Paolo Montaldo, Mario Cirillo, Constance Burgod, Elisabetta Caredda, Serena Ascione, Mauro Carpentieri, Simona Puzone, Alessandra D'Amico, Reema Garegrat, Marianna Lanza, Maria Moreno Morales, Gaurav Atreja, Vijaykumar Shivamurthappa, Ujwal Kariholu, Narendra Aladangady, Paul Fleming, Asha Mathews, Balamurugan Palanisami, Joanne Windrow, Karen Harvey, Aung Soe, Santosh Pattnayak, Palaniappan Sashikumar, Sundeep Harigopal, Ronit Pressler, Martin Wilson, Enrico De Vita, Seetha Shankaran, Sudhin Thayyil
IMPORTANCE: Although whole-body hypothermia is widely used after mild neonatal hypoxic-ischemic encephalopathy (HIE), safety and efficacy have not been evaluated in randomized clinical trials (RCTs), to our knowledge. OBJECTIVE: To examine the effect of 48 and 72 hours of whole-body hypothermia after mild HIE on cerebral magnetic resonance (MR) biomarkers. DESIGN, SETTING, AND PARTICIPANTS: This open-label, 3-arm RCT was conducted between October 31, 2019, and April 28, 2023, with masked outcome analysis...
May 1, 2024: JAMA Network Open