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https://www.readbyqxmd.com/read/29232031/systematic-review-and-meta-analysis-of-reported-adverse-events-of-long-term-intranasal-oxytocin-treatment-for-autism-spectrum-disorder
#1
REVIEW
Qizheng Cai, Lei Feng, Kai Zhen Yap
Recent studies suggested oxytocin as a possible drug to treat social deficits caused by Autism Spectrum Disorder (ASD), but the safety of intranasal oxytocin in autistic patients is not established. The aim of this review was to characterise the side effect profile of long-term intranasal oxytocin in treatment of ASD compared to placebo. All randomised controlled trials of intranasal oxytocin in the treatment of ASD published before 1 January 2017 that reported safety data were identified from databases including Pubmed, Embase, Cochrane Library, and International Pharmaceutical Abstract...
December 12, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29216643/emerging-treatment-options-in-atopic-dermatitis-topical-therapies
#2
Uffe Nygaard, Mette Deleuran, Christian Vestergaard
Atopic dermatitis is a chronic inflammatory skin disorder affecting children and adults, with the majority presenting mild to moderate disease severity. The use of topical corticosteroids (TCSs) in combination with emollients has been the mainstay for treating mild to moderate atopic dermatitis since the 1950s, and as a supplement to systemic treatment in severe disease. However, while very effective, TCSs are often accompanied by poor adherence due to corticophobia (fear of using corticosteroids in patients or doctors), unwanted side effects, and in some cases insufficient clinical response...
December 8, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29200562/prevalence-and-sociodemographic-profile-of-lithium-induced-cutaneous-side-effects-in-bipolar-affective-disorder-patients-a-1-year-prospective-observational-study-in-south-india
#3
B S Suganya Priyadharshini, I Syed Ummar
Objectives: Objective in our study is i) To assess the prevalence and sociodemographic profile of cutaneous side effects in bipolar affective disorder patients (BPAD) on lithium. ii) To assess the course of pre-existing skin reactions, when patient is initiated on lithium therapy. Methods: Lithium induced cutaneous side effects were assessed at baseline and monthly for 6 months followed by every 2 months over a year. Dermatologist opinion obtained to diagnose and treat for each patient who developed cutaneous side effects...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29193016/dupilumab-with-concomitant-topical-corticosteroids-in-adult-patients-with-atopic-dermatitis-who-are-not-adequately-controlled-with-or-are-intolerant-to-ciclosporin-a-or-when-this-treatment-is-medically-inadvisable-a-placebo-controlled-randomized-phase-3-clinical
#4
M de Bruin-Weller, D Thaçi, C H Smith, K Reich, M Cork, A Radin, Q Zhang, B Akinlade, A Gadkari, L Eckert, T Hultsch, Z Chen, G Pirozzi, N M H Graham, B Shumel
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that may require systemic therapy. Ciclosporin A (CsA) is a widely-used, potent immunosuppressant for AD. CsA is not effective in all patients, and side effects limit its use. Dupilumab, a fully human anti-interleukin (IL)-4 receptor-alpha monoclonal antibody, inhibits signaling of IL-4 and IL-13, key drivers of type 2/Th2-mediated inflammation, and is approved in the U.S.A. and the E.U. for the treatment of adults with moderate-to-severe AD...
November 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29192424/interventions-for-old-world-cutaneous-leishmaniasis
#5
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Ludovic Reveiz, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
December 1, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29192000/drooling-reduction-intervention-randomised-trial-dri-comparing-the-efficacy-and-acceptability-of-hyoscine-patches-and-glycopyrronium-liquid-on-drooling-in-children-with-neurodisability
#6
Jeremy R Parr, Emma Todhunter, Lindsay Pennington, Deborah Stocken, Jill Cadwgan, Anne E O'Hare, Catherine Tuffrey, Jane Williams, Mike Cole, Allan F Colver
OBJECTIVE: Investigate whether hyoscine patch or glycopyrronium liquid is more effective and acceptable to treat drooling in children with neurodisability. DESIGN: Multicentre, single-blind, randomised controlled trial. SETTING: Recruitment through neurodisability teams; treatment by parents. PARTICIPANTS: Ninety children with neurodisability who had never received medication for drooling (55 boys, 35 girls; median age 4 years)...
November 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29191439/effects-of-cerebellar-neuromodulation-in-movement-disorders-a%C3%A2-systematic-review
#7
REVIEW
Carina França, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Ricardo Galhardoni, Valquiria Silva, Egberto Reis Barbosa, Rubens Gisbert Cury
BACKGROUND: The cerebellum is involved in the pathophysiology of many movement disorders and its importance in the field of neuromodulation is growing. OBJECTIVES: To review the current evidence for cerebellar modulation in movement disorders and its safety profile. METHODS: Eligible studies were identified after a systematic literature review of the effects of cerebellar modulation in cerebellar ataxia, Parkinson's disease (PD), essential tremor (ET), dystonia and progressive supranuclear palsy (PSP)...
November 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29179250/pi3k-inhibitors-understanding-toxicity-mechanisms-and-management
#8
REVIEW
I Brian Greenwell, Andrew Ip, Jonathon B Cohen
The phosphatidylinositol 3-kinase (PI3K) pathway has attracted immense interest as a therapeutic target for cancer treatment. Idelalisib was the first PI3K inhibitor approved by the US Food and Drug Administration and is utilized in the treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma. Copanlisib has subsequently been approved for relapsed follicular lymphoma in patients who have received at least two prior systemic therapies. There are multiple other PI3K agents currently in development; these target various combinations of PI3K isoforms...
November 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29163463/selective-glucocorticoid-receptor-properties-of-gsk866-analogs-with-cysteine-reactive-warheads
#9
Chandra S Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W C Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand-binding strategies, classified as selective glucocorticoid receptor (GR) agonists (SEGRAs) or selective glucocorticoid receptor modulators (SEGRMs). In the current study, GSK866 analogs with electrophilic covalent-binding warheads were developed with potential SEGRA properties to improve their clinical safety profile for long-lasting topical skin disease applications...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29149474/interventions-for-old-world-cutaneous-leishmaniasis
#10
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29131139/capsaicin-used-on-skin-influences-ion-transport-pathways-an-in-vitro-study
#11
Iga Hołyńska-Iwan, Inga Dziembowska, Paulina Smyk, Magdalena Lampka, Dorota Olszewska-Słonina
Acute, adverse skin effects to capsaicin can be activated by inhibition of sodium transport not only in nociceptive neurons, but also in keratinocytes. The aim of the current study was to describe and compare immediate (15 s) and prolonged (30 min) effects of capsaicin on epidermal (not neural) sodium transport using a rabbit skin model. Skin fragments (n = 169) were incubated in 4 conditions: undisturbed ion transport (U; n = 48); inhibited sodium transport (INa; n = 34) with amiloride used as sodium transport blocker; long-term irritation by capsaicin with undisturbed ion transport (CAPSA-U; n = 43) and with inhibited sodium transport (CAPSA-INa; n = 35)...
November 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29103323/treatment-of-molluscum-contagiosum-with-an-east-indian-sandalwood-oil-product
#12
Malika Haque, Daniel L Coury
OBJECTIVES: To evaluate the safety and efficacy of an East Indian sandalwood oil (EISO) product as a topical treatment for molluscum contagiosum. MATERIALS AND METHODS: Ten subjects ranging in age from 22 months to 29 years were recruited. Subjects were instructed to apply an EISO product to the lesions twice daily. Subjects were monitored every two to three weeks during the study and were questioned regarding local or systemic side effects. Assessment of response was recorded by counting lesions and documented by photographs...
November 22, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29096940/anti-pd1-pdl1-induced-psoriasis
#13
Dimitra Voudouri, Vasiliki Nikolaou, Konstantinos Laschos, Andriani Charpidou, Nikolaos Soupos, Ioanna Triantafyllopoulou, Ioanna Panoutsopoulou, Gerasimos Aravantinos, K Syrigos, A Stratigos
BACKGROUND: Immune checkpoint inhibitors are novel agents approved for the treatment of late-stage malignancies. Despite its important clinical benefits, checkpoint inhibition is associated with a unique spectrum of side effects known as immune-related adverse events. Skin toxicities are the most frequent immune-related adverse events during anti-PD1 blockade therapies. Among them, rare cases of psoriasis exacerbation have been reported. METHODS: We present the clinical characteristics of exacerbated psoriasis in 5 patients under anti-PD1/PDL1 therapy...
October 18, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/29082832/near-infrared-light-for-on-demand-drug-delivery
#14
Dong-Jin Lim, Hansoo Park
There are currently many basic technologies for the controlled release of therapeutic molecules for the treatment of chronic pathologies such as arthritis, asthma, and diabetes. Examples of such technologies include selectively dissolvable capsules and tablets that are designed to respond to specific stimuli-such as pH, temperature, or specific enzymes-in a time-specific fashion. However, because of the biological variations between different individuals, which contribute to differences in the environments of therapeutic target locations, these technologies are not fully controllable...
October 30, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29068253/topical-e6005-rvt-501-a-novel-phosphodiesterase-4-inhibitor-for-the-treatment-of-atopic-dermatitis
#15
REVIEW
Masutaka Furue, Takafumi Kadono, Gaku Tsuji, Takeshi Nakahara
Local adverse effects of steroid use and the burning sensation of calcineurin inhibitors impair patients' adherence to treatment and decrease the treatment response in atopic dermatitis (AD). Steroid phobia appears to be a psychological problem in patients with AD. Topical non-steroidal remedies are in demand. Areas covered: This manuscript reviews the current literature on preclinical and clinical studies regarding topical E6005/RVT-501, a novel phosphodiesterase 4 inhibitor. We also discuss the mechanistic background of E6005/RVT-501 in the treatment of AD...
December 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29067616/a-clinical-review-of-phototherapy-for-psoriasis
#16
REVIEW
Ping Zhang, Mei X Wu
Psoriasis is an autoimmune inflammatory skin disease. In the past several decades, phototherapy has been widely used to treat stable psoriatic lesions, including trunk, scalp, arms and legs, and partial nail psoriasis. A variety of light/lasers with different mechanisms of action have been developed for psoriasis including ultraviolet B (UVB), psoralen ultraviolet A (PUVA), pulsed dye laser (PDL), photodynamic therapy (PDT), intense pulsed light (IPL), light-emitting diodes (LED), and so on. Because light/laser each has specific therapeutic and adverse effects, it is important to adequately choose the sources and parameters in management of psoriasis with different pathogenic sites, severities, and duration of the disorder...
October 24, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29066552/fkbp12-dependent-inhibition-of-calcineurin-mediates-immunosuppressive-antifungal-drug-action-in-malassezia
#17
Giuseppe Ianiri, Shelly Applen Clancey, Soo Chan Lee, Joseph Heitman
The genus Malassezia includes yeasts that are commonly found on the skin or hair of animals and humans as commensals and are associated with a number of skin disorders. We have previously developed an Agrobacterium tumefaciens transformation system effective for both targeted gene deletion and insertional mutagenesis in Malassezia furfur and M. sympodialis In the present study, these molecular resources were applied to characterize the immunophilin FKBP12 as the target of tacrolimus (FK506), ascomycin, and pimecrolimus, which are calcineurin inhibitors that are used as alternatives to corticosteroids in the treatment of inflammatory skin disorders such as those associated with Malassezia species...
October 24, 2017: MBio
https://www.readbyqxmd.com/read/29063519/clinical-pharmacokinetics-and-pharmacodynamics-of-oxazolidinones
#18
REVIEW
Claire Roger, Jason A Roberts, Laurent Muller
Oxazolidinones are a class of synthetic antimicrobial agents with potent activity against a wide range of multidrug-resistant Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Oxazolidinones exhibit their antibacterial effects by inhibiting protein synthesis acting on the ribosomal 50S subunit of the bacteria and thus preventing formation of a functional 70S initiation complex. Currently, two oxazolidinones have been approved by the US Food and Drug Administration: linezolid and more recently tedizolid...
October 23, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29051065/dihydroergotamine-mesylate-loaded-dissolving-microneedle-patch-made-of-polyvinylpyrrolidone-for-management-of-acute-migraine-therapy
#19
Cetin Tas, Jessica C Joyce, Hiep X Nguyen, Padmanabhan Eangoor, Jennifer S Knaack, Ajay K Banga, Mark R Prausnitz
Migraine is a widespread neurological disease with negative effects on quality of life and productivity. Moderate to severe acute migraine attacks can be treated with dihydroergotamine mesylate (DHE), an ergot derivative that is especially effective in non-responders to triptan derivatives. To overcome limitations of current DHE formulations in subcutaneous injection and nasal spray such as pain, adverse side effects and poor bioavailability, a new approach is needed for DHE delivery enabling painless self-administration, quick onset of action, and high bioavailability...
October 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29034138/testosterone-pellet-associated-dermatitis-report-and-review-of-testopel-related-cutaneous-adverse-effects
#20
Lucas A Heldt Manica, Philip R Cohen
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application...
August 11, 2017: Curēus
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