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https://www.readbyqxmd.com/read/28427955/preventing-alcohol-and-tobacco-exposed-pregnancies-choices-plus-in-primary-care
#1
Mary M Velasquez, Kirk L von Sternberg, R Louise Floyd, Danielle Parrish, Alicia Kowalchuk, Nanette S Stephens, Britta Ostermeyer, Charles Green, J Paul Seale, Patricia Dolan Mullen
INTRODUCTION: Alcohol and tobacco use are common among U.S. women, yet if used during pregnancy these substances present significant preventable risks to prenatal and perinatal health. Because use of alcohol and tobacco often continue into the first trimester and beyond, especially among women with unintended pregnancies, effective evidence-based approaches are needed to decrease these risk behaviors. This study was designed to test the efficacy of CHOICES Plus, a preconception intervention for reducing the risk of alcohol- and tobacco-exposed pregnancies (AEPs and TEPs)...
April 17, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28414803/new-metric-for-optimizing-continuous-loop-averaging-deconvolution-clad-sequences-under-the-1-f-noise-model
#2
Xian Peng, Han Yuan, Wufan Chen, Tao Wang, Lei Ding
Continuous loop averaging deconvolution (CLAD) is one of the proven methods for recovering transient auditory evoked potentials (AEPs) in rapid stimulation paradigms, which requires an elaborated stimulus sequence design to attenuate impacts from noise in data. The present study aimed to develop a new metric in gauging a CLAD sequence in terms of noise gain factor (NGF), which has been proposed previously but with less effectiveness in the presence of pink (1/f) noise. We derived the new metric by explicitly introducing the 1/f model into the proposed time-continuous sequence...
2017: PloS One
https://www.readbyqxmd.com/read/28406091/daptomycin-associated-eosinophilic-pneumonia-with-rechallenge-a-case-report%C3%A2
#3
Melanie Nickerson, Ashish Bhargava, Pramodini B Kale-Pradhan
PURPOSE: A case of daptomycin-associated acute eosinophilic pneumonia (AEP) with positive rechallenge is reported. SUMMARY: AEP associated with daptomycin is reported in the literature, and the product labeling contains a warning and precaution statement. Criteria for diagnosing daptomycin-induced AEP varies and generally includes bronchoalveolar lavage (BAL) eosinophils ≥ 25%. We report a case of a 70-year-old woman with cough, shortness of breath, and altered mental status who presented ~ 9 days after starting therapy with daptomycin to treat methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis...
April 13, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28396594/human-primpol-activity-is-enhanced-by-rpa
#4
María I Martínez-Jiménez, Antonio Lahera, Luis Blanco
Human PrimPol is a primase belonging to the AEP superfamily with the unique ability to synthesize DNA primers de novo, and a non-processive DNA polymerase able to bypass certain DNA lesions. PrimPol facilitates both mitochondrial and nuclear replication fork progression either acting as a conventional TLS polymerase, or repriming downstream of blocking lesions. In vivo assays have shown that PrimPol is rapidly recruited to sites of DNA damage by interaction with the human replication protein A (RPA). In agreement with previous findings, we show here that the higher affinity of RPA for ssDNA inhibits PrimPol activities in short ssDNA templates...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394257/cooperative-gene-activation-by-af4-and-dot1l-drives-mll-rearranged-leukemia
#5
Hiroshi Okuda, Boban Stanojevic, Akinori Kanai, Takeshi Kawamura, Satoshi Takahashi, Hirotaka Matsui, Akifumi Takaori-Kondo, Akihiko Yokoyama
The eleven-nineteen leukemia (ENL) protein family, composed of ENL and AF9, is a common component of 3 transcriptional modulators: AF4-ENL-P-TEFb complex (AEP), DOT1L-AF10-ENL complex (referred to as the DOT1L complex) and polycomb-repressive complex 1 (PRC1). Each complex associates with chromatin via distinct mechanisms, conferring different transcriptional properties including activation, maintenance, and repression. The mixed-lineage leukemia (MLL) gene often fuses with ENL and AF10 family genes in leukemia...
April 10, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28388882/an-abdominal-ectopic-pregnancy-following-a-frozen-thawed-art-cycle-a-case-report-and-review-of-the-literature
#6
Atsushi Yanaihara, Shirei Ohgi, Kenichirou Motomura, Yuko Hagiwara, Tae Mogami, Keisuke Saito, Takumi Yanaihara
BACKGROUND: Ectopic pregnancy (EP) occurs in 1% of pregnancies and is reported to be more common in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) pregnancies. An abdominal ectopic pregnancy (AEP) is a rare form of EP, and there are few reports of an AEP after IVF/ICSI. In this case report, a rare case of AEP after frozen-thawed cycle of ICSI is presented. CASE PRESENTATION: After a frozen-thawed cycle of ICSI, the beta-human chorionic gonadotropin (HCG) level at 4 weeks 0 days of gestation was 3...
April 7, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28387007/preventing-alcohol-exposed-pregnancies-a-randomized-controlled-trial-of-a-self-administered-version-of-project-choices-with-college-students-and-nonstudents
#7
Linda Carter Sobell, Mark B Sobell, Kenneth Johnson, Nicholas Heinecke, Sangeeta Agrawal, Burt Bolton
BACKGROUND: Alcohol-exposed pregnancies (AEPs) are a preventable cause of birth defects and developmental disabilities for which many women are at risk. The initial 5-session Project CHOICES intervention was found to prevent AEPs. In the ensuing decade, there have been several additional CHOICES-like studies. The present study, Project Healthy CHOICES, had two objectives: (a) to compare outcomes for students vs. nonstudents; and (b) to test a self-administered mail-based version of the Project CHOICES intervention...
April 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28377708/increased-evoked-potentials-to-arousing-auditory-stimuli-during-sleep-implication-for-the-understanding-of-dream-recall
#8
Raphael Vallat, Tarek Lajnef, Jean-Baptiste Eichenlaub, Christian Berthomier, Karim Jerbi, Dominique Morlet, Perrine M Ruby
High dream recallers (HR) show a larger brain reactivity to auditory stimuli during wakefulness and sleep as compared to low dream recallers (LR) and also more intra-sleep wakefulness (ISW), but no other modification of the sleep macrostructure. To further understand the possible causal link between brain responses, ISW and dream recall, we investigated the sleep microstructure of HR and LR, and tested whether the amplitude of auditory evoked potentials (AEPs) was predictive of arousing reactions during sleep...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28377706/cortical-measures-of-binaural-processing-predict-spatial-release-from-masking-performance
#9
Melissa A Papesh, Robert L Folmer, Frederick J Gallun
Binaural sensitivity is an important contributor to the ability to understand speech in adverse acoustical environments such as restaurants and other social gatherings. The ability to accurately report on binaural percepts is not commonly measured, however, as extensive training is required before reliable measures can be obtained. Here, we investigated the use of auditory evoked potentials (AEPs) as a rapid physiological indicator of detection of interaural phase differences (IPDs) by assessing cortical responses to 180° IPDs embedded in amplitude-modulated carrier tones...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28361683/comparative-network-stratification-analysis-for-identifying-functional-interpretable-network-biomarkers
#10
Chuanchao Zhang, Juan Liu, Qianqian Shi, Tao Zeng, Luonan Chen
BACKGROUND: A major challenge of bioinformatics in the era of precision medicine is to identify the molecular biomarkers for complex diseases. It is a general expectation that these biomarkers or signatures have not only strong discrimination ability, but also readable interpretations in a biological sense. Generally, the conventional expression-based or network-based methods mainly capture differential genes or differential networks as biomarkers, however, such biomarkers only focus on phenotypic discrimination and usually have less biological or functional interpretation...
March 14, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28345579/inhibition-of-delta-secretase-improves-cognitive-functions-in-mouse-models-of-alzheimer-s-disease
#11
Zhentao Zhang, Obiamaka Obianyo, Elfriede Dall, Yuhong Du, Haian Fu, Xia Liu, Seong Su Kang, Mingke Song, Shan-Ping Yu, Chiara Cabrele, Mario Schubert, Xiaoguang Li, Jian-Zhi Wang, Hans Brandstetter, Keqiang Ye
δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the amyloid-β and tau pathology in Alzheimer's disease (AD). Here we report the therapeutic effect of an orally bioactive and brain permeable δ-secretase inhibitor in mouse models of AD. We performed a high-throughput screen and identified a non-toxic and selective δ-secretase inhibitor, termed compound 11, that specifically blocks δ-secretase but not other related cysteine proteases...
March 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28322452/macrocyclization-by-asparaginyl-endopeptidases
#12
REVIEW
Amy M James, Joel Haywood, Joshua S Mylne
Contents I. II. III. IV. References SUMMARY: Plant asparaginyl endopeptidases (AEPs) are important for the post-translational processing of seed storage proteins via cleavage of precursor proteins. Some AEPs also function as peptide bond-makers during the biosynthesis of several unrelated classes of cyclic peptides, namely the kalata-type cyclic peptides, PawS-Derived Peptides and cyclic knottins. These three families of gene-encoded peptides have different evolutionary origins, but all have recruited AEPs for their maturation...
March 21, 2017: New Phytologist
https://www.readbyqxmd.com/read/28286263/acute-eosinophilic-pneumonia-correlation-of-clinical-characteristics-with-underlying-cause
#13
Federica De Giacomi, Paul A Decker, Robert Vassallo, Jay H Ryu
BACKGROUND: Acute eosinophilic pneumonia (AEP) is an uncommon disease, often indistinguishable from acute respiratory distress syndrome or community-acquired pneumonia at initial presentation. AEP can be idiopathic but identifiable causes include medications and inhalational exposures including cigarette smoke. METHODS: Using a computer-assisted search, we retrospectively identified and reviewed the medical records of all patients diagnosed with AEP between January 1, 1998 and June 30, 2016 at our institution...
March 9, 2017: Chest
https://www.readbyqxmd.com/read/28282514/the-proteomic-profile-of-the-acquired-enamel-pellicle-according-to-its-location-in-the-dental-arches
#14
Talita Mendes da Silva Ventura, Luiza de Paula Silva Cassiano, Cíntia Maria de Souza E Silva, Even Akemi Taira, Aline de Lima Leite, Daniela Rios, Marília Afonso Rabelo Buzalaf
OBJECTIVE: This study evaluated the variation in the protein profile of the acquired enamel pellicle (AEP) formed in vivo according to its location in the dental arches. DESIGN: The AEP was formed for 120min in 9 volunteers. Pellicle formed at upper+lower anterior facial (ULAFa; teeth 13-23 and 33-43), upper anterior palatal (UAPa; teeth 13-23), lower anterior lingual (LALi; teeth 33-43), upper+lower posterior facial (ULPFa; teeth 14-17 24-27, 34-37 and 44-47), upper posterior palatal (UPPa; teeth 14-17 and 24-27) and lower posterior lingual (LPLi; teeth 34-37 and 44-47) regions were collected separately and processed for analysis by label-free LC-ESI-MS/MS...
March 3, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28278071/the-expression-of-asparaginyl-endopeptidase-promotes-growth-potential-in-epithelial-ovarian-cancer
#15
Qinyi Zhu, Meiling Tang, Xipeng Wang
Epithelial ovarian cancer (EOC) is the most common and lethal cancer-related death among females in the world. Asparaginyl endopeptidase (AEP) is a member of C13 family peptidases and expressed in the extracellular matrix and tumor cells. The aim of this article is to explore the function of asparaginyl endopeptidase in epithelial ovarian cancer. The expression of AEP was examined in 20 EOC samples, 3 EOC metastasis samples, 6 fallopian tube metastasis samples, 4 peritoneum metastasis samples and 20 benign ovarian tumor samples by immunohistochemistry...
March 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28269451/simultaneous-evaluation-of-prepulse-inhibition-with-emg-and-eeg-using-advanced-artifact-removal-techniques
#16
Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum
Prepulse inhibition (PPI) consists of a reduction of the acoustic startle reflex (SR) magnitude (measured with EMG) when a startling stimulus is preceded by a non-startling one. This behavior has been extensively investigated in studies related to schizophrenia, since sensory-motor deficit plays a central role in its pathophysiology. However, the same auditory stimuli that trigger the SR also provoke intense auditory evoked responses (AEP), which can be measured with EEG. Comparing these two types of responses, acquired simultaneously, is a great opportunity to investigate the dependence and interdependence of their neural pathways...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267801/t-complex-measures-in-bilingual-spanish-english-and-turkish-german-children-and-monolingual-peers
#17
Tanja Rinker, Valerie L Shafer, Markus Kiefer, Nancy Vidal, Yan H Yu
BACKGROUND: Lateral temporal neural measures (Na and T-complex Ta and Tb) of the auditory evoked potential (AEP) index maturation of auditory/speech processing. These measures are also sensitive to language experience in adults. This paper examined neural responses to a vowel sound at temporal electrodes in four- to five-year-old Spanish-English bilinguals and English monolinguals and in five- to six-year-old Turkish-German bilinguals and German monolinguals. The goal was to determine whether obligatory AEPs at temporal electrode sites were modulated by language experience...
2017: PloS One
https://www.readbyqxmd.com/read/28254512/electrocorticographic-delineation-of-human-auditory-cortical-fields-based-on-effects-of-propofol-anesthesia
#18
Kirill V Nourski, Matthew I Banks, Mitchell Steinschneider, Ariane E Rhone, Hiroto Kawasaki, Rashmi N Mueller, Michael M Todd, Matthew A Howard
The functional organization of human auditory cortex remains incompletely characterized. While the posteromedial two thirds of Heschl's gyrus (HG) is generally considered to be part of core auditory cortex, additional subdivisions of HG remain speculative. To further delineate the hierarchical organization of human auditory cortex, we investigated regional heterogeneity in the modulation of auditory cortical responses under varying depths of anesthesia induced by propofol. Non-invasive studies have shown that propofol differentially affects auditory cortical activity, with a greater impact on non-core areas...
February 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/28227697/simultaneous-evaluation-of-prepulse-inhibition-with-emg-and-eeg-using-advanced-artifact-removal-techniques
#19
Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Paulo R Menezes, Claudemiro V Noya, Rosana Shuhama, Milton A Avila, Cristina M Del-Ben, Cristiane Salum, Rodrigo S Martin, Maria I Zimiani
Prepulse inhibition (PPI) consists of a reduction of the acoustic startle reflex (SR) magnitude (measured with EMG) when a startling stimulus is preceded by a non-startling one. This behavior has been extensively investigated in studies related to schizophrenia, since sensory-motor deficit plays a central role in its pathophysiology. However, the same auditory stimuli that trigger the SR also provoke intense auditory evoked responses (AEP), which can be measured with EEG. Comparing these two types of responses, acquired simultaneously, is a great opportunity to investigate the dependence and interdependence of their neural pathways...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223821/asparaginyl-endopeptidase-improves-the-resistance-of-microtubule-targeting-drugs-in-gastric-cancer-through-iqgap1-modulating-the-egfr-jnk-erk-signaling-pathway
#20
Yuehong Cui, Qian Li, Hong Li, Yan Wang, Hongshan Wang, Weidong Chen, Shangmin Zhang, Jian Cao, Tianshu Liu
PURPOSE: In recent years, understanding of the role of asparaginyl endopeptidase (AEP) in tumorigenesis has steadily increased. In this study, we investigated whether AEP expression correlates with sensitivity to chemotherapeutic drugs in gastric cancer and explored the mechanism. PATIENTS AND METHODS: AEP expression in the serum of patients' peripheral blood was measured by enzyme-linked immunosorbent assay. Patient survival time was evaluated using univariate and multivariate analyses...
2017: OncoTargets and Therapy
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