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https://www.readbyqxmd.com/read/28227697/simultaneous-evaluation-of-prepulse-inhibition-with-emg-and-eeg-using-advanced-artifact-removal-techniques
#1
Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Paulo R Menezes, Claudemiro V Noya, Rosana Shuhama, Milton A Avila, Cristina M Del-Ben, Cristiane Salum, Rodrigo S Martin, Maria I Zimiani
Prepulse inhibition (PPI) consists of a reduction of the acoustic startle reflex (SR) magnitude (measured with EMG) when a startling stimulus is preceded by a non-startling one. This behavior has been extensively investigated in studies related to schizophrenia, since sensory-motor deficit plays a central role in its pathophysiology. However, the same auditory stimuli that trigger the SR also provoke intense auditory evoked responses (AEP), which can be measured with EEG. Comparing these two types of responses, acquired simultaneously, is a great opportunity to investigate the dependence and interdependence of their neural pathways...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223821/asparaginyl-endopeptidase-improves-the-resistance-of-microtubule-targeting-drugs-in-gastric-cancer-through-iqgap1-modulating-the-egfr-jnk-erk-signaling-pathway
#2
Yuehong Cui, Qian Li, Hong Li, Yan Wang, Hongshan Wang, Weidong Chen, Shangmin Zhang, Jian Cao, Tianshu Liu
PURPOSE: In recent years, understanding of the role of asparaginyl endopeptidase (AEP) in tumorigenesis has steadily increased. In this study, we investigated whether AEP expression correlates with sensitivity to chemotherapeutic drugs in gastric cancer and explored the mechanism. PATIENTS AND METHODS: AEP expression in the serum of patients' peripheral blood was measured by enzyme-linked immunosorbent assay. Patient survival time was evaluated using univariate and multivariate analyses...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28202283/from-typical-sequences-to-typical-genotypes
#3
Omri Tal, Tat Dat Tran, Jacobus Portegies
We demonstrate an application of a core notion of information theory, typical sequences and their related properties, to analysis of population genetic data. Based on the asymptotic equipartition property (AEP) for nonstationary discrete-time sources producing independent symbols, we introduce the concepts of typical genotypes and population entropy and cross entropy rate. We analyze three perspectives on typical genotypes: a set perspective on the interplay of typical sets of genotypes from two populations, a geometric perspective on their structure in high dimensional space, and a statistical learning perspective on the prospects of constructing typical-set based classifiers...
February 12, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28199119/engineering-a-catalytically-efficient-recombinant-protein-ligase
#4
Renliang Yang, Yee Hwa Wong, Giang K T Nguyen, James P Tam, Julien Lescar, Bin Wu
Breaking and forming peptidyl bonds are fundamental biochemical reactions in protein chemistry. Unlike proteases that are abundantly available, fast-acting ligases are rare. OaAEP1 is an enzyme isolated from the cyclotide-producing plant oldenlandia affinis that displayed weak peptide cyclase activity, despite having a similar structural fold with other asparaginyl endopeptidases (AEP). Here we report the first atomic structure of OaAEP1, at a resolution of 2.56 Å, in its pre-activation form. Our structure and biochemical analysis of this enzyme reveals its activation mechanism as well as structural features important for its ligation activity...
February 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28196751/-hospital-emergencies-arising-from-nursing-homes-in-a-region-evolution-characteristics-and-appropriateness
#5
Inma Sánchez-Pérez, Nuri Comes Garcia, Lola Romero Piniella, Gemma Prats Martos, Gemma Arnau Bataller, Jordi Coderch
OBJECTIVE: Hospital emergencies (HE) arising from nursing homes (NH) are on the rise. We analyse the evolution, characteristics and appropriateness of HE of NH residents in a region, as well as resulting hospital admissions. METHOD: Retrospective descriptive study between 2010 and 2013 of institutionalised residents of 11 NH located in Baix Empordà (704 beds) and Palamós Hospital. VARIABLES: Gender, age, morbidity and relative weight according to clinical risk groups (CRG), NH, length of stay, diagnosis of the emergency, appropriateness of HE according to Bermejo's criteria and the HE appropriateness protocol (HEAP), and appropriateness of hospitalisations according to the Appropriateness Evaluation Protocol (AEP)...
February 10, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28173632/impact-of-the-choices-intervention-in-preventing-alcohol-exposed-pregnancies-in-american-indian-women
#6
Jessica D Hanson, Morgan E Nelson, Jamie L Jensen, Amy Willman, Jacque Jacobs-Knight, Karen Ingersoll
BACKGROUND: Fetal Alcohol Spectrum Disorders (FASD) comprise a continuum of lifelong outcomes in those born prenatally exposed to alcohol. Although studies have shown no differences in rates by race, FASD is of particular concern for American Indian communities. One tribally-run prevention program is the Oglala Sioux Tribe (OST) CHOICES Program, which is modeled after the evidence-based CHOICES program that was focused on preconceptional prevention of alcohol-exposed pregnancy (AEP) by reducing risky drinking in women at-risk for pregnancy and/or preventing unintended pregnancy...
February 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28139852/eosinophil-transendothelial-migration-induced-by-the-bronchoalveolar-lavage-fluid-of-acute-eosinophilic-pneumonia
#7
Kazuyuki Nakagome, Hisakazu Shoda, Tetsu Shirai, Fuyumi Nishihara, Tomoyuki Soma, Yoshitaka Uchida, Yoshio Sakamoto, Makoto Nagata
BACKGROUND AND OBJECTIVE: Acute eosinophilic pneumonia (AEP) is characterized by a massive pulmonary infiltration of eosinophils. Mechanisms regulating the selective accumulation of eosinophils in AEP have not been fully established. The objective of this study was to evaluate the mechanisms of eosinophil accumulation in alveolar spaces through examination of bronchoalveolar lavage fluid (BALF) from AEP patients (AEP-BALF). METHODS: Eosinophils were isolated from the blood of healthy subjects and were placed on a human pulmonary microvascular endothelial cell monolayer cultured on Transwell filters (Coster, Cambridge, MA, USA)...
January 31, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28089392/-views-of-the-spanish-paediatric-association-bioethics-committee-on-the-refusal-of-essential-and-non-essential-treatment-in-minors
#8
Marta Sánchez Jacob, María Tasso Cereceda, Carmen Martínez González, Federico de Montalvo Jááskeläinem, Isolina Riaño Galán
The conflicts that arise when minors or their legal representatives refuse to receive medical treatment considered necessary by the paediatrician pose a serious ethical dilemma and also have a considerable emotional impact. In order to adequately tackle this rejection of medical treatment, there is to identify and attempt to understand the arguments of the people involved, to consider the context in each individual case and be conversant with the procedure to follow in life-threatening scenarios, taking into account bioethical considerations and the legal framework...
January 11, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28067825/primpol-prime-time-to-reprime
#9
REVIEW
Thomas A Guilliam, Aidan J Doherty
The complex molecular machines responsible for genome replication encounter many obstacles during their progression along DNA. Tolerance of these obstructions is critical for efficient and timely genome duplication. In recent years, primase-polymerase (PrimPol) has emerged as a new player involved in maintaining eukaryotic replication fork progression. This versatile replicative enzyme, a member of the archaeo-eukaryotic primase (AEP) superfamily, has the capacity to perform a range of template-dependent and independent synthesis activities...
January 6, 2017: Genes
https://www.readbyqxmd.com/read/28045650/reduction-in-alert-fatigue-in-an-assisted-electronic-prescribing-system-through-the-lean-six-sigma-methodology
#10
Mª Jesús Cuéllar Monreal, Jorge Reig Aguado, Isabel Font Noguera, José Luis Poveda Andrés
OBJECTIVE: To reduce the alert fatigue in our Assisted Electronic Prescribing System (AEPS), through the Lean Six Sigma (LSS) methodology. METHOD: An observational (transversal) and retrospective study, in a general hospital with 850 beds and AEPS. The LSS methodology was followed in order to evaluate the alert fatigue situation in the AEPS system, to implement improvements, and to assess outcomes. The alerts generated during two trimesters studied (before and after the intervention) were analyzed...
January 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28038948/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2017-recommendations
#11
David Moreno-Pérez, Francisco José Álvarez García, Javier Arístegui Fernández, María José Cilleruelo Ortega, José María Corretger Rauet, Nuria García Sánchez, Ángel Hernández Merino, Teresa Hernández-Sampelayo Matos, Manuel Merino Moína, Luis Ortigosa Del Castillo, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics (CAV- AEP) annually publishes the immunisation schedule which, in our opinion, is considered optimal for children resident in Spain, taking into account the evidence available on current vaccines. Pneumococcal and varicella immunisation in early childhood is already included in all funded vaccines present in the regional immunisation programmes. Furthermore, this committee establishes recommendations on vaccines not included in official calendars (non-funded immunisations), such as rotavirus, meningococcal B, and meningococcal ACWY...
February 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28031826/acute-eosinophilic-pneumonia-following-heat-not-burn-cigarette-smoking
#12
Takahiro Kamada, Yosuke Yamashita, Hiromi Tomioka
A 20-year-old man was admitted with acute respiratory failure. He had started smoking 20 heat-not-burn cigarettes (HC) per day 6 months previously, then purchased a second device for smoking HC to increase smoking to 40 cigarettes per day 2 weeks before hospitalization. Acute eosinophilic pneumonia (AEP) was diagnosed based on medical history, chest high-resolution computed tomographic findings, and bronchoalveolar lavage fluid eosinophilia. On starting treatment with prednisolone, the patient exhibited complete recovery...
November 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28003110/eosinophilic-pneumonia-caused-by-daptomycin-six-cases-from-two-institutions-and-a-review-of-the-literature
#13
Jun Hirai, Mao Hagihara, Shusaku Haranaga, Takeshi Kinjo, Hiroe Hashioka, Hideo Kato, Daisuke Sakanashi, Yuka Yamagishi, Hiroshige Mikamo, Jiro Fujita
Here we report six cases of daptomycin (DAP)-induced eosinophilic pneumonia (DIEP) encountered at two medical centers and present a review of 43 DIEP patients from 26 studies to compare the clinical characteristics and radiographic findings of acute and chronic eosinophilic pneumonia (AEP; CEP). Four of the six patients did not exhibit respiratory symptoms, and one patient with only fever was misdiagnosed with DAP-induced fever. According to our literature review and the present findings, male sex and old age were dominant risk factors for DIEP...
December 18, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27965573/7-8-dihydroxyflavone-ameliorates-cognitive-impairment-by-inhibiting-expression-of-tau-pathology-in-apoe-knockout-mice
#14
Yang Tan, Shuke Nie, Wende Zhu, Fang Liu, Hailong Guo, Jiewen Chu, Xue B Cao, Xingjun Jiang, Yunjian Zhang, Yuzhen Li
7,8-Dihydroxyflavone (7,8-DHF), a tyrosine kinase B agonist that mimics the neuroprotective properties of brain-derived neurotrophic factor, which can not efficiently deliver into the brain, has been reported to be useful in ameliorating cognitive impairment in many diseases. Researches have indicated that apolipoprotein E-knockout (ApoE-KO) mouse was associated with cognitive alteration via various mechanisms. Our present study investigated the possible mechanisms of cognitive impairment of ApoE-KO mouse fed with western type diet and the protective effects of 7,8-DHF in improving spatial learning and memory in ApoE-KO mouse...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27933855/mesoporous-silica-nanoparticles-with-large-pores-for-the-encapsulation-and-release-of-proteins
#15
Jing Tu, Aimee L Boyle, Heiner Friedrich, Paul H H Bomans, Jeroen Bussmann, Nico A J M Sommerdijk, Wim Jiskoot, Alexander Kros
Mesoporous silica nanoparticles (MSNs) have been explored extensively as solid supports for proteins in biological and medical applications. Small (<200 nm) MSNs with ordered large pores (>5 nm), capable of encapsulating therapeutic small molecules suitable for delivery applications in vivo, are rare however. Here we present small, elongated, cuboidal, MSNs with average dimensions of 90 × 43 nm that possess disk-shaped cavities, stacked on top of each other, which run parallel to the short axis of the particle...
November 30, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27914993/-solid-paediatricians-in-fluid-times-reviving-professionalism
#16
Carmen Martínez González, María Tasso Cereceda, Marta Sánchez Jacob, Isolina Riaño Galán
Professionalism is rarely taught formally. It is learned by osmosis through the hidden curriculum: a set of attitudes that each one of us transmits unconsciously to students, medical residents, and colleagues. All of us are a model or counter-model of professionalism through a series of values that have been the pillars of our profession since Hippocrates. Values that do not seem to be strong enough to pass our time. There are specific factors of the 21st century such as the financial crisis, the highly technical nature of medicine, bureaucratisation or trivialisation of the medical process that could explain, but not justify, the decline in the values of our profession: Empathy, integrity, solidarity, the altruism, or confidentiality...
November 30, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27905202/care-in-subsequent-pregnancies-following-stillbirth-an-international-survey-of-parents
#17
A M Wojcieszek, F M Boyle, J M Belizán, J Cassidy, P Cassidy, Jjhm Erwich, L Farrales, M M Gross, Aep Heazell, S H Leisher, T Mills, M Murphy, K Pettersson, C Ravaldi, J Ruidiaz, D Siassakos, R M Silver, C Storey, A Vannacci, P Middleton, D Ellwood, V Flenady
OBJECTIVE: To assess the frequency of additional care, and parents' perceptions of quality, respectful care, in pregnancies subsequent to stillbirth. DESIGN: Multi-language web-based survey. SETTING: International. POPULATION: A total of 2716 parents, from 40 high- and middle-income countries. METHODS: Data were obtained from a broader survey of parents' experiences following stillbirth. Data were analysed using descriptive statistics and stratified by geographic region...
November 30, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27894890/convergent-individual-differences-in-visual-cortices-but-not-the-amygdala-across-standard-amygdalar-fmri-probe-tasks
#18
Victoria Villalta-Gil, Kendra E Hinton, Bennett A Landman, Benjamin C Yvernault, Scott F Perkins, Allison S Katsantonis, Courtney L Sellani, Benjamin B Lahey, David H Zald
: The amygdala (AMG) has been repeatedly implicated in the processing of threatening and negatively valenced stimuli and multiple fMRI paradigms have reported personality, genetic, and psychopathological associations with individual differences in AMG activation in these paradigms. Yet the interchangeability of activations in these probes has not been established, thus it remains unclear if we can interpret AMG responses on specific tasks as general markers of its reactivity. In this study we aimed to assess if different tasks that have been widely used within the Affective Neuroscience literature consistently recruit the AMG...
February 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/27870483/transcriptome-analysis-of-the-regenerating-tail-versus-the-scarring-limb-in-lizard-reveals-pathways-leading-to-successful-versus-unsuccessful-organ-regeneration-in-amniotes
#19
Nicola Vitulo, Luisa Dalla Valle, Tatjana Skobo, Giorgio Valle, Lorenzo Alibardi
BACKGROUND: lizards are amniotes regenerating the tail but not the limb and no information on their different gene expression is available. RESULTS: transcriptomes of regenerating tail and limb blastemas show differences in gene expression between the two organs. In tail blastema snoRNAs and Wnt signals appear up-regulated probably in association with the Apical Epidermal Peg (AEP), an epithelial region that sustains tail regeneration but is absent in the limb. A balance between pro-oncogenes and tumor suppressors is likely present in tail blastema allowing a regulated proliferation...
November 21, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27865805/transcriptional-activation-by-mll-fusion-proteins-in-leukemogenesis
#20
REVIEW
Akihiko Yokoyama
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause aggressive leukemia. Fusion proteins of MLL and a component of the AF4 family/ENL family/P-TEFb complex (AEP) are responsible for two-thirds of MLL-associated leukemia cases. MLL-AEP fusion proteins trigger aberrant self-renewal of hematopoietic progenitors by constitutively activating self-renewal-related genes. MLL-AEP fusion proteins activate transcription initiation by loading the TATA-binding protein (TBP) to the TATA element via selectivity factor 1...
November 16, 2016: Experimental Hematology
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