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https://www.readbyqxmd.com/read/27905202/care-in-subsequent-pregnancies-following-stillbirth-an-international-survey-of-parents
#1
A M Wojcieszek, F M Boyle, J M Belizán, J Cassidy, P Cassidy, Jjhm Erwich, L Farrales, M M Gross, Aep Heazell, S H Leisher, T Mills, M Murphy, K Pettersson, C Ravaldi, J Ruidiaz, D Siassakos, R M Silver, C Storey, A Vannacci, P Middleton, D Ellwood, V Flenady
OBJECTIVE: To assess the frequency of additional care, and parents' perceptions of quality, respectful care, in pregnancies subsequent to stillbirth. DESIGN: Multi-language web-based survey. SETTING: International. POPULATION: A total of 2716 parents, from 40 high- and middle-income countries. METHODS: Data were obtained from a broader survey of parents' experiences following stillbirth. Data were analysed using descriptive statistics and stratified by geographic region...
November 30, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27894890/convergent-individual-differences-in-visual-cortices-but-not-the-amygdala-across-standard-amygdalar-fmri-probe-tasks
#2
Victoria Villalta-Gil, Kendra E Hinton, Bennett A Landman, Benjamin C Yvernault, Scott F Perkins, Allison S Katsantonis, Courtney L Sellani, Benjamin B Lahey, David H Zald
: The amygdala (AMG) has been repeatedly implicated in the processing of threatening and negatively valenced stimuli and multiple fMRI paradigms have reported personality, genetic, and psychopathological associations with individual differences in AMG activation in these paradigms. Yet the interchangeability of activations in these probes has not been established, thus it remains unclear if we can interpret AMG responses on specific tasks as general markers of its reactivity. In this study we aimed to assess if different tasks that have been widely used within the Affective Neuroscience literature consistently recruit the AMG...
November 25, 2016: NeuroImage
https://www.readbyqxmd.com/read/27870483/transcriptome-analysis-of-the-regenerating-tail-versus-the-scarring-limb-in-lizard-reveals-pathways-leading-to-successful-versus-unsuccessful-organ-regeneration-in-amniotes
#3
Nicola Vitulo, Luisa Dalla Valle, Tatjana Skobo, Giorgio Valle, Lorenzo Alibardi
BACKGROUND: lizards are amniotes regenerating the tail but not the limb and no information on their different gene expression is available. RESULTS: transcriptomes of regenerating tail and limb blastemas show differences in gene expression between the two organs. In tail blastema snoRNAs and Wnt signals appear up-regulated probably in association with the Apical Epidermal Peg (AEP), an epithelial region that sustains tail regeneration but is absent in the limb. A balance between pro-oncogenes and tumor suppressors is likely present in tail blastema allowing a regulated proliferation...
November 21, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27865805/transcriptional-activation-by-mll-fusion-proteins-in-leukemogenesis
#4
REVIEW
Akihiko Yokoyama
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause aggressive leukemia. Fusion proteins of MLL and a component of the AF4 family/ENL family/P-TEFb complex (AEP) are responsible for two-thirds of MLL-associated leukemia cases. MLL-AEP fusion proteins trigger aberrant self-renewal of hematopoietic progenitors by constitutively activating self-renewal-related genes. MLL-AEP fusion proteins activate transcription initiation by loading the TATA-binding protein (TBP) to the TATA element via selectivity factor 1...
November 16, 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27716800/re-evaluation-of-phylogenetic-relationships-among-species-of-the-mangrove-genus-avicennia-from-indo-west-pacific-based-on-multilocus-analyses
#5
Xinnian Li, Norman C Duke, Yuchen Yang, Lishi Huang, Yuxiang Zhu, Zhang Zhang, Renchao Zhou, Cairong Zhong, Yelin Huang, Suhua Shi
Avicennia L. (Avicenniaceae), one of the most diverse mangrove genera, is distributed widely in tropical and subtropical intertidal zones worldwide. Five species of Avicennia in the Indo-West Pacific region have been previously described. However, their phylogenetic relationships were determined based on morphological and allozyme data. To enhance our understanding of evolutionary patterns in the clade, we carried out a molecular phylogenetic study using wide sampling and multiple loci. Our results support two monophyletic clades across all species worldwide in Avicennia: an Atlantic-East Pacific (AEP) lineage and an Indo-West Pacific (IWP) lineage...
2016: PloS One
https://www.readbyqxmd.com/read/27698009/acute-eosinophilic-pneumonia-masquerading-as-multiple-pulmonary-embolisms
#6
Takeshi Saraya, Sunao Mikura, Miku Oda, Hajime Takizawa
A 47-year-old previously healthy man was admitted to the hospital with a 5-day history of fever, dry cough, and dyspnoea. Thoracic radiographs and CT scan showed extensive bilateral consolidation predominantly involving the central portions of the upper lung lobes, along with multiple scattered nodules. On taking a thorough history, it was found that the patient had visited a gritty 100-year-old Japanese folk house 1 week ago. An urgent bronchoscopy was performed, and the results were consistent with the findings of acute eosinophilic pneumonia (AEP)...
October 3, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27697099/high-traf6-expression-is-associated-with-esophageal-carcinoma-recurrence-and-prompts-cancer-cell-invasion
#7
Xinyang Liu, Zhichao Wang, Guoliang Zhang, Qikun Zhu, Hui Zeng, Tao Wang, Feng Gao, Zhan Qi, Jinwen Zhang, Rui Wang
Esophageal cancer is one of the most common types of cancer and it has a poor prognosis. The molecular mechanisms of esophageal cancer progression remain largely unknown. In this study, we aimed to investigate the clinical significance and biological function of tumor necrosis factor receptor associated factor 6 (TRAF6) in esophageal cancer. Expression of TRAF6 in esophageal cancer was examined and its correlation with clinicopathological factors and patient prognosis was analyzed. A series of functional and mechanism assays were performed to further investigate the function and underlying mechanisms in esophageal cancer...
September 30, 2016: Oncology Research
https://www.readbyqxmd.com/read/27694294/survey-of-advanced-education-in-prosthodontics-directors-and-residents-on-practices-in-esthetic-dentistry
#8
James L Sheets, Judy Chia-Chun Yuan, Cortino Sukotjo, Alvin G Wee
The aim of this study was to determine the difference between the intended education by advanced education in prosthodontics (AEP) program directors and the perceived education received by AEP residents with respect to concepts of esthetic dentistry. Residents' confidence levels and current practices were also determined based on program level, with first- and second-year residents combined into "junior residents" and third- and fourth-year residents combined into "senior residents." Surveys were distributed to all U...
October 2016: Journal of Dental Education
https://www.readbyqxmd.com/read/27679628/increasing-resilience-in-adolescents-the-importance-of-social-connectedness-in-adventure-education-programmes
#9
Damian Scarf, Jillian G Hayhurst, Benjamin C Riordan, Mike Boyes, Ted Ruffman, John A Hunter
OBJECTIVE: Mental health problems are a leading cause of health-related disability during adolescence. The objectives of the current study were to investigate whether participating in an adventure education programme (AEP) increased adolescents' resilience and elucidate how social connectedness contributes to any increase. METHOD: Adolescents who participated in the AEP had their resilience measured on the first (Time 1) and last day (Time 2) of a 10-day voyage...
September 27, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/27660925/suppression-of-asparaginyl-endopeptidase-inhibits-polyomavirus-middle-t-antigen-induced-tumor-formation-and-metastasis
#10
Cheng Xu, Lu Cao, Jianhua Liu, Zhongrun Qian, Yu Peng, Wenjing Zhu, Yongming Qiu, Yingying Lin
Elevated circulating asparaginyl endopeptidase (AEP), a novel lysosomal protease, has been found in breast cancer, and AEP is thus considered to be a prognostic factor in this disease. However, the pathological functions of circulating AEP in the development of breast cancer and the potential of AEP-targeted therapy remain unclear. We used MMTV-PyVmT transgenic mice, which spontaneously develop mammary tumors. Western blotting showed overexpression of AEP in both primary tumor tissue and lung metastases compared to their normal counterparts...
September 22, 2016: Oncology Research
https://www.readbyqxmd.com/read/27646864/hearing-sensitivity-differs-between-zebrafish-lines-used-in-auditory-research
#11
J David Monroe, Dustin P Manning, Phillip M Uribe, Ashwin Bhandiwad, Joseph A Sisneros, Michael E Smith, Allison B Coffin
Zebrafish are increasingly used in auditory studies, in part due to the development of several transgenic lines that express hair cell-specific fluorescent proteins. However, it is largely unknown how transgene expression influences auditory phenotype. We previously observed reduced auditory sensitivity in adult Brn3c:mGFP transgenic zebrafish, which express membrane-bound green fluorescent protein (GFP) in sensory hair cells. Here, we examine the auditory sensitivity of zebrafish from multiple transgenic and background strains...
September 16, 2016: Hearing Research
https://www.readbyqxmd.com/read/27642564/acute-eosinophilic-pneumonia-following-recent-cigarette-smoking
#12
Lokendra K Thakur, Kunal Kishor Jha
In this report we describe the case of an 18 year old female who presented with fever, shortness of breath, and chest pain. Chest X-ray revealed diffuse bilateral infiltrates and eosinophilia was reported from her broncholaveolar lavage (BAL) fluid. She started smoking 3 weeks prior to the onset of symptoms and based on her clinical presentation, BAL findings and dramatic improvement, acute eosinophilic pneumonia (AEP) was diagnosed.
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27631468/agronomic-characteristics-related-to-grain-yield-and-nutrient-use-efficiency-for-wheat-production-in-china
#13
Limin Chuan, Ping He, Tongke Zhao, Huaiguo Zheng, Xinpeng Xu
In order to make clear the recent status and trend of wheat (Triticum aestivum L.) production in China, datasets from multiple field experiments and published literature were collected to study the agronomic characteristics related to grain yield, fertilizer application and nutrient use efficiency from the year 2000 to 2011. The results showed that the mean grain yield of wheat in 2000-2011 was 5950 kg/ha, while the N, P2O5 and K2O application rates were 172, 102 and 91 kg/ha on average, respectively. The decrease in N and P2O5 and increase in K2O balanced the nutrient supply and was the main reason for yield increase...
2016: PloS One
https://www.readbyqxmd.com/read/27619970/is-the-efficacy-of-sacral-nerve-stimulation-for-faecal-incontinence-dependent-on-the-number-of-active-electrode-poles-achieved-during-permanent-lead-insertion
#14
Jakob Duelund-Jakobsen, Lilli Lundby, Paul-Antoine Lehur, Vincent Wyart, Søren Laurberg, Steen Buntzen
: Sacral nerve stimulation (SNS) is effective for faecal incontinence (FI). Little is known about the relationship between the implantation technique and the functional outcome. AIM: The study aimed to explore the relationship between the numbers of active electrode poles (AEP) used during permanent lead placement and subsequent function, therapeutic amplitude and the need for extra appointments between scheduled follow-up visits. METHOD: 186 patients with FI who underwent permanent implantation between May-2009 and March-2015 with a tined (barbed) lead (3093/3080-Medtronic) using the straight stylet were registered on the European two-centre SNS prospective database (SNSPD)...
September 13, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27605367/alcohol-and-hiv-risk-among-russian-women-of-childbearing-age
#15
Tatiana Balachova, Alla Shaboltas, Andrey Nasledov, Mark Chaffin, Julia Batluk, Som Bohora, Barbara Bonner, Kendall Bryant, Larissa Tsvetkova, Elena Volkova
Russia has one of the fastest rising rates of HIV among women in the world. This study sought to identify key factors in HIV transmission among women in Russia. Data were collected as part of a larger clinical trial to prevent alcohol-exposed pregnancies (AEP). Women at risk for an AEP were recruited at women's clinics; 708 women, aged 18-44 (M = 29.04 years), completed HIV risk surveys. Structural Equation Modeling was used to test the relationships between alcohol use and sex behavior constructs with HIV/STI risk...
September 7, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27594924/automatic-cortical-representation-of-auditory-pitch-changes-in-rett-syndrome
#16
John J Foxe, Kelly M Burke, Gizely N Andrade, Aleksandra Djukic, Hans-Peter Frey, Sophie Molholm
BACKGROUND: Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/27591923/a-polysaccharide-from-the-leaves-of-aralia-elata-induces-apoptosis-in-u-2-os-cells-via-mitochondrial-dependent-pathway
#17
Guangchen Liu, Yu Sheng, Mei Zhang, Dahui Sun
In the present study, we isolated and characterized one purified polysaccharide (AEP-1) from the leaves of Aralia elata, and investigated its effect on human osteosarcoma (OS) U-2 OS cell line and analyzed its mechanism. MTT assays showed that AEP-1 markedly inhibited the growth of U-2 OS cells in a dose- and time-dependent fashion, suggesting a cytotoxic effect. The AEP-1 also dose-dependently induced DNA fragmentation and caused apoptotic death in U-2 OS cells. The event of apoptosis was accompanied by increased ratio of Bax/Bcl-2, depolarization of mitochondrial membrane potential (Δym) and the release of cytochrome c from mitochondria into the cytoplasm...
August 31, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27590439/asparaginyl-endopeptidase-promotes-proliferation-and-invasiveness-of-prostate-cancer-cells-via-pi3k-akt-signaling-pathway
#18
Wenjing Zhu, Yiqun Shao, Ming Yang, Moran Jia, Yu Peng
Recurrence and metastasis are the major lethal causes of prostate cancer. It is urgent to find out the mechanisms and key factors governing prostate cancer progression and metastasis for developing new therapeutic strategies. Asparaginyl endopeptidase (AEP) overexpression has been found in a number of solid tumors. In prostate cancer, AEP has also been shown to exhibit a vesicular staining pattern and significantly associated with advanced tumor stage, high Gleason score, perineural invasion, and larger tumor...
December 15, 2016: Gene
https://www.readbyqxmd.com/read/27564129/tbp-loading-by-af4-through-sl1-is-the-major-rate-limiting-step-in-mll-fusion-dependent-transcription
#19
Hiroshi Okuda, Satoshi Takahashi, Akifumi Takaori-Kondo, Akihiko Yokoyama
Gene rearrangement of the mixed lineage leukemia (MLL) gene causes leukemia by inducing the constitutive expression of a gene subset normally expressed only in the immature haematopoietic progenitor cells. MLL gene rearrangements often generate fusion products of MLL and a component of the AF4 family/ENL family/P-TEFb (AEP) complex. MLL-AEP fusion proteins have the potential of constitutively recruiting the P-TEFb elongation complex. Thus, it is hypothesized that relieving the promoter proximal pausing of RNA polymerase II is the rate-limiting step of MLL fusion-dependent transcription...
October 17, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27556227/expanding-the-knowledge-of-the-chemical-structure-of-glycoconjugates-from-trypanosoma-cruzi-tci-genotype-contribution-to-taxonomic-studies
#20
Leonardo M Fonseca, Tatiana C Garcez, Luciana Penha, Leonardo Freire-DE-Lima, Emmanuel Maes, Kelli M Costa, Lucia Mendonça-Previato, Jose O Previato
One of the main obstacles to the treatment of Chagas disease is the genetic and phenotypical variance displayed by T. cruzi strains, resulting in differences in morphology, virulence, pathogenicity and drug susceptibility. To better understand the role of glycoconjungates in Chagas disease, we performed the molecular characterization of the O-linked chains from mucins and glycoinositolphospholipids (GIPLs) of the Silvio X10 clone 1 strain. We demonstrated the presence of a β-galactofuranose (β-Galf) unity linked to the O-4 position of the α-N-acetylglucosamine (α-GlcNAc)O-4 in Tc-mucins...
September 2016: Anais da Academia Brasileira de Ciências
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