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https://www.readbyqxmd.com/read/29783015/extracts-of-compound-muniziqi-granule-suppressed-uterus-contraction-and-ameliorated-oxytocin-inducedprimary-dysmenorrhea
#1
Yue Wei, Tingyun Ma, Hanxue Wang, Jianguo Xing, Yuwen Wang, Zhengyi Gu, Dandan Mu, Qiang Yin, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Muniziqi granule (CMG) is usually used as a traditional Uighur medicine to treat acne, chloasma, skin inflammation, primary dysmenorrhea (PDM), and menopausal syndrome. However, there are no sufficient data to support the clinic uses of CMG in PDM. AIM OF THE STUDY: This work aims to examine the effect of CMG as a treatment for PDM and reveal its possible therapeutic mechanism. MATERIALS AND METHODS: In vivo and in vitro mouse PDM models were utilized in this study...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29769405/%C3%AE-synuclein-stimulation-of-monoamine-oxidase-b-and-legumain-protease-mediates-the-pathology-of-parkinson-s-disease
#2
Seong Su Kang, Eun Hee Ahn, Zhentao Zhang, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Susov Dhakal, P Michael Iuvone, Xuebing Cao, Keqiang Ye
Dopaminergic neurodegeneration in Parkinson's disease (PD) is associated with abnormal dopamine metabolism by MAO-B (monoamine oxidase-B) and intracellular α-Synuclein (α-Syn) aggregates, called the Lewy body. However, the molecular relationship between α-Syn and MAO-B remains unclear. Here, we show that α-Syn directly binds to MAO-B and stimulates its enzymatic activity, which triggers AEP (asparagine endopeptidase; legumain) activation and subsequent α-Syn cleavage at N103, leading to dopaminergic neurodegeneration...
May 16, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29761891/processed-electroencephalogram-and-evoked-potential-techniques-for-amelioration-of-postoperative-delirium-and-cognitive-dysfunction-following-non-cardiac-and-non-neurosurgical-procedures-in-adults
#3
REVIEW
Yodying Punjasawadwong, Waraporn Chau-In, Malinee Laopaiboon, Sirivimol Punjasawadwong, Pathomporn Pin-On
BACKGROUND: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) may complicate a patient's postoperative recovery in several ways. Monitoring of processed electroencephalogram (EEG) or evoked potential (EP) indices may prevent or minimize POD and POCD, probably through optimization of anaesthetic doses. OBJECTIVES: To assess whether the use of processed EEG or auditory evoked potential (AEP) indices (bispectral index (BIS), narcotrend index, cerebral state index, state entropy and response entropy, patient state index, index of consciousness, A-line autoregressive index, and auditory evoked potentials (AEP index)) as guides to anaesthetic delivery can reduce the risk of POD and POCD in non-cardiac surgical or non-neurosurgical adult patients undergoing general anaesthesia compared with standard practice where only clinical signs are used...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29758238/electrophysiological-correlates-of-timbre-imagery-and-perception
#4
Przemysław Tużnik, Paweł Augustynowicz, Piotr Francuz
The primary objective of the present study was to verify whether the differences in imagined timbre are reflected by the event-related potentials (ERPs). It was verified the hypotheses that imagining of sounds, varying in spectral characteristics of timbre, influence the amplitude of the late positive component (LPC), associated with auditory imagery-related processes. It was also verified whether the manipulation of the perceived timbre corresponds to the amplitude fluctuations of the auditory evoked potentials (AEPs) N1 and P2...
May 11, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29745533/-noise-attenuation-analysis-on-auditory-evoked-potential-based-on-maximum-length-sequence
#5
Yun'er Chen, Chang'an Zhan, Xian Peng, Qiuyang Fu, Tao Wang
The maximum length sequence (m-sequence) has been successfully used to study the linear/nonlinear components of auditory evoked potential (AEP) with rapid stimulation. However, more study is needed to evaluate the effect of the m-sequence order in terms of the noise attenuation performance. This study aimed to address this issue using response-free electroencephalogram (EEG) and EEGs with nonlinear AEPs. We examined the noise attenuation ratios to evaluate the noise variation for the calculations of superimposed averaging and cross-correlation, respectively, which constitutes the main process in the deconvolution method using the dataset of spontaneous EEGs to simulate the cases of different orders (order 5 to 12) of m-sequences...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29741798/a-pilot-rct-of-an-internet-intervention-to-reduce-the-risk-of-alcohol-exposed-pregnancy
#6
Karen Ingersoll, Christina Frederick, Kirsten MacDonnell, Lee Ritterband, Holly Lord, Brogan Jones, Lauren Truwit
BACKGROUND: Preventing alcohol-exposed pregnancies (AEPs) could reduce the incidence of fetal alcohol spectrum disorders. Previous face-to-face interventions significantly reduced risk for AEP, but a scalable intervention is needed to reach more women at risk. METHODS: This study compared a 6 Core automated, interactive, and tailored Internet intervention, the Contraception and Alcohol Risk Reduction Internet Intervention (CARRII), to a static patient education (PE) website for its effect on AEP risk...
May 9, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29736486/aggregate-exposure-pathways-in-support-of-risk-assessment
#7
Yu-Mei Tan, Jeremy A Leonard, Stephen Edwards, Justin Teeguarden, Alicia Paini, Peter Egeghy
Over time, risk assessment has shifted from establishing relationships between exposure to a single chemical and a resulting adverse health outcome, to evaluation of multiple chemicals and disease outcomes simultaneously. As a result, there is an increasing need to better understand the complex mechanisms that influence risk of chemical and non-chemical stressors, beginning at their source and ending at a biological endpoint relevant to human or ecosystem health risk assessment. Just as the Adverse Outcome Pathway (AOP) framework has emerged as a means of providing insight into mechanism-based toxicity, the exposure science community has seen the recent introduction of the Aggregate Exposure Pathway (AEP) framework...
June 2018: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29729592/role-of-inter-trial-phase-coherence-in-atypical-auditory-evoked-potentials-to-speech-and-nonspeech-stimuli-in-children-with-autism
#8
Luodi Yu, Suiping Wang, Dan Huang, Xueyuan Wu, Yang Zhang
OBJECTIVE: This autism study investigated how inter-trial phase coherence (ITPC) drives abnormalities in auditory evoked potential (AEP) responses for speech and nonspeech stimuli. METHODS: Auditory P1-N2 responses and ITPCs in the theta band (4-7 Hz) for pure tones and words were assessed with EEG data from 15 school-age children with autism and 16 age-matched typically developing (TD) controls. RESULTS: The autism group showed enhanced P1 and reduced N2 for both speech and nonspeech stimuli in comparison with the TD group...
April 19, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29728212/-admission-discharge-and-triage-guidelines-for-paediatric-intensive-care-units-in-spain
#9
Pedro de la Oliva, Francisco José Cambra-Lasaosa, Manuel Quintana-Díaz, Corsino Rey-Galán, Juan Ignacio Sánchez-Díaz, María Cruz Martín-Delgado, Juan Carlos de Carlos-Vicente, Ramón Hernández-Rastrollo, María Soledad Holanda-Peña, Francisco Javier Pilar-Orive, Esther Ocete-Hita, Antonio Rodríguez-Núñez, Ana Serrano-González, Luis Blanch
A paediatric intensive care unit (PICU) is a separate physical facility or unit specifically designed for the treatment of paediatric patients who, because of the severity of illness or other life-threatening conditions, require comprehensive and continuous inten-sive care by a medical team with special skills in paediatric intensive care medicine. Timely and personal intervention in intensive care reduces mortality, reduces length of stay, and decreases cost of care. With the aim of defending the right of the child to receive the highest attainable standard of health and the facilities for the treatment of illness and rehabilitation, as well as ensuring the quality of care and the safety of critically ill paediatric patients, the Spanish Association of Paediatrics (AEP), Spanish Society of Paediatric Intensive Care (SECIP) and Spanish Society of Critical Care (SEMICYUC) have approved the guidelines for the admission, discharge and triage for Spanish PICUs...
May 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29725016/c-ebp%C3%AE-regulates-delta-secretase-expression-and-mediates-pathogenesis-in-mouse-models-of-alzheimer-s-disease
#10
Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Peter F Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
Delta-secretase cleaves both APP and Tau to mediate the formation of amyloid plaques and neurofibrillary tangle in Alzheimer's disease (AD). However, how aging contributes to an increase in delta-secretase expression and AD pathologies remains unclear. Here we show that a CCAAT-enhancer-binding protein (C/EBPβ), an inflammation-regulated transcription factor, acts as a key age-dependent effector elevating both delta-secretase (AEP) and inflammatory cytokines expression in mediating pathogenesis in AD mouse models...
May 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29704679/evaluating-the-longer-term-cognitive-effects-of-adjunctive-perampanel-compared-to-lacosamide-in-a-naturalistic-outpatient-setting
#11
Carolin Meschede, Juri-Alexander Witt, Michael Rademacher, Randi D von Wrede, Christian E Elger, Christoph Helmstaedter
PURPOSE: This retrospective longitudinal study aims to compare the longer-term cognitive and behavioral side effects of adjunctive antiepileptic treatment with perampanel (PER) and lacosamide (LCM), two third generation antiepileptic drugs with suggested favorable cognitive profiles. The two drugs were monitored according to a previously established routine diagnostic protocol (Helmstaedter et al. E&B 2013;26:182-7) which facilitates the retrospective comparison of antiepileptic drug tolerability in a naturalistic outpatient setting...
April 22, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29699643/admission-discharge-and-triage-guidelines-for-paediatric-intensive-care-units-in-spain
#12
Pedro de la Oliva, Francisco José Cambra-Lasaosa, Manuel Quintana-Díaz, Corsino Rey-Galán, Juan Ignacio Sánchez-Díaz, María Cruz Martín-Delgado, Juan Carlos de Carlos-Vicente, Ramón Hernández-Rastrollo, María Soledad Holanda-Peña, Francisco Javier Pilar-Orive, Esther Ocete-Hita, Antonio Rodríguez-Núñez, Ana Serrano-González, Luis Blanch
A paediatric intensive care unit (PICU) is a separate physical facility or unit specifically designed for the treatment of paediatric patients who, because of the severity of illness or other life-threatening conditions, require comprehensive and continuous inten-sive care by a medical team with special skills in paediatric intensive care medicine. Timely and personal intervention in intensive care reduces mortality, reduces length of stay, and decreases cost of care. With the aim of defending the right of the child to receive the highest attainable standard of health and the facilities for the treatment of illness and rehabilitation, as well as ensuring the quality of care and the safety of critically ill paediatric patients, the Spanish Association of Paediatrics (AEP), Spanish Society of Paediatric Intensive Care (SECIP) and Spanish Society of Critical Care (SEMICYUC) have approved the guidelines for the admission, discharge and triage for Spanish PICUs...
May 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29689717/mechanism-of-tau-hyperphosphorylation-involving-lysosomal-enzyme-asparagine-endopeptidase-in-a-mouse-model-of-brain-ischemia
#13
Gustavo Basurto-Islas, Jin-Hua Gu, Yunn Chyn Tung, Fei Liu, Khalid Iqbal
Dementias including Alzheimer's disease (AD) are multifactorial disorders that involve several different etiopathogenic mechanisms. Cerebral ischemia has been suspected in the altered regulation of protein kinases and phosphatases that leads to hyperphosphorylation of tau and further neurofibrillary pathology, a key hallmark of AD and related neurodegenerative diseases. However, the deregulation of these enzymes and their relationship with ischemia and AD remain unclear. Previously, we reported a mechanism by which the lysosomal enzyme asparagine endopeptidase (AEP) is associated with brain acidosis and AD...
April 14, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29688874/a-putative-electrophysiological-biomarker-of-auditory-sensory-memory-encoding-is-sensitive-to-pharmacological-alterations-of-excitatory-inhibitory-balance-in-male-macaque-monkeys
#14
William B Holliday, Kate Gurnsey, Robert A Sweet, Tobias Teichert
BACKGROUND: The amplitude of the auditory evoked N1 component that can be derived from noninvasive electroencephalographic recordings increases as a function of time between subsequent tones. N1 amplitudes in individuals with schizophrenia saturate at a lower asymptote, thus giving rise to a reduced dynamic range. Reduced N1 dynamic range is a putative electrophysiological biomarker of altered sensory memory function in individuals with the disease. To date, it is not clear what determines N1 dynamic range and what causes reduced N1 dynamic range in individuals with schizophrenia...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29678759/what-s-what-in-auditory-cortices
#15
Chrysa Retsa, Pawel J Matusz, Jan W H Schnupp, Micah M Murray
Distinct anatomical and functional pathways are postulated for analysing a sound's object-related ('what') and space-related ('where') information. It remains unresolved to which extent distinct or overlapping neural resources subserve specific object-related dimensions (i.e. who is speaking and what is being said can both be derived from the same acoustic input). To address this issue, we recorded high-density auditory evoked potentials (AEPs) while participants selectively attended and discriminated sounds according to their pitch, speaker identity, uttered syllable ('what' dimensions) or their location ('where')...
April 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29673933/lysophosphatidic-acid-induces-neuronal-cell-death-via-activation-of-asparagine-endopeptidase-in-cerebral-ischemia-reperfusion-injury
#16
Chao Wang, Jie Zhang, Junchun Tang, Yi-Yi Li, YanXia Gu, Ying Yu, Jing Xiong, Xueqing Zhao, Zheng Zhang, Ting-Ting Li, Jutao Chen, Qi Wan, Zhaohui Zhang
Lysophosphatidic acid (LPA), an extracellular signaling molecule, influences diverse biological events, including the pathophysiological process induced after ischemic brain injury. However, the molecular mechanisms mediating the pathological change after ischemic stroke remain elusive. Here we report that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is regulated by LPA during stroke. AEP proteolytically cleaves tau and generates tauN368 fragments, triggering neuronal death. Inhibiting the generation of LPA reduces the expression of AEP and tauN368, and alleviates neuronal cell death...
April 16, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29614402/fish-can-smell-trace-metals-at-environmentally-relevant-concentrations-in-freshwater
#17
Ebrahim Lari, Sarah J Bogart, Greg G Pyle
The objective of the present study was to investigate the ability of the olfactory system of rainbow trout (Oncorhynchus mykiss) to detect three trace metals, cadmium (Cd), copper (Cu), and nickel (Ni), using electro-olfactography (EOG). The olfactory response to all three metals was measured at either 10-6  M or at a concentration established by Alberta Environment and Parks (AEP) as the criterion for the protection of aquatic life. Results of the present study demonstrated that the olfactory system of rainbow trout can detect all three metals (i...
March 27, 2018: Chemosphere
https://www.readbyqxmd.com/read/29610018/study-of-the-standard-direct-costs-of-various-techniques-of-advanced-endoscopy-comparison-with-surgical-alternatives
#18
Carme Loras, Vicenç Mayor, Fernando Fernández-Bañares, Maria Esteve
INTRODUCTION: The complexity of endoscopy has carried out an increase in cost that has a direct effect on the healthcare systems. However, few studies have analyzed the cost of advanced endoscopic procedures (AEP). OBJECTIVES: To carry out a calculation of the standard direct costs of AEP, and to make a financial comparison with their surgical alternatives. METHODS: Calculation of the standard direct cost in carrying out each procedure. An endoscopist detailed the time, personnel, materials, consumables, recovery room time, stents, pathology and medication used...
March 12, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29608762/the-zn-finger-domain-of-human-primpol-is-required-to-stabilize-the-initiating-nucleotide-during-dna-priming
#19
María I Martínez-Jiménez, Patricia A Calvo, Sara García-Gómez, Susana Guerra-González, Luis Blanco
Human PrimPol is a monomeric enzyme whose DNA primase activity is required to rescue stalled replication forks during nuclear and mitochondrial DNA replication. PrimPol contains an Archeal-Eukaryotic Primases (AEP) core followed by a C-terminal Zn finger-containing domain (ZnFD), that is exclusively required for primer formation and for PrimPol function in vivo. The present study describes the sequential substrate interactions of human PrimPol during primer synthesis, and the relevance of the ZnFD at each individual step...
March 28, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29607784/sertraline-induced-acute-eosinophilic-pneumonia
#20
Mayssan Muftah, Rama Nassri, Ammar Nassri, Paul Harford
Acute Eosinophilic Pneumonia (AEP) is a rare, potentially fatal disease often characterized by a short febrile illness, hypoxemic respiratory failure, diffuse pulmonary opacities and evidence of pulmonary eosinophilia. AEP can be idiopathic, but has documented associations with multiple drugs. We present the first case highlighting Sertraline specifically as a cause of drug-induced AEP in the English literature.
April 2, 2018: Current Drug Safety
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