Gustavo A Angarita, Brian Pittman, Annamalai Nararajan, Talia F Mayerson, Abhinav Parate, Benjamin Marlin, Ralitza R Gueorguieva, Marc N Potenza, Deepak Ganesan, Robert T Malison
BACKGROUND: Our group has established the feasibility of using on-body electrocardiographic (ECG) sensors to detect cocaine use in the human laboratory. The purpose of the current study was to test whether ECG sensors and features are capable of discriminating cocaine use from other non-cocaine sympathomimetics. METHODS: Eleven subjects with cocaine use disorder wore the Zephyr BioHarness™ 3 chest band under six experimental (drug and non-drug) conditions, including 1) laboratory, intravenous cocaine self-administration, 2) after a single oral dose of methylphenidate, 3) during aerobic exercise, 4) during tobacco use (N=7 who smoked tobacco), and 5) during routine activities of daily inpatient living (unit activity)...
July 14, 2023: Drug and Alcohol Dependence