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functional mitral regurgitation

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https://www.readbyqxmd.com/read/29455830/transaortic-alfieri-edge-to-edge-repair-for-functional-mitral-regurgitation
#1
Ken-Ichi Imasaka, Eiki Tayama, Shigeki Morita, Ryohei Toriya, Yukihiro Tomita
There is controversy about handling functional mitral regurgitation in patients undergoing aortic valve or proximal aortic operations. We describe a transaortic Alfieri edge-to-edge repair for functional mitral regurgitation that reduces operative excessive invasion and prolonged cardiopulmonary bypass time. Between May 2013 and December 2016, 10 patients underwent transaortic Alfieri edge-to-edge mitral repair. There were no operative deaths. The severity of mitral regurgitation immediately after the operation by transesophageal echocardiography was none or trivial in all patients...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29449412/hemodynamic-characteristics-in-significant-symptomatic-and-asymptomatic-primary-mitral-valve-regurgitation-at-rest-and-during-exercise
#2
Rine Bakkestrøm, Ann Banke, Nicolaj L Christensen, Redi Pecini, Akhmadjon Irmukhamedov, Mads Andersen, Barry A Borlaug, Jacob E Møller
BACKGROUND: In severe asymptomatic primary mitral valve regurgitation without risk factors, surgery strategy is controversial. We sought to clarify whether being symptomatic corresponds to the hemodynamic burden and reduced exercise capacity. A better understanding of this may contribute to optimize timing of surgery. METHODS AND RESULTS: Subjects with asymptomatic (New York Heart Association functional class I, n=29) or symptomatic (New York Heart Association functional class II and III, n=28) significant primary mitral valve regurgitation (effective regurgitant orifice, ≥0...
February 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29444321/left-ventricular-regional-dyssynchrony-predicts-improvements-in-moderate-ischaemic-mitral-regurgitation-after-off-pump-coronary-artery-bypass
#3
Xiaotian Sun, Guoqian Huang, Jiechun Huang, Meng Shi, Fangrui Wang, Liewen Pang, Yiqing Wang
OBJECTIVES: The aim of this study was to explore the predictors of the improvement in moderate ischaemic mitral regurgitation (IMR) after off-pump coronary artery bypass grafting (OPCAB) focusing on left ventricular (LV) dyssynchrony. METHODS: A prospective study was performed among 135 patients (age at surgery, mean ± SD: 67.0 ± 8.2 years, 33.3% women) with prior myocardial infarction and moderate IMR undergoing OPCAB from 2008 to 2015. Preoperative and follow-up clinical and echocardiographic parameters were analysed, focusing on LV global/regional dyssynchrony...
February 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29442998/acute-kidney-injury-following-percutaneous-edge-to-edge-vs-minimally-invasive-surgical-mitral-valve-repair-incidence-predictors-and-prognostic-value
#4
Maria Isabel Körber, Maximilian Scherner, Kathrin Kuhr, Hugai Kasisada, Svenja Ney, Roman Pfister, Parwis Rahmanian, Jens Wippermann, Thorsten Wahlers, Stephan Baldus, Volker Rudolph
AIMS: This study sought to determine the incidence and identify predictors of acute kidney injury (AKI) following percutaneous edge-to-edge mitral valve repair (PMVR) and compare the risk of AKI between PMVR and surgical mitral valve repair (SMVR). METHODS AND RESULTS: We performed a single-centre analysis of 378 patients receiving treatment for mitral regurgitation (196 consecutive patients undergoing PMVR and 182 patients undergoing SMVR). The incidence of AKI (any stage according to KDIGO) following PMVR was 17...
October 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29426020/to-clip-or-not-to-clip-can-we-predict-which-patients-with-functional-mitral-regurgitation-will-benefit-from-transcatheter-mitral-valve-repair
#5
EDITORIAL
Stephanie El Hajj, Sheldon E Litwin
No abstract text is available yet for this article.
February 6, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29420603/impact-of-underlying-heart-disease-per-se-on-the-utility-of-preoperative-nt-probnp-in-adult-cardiac-surgery
#6
Huiqi Jiang, Henrik Hultkvist, Jonas Holm, Farkas Vanky, Yanqi Yang, Rolf Svedjeholm
OBJECTIVE: The primary aim was to investigate the role of underlying heart disease on preoperative NT-proBNP levels in patients admitted for adult cardiac surgery, after adjusting for the known confounders age, gender, obesity and renal function. The second aim was to investigate the predictive value of preoperative NT-proBNP with regard to severe postoperative heart failure (SPHF) and postoperative mortality. METHODS: A retrospective cohort study based on preoperative NT-proBNP measurements in an unselected cohort including all patients undergoing first time surgery for coronary artery disease (CAD; n = 2226), aortic stenosis (AS; n = 406) or mitral regurgitation (MR; n = 346) from April 2010 to August 2016 in the southeast region of Sweden (n = 2978)...
2018: PloS One
https://www.readbyqxmd.com/read/29416201/study-of-echocardiographic-changes-after-kidney-transplantation-in-end-stage-renal-disease-patients
#7
Hamidreza Omrani, Alireza Rai, Zahra Daraei, Masoud Sadeghi
Background: Cardiovascular complications are the leading cause of mortality in end-stage renal disease (ESRD) patients. This study aimed to evaluate the efficacy of kidney transplantation on the cardiovascular status in ESRD patients. Methods: During 2012 to 2014 and in a cross-sectional study, 181 patients were randomly selected for this study. All patients were followed for periods of 6 and 12 months after kidney transplantation. The patients with ESRD and kidney transplant recipients; the patients with left ventricle ejection fraction<50%, left ventricular hypertrophy, mitral valve regurgitation and tricuspid valve regurgitation were included to study and the patients with kidney transplant rejection, myocardial infarction, high blood pressure with treatment-resistant, high blood pressure and addicted patients were censored...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29408823/torsion-mechanics-as-an-indicator-of-more-advanced-left-ventricular-systolic-dysfunction-in-secondary-mitral-regurgitation-in-patients-with-dilated-cardiomyopathy-a-2d-speckle-tracking-analysis
#8
Elena Kinova, Natalia Spasova, Angelina Borizanova, Assen Goudev
Left ventricular (LV) twist serves as a compensatory mechanism in systolic dysfunction and its degree of reduction may reflect a more advanced stage of disease. AIM: The aim was to investigate twist alterations depending on the degree of functional mitral regurgitation (MR) by speckle-tracking echocardiography. METHODS: Sixty-three patients with symptomatic dilated cardiomyopathy (DCM) were included. Patients were divided according to MR vena contracta width (VCW): group 1 with VCW <7 mm (mild/moderate MR) and group 2 with VCW ≥7 mm (severe MR)...
February 6, 2018: Cardiology
https://www.readbyqxmd.com/read/29408247/peratrial-device-closure-of-different-locations-of-mitral-paravalvular-leaks
#9
Li Hongxin, Guo Wenbin, Hai-Zhou Zhang, Fei Liang, Gui-Dao Yuan, Zeeshan Farhaj, Jun Zhang
BACKGROUND: The current approaches of transcatheter closure of mitral paravalvular leak (MPVL) have different drawbacks. The challenges come from transseptal puncture, accessing the MPVL site, and the absence of dedicated delivery systems. This study introduces a novel peratrial approach for device closure of different locations of MPVLs using a probe-assisted delivery system under three-dimensional transesophageal echocardiography. METHODS: A 4.0 cm minithoracotomy incision was made in the fourth right interspaces...
February 2, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29404848/eliminating-regurgitation-reduces-fibrotic-remodeling-of-functional-mitral-regurgitation-conditioned-valves
#10
Patrick S Connell, Dragoslava P Vekilov, Christine M Diaz, Seulgi E Kim, K Jane Grande-Allen
Functional mitral regurgitation (FMR) is an insidious and poorly understood condition affecting patients with myocardial disease. While current treatments reduce regurgitation, their ability to reverse mitral valve pathology is unclear. We utilized a pseudo-physiological flow loop to study how repair impacted valve composition. Porcine mitral valves were cultured in control geometry (native papillary muscle position and annular area) or high-tension FMR geometry (5 mm apical and 5 mm lateral displacement of papillary muscles, 65% increased annular area) for 2 weeks...
February 5, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29399763/significant-mitral-regurgitation-predicts-the-long-term-prognosis-in-patients-receiving-cardiac-resynchronization-therapy
#11
Han Jin, Shengwen Yang, Wei Hua, Min Gu, Hongxia Niu, Ligang Ding, Jing Wang, Cong Xue, Shu Zhang
BACKGROUND: Cardiac resynchronization therapy (CRT) has been shown to reduce Functional mitral regurgitation (FMR), although the relationship between significant mitral regurgitation (SMR) and the clinical prognosis of CRT remains uncertain. AIM: To investigate the association of baseline of SMR with long-term outcomes in patients undergoing CRT. METHODS: A total of 296 consecutive patients undergoing CRT were enrolled. SMR was quantified by color Doppler in all the patients at baseline and defined as grading scale ≥ 3...
February 5, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29395366/acute-intraoperative-echocardiographic-changes-after-transapical-off-pump-mitral-valve-repair-with-neochord-implantation
#12
Andrea Colli, Laura Besola, Matteo Montagner, Nicola Soriani, Erica Manzan, Eleonora Bizzotto, Fabio Zucchetta, Danila Azzolina, Roberto Bellu, Cristiano Sarais, Demetrio Pittarello, Gino Gerosa
OBJECTIVES: Our aim is to investigate the acute intraoperative effects of the NeoChord repair procedure on mitral valve (MV) annular geometry and LV function and the impact of these changes on MR at 1-year follow-up. BACKGROUND: Recently transapical off-pump mitral valve repair with NeoChord implantation has been demonstrated to be safe and effective in patients with degenerative mitral regurgitation (DMR). METHODS: We retrospectively analyzed baseline and early postoperative 3-dimensional transesophageal echocardiography of 66 patients who underwent NeoChord repair for isolated posterior leaflet MV disease using semiautomatic off-line analysis software...
January 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29395191/beneficial-effects-of-restrictive-annuloplasty-on-subvalvular-geometry-in-patients-with-functional-mitral-regurgitation-and-advanced-cardiomyopathy
#13
Satoshi Kainuma, Toshihiro Funatsu, Haruhiko Kondoh, Takenori Yokota, Shusaku Maeda, Yasuhiro Shudo, Hajime Matsue, Masami Nishino, Takashi Daimon, Koichi Toda, Yoshiki Sawa, Kazuhiro Taniguchi
OBJECTIVES: The effects of restrictive mitral annuloplasty (RMA) on subvalvular geometry remains unknown. We evaluated changes in left ventricular (LV) function, severity of mitral regurgitation (MR), and leaflet tethering parameters after RMA and clarified their associations. METHODS: In 44 patients with clinically relevant functional MR who underwent RMA, distances between papillary muscle (PM) tips and anterior mitral annulus (PM tethering distance), leaflet angles relative to lines connecting annuli, and interpapillary muscle distance (IPMD) were serially quantified...
December 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29387972/effect-of-cardiac-resynchronization-therapy-on-mitral-valve-geometry-a-novel-aspect-as-reversed-mitral-remodeling
#14
Oguz Karaca, Beytullah Cakal, Mehmet Onur Omaygenc, Haci Murat Gunes, Filiz Kizilirmak, Sinem Deniz Cakal, Deniz Dilan Naki, Irfan Barutcu, Bilal Boztosun, Fethi Kilicaslan
Amelioration of the valvular geometry is a possible mechanism for mitral regurgitation (MR) improvement in patients receiving cardiac resynchronization therapy (CRT). We aimed to establish the precise definition, incidence, and predictors of reversed mitral remodeling (RMR), as well as the association with MR improvement and short-term CRT outcome. Ninety-five CRT recipients were retrospectively evaluated for the end-point of "MR response" defined as the absolute reduction in regurgitant volume (RegV) at 6 months...
January 31, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29385428/decellularized-mitral-valve-in-a-long-term-sheep-model
#15
Pavel Iablonskii, Serghei Cebotari, Anatol Ciubotaru, Samir Sarikouch, Klaus Hoeffler, Andres Hilfiker, Axel Haverich, Igor Tudorache
OBJECTIVES: The objective of this study was to evaluate surgical handling, in vivo hemodynamic performance and morphological characteristics of decellularized mitral valves (DMVs) in a long-term sheep model. METHODS: Ovine mitral valves were decellularized using detergents and β-mercaptoethanol. Orthotopic implantations were performed in 6-month-old sheep (41.3 ± 1.2 kg, n = 11) without annulus reinforcement. Commercially available stented porcine aortic valves [biological mitral valve (BMV), n = 3] were implanted conventionally and used as controls...
January 29, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29370363/second-cross-clamping-after-mitral-valve-repair-for-degenerative-disease-in-contemporary-practice
#16
Michele De Bonis, Elisabetta Lapenna, Ilaria Giambuzzi, Roberta Meneghin, Giovanni Affronti, Federico Pappalardo, Alessandro Castiglioni, Cinzia Trumello, Nicola Buzzatti, Andrea Giacomini, Marcello Raimondi Lucchetti, Ottavio Alfieri
OBJECTIVES: Scanty data are available on 'second cross-clamping' following mitral valve repair in contemporary practice. The aim of this study was to evaluate the incidence, causes and outcomes of this event in patients referred for mitral repair for severe degenerative mitral regurgitation (MR). METHODS: The study population included 2318 patients with severe degenerative MR referred for mitral repair. A second cross-clamping was performed in 94 (4%) patients. Causes of the second cross-clamping, revising repair procedures, immediate echocardiographic outcomes and postoperative course were assessed and compared with the 'single cross-clamping cases' (2224 patients used as control)...
January 22, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29360063/optimizing-mitral-repair-in-functional-regurgitation-transcatheter-annuloplasty-can-counteract-left-ventricle-mitral-ring-mismatch
#17
Nicola Buzzatti, Paolo Denti, Ottavio Alfieri, Giovanni La Canna
No abstract text is available yet for this article.
January 23, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29358003/predicting-device-failure-after-percutaneous-repair-of-functional-mitral-regurgitation-in-advanced-heart-failure-implications-for-patient-selection
#18
Davide Stolfo, Antonio De Luca, Gaetano Morea, Marco Merlo, Giancarlo Vitrella, Thomas Caiffa, Giulia Barbati, Serena Rakar, Renata Korcova, Andrea Perkan, Bruno Pinamonti, Aniello Pappalardo, Alessandra Berardini, Elena Biagini, Francesco Saia, Francesco Grigioni, Claudio Rapezzi, Gianfranco Sinagra
BACKGROUND: Patients with heart failure (HF) and severe symptomatic functional mitral regurgitation (FMR) may benefit from MitraClip implantation. With increasing numbers of patients being treated the success of procedure becomes a key issue. We sought to investigate the pre-procedural predictors of device failure in patients with advanced HF treated with MitraClip. METHODS: From April 2012 to November 2016, 76 patients with poor functional class (NYHA class III-IV) and severe left ventricular (LV) remodeling underwent MitraClip implantation at University Hospitals of Trieste and Bologna (Italy)...
January 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29356100/layer-specific-deformation-analysis-in-severe-aortic-valve-stenosis-primary-mitral-valve-regurgitation-and-healthy-individuals-validated-against-invasive-hemodynamic-measurements-of-heart-function
#19
Rine Bakkestrøm, Nicolaj L Christensen, Emil Wolsk, Ann Banke, Jordi S Dahl, Mads J Andersen, Finn Gustafsson, Christian Hassager, Jacob E Møller
AIM: Speckle tracking echocardiography is considered valuable in assessing left ventricular (LV) function. The method has been refined to assess deformation in different myocardial layers, but the effect of volume vs pressure overload on this pattern is unknown. The aim was to test whether layer-specific myocardial strain (LSS) obtained by speckle tracking echocardiography exhibits different patterns in conditions with different loading conditions. METHODS AND RESULTS: Forty patients with asymptomatic severe aortic stenosis (AS) (AVA 0...
January 21, 2018: Echocardiography
https://www.readbyqxmd.com/read/29349803/assessment-of-mitral-annulus-and-mitral-leaflet-in-nonvalvular-atrial-fibrillation-patients-with-various-degrees-of-mitral-regurgitation-real-time-3d-transesophageal-echocardiography
#20
Yongjuan Luo, Yanbo Zhu, Xin Guan, Yunjia Lin
AIM: To study the changes of mitral valve (MV) in patients with nonvalvular atrial fibrillation (NVAF)-related mitral regurgitation (MR) and the relationship between MV parameters and the enlarged left atrium (LA). MATERIALS AND METHODS: A total of 43 patients with NVAF were divided into two groups: (1) the MR1 group with mild MR and (2) the MR2 group with moderate-to-severe MR. Real time 3D transesophageal echocardiography (TEE) was performed to detect the structure of MV...
January 19, 2018: Echocardiography
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