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Ganglioneuromas

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https://www.readbyqxmd.com/read/29771688/plexiform-atypical-spitz-tumor-with-rosette-like-giant-cells-a-histologic-and-immunohistochemical-study-on-a-case-suggesting-ganglioneuroblastic-differentiation-review-of-the-literature-and-considerations-on-histogenesis
#1
Elena Castelli, Elisabetta Orlando, Giuseppe Pistone, Maria R Bongiorno
Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29770149/diffuse-gastric-ganglioneuromatosis-novel-presentation-of-pten-hamartoma-syndrome-case-report-and-review-of-gastric-ganglioneuromatous-proliferations-and-a-novel-pten-gene-mutation
#2
Alexander J Williams, Emily S Doherty, Michael H Hart, Douglas J Grider
Gastrointestinal ganglioneuromatous proliferations are rare, most often found in the colon, and are three types: polypoid ganglioneuromas, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. We present a case of diffuse ganglioneuromatosis in the posterior gastric wall in a nine-year-old female. To our knowledge, this is the first reported case of diffuse ganglioneuromatosis located in the stomach. Only six cases of gastric ganglioneuromatous proliferations have previously been reported, two in English and none were diffuse ganglioneuromatosis...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29755017/endoscopic-papillectomy-of-benign-ampullary-lesions-outcomes-from-a-multicenter-study
#3
Tan Attila, Erkan Parlak, Emrah Alper, Selçuk Dişibeyaz, Bahattin Çiçek, Bülent Ödemiş
BACKGROUND/AIMS: Endoscopic papillectomy (EP) has emerged as an alternative to surgery in the management of ampullary lesions. The aim of this study is to evaluate feasibility, efficacy, safety, outcome, and impact of EP in the management of benign ampullary lesions. MATERIALS AND METHODS: This is a multicenter, retrospective study of 44 patients who had EP of benign ampullary lesions. RESULTS: Over the 11-year period, 44 (55.7%) of 79 patients underwent EP for benign ampullary lesions...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29737901/chromogranin-a-and-neuron-specific-enolase-in-neuroblastoma-correlation-to-stage-and-prognostic-factors
#4
Kleopatra Georgantzi, Erik G Sköldenberg, Mats Stridsberg, Per Kogner, Åke Jakobson, Eva Tiensuu Janson, Rolf H B Christofferson
Chromogranin A (CgA) and neuron specific enolase (NSE) are important markers in adult neuroendocrine tumors (NET). Neuroblastoma (NB) has certain neuroendocrine properties. The aim of this study was to correlate blood concentrations of CgA, chromogranin B (CgB), and NSE to prognostic factors and outcome in children with NB. Blood samples from 92 patients with NB, 12 patients with benign ganglioneuroma (GN), 21 patients with non-NB solid tumors, 10 patients with acute leukemias, and 69 healthy children, were analyzed...
May 8, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29720264/usefulness-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-detection-of-a-neuroblastic-nodule-in-a-ganglioneuroblastoma-a-case-report
#5
Yuka Takeda, Hideki Sano, Asuka Kawano, Kazuhiro Mochizuki, Nobuhisa Takahashi, Shogo Kobayashi, Yoshihiro Ohara, Kazuhiro Tasaki, Mitusuaki Hosoya, Atsushi Kikuta
BACKGROUND: Ganglioneuroblastoma, nodular is defined as a composite tumor of biologically distinct clones. The peripheral neuroblastic tumors in this category are characterized by the presence of grossly visible neuroblastoma nodules coexisting with ganglioneuroblastoma, intermixed, or with ganglioneuroma. Making a correct diagnosis of ganglioneuroblastoma, nodular is often difficult by biopsy or partial tumor resection, because the neuroblastic nodule could be hidden and not sampled for pathological examination...
May 3, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29699729/pacap-and-vip-regulate-hypoxia-inducible-factors-in-neuroblastoma-cells-exposed-to-hypoxia
#6
Grazia Maugeri, Agata Grazia D'Amico, Daniela Maria Rasà, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two related peptides acting as neurotransmitters/neuromodulators in central and peripheral nervous system. They are also involved in cancer showing a controversial role. Particulary, they are implicated in neuroblastoma differentiation (NB). This pediatric tumor can evolve to a malignant metastatic disease or spontaneously regress towards a benign form, known as ganglioneuroblastoma/ganglioneuroma. A negative hallmark of neoplasia progression is represented by hypoxic microenvironment...
April 17, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29698954/giant-thoracolumbar-dumbbell-ganglioneuroma
#7
Felipe José Santaella, Pedro Tadao Hamamoto Filho, Gianfelipe Belini Poliseli, Victor Azevedo de Oliveira, Luis Gustavo Ducati, Marcelo Padovani de Toledo Moraes, Marco Antônio Zanini
No abstract text is available yet for this article.
April 26, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29697927/robotic-excision-of-complex-adrenal-mass-with-retrocaval-extension-and-encasement-of-renal-hilum-with-renal-preservation
#8
Vishnu Raveendran, Ramaprasad Manasseri Koduveli, Kishore Thekke Adiyat
OBJECTIVE: The purpose of this video is to present robotic excision of a complex adrenal mass with retrocaval extension and encasement of renal hilum in a 16 year old boy. Biochemical screening was negative for metabolically active component. Computerized tomographic scan with contrast revealed a homogenous mass of approximately 10.8 cm x 6.2 cm x 4.2 cm in the suprarenal area on right side that was extend-ing behind inferior vena cava and encasing renal hilar vessels. Imaging findings were that of a classical ganglioneuroma...
April 5, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29656130/robotic-resection-of-benign-nonadrenal-retroperitoneal-tumors-a-consecutive-case-series
#9
Qu Liu, Yuanxing Gao, Zhiming Zhao, Guodong Zhao, Rong Liu, Wan Yee Lau
BACKGROUND: The deep location, narrow operative space and proximity to major vessels make minimally invasive resection of nonadrenal retroperitoneal tumors (NTRs) challenging and rarely reported. This study aimed to evaluate the safety and feasibility of robotic resection of benign nonadrenal retroperitoneal tumors. METHODS: The demographics and perioperative outcomes of a consecutive series of patients who underwent robotic NTR resection between January 1, 2015, and August 30, 2017, were analyzed...
April 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29619527/neuroblastic-tumors-in-young-adults-as-a-sequela-of-malignant-neuroblastoma-report-of-two-cases
#10
Takuya Adachi, Minato Yokoyama, Yasuhisa Fujii, Yuko Kinowaki, Susumu Kirimura, Kazunori Kubota, Yukihisa Saida, Ukihide Tateishi
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma share the same histological spectrum which originates from neural crest cells. We present herein two young adult patients with neuroblastic tumors with lymph node metastases. Both the patients were diagnosed incidentally as having retroperitoneal masses, which showed little or no immature cells despite coexistence of lymph node involvement. The tumors were considered to represent spontaneous regression of malignant neuroblastoma. Radiologists should consider the possibility of spontaneous regression of neuroblastic tumors, when poorly enhanced multi-component masses at the retroperitoneum with lymph node involvement are visualized...
April 4, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29594468/extensive-spinal-extradural-ganglioneuroma-of-the-lumbar-spine-mimicking-lymphoma
#11
REVIEW
Seung Hun Kang, Sang Min Lee, Doo Hoe Ha, Hye Jin Lee
BACKGROUND: Ganglioneuromas are rare, benign, well-differentiated tumors arising from neural crest cells that commonly occur in the posterior mediastinum, retroperitoneum, cervical spine, and adrenal gland. We report an unusual case of an extensive spinal extradural ganglioneuroma, circumferentially and longitudinally affecting the extradural space of the lumbar spine and continuously invading bilateral psoas muscles. CASE DESCRIPTION: A 32-year-old man presented with a 1-week history of abdominal pain and diarrhea...
March 29, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29570257/retroperitoneoscopic-resection-of-retroperitoneal-nonadrenal-ganglioneuromas-our-technique-and-clinical-outcomes
#12
Changjin Shi, Feng Li, Yanchao Wang, Long Pei, Tao Wang
OBJECTIVE: To report our experience of retroperitoneoscopic technique in semi-lateral decubitus position for the retroperitoneal nonadrenal ganglioneuromas in 18 patients, and to evaluate its clinical outcomes. MATERIALS AND METHODS: From January 2012 to May 2016, 18 patients with retroperitoneal nonadrenal ganglioneuromas underwent retroperitoneoscopic resection. With the patients in semi-lateral decubitus position, a 4-port retroperitoneal approach was used. Data were collected on the tumor size, tumor location, perioperative outcomes, pathology, and lastknown disease status...
March 23, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29569258/primary-cutaneous-ganglioneuroma-anatomoclinical-study-of-4-cases-with-focus-on-merkel-cells
#13
David Romero-Pérez, Marie-Hélène Jegou, Claire Lecointre, Isabelle Penchet, Bernard Cribier
Cutaneous ganglioneuromas (CGN) are exceptional. We aim to describe the anatomoclinical profile of primary CGN and report 4 cases. Patients were 2 men and 2 women aged 53-to-76-years-old, who had flesh-colored nodules on the back, associated with adjacent keratotic changes, i.e. epidermal nevus (1 case) or seborrheic keratosis (3 cases). Histopathology showed ganglion cells within a proliferation of Schwann cells. The epidermis was acanthotic, associated with sebaceous induction in 2 cases, and with follicular hyperplasia as in fibroepithelial tumors (1 case), or with tricholemmoma (2 cases)...
March 22, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29554323/intraoperative-nerve-monitoring-in-robotic-assisted-resection-of-presacral-ganglioneuroma-operative-technique
#14
Tomas Garzon-Muvdi, Allan Belzberg, Mohamad E Allaf, Jean-Paul Wolinsky
BACKGROUND: Robotic-assisted techniques have been implemented in the surgical treatment of tumors in the pelvis, abdomen, and thorax. In pelvic tumors, robotic-assisted techniques evade the need for sizable surgical exposure, but make stimulation of the nerves of the sacral plexus very difficult. OBJECTIVE: To describe how laparoscopic robotic-assisted surgery can couple with tools such as the nerve stimulator to aid in the resection of presacral masses emanating from the neural elements and potentially improve neurological outcome by preventing inadvertent injury to involved nerves...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29532434/a-rare-cause-of-chronic-ataxia-in-childhood-ganglioneuroma
#15
Elif Acar Arslan, Tülay Kamaşak, Betül Diler Turgut, İsmail Saygın, Haluk Sarıhan, Ali Cansu
No abstract text is available yet for this article.
April 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29503221/collaborating-with-our-adult-colleagues-a-case-series-of-robotic-surgery-for-suspicious-and-cancerous-lesions-in-children-and-young-adults-performed-in-a-free-standing-children-s-hospital
#16
Briony K Varda, Patricia Cho, Andrew A Wagner, Richard S Lee
BACKGROUND: In adult urologic oncology the use of robotics has become commonplace; in pediatric urology it is rare. Herein, we describe a collaboration between an adult and a pediatric urologist performing robotic surgery for children and young adults with suspicious or cancerous genitourinary (GU) lesions. OBJECTIVES: To evaluate clinical and oncologic outcomes in children and young adults undergoing robotic surgery for suspicious or cancerous lesions of the GU tract; to describe our collaborative model between an adult and pediatric surgeon at a free-standing children's hospital...
March 2, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29448302/retroperitoneal-laparoscopic-adrenalectomy-with-transient-renal-artery-occlusion-for-large-adrenal-tumors-%C3%A2-8-cm
#17
Binbin Gong, Ming Ma, Wenjie Xie, Xiaorong Yang, Ting Sun
OBJECTIVES: To analyze our experience in retroperitoneal laparoscopic adrenalectomy (RLA) with transient renal artery occlusion for large adrenal tumors (≥8 cm) and to explore the safety and feasibility of this surgical procedure. METHODS: A retrospective cohort study was conducted with a surgical data review of 18 patients with large adrenal tumors who underwent RLA with transient renal artery occlusion in our hospital. RESULTS: Eighteen patients were treated by RLA with transient occlusion of the renal artery, and none were converted to open adrenalectomy...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29437731/massive-thoracic-ganglioneuroma-with-significant-mass-effect-on-left-hemithorax
#18
Jacob T Lambdin, Kyongjune B Lee, Gregory Trachiotis, Carlose Picone
A 42-year-old, otherwise healthy, woman presented with persistent left-sided chest pain. A chest X-ray revealed a large opacity in the left hemithorax which prompted further investigation with an MRI. MRI revealed a large left apical mass occupying approximately two-thirds of the left hemithorax. The mass was investigated further with a CT with contrast which did not reveal any vascular involvement or invasion into adjacent structures. The patient successfully underwent tumour resection via left thoracotomy...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29383425/adrenal-ganglioneuroma-features-and-outcomes-of-42-cases-in-a-chinese-population
#19
Jing Xie, Jun Dai, Wen-Long Zhou, Fu-Kang Sun
BACKGROUND: Adrenal ganglioneuromas (AGNs) are extremely rare benign neoplasms. This study is to share our experience regarding diagnostic and operative management of these tumors. METHODS: Clinical details as well as follow-up data were retrospectively analyzed in 42 primary AGN patients who received operative resection at a tertiary referral hospital in China between May 2005 and July 2016. RESULTS: The mean age of the patients at diagnosis was 35...
January 30, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29369484/characteristics-and-management-of-ganglioneuroma-and-ganglioneuroblastoma-intermixed-in-children-and-adolescents
#20
Natasha Alexander, Katie Sullivan, Furqan Shaikh, Meredith S Irwin
BACKGROUND: Ganglioneuromas (GNs) usually demonstrate favorable histological and clinical features. Surgery is often performed due to clinical symptoms and/or theoretical concerns that GN may transform into neuroblastoma (NB); however, several studies have identified significant GN-surgical morbidities. OBJECTIVES: We compared the natural history, biological and clinical features of GN and ganglioneuroblastoma-intermixed (GNB-I) managed by surgery or observation to inform management and surveillance...
January 25, 2018: Pediatric Blood & Cancer
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