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https://www.readbyqxmd.com/read/29301718/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2018-recommendations
#1
David Moreno-Pérez, Francisco José Álvarez García, Javier Álvarez Aldeán, María José Cilleruelo Ortega, María Garcés Sánchez, Nuria García Sánchez, Ángel Hernández Merino, María Méndez Hernández, Manuel Merino Moína, Abián Montesdeoca Melián, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics annually publishes the immunisation schedule considered optimal for children resident in Spain, according to available evidence on current vaccines. Regarding funded immunisations, 2+1 strategy (2, 4, 11-12 months) with hexavalent (DTPa-IPV-Hib-HB) and 13-valent pneumococcal vaccines are recommended. Administration of the 6-year booster dose with DTPa is recommended, and a poliomyelitis dose for children who had received the 2+1 scheme, as well as Tdap vaccine for adolescents and pregnant women in every pregnancy between 27 and 32 weeks' gestation...
January 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29297800/auditory-evoked-potentials-and-behavioral-considerations-with-hearing-loss-in-small-cetaceans-application-as-a-standard-diagnostic-test-in-health-assessment
#2
Megan M Strobel, Dorian S Houser, Kathleen T Moore, Michelle R Davis, Patricia L Clough, Lydia A Staggs, Holli C Eskelinen, Robin J Bates, Michael T Walsh
The primary sense in odontocetes is hearing and a large portion of the odontocete brain is devoted to the auditory processing of echolocation signals. Hearing deficits in odontocetes potentially compromise the ability to forage, navigate, socialize, and evade predators. This presents a challenge to survival and reproduction in wild odontocetes and can affect the general welfare of odontocetes under human care. Currently, little empirical information on how odontocete behavior is affected by hearing loss exists...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29295929/the-prodrug-of-7-8-dihydroxyflavone-development-and-therapeutic-efficacy-for-treating-alzheimer-s-disease
#3
Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, Keqiang Ye
The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer's disease (AD). However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic (PK) profile. To alleviate these preclinical obstacles, we used a prodrug strategy for elevating 7,8-DHF oral bioavailability and brain exposure, and found that the optimal prodrug R13 has favorable properties and dose-dependently reverses the cognitive defects in an AD mouse model...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29247698/pathway-analysis-of-global-gene-expression-change-in-dendritic-cells-induced-by-the-polysaccharide-from-the-roots-of-actinidia-eriantha
#4
Jing Du, Xiangfeng Chen, Chenying Wang, Hongxiang Sun
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Actinidia eriantha Benth have been used clinically to treat a variety of cancer in traditional Chinese medicine. The polysaccharide from this drug (AEPS) was previously reported to be a potential antitumor agent with immunomodulatory activity. However, the mechanisms of its antitumor action in immunomodulation have not yet been well-defined. AIM OF THE STUDY: To investigate the effects of AEPS on the phenotypic and functional maturation of dendritic cells and to explore the intracellular signaling mechanisms of its antitumor action in the immunomodulation...
December 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29236648/a-putative-electrophysiological-biomarker-of-auditory-sensory-memory-encoding-is-sensitive-to-pharmacological-alterations-of-excitatory-inhibitory-balance-in-male-macaque-monkeys
#5
William B Holliday, Kate Gurnsey, Robert A Sweet, Tobias Teichert
BACKGROUND: The amplitude of the auditory evoked N1 component that can be derived from noninvasive electroencephalographic recordings increases as a function of time between subsequent tones. N1 amplitudes in individuals with schizophrenia saturate at a lower asymptote, thus giving rise to a reduced dynamic range. Reduced N1 dynamic range is a putative electrophysiological biomarker of altered sensory memory function in individuals with the disease. To date, it is not clear what determines N1 dynamic range and what causes reduced N1 dynamic range in individuals with schizophrenia...
December 13, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29236470/a-case-study-application-of-the-aggregate-exposure-pathway-aep-and-adverse-outcome-pathway-aop-frameworks-to-facilitate-the-integration-of-human-health-and-ecological-endpoints-for-cumulative-risk-assessment-cra
#6
David E Hines, Stephen Edwards, Rory B Conolly, Annie M Jarabek
Cumulative risk assessment (CRA) methods promote the use of a conceptual site model (CSM) to apportion exposures and integrate risk from multiple stressors. While CSMs may encompass multiple species, evaluating endpoints across taxa can be challenging due to data availability and physiological differences among organisms. Adverse Outcome Pathways (AOPs) describe biological mechanisms leading to adverse outcomes (AOs) by assembling causal pathways with measurable intermediate steps termed key events (KEs), thereby providing a framework for integrating data across species...
December 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29225987/daptomycin-induced-acute-eosinophilic-pneumonia-late-onset-and-quick-recovery
#7
Mohamad Rachid, Khansa Ahmad, Meghan Saunders-Kurban, Aelia Fatima, Aditya Shah, Anas Nahhas
Background: Daptomycin is a cyclic lipopeptide antibiotic that provides great coverage for gram positive cocci. From the early years of daptomycin use, concerns were raised regarding the pulmonary side effects of daptomycin and potential development of acute eosinophilic pneumonia (AEP) secondary to daptomycin therapy. Discussion: AEP could be idiopathic or induced by drugs or toxins. It is a distinct entity from atopic diseases and autoimmune, parasitic, or fungal infections that can also cause pulmonary eosinophilia...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29222679/-objective-audiometry-and-clinical-application
#8
M Cebulla, D Ehrmann-Müller, W Shehata-Dieler
Subjective and objective hearing tests are used for evaluation of hearing impairments. Objective methods include impedance measurement with tympanometry and stapedius reflex measurement, otoacoustic emissions (OAE), and auditory evoked potentials (AEP). Combined with statistical analysis, the introduction of auditory steady state responses (ASSR) has enabled objective hearing tests in newborn hearing screening and automated hearing threshold assessment. The type and degree of hearing loss can be determined using the abovementioned methods...
December 8, 2017: HNO
https://www.readbyqxmd.com/read/29222007/current-concepts-in-pathogenesis-diagnosis-and-management-of-smoking-related-interstitial-lung-diseases
#9
REVIEW
Anupam Kumar, Sujith V Cherian, Robert Vassallo, Eunhee S Yi, Jay H Ryu
Tobacco exposure results in various changes to the airways and lung parenchyma. While emphysema represents the more common injury pattern, in some individuals, cigarette smoke injures alveolar epithelial and other lung cells resulting in diffuse infiltrates and parenchymal fibrosis. Smoking can trigger interstitial injury patterns mediated via recruitment and inappropriate persistence of myeloid and other immune cells including eosinophils. As our understanding of the role of cigarette smoke constituents in triggering lung injury continues to evolve, so does our recognition of the spectrum of smoking-related interstitial lung changes...
December 5, 2017: Chest
https://www.readbyqxmd.com/read/29198957/novel-families-of-archaeo-eukaryotic-primases-in-mobile-genetic-elements-of-bacteria-and-archaea
#10
Darius Kazlauskas, Guennadi Sezonov, Nicole Charpin, Česlovas Venclovas, Patrick Forterre, Mart Krupovic
Cellular organisms in different domains of life employ structurally unrelated, non-homologous DNA primases for synthesis of a primer for DNA replication. Archaea and eukaryotes encode enzymes of the archaeo-eukaryotic primase (AEP) superfamily, whereas bacteria uniformly use primases of the DnaG family. However, AEP genes are widespread in bacterial genomes raising questions regarding their provenance and function. Here, using an archaeal primase-polymerase PolpTN2 encoded by pTN2 plasmid as a seed for sequence similarity searches, we recovered over 800 AEP homologs from bacteria belonging to twelve highly diverse phyla...
November 30, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29193794/making-stillbirths-visible-a-systematic-review-of-globally-reported-causes-of-stillbirth
#11
REVIEW
H E Reinebrant, S H Leisher, M Coory, S Henry, A M Wojcieszek, G Gardener, R Lourie, D Ellwood, Z Teoh, E Allanson, H Blencowe, E S Draper, J J Erwich, J F Frøen, J Gardosi, K Gold, S Gordijn, A Gordon, Aep Heazell, T Y Khong, F Korteweg, J E Lawn, E M McClure, J Oats, R Pattinson, K Pettersson, D Siassakos, R M Silver, Gcs Smith, Ö Tunçalp, V Flenady
BACKGROUND: Stillbirth is a global health problem. The World Health Organization (WHO) application of the International Classification of Diseases for perinatal mortality (ICD-PM) aims to improve data on stillbirth to enable prevention. OBJECTIVES: To identify globally reported causes of stillbirth, classification systems, and alignment with the ICD-PM. SEARCH STRATEGY: We searched CINAHL, EMBASE, Medline, Global Health, and Pubmed from 2009 to 2016...
January 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29184956/influence-of-imide-substituents-on-the-h-type-aggregates-of-perylene-diimides-bearing-cetyloxy-side-chains-at-bay-positions
#12
Michael Ruby Raj, Rajamani Margabandu, Ramalinga Viswanathan Mangalaraja, Sambandam Anandan
A series of perylene-3,4:9,10-tetracarboxylic acid diimides (PDIs, namely TYR-PDI, AEP-PDI, CET-PDI, ANP-PDI and KOD-PDI), comprising long linear cetyloxy side-chains functionalized at the 1,7-bay positions and the different substituents (i.e., hydrophobic/hydrophilic segments) symmetrically linked at the two imide-positions of the perylene core were synthesized to investigate the influence of imide-substituent patterns on the aggregation behaviours of PDIs. The photophysical properties of these PDIs were studied by UV-Vis absorption, fluorescence and time-resolved photoluminescence spectroscopy...
November 29, 2017: Soft Matter
https://www.readbyqxmd.com/read/29178394/maturation-in-auditory-event-related-potentials-explains-variation-in-language-ability-in-children
#13
Elaine Y L Kwok, Marc F Joanisse, Lisa M D Archibald, Margot E Stothers, Heather M Brown, Janis Oram Cardy
Processing of auditory information in the cortex continues to develop into later childhood and adolescence. Recent research has indicated that intraclass correlation (ICC) is the best method for capturing maturation in auditory event-related potentials (AEPs) of school-age children. However, the sensitivity of the ICC approach in discerning AEP changes in children has not been consistently demonstrated and positive results have not been replicated. We attempted this replication and further explored whether AEP maturation estimated using the ICC approach predicts cognitive and linguistic abilities in addition to chronological age...
November 27, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29171825/guardians-of-the-mycobacterial-genome-a-review-on-dna-repair-systems-in-mycobacterium-tuberculosis
#14
Amandeep Singh
The genomic integrity of Mycobacterium tuberculosis is continuously threatened by the harsh survival conditions inside host macrophages, due to immune and antibiotic stresses. Faithful genome maintenance and repair must be accomplished under stress for the bacillus to survive in the host, necessitating a robust DNA repair system. The importance of DNA repair systems in pathogenesis is well established. Previous examination of the M. tuberculosis genome revealed homologues of almost all the major DNA repair systems, i...
November 24, 2017: Microbiology
https://www.readbyqxmd.com/read/29167648/paired-associative-stimulation-of-the-temporal-cortex-effects-on-the-auditory-steady-state-response
#15
Sarah Engel, Robert Daniel Heinrich Markewitz, Berthold Langguth, Martin Schecklmann
Background: Paired associative stimulation (PAS) is the repeated combination of a sensory stimulus with transcranial magnetic stimulation (TMS) in close temporal association. Recently, a study demonstrated that PAS of an auditory stimulus together with TMS of the temporal cortex is capable of changing the amplitude of auditory evoked potentials (AEP). Objective: This study examined the influence of tone duration and habituation in temporal cortex PAS as elicited by 40 and 20 Hz amplitude modulated auditory steady-state responses (aSSR)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29165072/mpeg-pla-micelle-for-delivery-of-effective-parts-of-andrographis-paniculata
#16
Hailu Yao, Shiyong Song, Xiaolu Miao, Xiao Liu, Zhen Wang, Xiaoting Shao, Yu Zhang, Guang Han
Many studies have shown that Andrographis paniculata (Burm. f.) Nees has a good anti-tumor effect, but poor solubility in water and poor bioavailability hinder the modernization of it. To formulate the effective parts (mainly diterpene lactones) of Andrographis paniculata (AEP) into targeting drug delivery system, a series of poly(ethylene glycol)-poly(D.L-lactic acid)(mPEG-PLA) with different ratio of hydrophilic and hydrophobic segment were synthetized to encapsulate AEP. AEP micelles were prepared by a simple solvent-evaporation method...
November 19, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29162999/language-experience-with-a-native-language-phoneme-sequence-modulates-the-effects-of-attention-on-cortical-sensory-processing
#17
Monica Wagner, Jungmee Lee, Francesca Mingino, Colleen O'Brien, Adam Constantine, Valerie L Shafer, Mitchell Steinschneider
Auditory evoked potentials (AEP) reflect spectro-temporal feature changes within the spoken word and are sufficiently reliable to probe deficits in auditory processing. The current research assessed whether attentional modulation would alter the morphology of these AEPs and whether native-language experience with phoneme sequences would influence the effects of attention. Native-English and native-Polish adults listened to nonsense word pairs that contained the phoneme sequence onsets /st/, /sət/, /pət/ that occur in both the Polish and English languages and the phoneme sequence onset /pt/ that occurs in the Polish language, but not the English language...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29152887/association-between-maternal-sleep-practices-and-late-stillbirth-findings-from-a-stillbirth-case-control-study
#18
Aep Heazell, M Li, J Budd, Jmd Thompson, T Stacey, R S Cronin, B Martin, D Roberts, E A Mitchell, Lme McCowan
OBJECTIVE: To report maternal sleep practices in women who experienced a stillbirth compared with controls with ongoing live pregnancies at similar gestation. DESIGN: Prospective case-control study. SETTING: Forty-one maternity units in the United Kingdom. POPULATION: Women who had a stillbirth after ≥ 28 weeks' gestation (n = 291) and women with an ongoing pregnancy at the time of interview (n = 733). METHODS: Data were collected using an interviewer-administered questionnaire that included questions on maternal sleep practices before pregnancy, in the four weeks prior to, and on the night before the interview/stillbirth...
November 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29138026/hybrid-dna-i-motif-aminoethylprolyl-pna-pc5-enhance-the-stability-of-dna-dc5-i-motif-structure
#19
Chandrasekhar Reddy Gade, Nagendra K Sharma
This report describes the synthesis of C-rich sequence, cytosine pentamer, of aep-PNA and its biophysical studies for the formation of hybrid DNA:aep-PNAi-motif structure with DNA cytosine pentamer (dC5) under acidic pH conditions. Herein, the CD/UV/NMR/ESI-Mass studies strongly support the formation of stable hybrid DNA i-motif structure with aep-PNA even near acidic conditions. Hence aep-PNA C-rich sequence cytosine could be considered as potential DNA i-motif stabilizing agents in vivo conditions.
November 3, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29135872/the-role-of-auditory-evoked-potentials-in-the-context-of-cochlear-implant-provision
#20
Sebastian Hoth, Oliver Christian Dziemba
: Auditory evoked potentials (AEP) are highly demanded during the whole process of equipping patients with cochlear implants (CI). They play an essential role in preoperative diagnostics, intraoperative testing, and postoperative monitoring of auditory performance and success. The versatility of AEP's is essentially enhanced by their property to be evokable by acoustic as well as electric stimuli. Thus, the electric responses of the auditory system following acoustic stimulation and recorded by the conventional surface technique as well as by transtympanic derivation from the promontory (Electrocochleography [ECochG]) are used for the quantitative determination of hearing loss and, additionally, electrically evoked compound actions potentials (ECAP) can be recorded with the intracochlear electrodes of the implant just adjacent to the stimulation electrode to check the functional integrity of the device and its coupling to the auditory system...
December 2017: Otology & Neurotology
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