wrinkles. Fractional laser is effective on skin wrinkles and textural irregularities, but can induce postinflammatory hyperpigmentation (PIH), especially in Asians. This study evaluated the safety and efficacy of ablative fractional laser (AFL) in combination with IPL in the treatment of photoaging skin in Asians.This study included 28 Chinese women with Fitzpatrick skin type III and IV...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29480626/oral-stomatitis-and-mtor-inhibitors-a-review-of-current-evidence-in-20-915-patients
#16
L Lo Muzio, C Arena, G Troiano, A Villa
BACKGROUND: Traditional treatment of malignancies with chemotherapeutic agents is often affected by the damage inflicted on non-cancerous cells. Toxicities of the oral cavity, such as mucositis and stomatitis, are some of the most significant and unavoidable toxicities associated with anti-cancer therapies. For such reason, in the last decades, newer targeted agents have been developed aiming to decrease the rates of side effects on healthy cells. Unfortunately, targeted anti-cancer therapies also showed significant rate of toxicity on healthy tissues...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29465551/sirolimus-alternative-to-blood-transfusion-as-a-life-saver-in-blue-rubber-bleb-nevus-syndrome-a-case-report
#17
Ke-Ling Wang, Shu-Fang Ma, Ling-Yu Pang, Meng-Na Zhang, Lin-Yan Hu, Meng-Jia Liu, Li-Ping Zou
RATIONALE: Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations. The gastrointestinal bleeding and secondary iron deficiency anemia are the most common complications. There are currently no effective treatments for BRBNS. Here, we report a case of successful treatment with a small dose of sirolimus of a BRBN patient with a de novo gene mutation. PATIENT CONCERNS: A 12-year-old female was admitted to our hospital with multiple hemangiomas for 12 years...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464101/pneumatocele-during-sorafenib-therapy-first-report-of-an-unusual-complication
#18
Paloma Sangro, Idoia Bilbao, Nerea Fernández-Ros, Mercedes Iñarrairaegui, Javier Zulueta, J I Bilbao, Bruno Sangro
Sorafenib is a multi-kinase inhibitor and a vascular endothelial growth factor (VEGF) inhibitor approved to treat patients with advanced hepatocellular carcinoma, renal cell carcinoma and differentiated thyroid carcinoma. Its most common side effects are asthenia/fatigue, skin toxicity, diarrhea and arterial hypertension. Reported respiratory adverse reactions include dyspnea, cough, pleural effusion and hoarseness. The aim of this report is to describe for the first time the occurrence of pneumatocele in two patients treated with Sorafenib...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29444375/the-efficacy-and-safety-of-non-pharmacological-therapies-for-the-treatment-of-acne-vulgaris-a-systematic-review-and-best-evidence-synthesis
#19
F M C de Vries, A M Meulendijks, R J Driessen, A A van Dooren, E P M Tjin, P C M van de Kerkhof
BACKGROUND: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. However, sufficient evidence based support in the efficacy and safety of non-pharmacological therapies is lacking. OBJECTIVE: To assess the efficacy and safety of several non-pharmacological therapies in the treatment of acne vulgaris...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29441584/comparative-analysis-of-lacistema-pubescens-and-dexamethasone-on-topical-treatment-of-skin-inflammation-in-a-chronic-disease-model-and-side-effects
#20
Josiane M da Silva, Jéssica L M Conegundes, Nícolas C C Pinto, Renata F Mendes, Maria Christina M N Castañon, Elita Scio
OBJECTIVES: This study aimed to evaluate the chronic topical anti-inflammatory activity of the pharmaceutical formulation ProHLP containing the hexane fraction of Lacistema pubescens (HLP). It was also investigated the possible cutaneous and systemic adverse effects of HLP and ProHLP in mice when compared to dexamethasone. METHODS: The chronic topical anti-inflammatory activity was determined by croton oil multiple application-induced mouse ear oedema model. Histopathological analyses of ear tissue samples sensitized with croton oil were performed...
February 13, 2018: Journal of Pharmacy and Pharmacology
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