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https://www.readbyqxmd.com/read/28095548/integrated-cooling-vacuum-assisted-non-fractional-1540-nm-erbium-glass-laser-is-effective-in-treating-acne-scars
#1
Yael Politi, Assi Levi, Moshe Lapidoth
INTRODUCTION: Acne scars are a common result of in ammatory acne, affecting many patients worldwide. Among which, atrophic scars are the most prevalent form, presenting as dermal depressions caused by inflammatory degeneration of dermal collagen. Mid-infrared laser skin interaction is characterized by its modest absorption in water and nite penetration to the mid-dermis. Since collagen is a desirable laser target, 1540-nm wavelength is amenable for collagen remodeling within the depressed area of atrophic scars...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095547/prospective-internally-controlled-blind-reviewed-clinical-evaluation-of-cryolipolysis-combined-with-multipolar-radiofrequency-andvaripulsetechnology-for-enhanced-subject-results-in-circumferential-fat-reduction-and-skin-laxity-of-the-flanks
#2
Julius Few, Michael Gold, Neil Sadick
BACKGROUND: Increasing demand for non-invasive skin tightening and body contouring procedures has led to several technological in- novations in energy-based devices such as ultrasound, radiofrequency and cryolipolysis. An emerging trend in the eld is to evaluate whether combination therapies for skin laxity/body contouring using energy-based devices can deliver superior clinical results and patient satisfaction. As such, the objective of this prospective, internal-controlled, blind clinical study was to assess the safety and efficacy of cryolipolysis followed by multipolar radiofrequency with pulsed electromagnetic elds (PEMF) and adjustable pulsed suction for the treatment of skin laxity in the flanks...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28091849/dynamic-optical-absorption-characteristics-of-blood-after-slow-and-fast-heating
#3
Hao Jia, Bin Chen, Dong Li
Laser treatment is the most effective therapy in dermatology for vascular skin disorders, such as port-wine stains (PWS). Changes in heat-induced absorbance in blood must be determined for accurate numerical simulation and implementation of multi-pulse laser therapy for treatment of PWS. Thermally induced absorbance changes in hemoglobin in blood were compared in vitro between slow water bath heating and fast heating irradiated by using sub-millisecond Nd:YAG laser. Blood composition at different temperatures was calculated by comparing blood absorption spectra with those of pure HbO2, Hb, and metHb at room temperature...
January 13, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28071592/development-and-evaluation-of-zinc-phthalocyanine-nanoemulsions-for-use-in-photodynamic-therapy-for-leishmania-spp
#4
Luciana Betzler de Oliveira de Siqueira, Verônica da Silva Cardoso, Igor Almeida Rodrigues, Ana Lúcia Vazquez-Villa, Elisabete Pereira Dos Santos, Bruno da Costa Leal Ribeiro Guimarães, Cristal Dos Santos Cerqueira Coutinho, Alane Beatriz Vermelho, Eduardo Ricci Junior
Photodynamic therapy (PDT) combines light with photosensitizers (PS) for production of reactive oxygen species (ROS) that can kill infectious microorganisms such as bacteria, fungi and protozoa. The application of nanotechnology has enabled the advancement of PDT because many PS are insoluble in water, necessitating a nanocarrier as a physiologically acceptable carrier. Nanoemulsions are efficient nanocarriers for solubilizing liposoluble drugs, like the PS, in water. Cutaneous (CL) and mucocutaneous leishmaniasis (ML) are caused by different species of the genus Leishmania, transmitted to humans by sandfly bites...
February 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28044367/bilateral-half-head-comparison-of-1-anthralin-ointment-in-children-with-alopecia-areata
#5
Mustafa Özdemir, Ali Balevi
BACKGROUND/OBJECTIVES: Alopecia areata (AA) is one of the most difficult skin diseases to manage well. In children, anthralin is commonly used for the treatment of AA. Available research consists of a limited number of uncontrolled trials that assessed the effectiveness of anthralin in promoting hair growth in patients with AA. The objective of this study was to validate the clinical effectiveness of short-contact anthralin 1% ointment in children with AA. METHODS: Thirty children with chronic, severe, treatment-refractory, extensive AA were treated with 1% anthralin ointment...
January 3, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/27999741/characterization-of-nivolumab-associated-skin-reactions-in-patients-with-metastatic-non-small-cell-lung-cancer
#6
Omar Hasan Ali, Stefan Diem, Eva Markert, Wolfram Jochum, Katrin Kerl, Lars E French, Daniel E Speiser, Martin Früh, Lukas Flatz
Immune checkpoint inhibitors have led to considerable therapy improvement in cancer patients. Autoimmune side effects including skin reactions are frequently observed. In melanoma, those include rash and vitiligo and were shown to be associated with a prolonged overall survival. Little is known about skin reactions in non-small cell lung cancer (NSCLC) patients during immunotherapy. Here, we retrospectively investigated immune-related adverse skin reactions (irAEs) in 40 patients with metastatic NSCLC treated with the anti-PD-1 antibody nivolumab...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27995875/-patient-reported-outcome-of-tyrosine-kinase-inhibitor-related-side-effects-and-their-impact-on-daily-life-in-chinese-patients-with-chronic-myeloid-leukemia-in-the-chronic-phase
#7
L Yu, H B Wang, Q Jiang
Objective: To explore the impact of patient reported outcome of tyrosine kinase inhibitor (TKI) related side effects on daily life in Chinese patients with chronic myeloid leukemia (CML) in the chronic phase (CP). Methods: From May to November in 2014, anonymous questionnaires were distributed to adult CML patients who were receiving TKI treatment in China. The impact of TKI-related side effects on daily life were assessed by the score of 1 (no impact) to 5 (high impact) from patient self-report. Results: Data from 731 respondents in the CP who reported the score of the impact of TKI-related side effects on daily life were collected...
November 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27976363/acute-skin-and-hair-symptoms-followed-by-severe-delayed-eye-complications-in-subjects-using-the-synthetic-opioid-mt-45
#8
A Helander, M Bradley, A Hasselblad, L Norlén, I Vassilaki, M Bäckberg, J Lapins
BACKGROUND: The introduction of unclassified new psychoactive substances (NPS) on the recreational drugs market through open online sale ('legal highs' or 'Internet drugs') continues unabated and represents a growing health hazard. The use of NPS has resulted in numerous, severe, adverse events and fatalities, due to unintended overdose or unknown toxic side-effects. OBJECTIVES: To try to find a possible common underlying cause for the skin-hair-eye symptoms complex observed in three men...
December 14, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27943305/use-of-skin-lightening-products-among-selected-urban-communities-in-accra-ghana
#9
Margaret Lartey, Francis D Krampa, Mubarak Abdul-Rahman, Naa L Quarcoo, Phaedra Yamson, Paa G Hagan, Yao Tettey, Richard Gyasi, Andrew A Adjei
BACKGROUND: The practice of skin lightening has been reported from North America, Europe, Asia, and Africa. In literature, some prevalence rates exceed 50%, and both sexes are involved. Common agents used include hydroquinone, mercury, corticosteroids, and caustic agents. The agents are easily accessible and affordable with very little regulation. Cutaneous and systemic side effects occur but do not appear to be a deterrent, as the notion of light skin as a surrogate for beauty is strong...
January 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27934944/overexpression-of-glucocorticoid-induced-leucine-zipper-gilz-increases-susceptibility-to-imiquimod-induced-psoriasis-and-involves-cutaneous-activation-of-tgf-%C3%AE-1
#10
Elena Carceller, Marlies Ballegeer, Julie Deckers, Carlo Riccardi, Stefano Bruscoli, Tino Hochepied, Claude Libert, Paloma Pérez
Psoriasis vulgaris is a chronic inflammatory skin disease affecting millions of people. Its pathophysiology is complex and involves a skin compartment with epidermal and immune cells which produce cytokines, e.g. belonging to the IL-23-Th17-cell axis. Glucocorticoids (GCs) are the most common therapeutics used in cutaneous inflammatory disorders and GC-induced leucine zipper (GILZ) has emerged as a mediator of GCs due to its anti-inflammatory actions, theoretically lacking GC side-effects. We evaluated whether GILZ may provide a better therapeutic index in comparison to GCs during the onset and progression of psoriasis by generating and characterizing a mouse model with generalized overexpression of this protein (GILZ-Tg mice) and the imiquimod (IMQ) psoriasis model...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904178/topical-steroid-awareness-and-abuse-a-prospective-study-among-dermatology-outpatients
#11
T S Nagesh, A Akhilesh
BACKGROUND: Topical steroids are one of the most commonly abused drugs. There are only a few studies available which have highlighted the severity of this problem in India. However, these studies have concentrated mainly on the topical steroid abuse and its side effects over the face. AIMS: The aim of this study was to know the awareness among the people about various commonly available topical steroids and their combinations irrespective of usage and to know the extent of misuse of these drugs...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27885522/efficacy-and-safety-of-fractional-co2-laser-versus-fractional-er-yag-laser-in-the-treatment-of-facial-skin-wrinkles
#12
Reza M Robati, Elmira Asadi
Ablative fractional lasers were introduced for treating facial rhytides. Few studies have compared fractional CO2 and Er:YAG lasers on cutaneous photodamages by a split trial. The aim of the present study was to compare these modalities in a randomized controlled double-blind split-face design with multiple sessions and larger sample size compared to previous studies done before. Forty patients with facial wrinkles were enrolled. Patients were randomly assigned to receive three monthly treatments on each side of the face, one with a fractional CO2 and one with a fractional Er:YAG laser...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27882010/short-term-clinical-effect-of-conformal-radiotherapy-combined-with-tegafur-gimeracil-oteracil-potassium-in-treating-recurrent-esophagus-cancer
#13
Yuyan Jiao, Yuzhen Shen, Hua Yan, Yan Liu, Haihua Tan, Jianzhe Li
OBJECTIVE: To observe clinical effects of three-dimensional conformal radiotherapy combined with Tegafur Gimeracil Oteracil Potassium chemotherapy in the treatment of patients with recurrent esophagus cancer. METHODS: One hundred and twelve senile patients who suffered from esophagus cancer were selected and randomly divided into two groups, namely, observation group (56 cases) and control group (56 cases). The observation group adopted three-dimensional conformal radiotherapy combined with Tegafur Gimeracil Oteracil Potassium chemotherapy and the control group adopted three-dimensional conformal radiotherapy only...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27881112/photoprotective-potential-in-some-medicinal-plants-used-to-treat-skin-diseases-in-sri-lanka
#14
Mayuri Tharanga Napagoda, Benthota Malavi Arachchige Shamila Malkanthi, Subasinghe Appuhamillage Kaumudi Abayawardana, Mohomed Mallique Qader, Lalith Jayasinghe
BACKGROUND: The constant exposure to solar ultraviolet radiation (UV) has a variety of harmful effects on human health. Although synthetic sunscreen products have been introduced as a preventive/therapeutic strategy, with the realization of their adverse side effects, the recent trend is to search for human friendly alternative formulations especially of plant origin. Therefore, the present study focuses on evaluation of photoprotective activity of aqueous extracts (1 mg/ml) of eleven medicinal plants in Sri Lanka that have been widely employed in traditional medicine as treatment options for various skin diseases and to improve the complexion...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27873026/long-term-efficacy-and-side-effects-of-low-dose-tacrolimus-for-the-treatment-of-myasthenia-gravis
#15
Xiaoyong Tao, Wei Wang, Feng Jing, Zhongkui Wang, Yuping Chen, Dongning Wei, Xusheng Huang
The study evaluated the efficacy of low-dose tacrolimus for treating Myasthenia Gravis (MG). Data were collected from 97 patients treated with low-dose tacrolimus from February 2011 to April 2015. Metabolic analysis was performed to determine more accurate tacrolimus dosing and patients were followed-up within clinic every 6 months for up to 4 years. The myasthenia gravis-specific activities of daily living scale was used to assess MG symptoms and their effects on patients' daily activities. All side effects and adverse reactions were thoroughly documented...
November 21, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27853063/successful-re-administration-of-low-dose-of-methimazole-mmi-in-graves-disease-patients-who-experienced-allergic-cutaneous-reactions-to-mmi-at-initial-treatment-and-had-received-long-term-propylthiouracil-ptu
#16
Sumihisa Kubota
Objective When patients with Graves' disease show severe allergic cutaneous reactions, physicians often suggest that they undergo radioiodine therapy instead of receiving propylthiouracil (PTU), another antithyroid drug, because anti-neutrophil cytoplasmic antibody (ANCA) -related vasculitis can occur with PTU, especially with long-term use. However, some patients refuse radioiodine therapy and chose PTU. Sometimes PTU treatment may be prolonged. Since the frequency of adverse effects of methimazole (MMI) is dose-related, there is a possibility that we can re-administer a low dose without adverse effects to patients well-controlled with PTU who once experienced an allergic reaction to MMI...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27826967/palonosetron-induced-anaphylaxis-during-general-anesthesia-a-case-report
#17
Hyungjun Park, Kyunghwan Oh, Hoonhee Lee, Ji Hyang Lee, Sun Myoung Kang, So Young Park, Hyouk Soo Kwon, You Sook Cho, Hee Bom Moon, Tae Bum Kim
Palonosetron is a 5-hydroxytryptamine-3 (5-HT-3) receptor antagonist used for preventing postoperative nausea and vomiting. Compared with ondansetron and granisetron, it is a better drug because of prolonged action and minimal side effects. Some adverse effects of palonosetron have been reported. In this report, we describe a 37-year-old male who developed severe hypersensitivity reactions to palonosetron during surgery for kidney donation. His medical history was unremarkable, except for inguinal hernia with herniorrhaphy 8 years ago...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27820586/use-of-4mat-learning-theory-to-promote-better-skin-care-during-radiation-therapy-an-evidence-based-quality-improvement-project
#18
Carole Bauer, Morris Magnan, Pamela Laszewski
Radiation therapy is a key treatment modality for cancer patients, but it is associated with adverse side effects such as radiation dermatitis. To mitigate the adverse effects of radiation on the skin, patients must participate in skin-related self-care. However, even with self-care instruction, adherence can be poor. This quality improvement project used best available evidence for skin care in patients undergoing radiation therapy and a theoretical framework, 4MATing, to provide a structured approach to patient education designed to enhance adherence to skin care recommendations...
November 2016: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/27786567/compound-glycyrrhizin-plus-conventional-therapy-for-psoriasis-vulgaris-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Jason Jingjie Yu, Claire Shuiqing Zhang, Meaghan E Coyle, Yiqi Du, Anthony Lin Zhang, Xinfeng Guo, Charlie Changli Xue, Chuanjian Lu
BACKGROUND: Psoriasis vulgaris is a chronic skin condition affecting patients' quality of life. Long-term use of conventional therapy increases risk of unwanted side effects. Compound glycyrrhizin in conjunction with conventional therapy has been used in clinical practice, but the evidence for such practice has not been evaluated systematically. OBJECTIVE: This review aims to evaluate the efficacy and safety of compound glycyrrhizin in combination with conventional therapy for psoriasis vulgaris...
February 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27778435/safety-and-efficacy-of-topical-ketoprofen-in-transfersome-gel-in-knee-osteoarthritis-a-systematic-review
#20
Vandit Sardana, Joanna Burzynski, Paul Zalzal
PURPOSE: Topical ketoprofen in Transfersome gel has been used for the alleviation of symptoms in osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with various side effects. Topical NSAIDs are known to have a lower side-effect profile when compared with systemic administration. The present systematic review aimed to determine the safety and efficacy of topical ketoprofen in Transfersome gel in knee osteoarthritis (OA). METHODS: A systematic literature review was performed...
October 24, 2016: Musculoskeletal Care
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