Yafei Deng, Canlin Li, Lanlan Huang, Peiwen Xiong, Yana Li, Yongjie Liu, Songyang Li, Weijian Chen, Qiang Yin, Yong Li, Qinglan Yang, Hongyan Peng, Shuting Wu, Xiangyu Wang, Qin Tong, Hongjuan Ouyang, Die Hu, Xinjia Liu, Liping Li, Jieyu You, Zhiyi Sun, Xiulan Lu, Zhenghui Xiao, Youcai Deng, Hongmei Zhao
BACKGROUND: The understanding of the heterogeneous cellular microenvironment of colonic polyps in paediatric patients with solitary juvenile polyps (SJPs), polyposis syndrome (PJS) and Peutz-Jeghers syndrome (PJS) remains limited. METHODS: We conducted single-cell RNA sequencing and multiplexed immunohistochemistry (mIHC) analyses on both normal colonic tissue and different types of colonic polyps obtained from paediatric patients. RESULTS: We identified both shared and disease-specific cell subsets and expression patterns that played important roles in shaping the unique cellular microenvironments observed in each polyp subtype...
January 2024: Clinical and Translational Medicine