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https://www.readbyqxmd.com/read/29333582/outpatient-erbium-yag-2940%C3%A2-nm-laser-treatment-for-snoring-a-prospective-study-on-40-patients
#1
Isabelle Fini Storchi, Steven Parker, Francesca Bovis, Stefano Benedicenti, Andrea Amaroli
Snoring is a sleep phenomenon due to the partial upper airway obstruction during sleep which causes vibration of the tissues of the rhino-oro-hypopharynx and less frequently the larynx. This study evaluated the use and effectiveness of the erbium:YAG 2940-nm laser as an adjunctive in providing treatment for patients suffering from chronic snoring-related sleep disorders. A prospective study of 40 consecutive patients with snoring and sleep disorders was performed, assessing data before and after three Er:YAG laser treatment sessions...
January 15, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29329519/eikenella-corrodens-endocarditis-and-liver-abscess-in-a-previously-healthy-male-a-case-report
#2
Anne Christine Nordholm, Ruth Ottilia Birgitta Vøgg, Henrik Permin, Terese Katzenstein
BACKGROUND: Eikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male. CASE PRESENTATION: A 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission there was elevated white blood cell count and C-reactive protein, as well as affected liver function tests...
January 12, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29323421/head-and-neck-cancer-tumor-seeding-at-the-percutaneous-endoscopic-gastrostomy-site
#3
REVIEW
June R Greaves
The National Institutes of Health National Cancer Institute estimates that over 13,000 new cases of head and neck cancer (HNC) will be diagnosed in 2017. Patients with HNC often require enteral nutrition (EN) via gastrostomy tube to provide nutrition support and hydration because of tumor obstruction of the oropharynx and/or cumulative effects of chemoradiation therapy. The percutaneous endoscopic gastrostomy (PEG) tube has become the preferred technique for EN access because placement is considered a minimally invasive procedure...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29315499/increased-pathologic-upstaging-with-rising-time-to-treatment-initiation-for-head-and-neck-cancer-a-mechanism-for-increased-mortality
#4
Roy Xiao, Matthew C Ward, Kailin Yang, David J Adelstein, Shlomo A Koyfman, Brandon L Prendes, Brian B Burkey
BACKGROUND: Time to treatment initiation (TTI) is increasing and is associated with worsening survival. In the current study, the authors sought to identify a mechanism for this relationship by assessing the effect of TTI on clinical-to-pathologic upstaging in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Using the National Cancer Data Base, the authors analyzed patients receiving definitive surgery for SCC of the oral cavity, oropharynx, larynx, and hypopharynx from 2005 through 2014...
January 9, 2018: Cancer
https://www.readbyqxmd.com/read/29312616/detection-of-hpv-related-oropharyngeal-cancer-in-oral-rinse-specimens
#5
Matthew Rosenthal, Bin Huang, Nora Katabi, Jocelyn Migliacci, Robert Bryant, Samuel Kaplan, Timothy Blackwell, Snehal Patel, Liying Yang, Zhiheng Pei, Yi-Wei Tang, Ian Ganly
Background: The majority of patients diagnosed with oropharyngeal squamous cell cancer (OPSCC) are due to HPV infection. At present, there are no reliable tests for screening HPV in patients with OPSCC. The objective of this study was to assess the Cobas® HPV Test on oral rinse specimens as an early, non-invasive tool for HPV-related OPSCC. Methods: Oral rinse specimens were collected from 187 patients (45 with OPSCC, 61 with oral cavity SCC (OCSCC) and 81 control patients who had benign or malignant thyroid nodules) treated at MSKCC...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29307651/acute-periprosthetic-joint-infection-due-to-fusobacterium-nucleatum-in-a-non-immunocompromised-patient-failure-using-a-debridement-antibiotics-implant-retention-approach
#6
Pablo S Corona, Mayli Lung, Dolors Rodriguez-Pardo, Carles Pigrau, Francisco Soldado, Carles Amat, Luis Carrera
Fusobacterium nucleatum is an obligately anaerobic gram-negative rod, a component of the microbiome of the oropharynx and the gastrointestinal and urogenital tracts, causing an array of human infections which often include periodontal pathologies. As far as we know, there are no previous publications about acute periprosthetic joint infection due to Fusobacterium sp.; we report the first case in the medical literature of an aggressive, acute knee prosthetic infection due to F. nucleatum in a non-immunocompromised patient, unsuccessfully treated with a DAIR approach (Debridement + Antibiotics + Implant Retention)...
January 4, 2018: Anaerobe
https://www.readbyqxmd.com/read/29303995/local-acetaldehyde-an-essential-role-in-alcohol-related-upper-gastrointestinal-tract-carcinogenesis
#7
REVIEW
Mikko T Nieminen, Mikko Salaspuro
The resident microbiome plays a key role in exposure of the upper gastrointestinal (GI) tract mucosa to acetaldehyde (ACH), a carcinogenic metabolite of ethanol. Poor oral health is a significant risk factor for oral and esophageal carcinogenesis and is characterized by a dysbiotic microbiome. Dysbiosis leads to increased growth of opportunistic pathogens (such as Candida yeasts) and may cause an up to 100% increase in the local ACH production, which is further modified by organ-specific expression and gene polymorphisms of ethanol-metabolizing and ACH-metabolizing enzymes...
January 5, 2018: Cancers
https://www.readbyqxmd.com/read/29302305/lemierre-syndrome-a-diagnostic-dilemma-in-paediatric-patients
#8
Fatemeh Rafati, Vishal Bhalla, Varun Chillal, Mani Thyagarajan
Lemierre's syndrome is a rare disease of the head and neck, characterized by an initial infection, usually within the oropharynx, which can develop into a septic thrombophlebitis. It can involve the jugular vein, facial veins and respiratory tract. A 7-year-old child attended our institution with a 1-week history of fever and cough. Initial imaging demonstrated a large left sided empyema with multiple cavitating lung lesions and persisting pneumothoraces secondary to the development of a bronchopleural fistula...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29297174/emergence-of-a-novel-staging-system-for-oropharyngeal-squamous-cell-carcinoma-based-on-hpv-status
#9
Aru Panwar, Erik Interval, William M Lydiatt Emba
The staging of oropharyngeal squamous cell carcinoma has undergone key changes in the eighth edition of the American Joint Committee on Cancer Staging Manual, set to take effect January 1, 2018. The most significant change relates to the development of a novel staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas, distinct from that for non-HPV-associated squamous cell carcinomas of the oropharynx. We describe the revised staging parameters and the rationale in support of the changes...
December 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29290281/optimising-volumetric-arc-radiotherapy-for-dental-rehabilitation-in-oropharynx-cancer-a-retrospective-dosimetry-review-and-feasibility-planning-study
#10
Sean M O'Cathail, Naveen Karir, Ketan Shah
PURPOSE: To assess the dosimetry to dentally relevant substructures within the mandible/maxilla, establish the predictors of increased mean anterior mandible dose and assess the feasibility of rationale optimisation of dose to the anterior mandible (AM) volume to aid reconstructive dental surgery planning, where the AM is a critical structure. MATERIALS AND METHODS: In a cohort of radically treated oropharynx cancer patients we conducted a retrospective dosimetry analysis of mandible/maxilla volumes, created using a published atlas...
January 2018: Oral Oncology
https://www.readbyqxmd.com/read/29283921/a-simulation-study-to-evaluate-improvements-in-anesthesia-work-environment-contamination-after-implementation-of-an-infection-prevention-bundle
#11
Grete H Porteous, Helen A Bean, Crystal M Woodward, Ryan P Beecher, Jennifer R Bernstein, Sarah Wilkerson, Ian Porteous, Robert L Hsiung
BACKGROUND: Microbiological contamination of the anesthesia work environment (AWE) is a potential source of health care-associated infections. Medication syringes, stopcocks, and many other areas are routinely contaminated during anesthetic care, and adherence to hand hygiene recommendations is poor. Using a simulation model, we investigated whether AWE contamination could be reduced by implementing an intervention bundle focused on infection prevention. METHODS: Twenty-five anesthesia providers were enrolled in this nonrandomized simulation scenario crossover design study...
December 26, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29280468/superiority-in-robustness-of-multifield-optimization-over-single-field-optimization-for-pencil-beam-proton-therapy-for-oropharynx-carcinoma-an-enhanced-robustness-analysis
#12
Kristin Stützer, Alexander Lin, Maura Kirk, Liyong Lin
PURPOSE: To compare the difference in robustness of single-field optimized (SFO) and robust multifield optimized (rMFO) proton plans for oropharynx carcinoma patients by an improved robustness analysis. METHODS AND MATERIALS: We generated rMFO proton plans for 11 patients with oropharynx carcinoma treated with SFO intensity modulated proton therapy with simultaneous integrated boost prescription. Doses from both planning approaches were compared for the initial plans and the worst cases from 20 optimization scenarios of setup errors and range uncertainties...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29279248/primary-surgical-management-with-radial-forearm-free-flap-reconstruction-in-t4-oropharyngeal-cancer-complications-and-functional-outcomes
#13
John R Sims, Eric J Moore
PURPOSE: Functional outcomes and complication rates after open surgery for advanced-stage oropharyngeal cancers are rarely reported. These measures are critical for choice of treatment modality and patient counseling. We describe the long term functional outcomes and associated complications of primary surgical management of T4 oropharyngeal cancers reconstructed with radial forearm free flaps. MATERIALS AND METHODS: A retrospective review was performed of 40 patients with T4 oropharyngeal cancers treated between 2005 and 2015 at a tertiary care center...
December 18, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29277334/neurological-disease-may-precede-lymphadenopathies-in-actinomyces-europaeus-infection
#14
Silvia Corcione, Antonio Curtoni, Ivana A Paolucci, Giovanni Di Perri, Francesco G De Rosa, Rossana Cavallo
Actinomyces species are part of the commensal flora of the mucous membranes of the oropharynx, gastrointestinal tract and female genital tract. Actinomyces europaeus is a short, nonmotile, facultative anaerobic rod first described in 1997, susceptible in vitro to a wide range of b-lactam antibiotics which are regarded as first choice. In this report we described the case of A. europaeus infection in a young female patient admitted to Intensive Care Unit and the possible damage of vascular endothelium due to a chronic progressive actinomycosis that at first involved neck soft tissue, then cervical lymphnodes, and finally extended to the vascular structure...
December 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29247568/oropharynx-directed-ipsilateral-irradiation-for-p16-positive-squamous-cell-carcinoma-involving-the-cervical-lymph-nodes-of-unknown-primary-origin
#15
Allen M Chen, Jessica Meshman, Sophia Hsu, Taeko Yoshizaki, Elliot Abemayor, Maie St John
BACKGROUND: The purpose of this study was to present our findings on the use of limited-field, oropharynx-directed ipsilateral irradiation for p16-positive squamous cell carcinoma of unknown primary origin. METHODS: Between April 2011 and January 2016, 25 patients with a histological diagnosis of p16-positive squamous cell carcinoma were selectively irradiated to the ipsilateral oropharynx and cervical neck for tumors of unknown primary origin. The dose to the oropharynx ranged from 54-60 Gy (median 60 Gy) in 30-33 fractions...
December 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/29247495/presenting-symptoms-and-long-term-survival-in-head-and-neck-cancer
#16
C M Douglas, K Ingarfield, A D McMahon, S A Savage, D I Conway, K MacKenzie
OBJECTIVES: To assess how type and number of symptoms are related to survival in head and neck cancer patients. DESIGN: Patients were followed-up for over 10 years from the Scottish Audit of Head and Neck Cancer; (national cohort of head and neck cancer patients in Scotland 1999 - 2001). September 2013, cohort was linked to national mortality data. First, second and third presenting symptoms were recorded at diagnosis. SETTING: National prospective audit - Scotland...
December 15, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29243259/a-unique-anomaly-of-the-ear-oculo-auriculo-vertebral-spectrum-or-an-isolated-disruption
#17
Eleonoor A R Theunissen, Isabella C M Hoogslag, Erik van Spronsen, Roelof J Oostra, Fenna A Ebbens
We present a rare case of a neonate with an isolated congenital condition of his right ear involving the outer ear, middle ear, eustachian tube, and the facial nerve, with an external opening into the skull that connects to the oropharynx. Taking this bizarre aspect of the exterior lesion and the oropharyngeal communication into account, we consider the condition presented here, which to our knowledge is the first of its kind to have resulted from a vascular disruption. Laryngoscope, 2017.
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29243245/treatment-deintensification-in-human-papillomavirus-positive-oropharynx-cancer-outcomes-from-the-national-cancer-data-base
#18
Shayan Cheraghlou, Phoebe K Yu, Michael D Otremba, Henry S Park, Aarti Bhatia, Cheryl K Zogg, Saral Mehra, Wendell G Yarbrough, Benjamin L Judson
BACKGROUND: The growing epidemic of human papillomavirus-positive (HPV+) oropharyngeal cancer and the favorable prognosis of this disease etiology have led to a call for deintensified treatment for some patients with HPV+ cancers. One of the proposed methods of treatment deintensification is the avoidance of chemotherapy concurrent with definitive/adjuvant radiotherapy. To the authors' knowledge, the safety of this form of treatment de-escalation is unknown and the current literature in this area is sparse...
December 15, 2017: Cancer
https://www.readbyqxmd.com/read/29235037/expression-and-significance-of-cytokeratin-7-a-squamocolumnar-junction-marker-in-head-and-neck-squamous-cell-carcinoma
#19
Mitra Mehrad, William D Dupont, W Dale Plummer, James S Lewis
The favorable features of high-risk human papillomavirus (HPV) in the head and neck are limited to those harboring transcriptionally-active HPV, which occur predominantly in the oropharynx (OP). Factors rendering the OP susceptible to HPV oncogenesis are largely unexplored. The role of cytokeratin 7 (CK7) in predisposition to HPV and cancer in the cervix has been evaluated. However, its significance in the H&N is unknown. CK7 immunohistochemistry was performed on a tissue microarray cohort of OP and non-oropharyngeal (NOP) squamous cell carcinomas (SCC) with known clinical follow-up and HPV E6/7 mRNA status...
December 12, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29229323/mri-based-assessment-of-3d-intrafractional-motion-of-head-and-neck-cancer-for-radiation%C3%A2-therapy
#20
Oliver J Gurney-Champion, Dualta McQuaid, Alex Dunlop, Kee H Wong, Liam C Welsh, Angela M Riddell, Dow-Mu Koh, Uwe Oelfke, Martin O Leach, Christopher M Nutting, Shreerang A Bhide, Kevin J Harrington, Rafal Panek, Kate L Newbold
PURPOSE: To determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Dynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC in the treatment position were analyzed. Dynamic contrast-enhanced magnetic resonance imaging consisted of 3D images acquired every 2.9 seconds for 4 minutes 50 seconds. Intrafractional tumor motion was studied in the 3 minutes 43 seconds of images obtained after initial contrast enhancement...
October 16, 2017: International Journal of Radiation Oncology, Biology, Physics
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