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https://www.readbyqxmd.com/read/28920116/development-of-a-smart-activity-based-probe-to-detect-subcellular-activity-of-asparaginyl-endopeptidase-in-living-cells
#1
Jong-Ah Hong, Na-Eun Choi, Yeo-Kyoung La, Ho Yeon Nam, Jiwon Seo, Jiyoun Lee
We developed a smart activity-based probe that detects the activity of asparaginyl endopeptidase (AEP) in live cells to monitor the dynamics of enzyme regulation. The newly designed probe generated a turn-on fluorescence signal in response to the activity of AEP in living cells without compromising the labelling efficiency or selectivity. Our probe closely reflected the enzyme activity in its native state, detecting subcellular AEP activity in colon cancer cells and neuronal cells.
September 18, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28906245/potential-audiological-and-mri-markers-of-tinnitus
#2
Kamakshi V Gopal, Binu P Thomas, Rajesh Nandy, Deng Mao, Hanzhang Lu
BACKGROUND: Subjective tinnitus, or ringing sensation in the ear, is a common disorder with no accepted objective diagnostic markers. PURPOSE: The purpose of this study was to identify possible objective markers of tinnitus by combining audiological and imaging-based techniques. RESEARCH DESIGN: Case-control studies. STUDY SAMPLE: Twenty adults drawn from our audiology clinic served as participants. The tinnitus group consisted of ten participants with chronic bilateral constant tinnitus, and the control group consisted of ten participants with no history of tinnitus...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28885966/the-effect-of-anthropomorphic-test-device-lower-leg-surrogate-selection-on-impact-mitigating-system-evaluation-in-low-and-high-rate-loading-conditions
#3
Cheryl E Quenneville, Ed Fournier, Nicholas Shewchenko
INTRODUCTION: The lower legs are at risk of substantial injury during events such as frontal automotive crashes and antivehicular mine blasts. Loading to occupants can be assessed using an instrumented anthropomorphic test device (ATD), whose measurements can be compared to established injury criteria. NATO's AEP-55 STANAG 4569 recognizes two surrogates for lower leg injury assessments from impacts with intruding floor pans resulting from underbelly blast loads; (1) the rigid Hybrid III instrumented lower leg, and; (2) the compliant MILitary Lower eXtremity (MIL-LX)...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28883656/the-presence-of-acquired-enamel-pellicle-changes-acid-induced-erosion-from-dissolution-to-a-softening-process
#4
Mahdi Mutahar, Guy Carpenter, David Bartlett, Matthew German, Rebecca Moazzez
Erosive wear undermines the structural properties of enamel resulting in irreversible enamel loss. A thin protein layer formed from natural saliva on tooth surfaces, acquired enamel pellicle (AEP), protects against erosive wear. The exact components in saliva responsible for such protection are not yet known. We prepared three solutions containing different components: proteins and ions [natural saliva (NS)], minerals with no proteins [artificial saliva (AS)] and neither proteins nor ions [deionised water (DW)]...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875265/possible-role-of-il-25-in-eosinophilic-lung-inflammation-in-patients-with-chronic-eosinophilic-pneumonia
#5
Shigeki Katoh, Masaki Ikeda, Nobuhiro Matsumoto, Hiroki Shimizu, Masaaki Abe, Yoshihiro Ohue, Keiji Mouri, Yoshihiro Kobashi, Masamitsu Nakazato, Mikio Oka
PURPOSE: Interleukin (IL)-25 and IL-33 induce IL-5 production by various types of cells, such as type 2 helper T (Th2) cells and type 2 innate lymphoid cells. The number of Th2 cells and concentration of IL-5 in the bronchoalveolar lavage fluid (BALF) are increased in patients with eosinophilic pneumonia (EP). To examine the contribution of IL-25 and IL-33 to eosinophilic inflammation of the lung in humans, we evaluated IL-5, IL-25 and IL-33 levels in the BALF of patients with EP. METHODS: IL-5, IL-25, and IL-33 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), idiopathic pulmonary fibrosis (IPF), and sarcoidosis...
September 5, 2017: Lung
https://www.readbyqxmd.com/read/28837608/reduced-statherin-in-acquired-enamel-pellicle-on-eroded-teeth-compared-to-healthy-teeth-in-the-same-subjects-an-in-vivo-study
#6
Mahdi Mutahar, Saoirse O'Toole, Guy Carpenter, David Bartlett, Manoharan Andiappan, Rebecca Moazzez
The aim of this in-vivo study was to compare total protein and four key salivary proteins present in the acquired enamel pellicle (AEP) on eroded and non-eroded surfaces in participants with erosive tooth wear. Participants with erosive tooth wear of dietary non-intrinsic origin, present on the occlusal surfaces of the lower first molars and an unaffected posterior occlusal surface in the same quadrant were recruited from restorative dental clinics at King's College London Dental Institute (n = 29, REC ref 14/EM/1171)...
2017: PloS One
https://www.readbyqxmd.com/read/28836038/the-effects-of-stimulus-parameters-on-auditory-evoked-potentials-of-carassius-auratus
#7
Jessica R Garabon, Dennis M Higgs
Whole-brain responses to sound are easily measured through auditory evoked potentials (AEP), but it is unclear how differences in experimental parameters affect these responses. The effect of varying parameters is especially unclear in fish studies, the majority of which use simple sound types and then extrapolate to natural conditions. The current study investigated AEPs in goldfish (Carassius auratus) using sounds of different durations (5, 10, and 20 ms) and frequencies (200, 500, 600 and 700 Hz) to test stimulus effects on latency and thresholds...
August 23, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28826672/delta-secretase-phosphorylation-by-srpk2-enhances-its-enzymatic-activity-provoking-pathogenesis-in-alzheimer-s-disease
#8
Zhi-Hao Wang, Pai Liu, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Shan Ping Yu, Jian-Zhi Wang, Keqiang Ye
Delta-secretase, a lysosomal asparagine endopeptidase (AEP), simultaneously cleaves both APP and tau, controlling the onset of pathogenesis of Alzheimer's disease (AD). However, how this protease is post-translationally regulated remains unclear. Here we report that serine-arginine protein kinase 2 (SRPK2) phosphorylates delta-secretase and enhances its enzymatic activity. SRPK2 phosphorylates serine 226 on delta-secretase and accelerates its autocatalytic cleavage, leading to its cytoplasmic translocation and escalated enzymatic activities...
September 7, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28820254/blockade-of-asparagine-endopeptidase-inhibits-cancer-metastasis
#9
Qi Qi, Obiamaka Obianyo, Yuhong Du, Haian Fu, Shiyong Li, Keqiang Ye
Asparagine endopeptidase (AEP), also called legumain, is highly expressed in various solid tumors, promoting cancer cell invasion, migration, and metastasis. It has been proposed to be a prognostic marker and therapeutic target for cancer treatment. However, an effective nonpeptide, small-molecule inhibitor against this protease has not yet been identified. Here we show that a family of xanthine derivatives selectively inhibit AEP and suppress matrix metalloproteinase (MMP) cleavage, leading to the inhibition of cancer metastasis...
September 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28818810/evaluating-quality-of-life-in-epilepsy-the-role-of-screening-for-adverse-drug-effects-depression-and-anxiety
#10
Jean-Arthur Micoulaud-Franchi, Fabrice Bartolomei, Roderick Duncan, Aileen McGonigal
OBJECTIVE: The objective of this study was to evaluate the contribution of validated screening tools for antiepileptic drug (AED) adverse effects, depression, and anxiety to measure the quality of life (QoL) in people with epilepsy (PWE). METHODS: Patients in a tertiary epilepsy service were screened for quality of life (using QOLIE-31), major depressive disorder (MDD) (NDDI-E), generalized anxiety disorder (GAD) (GAD-7), and AED effects (AEP). Mini International Neuropsychiatric Interview (MINI) generalized anxiety disorder module was also performed...
August 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28806986/antihyperlipidaemic-and-hepatoprotective-activities-of-acidic-and-enzymatic-hydrolysis-exopolysaccharides-from-pleurotus-eryngii-si-04
#11
Chen Zhang, Juan Li, Jing Wang, Xingling Song, Jianjun Zhang, Shang Wu, Chunlong Hu, Zhiyuan Gong, Le Jia
BACKGROUND: Hyperlipidaemia is the major risk factor contributing to the development and progression of atherosclerosis, fatty liver and cerebrovascular disease. Pleurotus eryngii (P. eryngii) is rich in biologically active components, especially polysaccharides that exhibit various biological activities, including reducing blood lipids. In the present study, three novel polysaccharide types, including exopolysaccharides (EPS), enzymatic EPS (EEPS) and acidic EPS (AEPS) were isolated, and the hypolipidaemic and hepatoprotective effects were investigated to better understand possible hypolipidaemic mechanisms and their hepatoprotective effects...
August 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28772264/development-of-auditory-evoked-responses-in-normally-developing-preschool-children-and-children-with-autism-spectrum-disorder
#12
Julia M Stephen, Dina E Hill, Amanda Peters, Lucinda Flynn, Tongsheng Zhang, Yoshio Okada
The cortical responses to auditory stimuli undergo rapid and dramatic changes during the first 3 years of life in normally developing (ND) children, with decreases in latency and changes in amplitude in the primary peaks. However, most previous studies have focused on children >3 years of age. The analysis of data from the early stages of development is challenging because the temporal pattern of the evoked responses changes with age (e.g., additional peaks emerge with increasing age) and peak latency decreases with age...
2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28759312/wanted-and-unwanted-care-the-double-edged-sword-of-partial-do-not-resuscitate-orders
#13
Nobuhiro Ariyoshi, Masayuki Nogi, Damon Sakai, Eiji Hiraoka, Daniel Fischberg
BACKGROUND: The interpretation of do-not-resuscitate orders (DNRs) may vary in nonarrest situations. To reduce ambiguity, many hospitals allow patients to elect partial DNRs. OBJECTIVE: To investigate the effect of partial DNRs on physicians' willingness to perform cardiopulmonary resuscitation (CPR) and nonarrest procedures. DESIGN: Cross-sectional study using scenario-based questionnaires between October 2015 and March 2016. A partial DNR was identified as a DNR with Adult Emergency Protocols (AEP) order...
July 31, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28756462/effects-of-gaba-b-receptor-positive-modulator-on-ketamine-induced-psychosis-relevant-behaviors-and-hippocampal-electrical-activity-in-freely-moving-rats
#14
Jingyi Ma, L Stan Leung
RATIONALE: Decreased GABAB receptor function is proposed to mediate some symptoms of schizophrenia. OBJECTIVES: In this study, we tested the effect of CGP7930, a GABAB receptor positive allosteric modulator, on ketamine-induced psychosis-relevant behaviors and hippocampal electrical activity in behaving rats. METHODS: Electrodes were bilaterally implanted into the hippocampus, and cannulae were placed into the lateral ventricles of Long-Evans rats...
July 29, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28753163/cortical-processing-of-vocal-and-nonvocal-sounds-in-cochlear-implanted-children-an-electrophysiological-study
#15
David Bakhos, John Galvin, Sylvie Roux, Emmanuel Lescanne, Nicole Bruneau
OBJECTIVES: For prelingually deaf children, cochlear implants (CIs) can restore auditory input to the auditory cortex and the ability to acquire spoken language. Language development is strongly intertwined with voice perception. The aim of this electrophysiological study was to investigate human voice processing using measures of cortical auditory evoked potentials (AEPs) in pediatric CI users. DESIGN: Cortical AEPs were measured in 8 CI children (4 to 12 years old) with good auditory and language performance and 8 normal-hearing (NH) age-matched controls...
July 27, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28749393/adverse-effects-drug-load-of-antiepileptic-drugs-in-patients-with-epilepsy-monotherapy-versus-polytherapy
#16
Rupa Joshi, Manjari Tripathi, Pooja Gupta, Sheffali Gulati, Yogendra Kumar Gupta
BACKGROUND & OBJECTIVES: Although the need for a combination of antiepileptic drugs (AEDs) in the treatment of epilepsy is well justified, but an associated increase in adverse effects (AEs) lends a restriction to polytherapy. The aim of this study was to evaluate AEs and drug load (prescribed daily dose/defined daily doses) of AEDs in patients with epilepsy (PWE). METHODS: Consecutive PWEs attending Epilepsy clinic in a tertiary care hospital in New Delhi, India, were enrolled in the study...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28733722/non-specific-chronic-low-back-pain-differences-in-spinal-kinematics-in-subgroups-during-functional-tasks
#17
Rebecca Hemming, Liba Sheeran, Robert van Deursen, Valerie Sparkes
PURPOSE: A multidimensional classification approach suggests that motor control impairment subgroups exist in non-specific chronic low back pain (NSCLBP). Differences in sitting lumbar posture have been identified between two such subgroups [flexion pattern (FP) and active extension pattern (AEP)] and healthy individuals; however, functional spinal movement has not been explored. This study will evaluate whether NSCLBP subgroups exhibit regional spinal kinematic differences, compared to healthy individuals, during functional tasks...
July 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28712020/considering-weight-loss-programs-and-public-health-partnerships-in-american-evangelical-protestant-churches
#18
D Gibbes Miller
The obesity epidemic is a critical public health threat facing the USA. With the advent of American Evangelical Protestant (AEP) weight loss guides and narratives, AEP churches could potentially aid public health agencies in combatting obesity, and some scholars have called for investment in partnerships between public health agencies and religious institutions. This paper examines the theological and social underpinnings of AEP weight loss programs and considers the potential benefits and risks of public health partnerships with AEP churches to combat obesity...
July 15, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28711476/treatment-in-early-psychosis-with-n-acetyl-cysteine-for-6months-improves-low-level-auditory-processing-pilot-study
#19
Chrysa Retsa, Jean-François Knebel, Eveline Geiser, Carina Ferrari, Raoul Jenni, Margot Fournier, Luis Alameda, Philipp S Baumann, Stephanie Clarke, Philippe Conus, Kim Q Do, Micah M Murray
Sensory impairments constitute core dysfunctions in schizophrenia. In the auditory modality, impaired mismatch negativity (MMN) has been observed in chronic schizophrenia and may reflect N-methyl-d-aspartate (NMDA) hypo-function, consistent with models of schizophrenia based on oxidative stress. Moreover, a recent study demonstrated deficits in the N100 component of the auditory evoked potential (AEP) in early psychosis patients. Previous work has shown that add-on administration of the glutathione precursor N-acetyl-cysteine (NAC) improves the MMN and clinical symptoms in chronic schizophrenia...
July 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28694072/acquired-equine-polyneuropathy-of-nordic-horses-a-conspicuous-inclusion-body-schwannopathy
#20
S Hanche-Olsen, K Matiasek, J Molín, M Rosati, C Hahn, K Hultin Jäderlund, G Gröndahl
Acquired equine polyneuropathy (AEP), formerly also known as Scandinavian knuckling syndrome, is one of the most prevalent polyneuropathies in equids in Norway and Sweden, with more than 400 cases registered since first observations in 1995. Despite geographical clustering and an association to forage feeding, its aetiology remains unknown. Clinically AEP is characterized by knuckling due to dysfunction of metatarsophalangeal extensor muscles. This neuropathological study aimed to gain further insights in the pathobiology of AEP and its underlying aetiopathogenesis...
June 16, 2017: Neuromuscular Disorders: NMD
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