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https://www.readbyqxmd.com/read/29163326/systematic-review-of-traumatic-brain-injuries-in-baseball-and-softball-a-framework-for-prevention
#1
Michael D Cusimano, Alice Zhu
Background: Traumatic brain injuries (TBIs) are an important public health challenge. The classification of baseball and softball as low contact sports and their association with extremity injuries cause individuals to overlook the risk of TBI in baseball and softball. Purpose: To summarize our knowledge of the epidemiology and risk factors of TBIs associated with baseball and softball with an aim to better design and implement preventive strategies. Methods: A search algorithm containing keywords that were synonymous to the terms "TBI," "baseball" was applied to the following nine databases: MEDLINE, Scopus, PubMed, EMBASE, CINAHL, Healthstar, PsychINFO, AMED, Cochrane library...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29162596/lactadherin-promotes-microvesicle-clearance-to-prevent-coagulopathy-and-improves-survival-of-severe-tbi-mice
#2
Yuan Zhou, Wei Cai, Zilong Zhao, Tristan Hilton, Min Wang, Jason Yeon, Wei Liu, Fangyi Zhang, Fu-Dong Shi, Xiaoping Wu, Perumal Thiagarajan, Min Li, Jianning Zhang, Jing-Fei Dong
Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellular microvesicles, including extracellular mitochondria, play a key role in the development of TBI-induced coagulopathy. Here, we further show in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 µg/kg 30 min before (preconditioning) or 30 min after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs...
November 21, 2017: Blood
https://www.readbyqxmd.com/read/29162266/plasma-free-carnitine-in-severe-trauma-influence-of-the-association-with-traumatic-brain-injury
#3
Fanny Vardon Bounes, Géraldine Faure, Antoine Rouget, Jean-Marie Conil, Bernard Georges, Thomas Geeraerts, Olivier Fourcade, Vincent Minville, Clément Delmas
BACKGROUND: Metabolic response to severe trauma requires early nutritional resuscitation. Carnitine is essential for lipolysis, the energy source during this hypercatabolic phase. However l-carnitine is not present in nutritional replacement solutions. Furthermore, free carnitine depletion, defined as carnitine plasma level under 36μmol/L, was not adequately reported in adult patients with severe trauma. The aim of this study was to assess plasma free carnitine levels and factors of variation in severe trauma...
November 15, 2017: Injury
https://www.readbyqxmd.com/read/29162023/pentobarbital-removal-during-continuous-venovenous-hemofiltration-case-report-and-review-of-the-literature
#4
David M Hensler, Deepika P McConnell, Kimberly E Levasseur-Franklin, Kasey M Greathouse
BACKGROUND: Renal replacement therapy may enhance the elimination of barbiturates. Pentobarbital clearance during continuous venovenous hemofiltration (CVVH) has not been described previously. We report a patient case involving the measurement of serial pentobarbital levels during CVVH and review relevant literature characterizing extracorporeal pentobarbital elimination. METHODS: The following is a retrospective report of a previously healthy 26-year-old woman who sustained a severe traumatic brain injury (TBI) and required administration of pentobarbital on hospital day 0 for intracranial pressure (ICP) control...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29160141/effects-of-mild-blast-traumatic-brain-injury-on-cerebral-vascular-histopathological-and-behavioral-outcomes-in-rats
#5
Uylissa A Rodriguez, Yaping Zeng, Donald James Deyo, Margaret O Parsley, Bridget E Hawkins, Donald S Prough, Douglas DeWitt
To determine the effects of mild blast-induced traumatic brain injury (bTBI), several groups of rats were subjected to blast injury or sham injury in a compressed air-driven shock tube. The effects of bTBI on relative cerebral perfusion (laser Doppler flowmetry, LDF), mean arterial blood pressure (MAP) cerebral vascular resistance were measured for two hrs post-bTBI. Dilator responses to reduced intravascular pressure were measured in isolated middle cerebral arterial (MCA) segments, ex vivo, 30 and 60 min post-bTBI...
November 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29159600/early-seizure-prophylaxis-in-traumatic-brain-injuries-revisited-a-prospective-observational-study
#6
Desmond Khor, Jinglan Wu, Quanqiu Hong, Elizabeth Benjamin, Shuiming Xiao, Kenji Inaba, Demetrios Demetriades
INTRODUCTION: Pharmacological prophylaxis for early seizures following traumatic brain injury (TBI) is a recommendation in the Brain Trauma Foundation Guidelines. However, several studies have challenged the efficacy and safety of this practice, resulting in varied practice across centers around the world. The purpose of the present study was to compare the incidence of early clinical seizures following TBI, between two large centers, a US Center that practises routine seizure prophylaxis and a Chinese Center that does not use seizure prophylaxis following TBI...
November 20, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29158675/transplantation-of-bone-mesenchymal-stem-cells-promotes-angiogenesis-and-improves-neurological-function-after-traumatic-brain-injury-in-mouse
#7
Shewei Guo, Yingwei Zhen, Anran Wang
Traumatic brain injury (TBI) has emerged as a leading cause of mortality and morbidity worldwide. Transplantation of bone mesenchymal stem cells (BMSCs) has emerged as a promising treatment for various central nervous system diseases. This study aims to evaluate the effect of BMSCs transplantation by intravenous injection on neurological function and angiogenesis of the TBI mice. C57BL/6 male mice were randomly divided into four groups: control, sham, TBI, and BMSC. Functional neurological evaluation was performed 1, 4, 7, 14, and 21 days after TBI using neurological severity scores...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29157855/imaging-the-role-of-myelin-in-concussion
#8
REVIEW
Alexander Mark Weber, Carlos Torres, Alexander Rauscher
Myelin water imaging (MWI) provides mild traumatic brain injury (mTBI) researchers with a specific myelin biomarker and helps to further elucidate microstructural and microarchitectural changes of white matter after mTBI. Improvement of scanner hardware and software with the implementation of MWI across scanner platforms will likely result in increased research regarding the role of myelin in traumatic brain injury (TBI). Future research should include detailed investigation of myelin between 2 weeks and 2 months after injury, the use of MWI in moderate and severe TBI, and investigation of the role of myelin in chronic TBI...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157846/definition-of-traumatic-brain-injury-neurosurgery-trauma-orthopedics-neuroimaging-psychology-and-psychiatry-in-mild-traumatic-brain-injury
#9
REVIEW
Mubashir Pervez, Ryan S Kitagawa, Tiffany R Chang
Traumatic brain injury (TBI) disrupts the normal function of the brain. This condition can adversely affect a person's quality of life with cognitive, behavioral, emotional, and physical symptoms that limit interpersonal, social, and occupational functioning. Although many systems exist, the simplest classification includes mild, moderate, and severe TBI depending on the nature of injury and the impact on the patient's clinical status. Patients with TBI require prompt evaluation and multidisciplinary management...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157017/comprehensive-assessment-of-shockwave-intensity-transcriptomic-biomarker-discovery-for-primary-blast-induced-mild-traumatic-brain-injury-using-the-mammalian-hair-follicle
#10
Jing Zhang, Rosalinda Knight, Yushan Wang, Thomas W Sawyer, Christopher J Martyniuk, Valerie S Langlois
OBJECTIVE: Primary blast-induced mild traumatic brain injury (mTBI) is an injury experienced during modern warfare due to exposure to the pressure waves produced by the detonation of explosives. With virtually no apparent physical damage or symptoms presented, there is a need for more objective and accessible mTBI biomarkers posing minimal invasiveness risk. METHODS: We measured the transcriptomic sensitivity of the hair follicles in relation to the severity of primary blast-derived TBI...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29157000/pre-injury-psychosocial-and-demographic-predictors-of-long-term-functional-outcomes-post-tbi
#11
Katharine S Seagly, Rochelle L O'Neil, Robin A Hanks
OBJECTIVE: To determine whether pre-injury psychosocial and demographic factors differentially influence long-term functional outcomes post-TBI. SETTING: Urban rehabilitation hospital. PARTICIPANTS: 149 individuals, ages 16-75, who sustained a mild complicated, moderate or severe TBI, were enrolled in a TBI Model System (TBIMS), and had functional outcome data five-15 years post-injury. DESIGN: Archival data were analysed with SPSS-18 using multiple regression to determine amount of variance accounted for in five functional domains...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29156990/psychological-outcome-after-severe-traumatic-brain-injury-in-adolescents-and-young-adults-the-chronic-phase
#12
Karoline Doser, Ingrid Poulsen, Alexander Wuensch, Anne Norup
OBJECTIVES: Young individuals surviving severe traumatic brain injury (TBI) frequently experience a wide range of cognitive, emotional and behavioural consequences. This cross-sectional follow-up study investigated psychological outcome of young survivors in the chronic phase, and whether psychological outcome was associated with improvement of functional abilities during sub-acute admission. METHODS: Patients, who acquired a severe TBI during adolescence or early adulthood (n = 36) and received early intensive rehabilitation, were contacted for follow-up assessment concerning psychological outcome and completed the Adult Self Report 18-59 (ASR18-59)...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29155947/dementia-after-moderate-severe-traumatic-brain-injury-coexistence-of-multiple-proteinopathies
#13
Kimbra Kenney, Diego Iacono, Brian L Edlow, Douglas I Katz, Ramon Diaz-Arrastia, Kristen Dams-O'Connor, Daniel H Daneshvar, Allison Stevens, Allison L Moreau, Lee S Tirrell, Ani Varjabedian, Anastasia Yendiki, Andre van der Kouwe, Azma Mareyam, Jennifer A McNab, Wayne A Gordon, Bruce Fischl, Ann C McKee, Daniel P Perl
We report the clinical, neuroimaging, and neuropathologic characteristics of 2 patients who developed early onset dementia after a moderate-severe traumatic brain injury (TBI). Neuropathological evaluation revealed abundant β-amyloid neuritic and cored plaques, diffuse β-amyloid plaques, and frequent hyperphosphorylated-tau neurofibrillary tangles (NFT) involving much of the cortex, including insula and mammillary bodies in both cases. Case 1 additionally showed NFTs in both the superficial and deep cortical layers, occasional perivascular and depth-of-sulci NFTs, and parietal white matter rarefaction, which corresponded with decreased parietal fiber tracts observed on ex vivo MRI...
November 16, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29154509/technology-assisted-rehabilitation-interventions-following-pediatric-brain-injury
#14
Shari L Wade, Megan E Narad, Emily L Shultz, Brad G Kurowski, Aimee E Miley, Jessica M Aguilar, Anna-Lynne R Adlam
INTRODUCTION: Following traumatic brain injury (TBI), children experience a variety of physical, motor, speech, and cognitive deficits that can have a long-term detrimental impact. The emergence and popularity of new technologies has led to research into the development of various apps, gaming systems, websites, and robotics that might be applied to rehabilitation. The objective of this narrative review was to describe the current literature technologically-assisted interventions for the rehabilitation of motor, neurocognitive, behavioral, and family impairments following pediatric TBI...
November 20, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29153039/higher-anxiety-symptoms-predict-progressive-hippocampal-atrophy-in-the-chronic-stages-of-moderate-to-severe-traumatic-brain-injury
#15
Alex R Terpstra, Todd A Girard, Brenda Colella, Robin E A Green
BACKGROUND: In the chronic stages of moderate-severe traumatic brain injury (TBI), progressive hippocampal volume loss-continuing well after acute neurological insults have resolved-has now been well documented. Previous research in other populations suggests that elevated anxiety symptoms are associated with compromise to the medial temporal lobes. OBJECTIVE: To examine whether higher anxiety symptoms predict greater hippocampal volume loss in moderate-severe TBI...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29150743/differential-response-of-neural-cells-to-trauma-induced-swelling-in-vitro
#16
A R Jayakumar, M Taherian, K S Panickar, N Shamaladevi, M E Rodriguez, B G Price, M D Norenberg
Brain edema and the associated increase in intracranial pressure are major consequences of traumatic brain injury (TBI) that accounts for most early deaths after TBI. We recently showed that acute severe trauma to cultured astrocytes results in cell swelling. We further examined whether trauma induces cell swelling in neurons and microglia. We found that severe trauma also caused cell swelling in cultured neurons, whereas no swelling was observed in microglia. While severe trauma caused cell swelling in both astrocytes and neurons, mild trauma to astrocytes, neurons, and microglia failed to cell swelling...
November 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29149808/delayed-hypoxemia-following-traumatic-brain-injury-exacerbates-long-term-behavioral-deficits
#17
McKenzie Davies, Addison Jacobs, David L Brody, Stuart H Friess
Hypoxemia during initial stabilization of patients with severe traumatic brain injury (TBI) has been associated with poorer outcomes. However, the effects of delayed hypoxemia occurring during intensive care following TBI on outcome is unclear. Preclinical models of TBI have rarely shown cognitive or behavioral deficits beyond six weeks post injury and commonly have not included modeling of secondary insults. We have previously developed a murine model of TBI followed by delayed hypoxemia to model the secondary insult of hypoxemia and brain hypoxia occurring in the intensive care setting...
November 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29149394/challenges-and-opportunities-for-pediatric-severe-tbi-review-of-the-evidence-and-exploring-a-way-forward
#18
Michael J Bell, P David Adelson, Stephen R Wisniewski
Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29149390/decompressive-craniectomy-and-csf-disorders-in-children
#19
Marie Manfiotto, Carmine Mottolese, Alexandru Szathmari, Pierre-Aurelien Beuriat, Olivier Klein, Matthieu Vinchon, Edouard Gimbert, Thomas Roujeau, Didier Scavarda, Michel Zerah, Federico Di Rocco
INTRODUCTION: Decompressive craniectomy (DC) is a lifesaving procedure but is associated to several post-operative complications, namely cerebrospinal fluid (CSF) dynamics impairment. The aim of this multicentric study was to evaluate the incidence of such CSF alterations after DC and review their impact on the overall outcome. MATERIAL AND METHODS: We performed a retrospective multicentric study to analyze the CSF disorders occurring in children aged from 0 to 17 years who had undergone a DC for traumatic brain injury (TBI) in the major Departments of Pediatric Neurosurgery of France between January 2006 and August 2016...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29149387/analgosedation-in-paediatric-severe-traumatic-brain-injury-tbi-practice-pitfalls-and-possibilities
#20
N Ketharanathan, Y Yamamoto, U Rohlwink, E D Wildschut, M Hunfeld, E C M de Lange, D Tibboel
Analgosedation is a fundamental part of traumatic brain injury (TBI) treatment guidelines, encompassing both first and second tier supportive strategies. Worldwide analgosedation practices continue to be heterogeneous due to the low level of evidence in treatment guidelines (level III) and the choice of analgosedative drugs is made by the treating clinician. Current practice is thus empirical and may result in unfavourable (often hemodynamic) side effects. This article presents an overview of current analgosedation practices in the paediatric intensive care unit (PICU) and addresses pitfalls both in the short and long term...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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