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https://www.readbyqxmd.com/read/28437284/a-retrospective-study-on-mycophenolic-acid-drug-interactions-effect-of-prednisone-sirolimus-and-tacrolimus-with-mpa
#1
Ana Catalina Alvarez-Elías, Elisa Catherine Yoo, Ekaterina Kirilova Todorova, Ram Nivas Singh, Guido Filler
Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is widely used as an antirejection drug following renal transplantation. There is growing evidence supporting the notion that there is substantial variability in the intra- and inter-patient exposure to MPA. Drug interactions involving MPA with tacrolimus, steroids, and sirolimus have been understudied. The objective of this study was to determine the relationship between MPA, steroids, tacrolimus, and sirolimus. MPA trough concentrations from 37 pediatric renal transplant recipients (mean age 7...
April 6, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28421984/stability-indicating-uplc-method-for-the-estimation-of-nadifloxacin-terbinafine-hydrochloride-mometasone-furoate-methyl-paraben-and-propyl-paraben-in-topical-pharmaceutical-dosage-form
#2
Dileep M Bhosale, Anna Pratima G Nikalje
A novel and simple ultra-performance LC method was developed for the estimation of nadifloxacin (NAD), terbinafine hydrochloride (TBH), mometasone furoate (MMF), methyl paraben (MP), and propyl paraben (PP) in a topical pharmaceutical dosage formulation. The analysis was carried out on a Waters Acquity UPLC ethylene bridged hybrid C18 column (50 × 2.1 mm, 1.7 μm) with a flow rate of 0.4 mL/min in gradient mode at a wavelength of 255 nm. Elution of all components was achieved within 9 min. The retention times of MP, NAD, PP, TBH, and MMF were observed at 1...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28421185/changes-in-composition-of-the-gut-bacterial-microbiome-after-fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-in-a-pediatric-heart-transplant-patient
#3
Kyle L Flannigan, Taylor Rajbar, Andrew Moffat, Leanna S McKenzie, Frank Dicke, Kevin Rioux, Matthew L Workentine, Thomas J Louie, Simon A Hirota, Steven C Greenway
The microbiome is increasingly recognized as an important influence on human health and many of the comorbidities that affect patients after solid organ transplantation (SOT) have been shown to involve changes in gut bacterial populations. Thus, microbiome changes in an individual patient may have important health implications after SOT but this area remains understudied. We describe changes in the composition of the fecal microbiome from a pediatric heart transplant recipient before and >2.5 years after he underwent repeated fecal microbiota transplantation (FMT) for recurrent Clostridium difficile infection (CDI)...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28413686/cytokine-profiles-of-amyopathic-dermatomyositis-with-interstitial-lung-diseases-treated-with-mycophenolate
#4
Masachika Hayashi, Ami Aoki, Katsuaki Asakawa, Takuro Sakagami, Toshiaki Kikuchi, Toshinori Takada
A 59-year-old Japanese man diagnosed with interstitial lung disease associated with amyopathic dermatomyositis with anti-melanoma differentiation-associated gene 5 (MDA-5) antibodies was treated with intravenous methyl prednisolone (PSL) 1000 mg, oral PSL 1 mg/kg, and oral cyclosporin 200 mg daily. His respiratory condition worsened after treatment with two times of intravenous cyclophosphamide and another steroid pulse therapy as well as PSL and cyclosporin. Addition of mycophenolate mofetil (MMF), 1...
July 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28412754/efficacy-and-safety-of-a-reduced-calcineurin-inhibitor-dose-combined-with-mycophenolate-mofetil-in-liver-transplant-patients-with-chronic-renal-dysfunction
#5
Pusen Wang, Weitao Que, Hao Li, Lvnan Yan, Zhiren Fu, Qifa Ye, Guihua Chen, Kefeng Dou, Shichun Lu, Zhanyu Yang, Zhijun Zhu, Zhihai Peng, Lin Zhong
Calcineurin inhibitors (CNIs) are frequently given at a reduced dose in combination with mycophenolate mofetil (MMF) to avoid nephrotoxicity, but the optimal reduction in CNI dose has not been established. In this prospective, open-label, multicenter study, liver transplant recipients with chronic renal dysfunction who were administered a CNI-based immunosuppressive regimen were included in the intent-to-treat (ITT) population. The primary endpoint was declination in renal function, which was defined as a ≥ 20% decrease in the glomerular filtration rate during the year following regimen adjustment...
February 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408734/mycophenolate-mofetil-and-pulmonary-fibrosis-after-kidney-transplantation-a-case-report
#6
Kazuhiro Takahashi, Pauline Go, Chad H Stone, Mohamed Safwan, Krishna G Putchakayala, William J Kane, Lauren E Malinzak, Dean Y Kim, Jason E Denny
BACKGROUND Mycophenolate mofetil (MMF) induced lung disease has been described in only a few isolated reports. We report a case of fatal respiratory failure associated with MMF after kidney transplantation. CASE REPORT A 50-year-old Hispanic male with a history of end-stage renal disease secondary to hypertension underwent deceased donor kidney transplantation. His preoperative evaluations were normal except for a chest x-ray which showed bilateral interstitial opacities. Tacrolimus and MMF were started on the day of surgery...
April 14, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28393747/relationship-of-goat-milk-flow-emission-variables-with-milking-routine-milking-parameters-milking-machine-characteristics-and-goat-physiology
#7
G Romero, R Panzalis, P Ruegg
The aim of this paper was to study the relationship between milk flow emission variables recorded during milking of dairy goats with variables related to milking routine, goat physiology, milking parameters and milking machine characteristics, to determine the variables affecting milking performance and help the goat industry pinpoint farm and milking practices that improve milking performance. In total, 19 farms were visited once during the evening milking. Milking parameters (vacuum level (VL), pulsation ratio and pulsation rate, vacuum drop), milk emission flow variables (milking time, milk yield, maximum milk flow (MMF), average milk flow (AVMF), time until 500 g/min milk flow is established (TS500)), doe characteristics of 8 to 10 goats/farm (breed, days in milk and parity), milking practices (overmilking, overstripping, pre-lag time) and milking machine characteristics (line height, presence of claw) were recorded on every farm...
April 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28391339/mycophenolate-mofetil-therapy-in-immunoglobulin-a-nephropathy-histological-changes-after-treatment
#8
Hannah Beckwith, Nick Medjeral-Thomas, Jack Galliford, Megan Griffith, Jeremy Levy, Liz Lightstone, Andrew Palmer, Candice Roufosse, Charles Pusey, H Terence Cook, Tom Cairns
Background: Endocapillary hypercellularity independently predicts renal outcome in immunoglobulin A nephropathy (IgAN). Mycophenolate mofetil (MMF) treatment is offered to patients presenting to the Imperial College Renal and Transplant Centre with IgAN and histological evidence of endocapillary hypercellularity. Clinical trials of MMF in IgAN have been inconclusive and have been limited by a lack of specific histological inclusion and exclusion criteria when recruiting patients. Evidence of histological improvement following MMF treatment would support its therapeutic use...
January 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28384208/comparison-of-renal-response-to-four-different-induction-therapies-in-japanese-patients-with-lupus-nephritis-class-iii-or-iv-a-single-centre-retrospective-study
#9
Hironari Hanaoka, Tomofumi Kiyokawa, Harunobu Iida, Kana Ishimori, Yukiko Takakuwa, Takahiro Okazaki, Hidehiro Yamada, Daisuke Ichikawa, Sayuri Shirai, Junki Koike, Shoichi Ozaki
The recent recommendations for the management of lupus nephritis suggest that racial background should be considered while choosing induction therapy. However, the responses to different induction regimens have been poorly studied in Japanese population. Here, we assessed the renal response to different induction therapies in Japanese patients with lupus nephritis class III or IV. The records of 64 patients with biopsy-proven lupus nephritis class III or IV were retrospectively evaluated according to therapy received: monthly intravenous cyclophosphamide (IVCY), the Euro-lupus nephritis trial (ELNT) protocol-IVCY, tacrolimus (TAC), or mycophenolate mofetil (MMF)...
2017: PloS One
https://www.readbyqxmd.com/read/28381044/three-dimensional-microfabrication-through-a-multimode-optical-fiber
#10
Edgar E Morales-Delgado, Loic Urio, Donald B Conkey, Nicolino Stasio, Demetri Psaltis, Christophe Moser
3D printing based on additive manufacturing is an advanced manufacturing technique that allows the fabrication of arbitrary macroscopic and microscopic objects. Many 3D printing systems require large optical elements or nozzles in proximity to the built structure. This prevents their use in applications in which there is no direct access to the area where the objects have to be printed. Here, we demonstrate three-dimensional microfabrication based on two-photon polymerization (TPP) through an ultra-thin printing nozzle of 560 µm in diameter...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28380758/few-mode-fiber-based-raman-distributed-temperature-sensing
#11
Meng Wang, Hao Wu, Ming Tang, Zhiyong Zhao, Yunli Dang, Can Zhao, Ruolin Liao, Wen Chen, Songnian Fu, Chen Yang, Weijun Tong, Perry Ping Shum, Deming Liu
We proposed and experimentally demonstrated a few mode fiber (FMF) based Raman distributed temperature sensor (RDTS) to extend the sensing distance with enhanced signal-to-noise ratio (SNR) of backscattered anti-Stokes spontaneous Raman scattering. Operating in the quasi-single mode (QSM) with efficient fundamental mode excitement, the FMF allows much larger input pump power before the onset of stimulated Raman scattering compared with the standard single mode fiber (SSMF) and mitigates the detrimental differential mode group delay (DMGD) existing in the conventional multimode fiber (MMF) based RDTS system...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28376288/mycophenolate-versus-placebo-for-systemic-sclerosis-related-interstitial-lung-disease-an-analysis-of-scleroderma-lung-studies-i-and-ii
#12
Elizabeth R Volkmann, Donald P Tashkin, Ning Li, Michael D Roth, Dinesh Khanna, Anna-Maria Hoffmann-Vold, Grace Kim, Jonathan Goldin, Philip J Clements, Daniel E Furst, Robert M Elashoff
OBJECTIVE: To compare mycophenolate (MMF) with placebo for the treatment of systemic sclerosis-related interstitial lung disease (SSc-ILD). METHODS: Participants enrolled in the placebo arm of Scleroderma Lung Study (SLS) I and the MMF arm of SLS II were included. SLS I randomized participants to oral cyclophosphamide (CYC) versus placebo for 1 year, while SLS II randomized participants to MMF for 2 years versus oral CYC for 1 year followed by 1 year of placebo...
April 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28375836/childhood-primary-large-vessel-cns-vasculitis-single-centre-experience-and-review-of-the-literature
#13
Sonja Walsh, Ralf Knöfler, Gabriele Hahn, Judith Lohse, Reinhard Berner, Sebastian Brenner, Martin Smitka, Maja von der Hagen, Christian M Hedrich
Ischaemic brain injuries are rare conditions in the paediatric age group. Main causes include non-arteriosclerotic arteriopathies, which in childhood usually result from primary vasculitis of large or small vessels and lead to impaired perfusion and subsequent ischaemic brain lesions. In accordance with the nomenclature of systemic forms, CNS vasculitis is subdivided into groups, based on the size of affected vessels: angiography-positive primary angiitis of medium sized and large vessels (pPACNS), and angiography-negative angiitis of small vessels (svPACNS)...
March 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28371372/b-cell-receptor-genes-associated-with-tolerance-identify-a-cohort-of-immunosuppressed-patients-with-improved-renal-allograft-graft-function
#14
Adam Asare, Sai Kanaparthi, Noha Lim, Deborah Phippard, Flavio Vincenti, John Friedewald, Martha Pavlakis, Emilio Poggio, Peter Heeger, Roslyn Mannon, Bryna E Burrell, Yvonne Morrison, Nancy Bridges, Inaki Sanz, Anil Chandraker, Kenneth A Newell, Laurence A Turka
We previously reported that two B cell receptor genes, IGKV1D-13 and IGKV4-1, were associated with tolerance following kidney transplantation. To assess the potential utility of this "signature" we conducted a prospective, multicenter study to determine the frequency of patients predicted tolerant within a cohort of patients deemed to be candidates for immunosuppressive minimization. At any single time point 25 - 30% of patients were predicted to be tolerant, while 13.7% consistently displayed the tolerance "signature" over the two-year study...
March 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28364217/the-efficacy-of-mycophenolate-mofetil-in-treating-takayasu-arteritis-a-systematic-review-and-meta-analysis
#15
Danping Dai, YangYang Wang, Haiying Jin, Yiyang Mao, Hao Sun
The purpose of this study is to assess the effectiveness of mycophenolate mofetil (MMF) in treating Takayasu arteritis (TA) patients. Embase, Cochrane Library, Pubmed, Clinicaltrials. Gov and three Chinese literature databases (VIP, CNKI, WanFang) were searched; randomized-controlled trials and observational studies that compared the efficacy before and after treatment with MMF were included. The efficacy outcomes were disease activity, the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) values and steroid dosage...
March 31, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28353583/influence-of-cyclosporine-and-everolimus-on-the-main-mycophenolate-mofetil-pharmacokinetic-parameters-cross-sectional-study
#16
Aurelija Noreikaitė, Franck Saint-Marcoux, Pierre Marquet, Edmundas Kaduševičius, Edgaras Stankevičius
The objective of the present study was to assess the effect of cyclosporine (CsA) on the pharmacokinetic parameters of mycophenolic acid (MPA), an active mycophenolate mofetil (MMF) metabolite, and to compare with the effect of everolimus (EVR).Anonymized medical records of 404 kidney recipients were reviewed. The main MPA pharmacokinetic parameters (AUC(0-12) and Cmax) were evaluated.The patients treated with a higher mean dose of CsA displayed higher MPA AUC(0-12) exposure in the low-dose MMF group (1000 mg/day) (40...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28344949/the-effect-of-anesthesia-on-the-ventilatory-functions-of-patients-with-maxillo-mandibular-fixation
#17
B I Akhiwu, H O Akhiwu, B D Saheeb, M M Habeeb
BACKGROUND: Maxillo-mandibular fixation (MMF) is a procedure still routinely practiced in developing countries. AIM: To determine the variations in pulmonary functions readings between cases treated under general anesthesia (GA) and those treated under local anesthesia (LA). METHODOLOGY: A descriptive hospital-based study of 106 patients was carried out from January 2011- December 2012. Information was obtained using a questionnaire and all study subjects had their baseline lung functions and their post-operative daily lung function parameters measured for the first week and then weekly for the next five weeks...
April 2016: Journal of the West African College of Surgeons
https://www.readbyqxmd.com/read/28340819/influence-of-proton-pump-inhibitors-on-mycophenolic-acid-pharmacokinetics-in-patients-with-renal-transplantation-and-the-relationship-with-cytochrome-2c19-gene-polymorphism
#18
H S Ciftci, M S Karadeniz, T Tefik, Y Caliskan, H Yazıcı, E Demir, A Turkmen, I Nane, F S Oguz, F Aydin
BACKGROUND: Most patients have serious digestive complications after renal transplantation. Therefore, it is important to protect gastrointestinal function to improve the survival rate of transplant patients. Proton pump inhibitors (PPIs) such as lansoprazole and rabeprazole are widely administered to renal transplant patients with mycophenolic acid (MPA) in the perioperative period. PPIs are metabolized by cytochrome (CYP) 2C19 enzymes. Mycophenolate sodium (MYF) and mycophenolate mofetil (MMF) have been used in immunosuppression...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28340811/tac-mmf-versus-csa-mmf-csa-aza-based-regimens-in-development-of-de-novo-complement-binding-anti-hla-antibodies-after-kidney-transplantation
#19
T Sahutoglu, S U Akgul, Y Caliskan, H Yazici, E Demir, E Kara, S Temurhan, F O Savran, A Turkmen
BACKGROUND: Immunosuppressive regimens with tacrolimus or cyclosporine A (CsA) were compared for graft-related outcomes in conjunction with complement-binding de novo donor-specific antibodies (DSAs). METHODS: Non-sensitized adult patients without rejection episodes within 3 months after transplantation were screened for the presence of de novo DSAs and C1q binding. Clinical and biopsy data were retrospectively obtained. RESULTS: The analysis included 118 patients (68 tacrolimus, 50 CsA), with mean age and follow-up of 36...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28340105/morin-stain-detects-aluminum-containing-macrophages-in-macrophagic-myofasciitis-and-vaccination-granuloma-with-high-sensitivity-and-specificity
#20
Rati Chkheidze, Dennis K Burns, Charles L White, Diana Castro, Julie Fuller, Chunyu Cai
Macrophagic myofasciitis (MMF) is an inflammatory condition associated with the intramuscular (i.m.) injection of aluminum adjuvant-containing vaccines. It is clinically characterized by myalgia, weakness, and chronic fatigue and histologically by aggregates of cohesive macrophages with abundant basophilic, periodic acid-Schiff (PAS)-positive, diastase-resistant granules that percolate through the peri- and endomysium without eliciting substantial myofiber damage. The definitive diagnosis of MMF requires demonstration of aluminum within these macrophages...
April 1, 2017: Journal of Neuropathology and Experimental Neurology
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