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Xinnian Li, Norman C Duke, Yuchen Yang, Lishi Huang, Yuxiang Zhu, Zhang Zhang, Renchao Zhou, Cairong Zhong, Yelin Huang, Suhua Shi
Avicennia L. (Avicenniaceae), one of the most diverse mangrove genera, is distributed widely in tropical and subtropical intertidal zones worldwide. Five species of Avicennia in the Indo-West Pacific region have been previously described. However, their phylogenetic relationships were determined based on morphological and allozyme data. To enhance our understanding of evolutionary patterns in the clade, we carried out a molecular phylogenetic study using wide sampling and multiple loci. Our results support two monophyletic clades across all species worldwide in Avicennia: an Atlantic-East Pacific (AEP) lineage and an Indo-West Pacific (IWP) lineage...
2016: PloS One
Takeshi Saraya, Sunao Mikura, Miku Oda, Hajime Takizawa
A 47-year-old previously healthy man was admitted to the hospital with a 5-day history of fever, dry cough, and dyspnoea. Thoracic radiographs and CT scan showed extensive bilateral consolidation predominantly involving the central portions of the upper lung lobes, along with multiple scattered nodules. On taking a thorough history, it was found that the patient had visited a gritty 100-year-old Japanese folk house 1 week ago. An urgent bronchoscopy was performed, and the results were consistent with the findings of acute eosinophilic pneumonia (AEP)...
October 3, 2016: BMJ Case Reports
Xinyang Liu, Zhichao Wang, Guoliang Zhang, Qikun Zhu, Hui Zeng, Tao Wang, Feng Gao, Zhan Qi, Jinwen Zhang, Rui Wang
Esophageal cancer is one of the most common types of cancer and it has a poor prognosis. The molecular mechanisms of esophageal cancer progression remain largely unknown. In this study, we aimed to investigate the clinical significance and biological function of tumor necrosis factor receptor associated factor 6 (TRAF6) in esophageal cancer. Expression of TRAF6 in esophageal cancer was examined and its correlation with clinicopathological factors and patient prognosis was analyzed. A series of functional and mechanism assays were performed to further investigate the function and underlying mechanisms in esophageal cancer...
September 30, 2016: Oncology Research
James L Sheets, Judy Chia-Chun Yuan, Cortino Sukotjo, Alvin G Wee
The aim of this study was to determine the difference between the intended education by advanced education in prosthodontics (AEP) program directors and the perceived education received by AEP residents with respect to concepts of esthetic dentistry. Residents' confidence levels and current practices were also determined based on program level, with first- and second-year residents combined into "junior residents" and third- and fourth-year residents combined into "senior residents." Surveys were distributed to all U...
October 2016: Journal of Dental Education
Damian Scarf, Jillian G Hayhurst, Benjamin C Riordan, Mike Boyes, Ted Ruffman, John A Hunter
OBJECTIVE: Mental health problems are a leading cause of health-related disability during adolescence. The objectives of the current study were to investigate whether participating in an adventure education programme (AEP) increased adolescents' resilience and elucidate how social connectedness contributes to any increase. METHOD: Adolescents who participated in the AEP had their resilience measured on the first (Time 1) and last day (Time 2) of a 10-day voyage...
September 27, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Cheng Xu, Lu Cao, Jianhua Liu, Zhongrun Qian, Yu Peng, Wenjing Zhu, Yongming Qiu, Yingying Lin
Elevated circulating asparaginyl endopeptidase (AEP), a novel lysosomal protease, has been found in breast cancer, and AEP is thus considered to be a prognostic factor in this disease. However, the pathological functions of circulating AEP in the development of breast cancer and the potential of AEP-targeted therapy remain unclear. We used MMTV-PyVmT transgenic mice, which spontaneously develop mammary tumors. Western blotting showed overexpression of AEP in both primary tumor tissue and lung metastases compared to their normal counterparts...
September 22, 2016: Oncology Research
J David Monroe, Dustin P Manning, Phillip M Uribe, Ashwin Bhandiwad, Joseph A Sisneros, Michael E Smith, Allison B Coffin
Zebrafish are increasingly used in auditory studies, in part due to the development of several transgenic lines that express hair cell-specific fluorescent proteins. However, it is largely unknown how transgene expression influences auditory phenotype. We previously observed reduced auditory sensitivity in adult Brn3c:mGFP transgenic zebrafish, which express membrane-bound green fluorescent protein (GFP) in sensory hair cells. Here, we examine the auditory sensitivity of zebrafish from multiple transgenic and background strains...
September 16, 2016: Hearing Research
Lokendra K Thakur, Kunal Kishor Jha
In this report we describe the case of an 18 year old female who presented with fever, shortness of breath, and chest pain. Chest X-ray revealed diffuse bilateral infiltrates and eosinophilia was reported from her broncholaveolar lavage (BAL) fluid. She started smoking 3 weeks prior to the onset of symptoms and based on her clinical presentation, BAL findings and dramatic improvement, acute eosinophilic pneumonia (AEP) was diagnosed.
2016: Respiratory Medicine Case Reports
Limin Chuan, Ping He, Tongke Zhao, Huaiguo Zheng, Xinpeng Xu
In order to make clear the recent status and trend of wheat (Triticum aestivum L.) production in China, datasets from multiple field experiments and published literature were collected to study the agronomic characteristics related to grain yield, fertilizer application and nutrient use efficiency from the year 2000 to 2011. The results showed that the mean grain yield of wheat in 2000-2011 was 5950 kg/ha, while the N, P2O5 and K2O application rates were 172, 102 and 91 kg/ha on average, respectively. The decrease in N and P2O5 and increase in K2O balanced the nutrient supply and was the main reason for yield increase...
2016: PloS One
Jakob Duelund-Jakobsen, Lilli Lundby, Paul-Antoine Lehur, Vincent Wyart, Søren Laurberg, Steen Buntzen
: Sacral nerve stimulation (SNS) is effective for faecal incontinence (FI). Little is known about the relationship between the implantation technique and the functional outcome. AIM: The study aimed to explore the relationship between the numbers of active electrode poles (AEP) used during permanent lead placement and subsequent function, therapeutic amplitude and the need for extra appointments between scheduled follow-up visits. METHOD: 186 patients with FI who underwent permanent implantation between May-2009 and March-2015 with a tined (barbed) lead (3093/3080-Medtronic) using the straight stylet were registered on the European two-centre SNS prospective database (SNSPD)...
September 13, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Tatiana Balachova, Alla Shaboltas, Andrey Nasledov, Mark Chaffin, Julia Batluk, Som Bohora, Barbara Bonner, Kendall Bryant, Larissa Tsvetkova, Elena Volkova
Russia has one of the fastest rising rates of HIV among women in the world. This study sought to identify key factors in HIV transmission among women in Russia. Data were collected as part of a larger clinical trial to prevent alcohol-exposed pregnancies (AEP). Women at risk for an AEP were recruited at women's clinics; 708 women, aged 18-44 (M = 29.04 years), completed HIV risk surveys. Structural Equation Modeling was used to test the relationships between alcohol use and sex behavior constructs with HIV/STI risk...
September 7, 2016: AIDS and Behavior
John J Foxe, Kelly M Burke, Gizely N Andrade, Aleksandra Djukic, Hans-Peter Frey, Sophie Molholm
BACKGROUND: Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses...
2016: Journal of Neurodevelopmental Disorders
Guangchen Liu, Yu Sheng, Mei Zhang, Dahui Sun
In the present study, we isolated and characterized one purified polysaccharide (AEP-1) from the leaves of Aralia elata, and investigated its effect on human osteosarcoma (OS) U-2 OS cell line and analyzed its mechanism. MTT assays showed that AEP-1 markedly inhibited the growth of U-2 OS cells in a dose- and time-dependent fashion, suggesting a cytotoxic effect. The AEP-1 also dose-dependently induced DNA fragmentation and caused apoptotic death in U-2 OS cells. The event of apoptosis was accompanied by increased ratio of Bax/Bcl-2, depolarization of mitochondrial membrane potential (Δym) and the release of cytochrome c from mitochondria into the cytoplasm...
August 31, 2016: International Journal of Biological Macromolecules
Wenjing Zhu, Yiqun Shao, Ming Yang, Moran Jia, Yu Peng
Recurrence and metastasis are the major lethal causes of prostate cancer. It is urgent to find out the mechanisms and key factors governing prostate cancer progression and metastasis for developing new therapeutic strategies. Asparaginyl endopeptidase (AEP) overexpression has been found in a number of solid tumors. In prostate cancer, AEP has also been shown to exhibit a vesicular staining pattern and significantly associated with advanced tumor stage, high Gleason score, perineural invasion, and larger tumor...
December 15, 2016: Gene
Hiroshi Okuda, Satoshi Takahashi, Akifumi Takaori-Kondo, Akihiko Yokoyama
Gene rearrangement of the mixed lineage leukemia (MLL) gene causes leukemia by inducing the constitutive expression of a gene subset normally expressed only in the immature haematopoietic progenitor cells. MLL gene rearrangements often generate fusion products of MLL and a component of the AF4 family/ENL family/P-TEFb (AEP) complex. MLL-AEP fusion proteins have the potential of constitutively recruiting the P-TEFb elongation complex. Thus, it is hypothesized that relieving the promoter proximal pausing of RNA polymerase II is the rate-limiting step of MLL fusion-dependent transcription...
October 17, 2016: Cell Cycle
Leonardo M Fonseca, Tatiana C Garcez, Luciana Penha, Leonardo Freire-DE-Lima, Emmanuel Maes, Kelli M Costa, Lucia Mendonça-Previato, Jose O Previato
One of the main obstacles to the treatment of Chagas disease is the genetic and phenotypical variance displayed by T. cruzi strains, resulting in differences in morphology, virulence, pathogenicity and drug susceptibility. To better understand the role of glycoconjungates in Chagas disease, we performed the molecular characterization of the O-linked chains from mucins and glycoinositolphospholipids (GIPLs) of the Silvio X10 clone 1 strain. We demonstrated the presence of a β-galactofuranose (β-Galf) unity linked to the O-4 position of the α-N-acetylglucosamine (α-GlcNAc)O-4 in Tc-mucins...
September 2016: Anais da Academia Brasileira de Ciências
N P M Todd, S Govender, J G Colebatch
Todd et al. (2014ab) have recently demonstrated the presence of vestibular-dependent contributions to auditory evoked potentials (AEPs) when passing through the vestibular threshold as determined by vestibular evoked myogenic potentials (VEMPs), including a particular deflection labeled as an N42/P52 prior to the long-latency AEPs N1 and P2. In this paper we report the results of an experiment to determine the effect of inter-stimulus interval (ISI) and regularity on potentials recorded above and below VEMP threshold...
August 3, 2016: Hearing Research
Fran López-Caballero, Katarzyna Zarnowiec, Carles Escera
Deviance detection is a key functional property of the auditory system that allows pre-attentive discrimination of incoming stimuli not conforming to a rule extracted from the ongoing constant stimulation, thereby proving that regularities in the auditory scene have been encoded in the auditory system. Using simple-feature stimulus deviations, regularity encoding and deviance detection have been reported in brain responses at multiple latencies of the human Auditory Evoked Potential (AEP), such as the Mismatch Negativity (MMN; peaking at 100-250ms from stimulus onset) and Middle-Latency Responses (MLR; peaking at 12-50ms)...
October 2016: Biological Psychology
Marcin Poreba, Rigmor Solberg, Wioletta Rut, Ngoc Nguyen Lunde, Paulina Kasperkiewicz, Scott J Snipas, Marko Mihelic, Dusan Turk, Boris Turk, Guy S Salvesen, Marcin Drag
Legumain (AEP) is a lysosomal cysteine protease that was first characterized in leguminous seeds and later discovered in higher eukaryotes. AEP upregulation is linked to a number of diseases including inflammation, arteriosclerosis, and tumorigenesis. Thus this protease is an excellent molecular target for the development of new chemical markers. We deployed a hybrid combinatorial substrate library (HyCoSuL) approach to obtain P1-Asp fluorogenic substrates and biotin-labeled inhibitors that targeted legumain...
August 18, 2016: Cell Chemical Biology
Damian Scarf, Saleh Moradi, Kate McGaw, Joshua Hewitt, Jillian G Hayhurst, Mike Boyes, Ted Ruffman, John A Hunter
This study sought to examine the role of belonging in the increases in resilience observed following an adventure education programme (AEP). First, we demonstrate that group belonging makes a significant contribution to the improvement in resilience participants' experienced over the course of the AEP. Second, we demonstrate that this increase in resilience is maintained 9 months following the AEP and that group belonging maintained a significant contribution when controlling for participants' initial resilience level and other psychosocial variables (i...
September 2016: British Journal of Social Psychology
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