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https://www.readbyqxmd.com/read/29783173/development-and-validation-of-an-analytical-method-for-regorafenib-and-its-metabolites-in-mouse-plasma
#1
Qiang Fu, Mingqing Chen, Shuiying Hu, Craig A McElroy, Ron H Mathijssen, Alex Sparreboom, Sharyn D Baker
An analytical method was developed for measuring the effect of OATP1B2 deficiency on plasma levels of the kinase inhibitor regorafenib and its metabolites regorafenib-N-oxide, N-desmethyl-regorafenib-N-oxide, and regorafenib-N-β-glucuronide (RG) in mice. Compounds were separated by liquid chromatography and monitored by a triple quadrupole mass spectrometer in the selected reaction monitoring mode after positive electrospray ionization. All calibration curves were linear in the selected concentration range (R2  ≥ 0...
May 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29782947/multifunctional-degradable-electronic-scaffolds-for-cardiac-tissue-engineering
#2
Ron Feiner, Sharon Fleischer, Assaf Shapira, Or Kalish, Tal Dvir
The capability to on-line sense tissue function, provide stimulation to control contractility and efficiently release drugs within an engineered tissue microenvironment may enhance tissue assembly and improve the therapeutic outcome of implanted engineered tissues. To endow cardiac patches with such capabilities we developed elastic, biodegradable, electronic scaffolds. The scaffolds were composed of electrospun albumin fibers that served as both a substrate and a passivation layer for evaporated gold electrodes...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29779975/design-and-synthesis-of-a-series-of-bioavailable-fatty-acid-synthase-fasn-kr-domain-inhibitors-for-cancer-therapy
#3
Tianbao Lu, Carsten Schubert, Maxwell D Cummings, Gilles Bignan, Peter J Connolly, Karine Smans, Donald Ludovici, Michael H Parker, Christophe Meyer, Christian Rocaboy, Richard Alexander, Bruce Grasberger, Sabine De Breucker, Norbert Esser, Erwin Fraiponts, Ron Gilissen, Boudewijn Janssens, Danielle Peeters, Luc Van Nuffel, Peter Vermeulen, James Bischoff, Lieven Meerpoel
We designed and synthesized a new series of fatty acid synthase (FASN) inhibitors with potential utility for the treatment of cancer. Extensive SAR studies led to highly active FASN inhibitors with good cellular activity and oral bioavailability, exemplified by compound 34. Compound 34 is a potent inhibitor of human FASN (IC50  = 28 nM) that effectively inhibits proliferation of A2780 ovarian cells (IC50  = 13 nM) in lipid-reduced serum (LRS). This cellular activity can be rescued by addition of palmitate, consistent with an on-target effect...
May 8, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29779973/impact-of-device-host-interaction-on-paravalvular-aortic-regurgitation-with-different-transcatheter-heart-valves
#4
Ramón Rodríguez-Olivares, Nahid El Faquir, Zouhair Rahhab, Lennart van Gils, Ben Ren, Rafi Sakhi, Marcel L Geleijnse, Ron van Domburg, Peter P T de Jaegere, Jose L Zamorano Gómez, Nicolas M Van Mieghem
AIMS: We sought to evaluate the interaction of different aortic root phenotypes with self-expanding (SEV), balloon-expandable (BEV) and mechanically expanded (MEV) and the impact on significant aortic regurgitation. METHODS AND RESULTS: We included 392 patients with a SEV (N = 205), BEV (N = 107) or MEV (N = 80). Aortic annulus eccentricity index and calcification were measured by multi-slice CT scan. Paravalvular aortic regurgitation was assessed by contrast aortography (primary analysis) and transthoracic echocardiography (secondary analysis)...
May 6, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29779179/clinical-outcomes-of-complete-revascularization-using-either-angiography-guided-or-fractional-flow-reserve-guided-drug-eluting-stent-implantation-in-non-culprit-vessels-in-st-elevation-myocardial-infarction-patients-insights-from-a-study-based-on-a-systematic
#5
REVIEW
Alexandre Hideo-Kajita, Hector M Garcia-Garcia, Kayode O Kuku, Solomon S Beyene, Viana Azizi, Yael F Meirovich, Gebremedhin D Melaku, Aaphtaab Dheendsa, Echo J Brathwaite, Sameer Desale, Mohammad Soud, Kazuhiro Dan, Yuichi Ozaki, Ron Waksman, Michael Lipinski
Current guidelines recommend that percutaneous coronary intervention (PCI) should be restricted to the culprit vessel in ST elevation myocardial infarction (STEMI) patients with multi-vessel disease (MVD) and without cardiogenic shock. However, newer data suggests that performing complete revascularization (CR) in MVD patients may lead to better outcomes compared to intervention in the culprit vessel only. The aim of this meta-analysis is to examine the available data to determine if CR (using either angio- or fractional flow reserve guidance-FFR) following primary PCI in STEMI patients without cardiogenic shock impacts clinical outcomes...
May 19, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778381/dietary-patterns-are-positively-associated-with-semen-quality
#6
Michal Efrat, Anat Stein, Haim Pinkas, Ron Unger, Ruth Birk
OBJECTIVE: To study association of semen quality with a priori whole dietary pattern indexes, which reflect real-world dietary practices and the numerous combinations by which foods are consumed: Healthy Eating Index (HEI), Dietary Approaches to Stop Hypertension (DASH), alternate Mediterranean Diet score (aMED), and Alternative Healthy Eating Index (AHEI). DESIGN: A cross-sectional single-center study. SETTING: Hospital fertility center and university...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29776393/medication-adherence-in-patients-with-schizophrenia-a-qualitative-study-of-the-patient-process-in-motivational-interviewing
#7
Jos Dobber, Corine Latour, Lieuwe de Haan, Wilma Scholte Op Reimer, Ron Peters, Emile Barkhof, Berno van Meijel
BACKGROUND: Motivational interviewing (MI) may be an effective intervention to improve medication adherence in patients with schizophrenia. However, for this patient group, mixed results have been found in randomized controlled trials. Furthermore, the process of becoming (more) motivated for long-term medication adherence in patients with schizophrenia is largely unexplored. METHOD: We performed a qualitative multiple case study of MI-sessions to analyse the interaction process affecting motivation in patients with schizophrenia...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29775922/acid-phosphatase-test-on-phadebas-%C3%A2-sheets-an-optimized-method-for-presumptive-saliva-and-semen-detection
#8
Yael Herman, Ilan Feine, Ron Gafny
The precise and efficient detection of semen and saliva in sexual assault case-work items is a critical step in the forensic pipeline. The outcome of this stage may have a profound impact on identifying perpetrators as well as on the investigation process and the final outcome in court. Semen detection is usually based on the activity of acid phosphatase (AP), an enzyme found in high concentration in the seminal plasma. Amylase, an enzyme catalyzing starch hydrolysis is found in high concentrations in saliva and therefore is a useful target for its detection...
April 30, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29775349/tuning-the-pairing-interaction-in-a-d-wave-superconductor-by-paramagnons-injected-through-interfaces
#9
M Naritsuka, P F S Rosa, Yongkang Luo, Y Kasahara, Y Tokiwa, T Ishii, S Miyake, T Terashima, T Shibauchi, F Ronning, J D Thompson, Y Matsuda
Unconventional superconductivity and magnetism are intertwined on a microscopic level in a wide class of materials. A new approach to this most fundamental and hotly debated issue focuses on the role of interactions between superconducting electrons and bosonic fluctuations at the interface between adjacent layers in heterostructures. Here we fabricate hybrid superlattices consisting of alternating atomic layers of the heavy-fermion superconductor CeCoIn_{5} and antiferromagnetic (AFM) metal CeRhIn_{5}, in which the AFM order can be suppressed by applying pressure...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29774862/ferrets-as-models-for-influenza-virus-transmission-studies-and-pandemic-risk-assessments
#10
Jessica A Belser, Wendy Barclay, Ian Barr, Ron A M Fouchier, Ryota Matsuyama, Hiroshi Nishiura, Malik Peiris, Charles J Russell, Kanta Subbarao, Huachen Zhu, Hui-Ling Yen
The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774611/nanoporous-metallic-networks-fabrication-optical-properties-and-applications
#11
REVIEW
Racheli Ron, Emir Haleva, Adi Salomon
Nanoporous metallic networks are a group of porous materials made of solid metals with suboptical wavelength sizes of both particles and voids. They are characterized by unique optical properties, as well as high surface area and permeability of guest materials. As such, they attract a great focus as novel materials for photonics, catalysis, sensing, and renewable energy. Their properties together with the ability for scaling-up evoke an increased interest also in the industrial field. Here, fabrication techniques of large-scale metallic networks are discussed, and their interesting optical properties as well as their applications are considered...
May 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29773666/ancient-genomes-document-multiple-waves-of-migration-in-southeast-asian-prehistory
#12
Mark Lipson, Olivia Cheronet, Swapan Mallick, Nadin Rohland, Marc Oxenham, Michael Pietrusewsky, Thomas Oliver Pryce, Anna Willis, Hirofumi Matsumura, Hallie Buckley, Kate Domett, Nguyen Giang Hai, Trinh Hoang Hiep, Aung Aung Kyaw, Tin Tin Win, Baptiste Pradier, Nasreen Broomandkhoshbacht, Francesca Candilio, Piya Changmai, Daniel Fernandes, Matthew Ferry, Beatriz Gamarra, Eadaoin Harney, Jatupol Kampuansai, Wibhu Kutanan, Megan Michel, Mario Novak, Jonas Oppenheimer, Kendra Sirak, Kristin Stewardson, Zhao Zhang, Pavel Flegontov, Ron Pinhasi, David Reich
Southeast Asia is home to rich human genetic and linguistic diversity, but the details of past population movements in the region are not well known. Here, we report genome-wide ancient DNA data from eighteen Southeast Asian individuals spanning from the Neolithic period through the Iron Age (4100-1700 years ago). Early farmers from Man Bac in Vietnam exhibit a mixture of East Asian (southern Chinese agriculturalist) and deeply diverged eastern Eurasian (hunter-gatherer) ancestry characteristic of Austroasiatic speakers, with similar ancestry as far south as Indonesia providing evidence for an expansive initial spread of Austroasiatic languages...
May 17, 2018: Science
https://www.readbyqxmd.com/read/29773429/real-life-experience-with-ponatinib-in-chronic-myeloid-leukemia-a-multicenter-observational-study
#13
Adi Shacham-Abulafia, Pia Raanani, David Lavie, Yulia Volchek, Ron Ram, Ilana Helman, Liat Shargian, Anna Gourevitch, Evgeni Chubar, Roy Ratzon, Uri Rozovski
BACKGROUND: The strict recruitment criteria of patients for clinical trials often lead to reduced generalizability of the findings. We studied how ponatinib is used outside clinical trials in patients with chronic myeloid leukemia (CML). PATIENTS AND METHODS: The present retrospective study included all patients with a diagnosis of CML who had received ponatinib in 7 medical centers in Israel. RESULTS: From 2011 to 2016, we identified 37 patients with CML who had received ponatinib, 21 in the chronic phase and 16 in the advanced phase...
May 7, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29772733/effect-of-babassu-natural-filler-on-pbat-phb-biodegradable-blends-an-investigation-of-thermal-mechanical-and-morphological-behavior
#14
Vinicius C Beber, Silvio de Barros, Mariana D Banea, Markus Brede, Laura H de Carvalho, Ron Hoffmann, Anna Raffaela M Costa, Elieber B Bezerra, Ingridy D S Silva, Katharina Haag, Katharina Koschek, Renate M R Wellen
Blending of biodegradable polymers in combination with low-price organic fillers has proven to be a suitable approach to produce cost-effective composites in order to address pollution issues and develop products with superior mechanical properties. In the present research work PBAT/PHB/Babassu composites with 25, 50, and 75% of each polymer and 20% of Babassu were produced by melting extrusion. Their thermal, mechanical, and morphological behavior was investigated by differential scanning calorimetry (DSC), tensile testing, and scanning electron microscopy (SEM)...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29771916/2018-iscb-accomplishments-by-a-senior-scientist-award
#15
Christiana N Fogg, Diane E Kovats, Ron Shamir
No abstract text is available yet for this article.
May 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29771913/2018-outstanding-contributions-to-iscb-award-russ-altman
#16
Christiana N Fogg, Diane E Kovats, Ron Shamir
No abstract text is available yet for this article.
May 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29771737/ethnic-disparities-in-treatment-rates-for-hypertension-and-dyslipidemia-an-analysis-by-different-treatment-indications-the-healthy-life-in-an-urban-setting-study
#17
Wilco Perini, Charles Agyemang, Marieke B Snijder, Ron J G Peters, Anton E Kunst
BACKGROUND: Studies have reported ethnic disparities in treatment rates for cardiovascular risk factors. These studies are generally based on treatment indications defined by individual cardiovascular risk factors (ICRF). However, according to most European guidelines, preventive treatment for these risk factors is recommended only among those with sufficient overall cardiovascular risk (OCR). OBJECTIVE: To determine ethnic disparities in treatment rates for hypertension and dyslipidemia among those with an indication for treatment based on ICRF and OCR...
May 15, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29771296/nationwide-cohort-study-of-antiretroviral-therapy-timing-treatment-dropout-and-virological-failure-in-china-2011-2015
#18
Yan Zhao, Zunyou Wu, Jennifer M McGoogan, Yiyi Sha, Decai Zhao, Ye Ma, Ron Brookmeyer, Roger Detels, Julio S G Montaner
Background: People living with HIV (PLWH) are still being diagnosed late, rendering the benefits of "early" antiretroviral therapy (ART; based on CD4 count) unattainable. Therefore, we aimed to evaluate the benefits of "immediate" ART (based on the time interval between diagnosis and treatment, regardless of CD4 count). Methods: A nationwide cohort of PLWH in China who initiated ART January 1, 2011 to December 31, 2014 and had baseline CD4 results >200 cells/μL were censored at 12 months, dropout, or death, whichever was first...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29769372/iglon5-mediated-neurodegeneration-is-a-differential-diagnosis-of-cns-whipple-disease
#19
Hugo Morales-Briceño, Belinda Cruse, Alessandro F Fois, Ming-Wei Lin, Jocelyn Jiang, Dev Banerjee, Ron Grunstein, Winny Varikatt, Michael Rodriguez, Claire Shepherd, Victor S C Fung
No abstract text is available yet for this article.
May 16, 2018: Neurology
https://www.readbyqxmd.com/read/29769347/avian-influenza-viruses-in-wild-birds-virus-evolution-in-a-multi-host-ecosystem
#20
Divya Venkatesh, Marjolein J Poen, Theo M Bestebroer, Rachel D Scheuer, Oanh Vuong, Mzia Chkhaidze, Anna Machablishvili, Jimsher Mamuchadze, Levan Ninua, Nadia B Fedorova, Rebecca A Halpin, Xudong Lin, Amy Ransier, Timothy B Stockwell, David E Wentworth, Divya Kriti, Jayeeta Dutta, Harm van Bakel, Anita Puranik, Marek J Slomka, Steve Essen, Ian H Brown, Ron A M Fouchier, Nicola S Lewis
Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways breed, winter or stage. The Republic of Georgia is located at the intersection of three migratory flyways: Central Asian Flyway, East Asian/East African Flyway and Black Sea/Mediterranean Flyway. For six consecutive years (2010-2016), we collected AIV samples from various duck and gull species that breed, migrate and overwinter in Georgia...
May 16, 2018: Journal of Virology
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