keyword
https://read.qxmd.com/read/38537053/characterizing-the-opioidergic-mechanisms-of-repetitive-transcranial-magnetic-stimulation-induced-analgesia-a-randomized-controlled-trial
#1
JOURNAL ARTICLE
Ying Liu, Junfeng Sun, Chaomin Wu, Jinxuan Ren, Yanni He, Na Sun, Hao Huang, QunShan Chen, Dan Liu, Yangyuxin Huang, Feng Xu, Lina Yu, Bernadette M Fitzgibbon, Robin F H Cash, Paul B Fitzgerald, Min Yan, Xianwei Che
Repetitive transcranial magnetic stimulation (rTMS) is a promising technology to reduce chronic pain. Investigating the mechanisms of rTMS analgesia holds the potential to improve treatment efficacy. Using a double-blind and placebo-controlled design at both stimulation and pharmacologic ends, this study investigated the opioidergic mechanisms of rTMS analgesia by abolishing and recovering analgesia in 2 separate stages across brain regions and TMS doses. A group of 45 healthy participants were equally randomized to the primary motor cortex (M1), the dorsolateral prefrontal cortex (DLPFC), and the Sham group...
March 26, 2024: Pain
https://read.qxmd.com/read/38536752/causal-functional-maps-of-brain-rhythms-in-working-memory
#2
JOURNAL ARTICLE
Miles Wischnewski, Taylor A Berger, Alexander Opitz, Ivan Alekseichuk
Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite a plethora of correlative neuroimaging evidence regarding the working memory architecture, our understanding of critical hubs causally controlling overall performance is incomplete. Causal interpretation requires cognitive testing following safe, temporal, and controllable neuromodulation of specific functional anatomical nodes. Such experiments became available in healthy humans with the advance of transcranial alternating current stimulation (tACS)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536478/effectiveness-of-calcimimetics-on-fractures-in-dialysis-patients-with-secondary-hyperparathyroidism-meta-analysis-of-randomized-trials
#3
JOURNAL ARTICLE
Takuya Wakamatsu, Suguru Yamamoto, Koji Matsuo, Masatomo Taniguchi, Takayuki Hamano, Masafumi Fukagawa, Junichiro James Kazama
INTRODUCTION: This study aimed to assess the effectiveness of calcimimetics in reducing the risk of fractures in dialysis patients with secondary hyperparathyroidism (SHPT). MATERIAL AND METHODS: A comprehensive literature search was conducted using PubMed, Embase, and Cochrane Library for articles published through December 9, 2023. The quality of each trial was evaluated using the Cochrane Collaboration tool. Meta-analysis was performed using a random-effects model, and effect measures across studies were synthesized...
March 27, 2024: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/38536442/a-phase-1-double-blinded-placebo-controlled-clinical-trial-to-evaluate-the-safety-and-immunogenicity-of-hev-239-hecolin%C3%A2-vaccine-in-healthy-us-adults
#4
JOURNAL ARTICLE
Carol M Kao, Christina A Rostad, Lauren E Nolan, Etza Peters, Jennifer Kleinhenz, Jacob D Sherman, Ashley Tippett, J Wai Kuo Shih, Inci Yildirim, Vivien Agbakoba, Tatiana Beresnev, Cassandra Ballou, Satoshi Kamidani, Vinit Karmali, Muktha Natrajan, Erin M Scherer, Nadine Rouphael, Evan J Anderson
INTRODUCTION: Establishing the safety and immunogenicity of a hepatitis E virus vaccine in multiple populations could facilitate broader access and prevent maternal and infant mortality. METHODS: We conducted a phase 1, randomized, double-blinded, placebo-controlled (4:1 vaccine: placebo) trial of 30 µg HEV-239 (Hecolin®, Xiamen Innovax Biotech Company Limited, China) administered intramuscularly in healthy US adults aged 18-45 years. Participants were vaccinated on days 1, 29, and 180...
March 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38536106/effects-of-photobiomodulation-therapy-on-the-expression-of-hypoxic-inducible-factor-vascular-endothelial-growth-factor-and-its-specific-receptor-a-randomized-control-trial-in-patients-with-diabetic-foot-ulcer
#5
JOURNAL ARTICLE
Giti Torkaman, Mahsa Hoseini-Sanati, Mehdi Hedayati, Maryam Mofid, Manouchehr Iranparvar Alamdari
Background: Impaired angiogenesis is a significant factor contributing to delayed healing in diabetic foot ulcers (DFUs) due to inadequate oxygenation. Objective: This study aimed to investigate the impact of photobiomodulation (PBM) using a Ga-As laser on the release of serum hypoxia-inducible factor 1-α (HIF-1α), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2, and nitric oxide (NO) in diabetic patients with DFUs. Materials and methods: In this double-blind RCT, a total of 30 patients with grade II DFUs were enrolled...
March 27, 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38536017/effects-of-empagliflozin-on-liver-fat-in-metabolic-dysfunction-associated-steatotic-liver-disease-patients-without-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#6
JOURNAL ARTICLE
Ka Shing Cheung, Ho Yu Ng, Rex Wan Hin Hui, Lok Ka Lam, Lung Yi Mak, Yuen Chi Ho, Jing Tong Tan, Esther W Chan, Wai Kay Seto, Man Fung Yuen, Wai K Leung
BACKGROUND AND AIMS: We investigated whether empagliflozin reduces hepatic steatosis in metabolic-dysfunction associated steatotic liver disease (MASLD) patients without diabetes mellitus (DM). APPROACH AND RESULTS: This was an investigator-initiated, double-blind, randomized, placebo-controlled trial recruiting adult subjects from the community. Eligible subjects without DM (fasting plasma glucose <7 mmol/L and HbA1c <6.5%) who had magnetic resonance imaging-proton density fat fraction [MRI-PDFF] ≥5% were randomly allocated to receive empagliflozin 10 mg daily or placebo (1:1 ratio) for 52 weeks (end of treatment, EOT)...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38535745/the-effect-of-oral-adenosine-triphosphate-atp-supplementation-on-anaerobic-exercise-in-healthy-resistance-trained-individuals-a-systematic-review-and-meta-analysis
#7
REVIEW
Roberto González-Marenco, Ivonne Azeret Estrada-Sánchez, Martha Medina-Escobedo, Rodolfo Chim-Aké, Roberto Lugo
Adenosine triphosphate (ATP) is an energy and signaling molecule. It is synthesized endogenously and can be taken as an oral supplement. This review aimed to identify the effects of oral ATP supplementation on anaerobic exercise in healthy resistance-trained adults. A systematic review and meta-analysis were performed based on the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) criteria. The inclusion criteria were articles published from 2000 to 2022, with anaerobic variables (maximal strength, maximum repetitions, and maximum anaerobic power) measurable in healthy adults with experience in resistance training, only randomized placebo-controlled clinical trials (RCTs), and with the acute (a single dose 30 min to 24 h before the tests) and/or chronic (>1 day) oral supplementation of ATP...
March 14, 2024: Sports
https://read.qxmd.com/read/38535518/acute-effects-of-various-doses-of-nitrate-rich-beetroot-juice-on-high-intensity-interval-exercise-responses-in-women-a-randomized-double-blinded-placebo-controlled-crossover-trial
#8
JOURNAL ARTICLE
Zhang Jiaqi, Dai Zihan, Stephen Heung-Sang Wong, Zheng Chen, Eric Tsz-Chun Poon
BACKGROUND: This study investigated the acute effects of various doses of nitrate-rich beetroot juice on the responses to high-intensity interval exercise in women. METHODS: A double-blinded, randomized, placebo-controlled, crossover trial was conducted with 13 recreationally active young women (age = 23 ± 2 years). All participants performed interval exercise (8 × 1-min bouts of cycling at 85% of peak power output [PPO] interspersed with 1-min active recovery at 20% of PPO) 2...
December 2024: Journal of the International Society of Sports Nutrition
https://read.qxmd.com/read/38535200/a-phase-i-iia-prospective-randomized-open-label-study-on-the-safety-and-efficacy-of-nebulized-liposomal-amphotericin-for-invasive-pulmonary-aspergillosis
#9
JOURNAL ARTICLE
Jesús Fortún, Elia Gómez-García de la Pedrosa, Alberto Martínez-Lorca, Patricia Paredes, Pilar Martín-Dávila, Alicia Gómez-López, María José Buitrago, Javier López-Jiménez, Francesca Gioia, Rosa Escudero, Maria Elena Alvarez-Alvarez, Cruz Soriano, Javier Moreno-García, Diana San Miguel, Noelia Vicente, Santiago Moreno
Although nebulized liposomal amphotericin B (NLAB) is being used in invasive pulmonary aspergillosis (IPA) prophylaxis, no clinical trial has shown its efficacy as a therapeutic strategy. NAIFI is the inaugural randomized, controlled clinical trial designed to examine the safety and effectiveness of NLAB (dosage: 25 mg in 6 mL, three times per week for 6 weeks) against a placebo, in the auxiliary treatment of IPA. Throughout the three-year clinical trial, thirteen patients (six NLAB, seven placebo) were included, with 61% being onco-hematological with less than 100 neutrophils/μL...
March 1, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535093/cardiopulmonary-exercise-testing-in-heart-failure
#10
REVIEW
Michel Juarez, Cristian Castillo-Rodriguez, Dina Soliman, Gaspar Del Rio-Pertuz, Kenneth Nugent
Cardiopulmonary exercise testing (CPET) provides important information for the assessment and management of patients with heart failure. This testing measures the respiratory and cardiac responses to exercise and allows measurement of the oxygen uptake (V˙O2 ) max and the relationship between minute ventilation (V˙E) and carbon dioxide excretion (V˙CO2 ). These two parameters help classify patients into categories that help predict prognosis, and patients with a V˙O2 < 14 mL/kg/min and V˙E/V˙CO2 slope >35 have a poor prognosis...
February 20, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534704/a-single-dose-of-piperacillin-plus-tazobactam-gel-as-an-adjunct-to-professional-mechanical-plaque-removal-pmpr-in-patients-with-peri-implant-mucositis-a-6-month-double-blind-randomized-clinical-trial
#11
JOURNAL ARTICLE
Ioana Ilyes, Marius Boariu, Darian Rusu, Vincenzo Iorio-Siciliano, Octavia Vela, Simina Boia, Georgios Kardaras, Petra Șurlin, Horia Calniceanu, Holger Jentsch, Alexandru Lodin, Stefan-Ioan Stratul
OBJECTIVES: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the clinical and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application of piperacillin plus tazobactam gel in the treatment of peri-implant mucositis (PiM) for up to 6 months. MATERIALS AND METHODS: The study included 31 patients with peri-implant mucositis (bleeding on probing (BoP) > 1 at at least one site at baseline, absence of peri-implant bone loss compared with a previous radiograph)...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38534664/efficacy-of-continuous-vs-intermittent-administration-of-cefepime-in-adult-icu-patients-with-gram-negative-bacilli-bacteremia-a-randomized-double-blind-clinical-study
#12
JOURNAL ARTICLE
Carlos Arturo Álvarez-Moreno, Laura Cristina Nocua-Báez, Guillermo Ortiz, Juan Carlos Torres, Gabriel Montenegro, Williams Cervera, Luis Fernando Zuluaga, Alonso Gómez
INTRODUCTION: The objective of this study was to compare the continuous infusion of cefepime with the intermittent infusion in patients with sepsis caused by Gram-negative bacilli (GNB). METHODS: Randomized 1:1 multicenter double-blinded placebo-controlled study with allocation concealment; multicenter study in the intensive care units of Colombia. Patients with sepsis, severe sepsis or septic shock, and GNB-suspected bacteremia. Cefepime was administered for 7 to 14 days over 30 m intermittently every 8 h over 24 h plus continuous saline solution (0...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38533961/correlates-of-plasma-nt-probnp-cyclic-gmp-ratio-in-heart-failure-with-preserved-ejection-fraction-an-analysis-of-the-relax-trial
#13
JOURNAL ARTICLE
Leonard Chiu, Vineet Agrawal, David Armstrong, Evan Brittain, Sheila Collins, Anna R Hemnes, Joseph A Hill, JoAnn Lindenfeld, Sanjiv J Shah, Lynne W Stevenson, Thomas J Wang, Deepak K Gupta
BACKGROUND: Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity. Correlates of natriuretic peptide/cGMP in patients with heart failure with preserved ejection fraction are not well understood. Among patients with heart failure with preserved ejection fraction in the RELAX (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure With Preserved Ejection Fraction) trial, we examined (1) cross-sectional correlates of circulating NT-proBNP (N-terminal pro-B-type natriuretic peptide)/cGMP ratio, (2) whether selective phosphodiesterase-5 inhibition by sildenafil changed the ratio, and (3) whether the effect of sildenafil on 24-week outcomes varied by baseline ratio...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533633/clinical-trial-randomized-controlled-trial-of-linaclotide-in-children-aged-6-17-years-with-functional-constipation
#14
JOURNAL ARTICLE
Carlo Di Lorenzo, Samuel Nurko, Jeffrey S Hyams, Gerardo Rodriguez-Araujo, Cristina Almansa, Valentina Shakhnovich, Miguel Saps, Michael Simon
OBJECTIVES: Linaclotide, a guanylate cyclase-C agonist, was recently approved in the United States for treatment of children 6-17 years old with functional constipation (FC). This study evaluated the safety and efficacy of several linaclotide doses in children 6-17 years old with FC. METHODS: In this multicenter, randomized, double-blind, placebo-controlled phase 2 study, 173 children with FC (based on Rome III criteria) were randomized to once-daily linaclotide (A: 9 or 18 μg, B: 18 or 36 μg, or C: 36 or 72 μg) or placebo in a 1:1:1:1 ratio for 6- to 11-year-olds (dosage determined by weight: 18 to <35 or ≥35 kg) and linaclotide (18, 36, 72, or 145 μg) or placebo in a 1:1:1:1:1 ratio for 12- to 17-year-olds...
March 27, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38533458/translating-knowledge-on-placebo-and-nocebo-effects-into-clinical-practice
#15
JOURNAL ARTICLE
Elif Buse Caliskan, Ulrike Bingel, Angelika Kunkel
INTRODUCTION: Positive and negative treatment expectations are powerful modulators of health and treatment outcomes. A substantial part of treatment success is due to contextual factors modulating patient's expectations towards a treatment. Consequently, treatment expectations should be a target of therapeutic interventions themselves. OBJECTIVES: This article highlights the neurobiological underpinnings of treatment expectations as well as strategies to modulate contextual factors to optimize treatment outcomes in daily clinical settings...
April 2024: Pain Reports
https://read.qxmd.com/read/38533363/systematic-review-and-network-meta-analysis-of-the-risk-of-herpes-zoster-with-biological-therapies-and-selective-janus-kinase-1-inhibitors-in-atopic-dermatitis
#16
JOURNAL ARTICLE
Daud Manzar, Nikhil Nair, Emmanuel Suntres, Myanca Rodrigues, Mohannad Abu-Hilal
INTRODUCTION: Atopic dermatitis (AD) patients have an increased risk of herpes zoster (HZ). The relationship of dupilumab, tralokinumab, upadacitinib, and abrocitinib to HZ incidence in AD patients remains unclear. AIM: To evaluate and compare the incidence and risk of HZ among patients with moderate to severe atopic dermatitis treated with advanced systemic therapies. MATERIAL AND METHODS: Systematic searches were conducted in Ovid Medline and Embase...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533223/effects-of-golf-instructors-professional-certification-levels-on-amateur-golfers-perception-of-instructor-expertise-instructor-credibility-and-lesson-participation-intention-testing-placebo-and-nocebo-effects
#17
JOURNAL ARTICLE
Hye Jin Yang, Ji-Hye Yang, Si Cheol Jung, Chulhwan Choi, Chul-Ho Bum
This study investigated the differences in amateur golfers' perceptions of instructor expertise, instructor credibility, and lesson participation intention depending on the golf instructor's certification level to investigate whether placebo and nocebo effects exist depending on the certification level. Accordingly, the study analyzed 153 amateur golfers with at least 1 year of playing experience, and the results were as follows: First, there was a difference in the perception of instructor expertise among amateur golfers depending on the golf instructor's certification level...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38533160/comparative-study-of-azithromycin-versus-doxycycline-effect-on-the-resistin-level-in-periodontitis-patients-with-type-2-diabetes-a-randomized-controlled-clinical-trial
#18
JOURNAL ARTICLE
Jazia A Alblowi, Zienab S Farid, Mai S Attia
AIM: The present study aimed to determine if azithromycin (AZM) and doxycycline therapy, as an adjunct to scaling and root planning (SRP), modulate host response and improve clinical outcomes in periodontitis patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: Forty-five periodontal sites in 15 periodontitis patients with T2DM received nonsurgical periodontal therapy (NSPT). In Group I, patients were placebo (not receiving any medication), Group II patients received systemic AZM therapy (AZM 250 mg/day for five days), and Group III patients received doxycycline (20 mg twice per day for three months...
February 2024: Curēus
https://read.qxmd.com/read/38533154/easing-the-burden-of-tinnitus-a-narrative-review-for-exploring-effective-pharmacological-strategies
#19
REVIEW
Seung Ho Kim, Ikhee Kim, Hantai Kim
Many individuals seek medical attention for tinnitus, desiring relief from the distress caused by the condition; however, the treatment process is far from straightforward. The most effective treatments for chronic subjective tinnitus, such as tinnitus retraining therapy (TRT) and cognitive behavioral therapy (CBT), require considerable time and efforts. As a result, many of them express a desire for alleviation through medication. While it is true that medication is not generally recommended in treatment guidelines for chronic subjective tinnitus, in specific situations such as when accompanied by symptoms of depression or anxiety-drugs like antidepressants or anxiolytics may have a meaningful impact on symptom reduction...
February 2024: Curēus
https://read.qxmd.com/read/38532920/the-effect-of-iron-supplementation-on-menstrual-bleeding-volume-and-hemoglobin-level-during-menstrual-bleeding-a-randomized-clinical-trial
#20
JOURNAL ARTICLE
Elnaz MokhtarKalimi, Marzeyeh Loripoor, Mohsen Rezaeian, MohammadReza Gholamrezapour
BACKGROUND: Many women around the world avoid taking iron supplements during their menstrual bleeding, thinking that menstrual bleeding will increase after taking these supplements. Due to the lack of relevant scientific evidence in this regard, this study was performed to determine the effect of iron supplementation on menstrual blood volume and hemoglobin level during menstrual bleeding. MATERIALS AND METHODS: In this three-blind randomized clinical trial, 160 non-anemic female students of Rafsanjan University of Medical Sciences were selected through a public call and then they were randomly assigned to two intervention and control groups...
2024: Journal of Education and Health Promotion
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