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https://www.readbyqxmd.com/read/27926746/analysis-and-compensation-for-the-effect-of-the-catheter-position-on-image-intensities-in-intravascular-optical-coherence-tomography
#1
Shengnan Liu, Jeroen Eggermont, Ron Wolterbeek, Alexander Broersen, Carol A G R Busk, Helle Precht, Boudewijn P F Lelieveldt, Jouke Dijkstra
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27925612/transthoracic-echocardiography-to-assess-aortic-regurgitation-after-tavr-a-comparison-with-periprocedural-transesophageal-echocardiography
#2
Alexandra Goncalves, Charles Nyman, David R Okada, Avinainder Singh, Jeffrey Swanson, Michael Cheezum, Michael Steigner, Marcelo Di Carli, Scott Solomon, Pinak B Shah, Deepak L Bhatt, Douglas Shook, Ron Blankstein
BACKGROUND: We aimed to compare periprocedural transesophageal echocardiography (TEE) with postprocedural transthoracic echocardiography (TTE) for the diagnosis of aortic regurgitation (AR). METHODS AND RESULTS: TEE and TTE images of 163 transcatheter aortic valve replacement (TAVR) patients (mean age 81 ± 8 years; 56% men) were reviewed separately and blinded to each other as well as to all clinical data. The median time between TEE during TAVR (TEE/TAVR) and TTE was 4 days (IQR 2-10 days)...
December 8, 2016: Cardiology
https://www.readbyqxmd.com/read/27925432/ceos-theory-a-comprehensive-approach-to-understanding-hard-to-maintain-behaviour-change
#3
Ron Borland
This paper provides a brief introduction to CEOS theory, a comprehensive theory for understanding hard to maintain behaviour change. The name CEOS is an acronym for Context, Executive, and Operational Systems theory. Behaviour is theorised to be the result of the moment by moment interaction between internal needs (operational processes) in relation to environmental conditions, and for humans this is augmented by goal-directed, executive action which can transcend immediate contingencies. All behaviour is generated by operational processes...
December 7, 2016: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/27924061/the-relationship-between-serum-fibrosis-markers-and-restrictive-ventricular-filling-in-patients-with-heart-failure-with-reduced-ejection-fraction-a-technetium-99m-radionuclide-ventriculography-study
#4
Yen-Tin Lin, Yen-Hung Lin, Xue-Ming Wu, Chi-Lun Ko, Ruoh-Fang Yen, Ying-Hsein Chen, Ron-Bin Hsu, Chi-Ming Lee, Shoei-Shen Wang, Ming-Fong Chen, Yen-Wen Wu
Myocardial fibrosis leads to a restrictive diastolic filling pattern of the left ventricle which is associated with a poor prognosis in patients with heart failure. We investigated the relationship between cardiac fibrosis and restrictive filling pattern of the left ventricle measured by Tc99m left ventriculography in patients with chronic symptomatic heart failure. Serum cardiac extracellular matrix markers including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2,9 (MMP-2,9), and tissue inhibitor of MMP-1 (TIMP-1) were analyzed...
December 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27922988/minimally-invasive-fundoplication-is-safe-and-effective-in-patients-with-severe-esophageal-hypomotility
#5
Michael B Goldberg, Abbas El-Sayed Abbas, Michael S Smith, Henry P Parkman, Ron Schey, Daniel T Dempsey
OBJECTIVE: Fundoplication is used to treat refractory gastroesophageal reflux disease (GERD). A subset of patients has coexisting esophageal dysmotility, including aperistalsis or hypoperistalsis. These patients may be at increased risk of dysphagia after fundoplication. To evaluate the outcomes of minimally invasive fundoplication (MIF) in patients with GERD and esophageal hypomotility. METHODS: Retrospective review of all patients who underwent MIF and had severe esophageal hypomotility from January 2003 to June 2013...
December 5, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27922699/adhesion-and-invasion-of-streptococcus-pneumoniae-to-primary-and-secondary-respiratory-epithelial-cells
#6
Sara Novick, Marilous Shagan, Karin Blau, Sarit Lifshitz, Noga Givon-Lavi, Nili Grossman, Lipa Bodner, Ron Dagan, Yaffa Mizrachi Nebenzahl
The interaction between Streptococcus pneumoniae (S. pneumoniae) and the mucosal epithelial cells of its host is a prerequisite for pneumococcal disease development, yet the specificity of this interaction between different respiratory cells is not fully understood. In the present study, three areas were examined: i) The capability of the encapsulated S. pneumoniae serotype 3 strain (WU2) to adhere to and invade primary nasal‑derived epithelial cells in comparison to primary oral‑derived epithelial cells, A549 adenocarcinoma cells and BEAS‑2B viral transformed bronchial cells; ii) the capability of the unencapsulated 3...
December 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27920232/a-message-from-the-editor-in-chief
#7
EDITORIAL
Ron Lindstrom
No abstract text is available yet for this article.
December 5, 2016: Healthcare Management Forum
https://www.readbyqxmd.com/read/27920153/urine-osmolality-response-to-tolvaptan-and-outcome-in-autosomal-dominant-polycystic-kidney-disease-results-from-the-tempo-3-4-trial
#8
Olivier Devuyst, Arlene B Chapman, Ron T Gansevoort, Eiji Higashihara, Ronald D Perrone, Vicente E Torres, Jaime D Blais, Wen Zhou, John Ouyang, Frank S Czerwiec
The vasopressin-cAMP-osmolality axis is abnormal in autosomal dominant polycystic kidney disease (ADPKD). In the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes 3:4 Trial, a 3-year randomized, placebo-controlled trial in adults, the vasopressin V2 receptor antagonist tolvaptan slowed ADPKD progression in patients with preserved GFR. Here, we investigated the determinants of baseline urine osmolality (Uosm) and its value as a severity marker of ADPKD, the factors influencing the response to tolvaptan, and whether change in Uosm associated with key trial end points...
December 5, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27919987/the-complete-loss-of-tyrosine-kinase-receptors-met-and-ron-is-a-poor-prognostic-factor-in-patients-with-extrahepatic-cholangiocarcinoma
#9
Yuki Hayashi, Junpei Yamaguchi, Toshio Kokuryo, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Masato Nagino
BACKGROUND: Although the survival of patients with cholangiocarcinoma has improved, the prognosis remains unfavorable. The overexpression of mesenchymal-epithelial transition factor (MET) and recepteur d'origine nantais (RON) has been considered to be indicative of a poor prognosis in some types of cancer. On the other hand, some studies have shown that the expression of MET and RON is a favorable prognostic factor in certain types of tumors. MATERIALS AND METHODS: Based on the immunohistochemical analysis of MET and RON, 290 patients who underwent resection for extrahepatic cholangiocarcinoma were divided into three groups: MET/RON-negative, -intermediate, and -positive...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919219/ston-exploring-biological-pathways-using-the-sbgn-standard-and-graph-databases
#10
Vasundra Touré, Alexander Mazein, Dagmar Waltemath, Irina Balaur, Mansoor Saqi, Ron Henkel, Johann Pellet, Charles Auffray
BACKGROUND: When modeling in Systems Biology and Systems Medicine, the data is often extensive, complex and heterogeneous. Graphs are a natural way of representing biological networks. Graph databases enable efficient storage and processing of the encoded biological relationships. They furthermore support queries on the structure of biological networks. RESULTS: We present the Java-based framework STON (SBGN TO Neo4j). STON imports and translates metabolic, signalling and gene regulatory pathways represented in the Systems Biology Graphical Notation into a graph-oriented format compatible with the Neo4j graph database...
December 5, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27918812/important-distinctions-concerning-pharmaceutical-company-sponsored-meals-and-prescribing-patterns
#11
Ron Cohen
No abstract text is available yet for this article.
December 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27918543/ficd-acts-bifunctionally-to-ampylate-and-de-ampylate-the-endoplasmic-reticulum-chaperone-bip
#12
Steffen Preissler, Claudia Rato, Luke A Perera, Vladimir Saudek, David Ron
Protein folding homeostasis in the endoplasmic reticulum (ER) is defended by an unfolded protein response that matches ER chaperone capacity to the burden of unfolded proteins. As levels of unfolded proteins decline, a metazoan-specific FIC-domain-containing ER-localized enzyme (FICD) rapidly inactivates the major ER chaperone BiP by AMPylating T518. Here we show that the single catalytic domain of FICD can also release the attached AMP, restoring functionality to BiP. Consistent with a role for endogenous FICD in de-AMPylating BiP, FICD(-/-) hamster cells are hypersensitive to introduction of a constitutively AMPylating, de-AMPylation-defective mutant FICD...
December 5, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27917919/niptric-an-online-tool-for-clinical-interpretation-of-non-invasive-prenatal-testing-nipt-results
#13
Birgit Sikkema-Raddatz, Lennart F Johansson, Eddy N de Boer, Elles M J Boon, Ron F Suijkerbuijk, Katelijne Bouman, Catia M Bilardo, Morris A Swertz, Martijn Dijkstra, Irene M van Langen, Richard J Sinke, Gerard J Te Meerman
To properly interpret the result of a pregnant woman's non-invasive prenatal test (NIPT), her a priori risk must be taken into account in order to obtain her personalised a posteriori risk (PPR), which more accurately expresses her true likelihood of carrying a foetus with trisomy. Our aim was to develop a tool for laboratories and clinicians to calculate easily the PPR for genome-wide NIPT results, using diploid samples as a control group. The tool takes the a priori risk and Z-score into account. Foetal DNA percentage and coefficient of variation can be given default settings, but actual values should be used if known...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917735/top-1-of-inpatients-administered-antimicrobial-agents-comprising-50-of-expenditures-a-descriptive-study-and-opportunities-for-stewardship-intervention
#14
Jennifer Dela-Pena, Luiza Kerstenetzky, Lucas Schulz, Ron Kendall, Alexander Lepak, Barry Fox
OBJECTIVE To characterize the top 1% of inpatients who contributed to the 6-month antimicrobial budget in a tertiary, academic medical center and identify cost-effective intervention opportunities targeting high-cost antimicrobial utilization. DESIGN Retrospective cohort study. PATIENTS Top 1% of the antimicrobial budget from July 1 through December 31, 2014. METHODS Patients were identified through a pharmacy billing database. Baseline characteristics were collected through a retrospective medical chart review...
December 5, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27917043/systematics-of-ecnomiohyla-tuberculosa-with-the-description-of-a-new-species-and-comments-on-the-taxonomy-of-trachycephalus-typhonius-anura-hylidae
#15
Santiago R Ron, Pablo J Venegas, H Mauricio Ortega-Andrade, Giussepe Gagliardi-Urrutia, Patricia E Salerno
Ecnomiohyla tuberculosa is an Amazonian hylid of uncertain phylogenetic position. Herein DNA sequences of mitochondrial and nuclear genes are used to determine its phylogenetic relationships. New sequences and external morphology of Trachycephalus typhonius are also analyzed to assess the status of Ecuadorian and Peruvian populations. The phylogeny shows unequivocally that Ecnomiohyla tuberculosa is nested within the genus Tepuihyla, tribe Lophiohylini. This position was unexpected because the remaining species of Ecnomiohyla belong to the tribe Hylini...
2016: ZooKeys
https://www.readbyqxmd.com/read/27916744/does-acute-coronary-syndrome-impact-on-the-incidence-of-thrombosis-after-the-implantation-of-absorb-bioresorbable-vascular-scaffold
#16
Yohei Sotomi, Yosuke Miyazaki, Carlos Colet, Taku Asano, Pannipa Suwannasom, Jan Tijssen, Robbert J de Winter, Ron Waksman, Michael J Lipinski, Yoshinobu Onuma, Patrick W Serruys
AIMS: In the drug eluting stent (DES) era, patients with acute coronary syndrome (ACS) had a higher risk of early stent thrombosis compared with stable patients. The present study evaluated whether the same is true for the bioresorbable vascular scaffold (BVS: Abbott Vascular, Santa Clara CA). METHODS AND RESULTS: We assessed the relationship between the incidence of definite/probable scaffold thrombosis (ScT) (overall ScT and early ScT) and ACS percentage with the latest publications including the most recent large randomized controlled trials...
December 6, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27916602/transcatheter-therapeutic-conference-2016-highlights-of-late-breaking-trials
#17
REVIEW
M Chadi Alraies, Kyle Buchanan, Arie Steinvil, Toby Rogers, Edward Koifman, Alexandre H Kajita, Ron Waksman
No abstract text is available yet for this article.
November 15, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27915208/maximizing-the-impact-of-physiologically-based-oral-absorption-modeling-and-simulation
#18
John I Chung, Ron C Kelly, Jan Wahlstrom, Benjamin Wu, Tian Wu, Fernando Alvarez-Nunez
The challenge of bringing innovative medicines to patients in combination with intense competition within the pharmaceutical industry have induced companies to develop quality medicines more efficiently and cost-effectively. State-of-the art approaches to advance drug development have never been so urgent. One such approach that has been gaining traction within the industry is the application of modeling and simulation. In this commentary, the benefits of physiologically-based oral absorption (PBOA) modeling and simulation in drug development are highlighted and suggestions for maximizing its impact are provided...
November 30, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27908294/outcomes-of-notifications-to-health-practitioner-boards-a-retrospective-cohort-study
#19
Matthew J Spittal, David M Studdert, Ron Paterson, Marie M Bismark
BACKGROUND: Medical boards and other practitioner boards aim to protect the public from unsafe practice. Previous research has examined disciplinary actions against doctors, but other professions (e.g., nurses and midwives, dentists, psychologists, pharmacists) remain understudied. We sought to describe the outcomes of notifications of concern regarding the health, performance, and conduct of health practitioners from ten professions in Australia and to identify factors associated with the imposition of restrictive actions...
December 2, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27907901/serum-amh-levels-in-healthy-women-from-brca1-2-mutated-families-are-they-reduced
#20
Theodora C van Tilborg, Inge A P Derks-Smeets, Anna M E Bos, Jan C Oosterwijk, Ron J van Golde, Christine E de Die-Smulders, Lizet E van der Kolk, Wendy A G van Zelst-Stams, Maria E Velthuizen, Annemieke Hoek, Marinus J C Eijkemans, Joop S E Laven, Margreet G E M Ausems, Frank J M Broekmans
STUDY QUESTION: Do BRCA1/2 mutation carriers have a compromised ovarian reserve compared to proven non-carriers, based on serum anti-Müllerian hormone (AMH) levels? SUMMARY ANSWER: BRCA1/2 mutation carriers do not show a lower serum AMH level in comparison to proven non-carriers, after adjustment for potential confounders. WHAT IS KNOWN ALREADY: It has been suggested that the BRCA genes play a role in the process of ovarian reserve depletion, although previous studies have shown inconsistent results regarding the association between serum AMH levels and BRCA mutation status...
November 2016: Human Reproduction
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